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1.
Niger J Clin Pract ; 25(10): 1745-1750, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2100047

ABSTRACT

Background: The C-reactive protein (CRP)/albumin ratio (CAR) is one of the new tools to assess the severity of inflammation. It is used to determine clinical severity and prognosis in many diseases. Aim: The present study aimed to investigate the relationship between C-reactive protein (CRP)/albumin ratio (CAR) and prognosis in pregnant patients with more severe COVID-19 infection. Retrospective study. Patients and Methods: The study was conducted in a retrospective manner by scanning the files of pregnant patients who had a positive polymerase chain reaction test result and were hospitalized in Adiyaman Training and Research Hospital. The patients were divided into two groups: patients who were admitted to the intensive care unit and patients who were not admitted. CRP/albumin ratio (CAR) levels were compared between these two groups. The cut-off value was determined in the prediction of intensive-care admission and poor prognosis. Results: 117 patient files were reviewed. 13 patients were followed up with intensive care, whereas 104 patients completed their treatment in the service. The CAR levels of the patients admitted to intensive care were significantly higher (P < 0.01). In the estimation of intensive-care admission, the CAR level was determined to be 0.970 in the area under the curve with 100% sensitivity and 86.5% specificity in the receiver operating characteristic (ROC) curve. The cut-off CAR level was calculated as 1.8. Conclusion: CAR is a valuable biomarker for predicting prognosis, as well as follow-ups of pregnant COVID-19 patients.


Subject(s)
C-Reactive Protein , COVID-19 , Humans , Pregnancy , Female , C-Reactive Protein/analysis , Retrospective Studies , Prognosis , Albumins
3.
Handbook of Research on the Impacts and Implications of COVID-19 on the Tourism Industry ; : 645-663, 2021.
Article in English | Scopus | ID: covidwho-2055614

ABSTRACT

The tourism sector is one of the main economic sectors of both developed and developing countries. It is one of the sectors that feels the most destructive effects of COVID-19 in terms of generating income, providing employment, and covering many sub-sectors. A number of practices, recommendations, and decisions have been put forward to minimize the devastating effects of the pandemic by the international bodies. Although the COVID-19 epidemic has been brought under control in some countries with various vaccination practices and a new normalization process has been entered into, the traces of its destructive effects are still visible in the tourism industry. Therefore, this chapter draws the attention of the reader to comprehensive and up to the present unconventional practices in the industry due to the impacts of COVID-19 on the tourism and hospitality industry. © 2021, IGI Global.

4.
Turkish Journal of Public Health ; 20(2):235-243, 2022.
Article in English | CAB Abstracts | ID: covidwho-2040552

ABSTRACT

Objective: Currently the Covid-19 pandemic is studied with great expectations by several epidemiological models with the aim of predicting the future behaviour of the pandemic. Determining the level of disorder in the pandemic can give us insight into the societal reactions to the pandemic the socio-economic structures and health systems in different countries.

5.
Annals of the Rheumatic Diseases ; 81:1662-1663, 2022.
Article in English | EMBASE | ID: covidwho-2008815

ABSTRACT

Background: Considering the concerns regarding COVID-19 vaccine safety among patients with rheumatic diseases due to a lack of data, an urgent need for studies evaluating safety profiles of vaccines emerged. Objectives: Vaccination against the coronavirus disease-2019 (COVID-19) started in March 2021 in the group using biological therapy in our country. In this study, post-vaccine real-life data of patients with spondyloarthritis (SpA) followed up with biological therapy were analyzed. Methods: Adult patients diagnosed with SpA who were followed up under biological therapy and vaccinated by CoronaVac inactive SARS-CoV-2 orBNT162b2 messenger RNA (mRNA) COVID-19 (Pfzer-BioNTech) vaccine were included in our observational, multicenter, prospective study. Results: A total of 287 patients (58.2% male;mean age: 47) were included in the study. 202 (%70,4) of patients were being followed up with the diagnosis of AS, 40 (%13,9) of them with PsA, 32 (%11,1) of them with nr-axSpA, 11 (%3,8) of them with enteropathic arthritis, and 2 (%0,7) of them with uSpA. The most common comorbidities were found to be HT (n:65;22.6%) and DM (n:38;13.2%). While 221 (77%) of the patients were receiving biological therapy alone, 27 (9.4%) patients were using methotrexate, 25 (8.7%) patients were using sul-fasalazine, and 12 (4.2%) patients were using lefunomide. The median duration of biological therapy was 40 weeks (19-75 IQR). The most commonly used treatment was infiximab (26.8%), adalimumab (23.3%) was the second (Table 1). It was determined that 207 (72.1%) of the patients preferred inactivated virus vaccine, while 80 (27.9%) preferred mRNA vaccine. When the time between the biological treatment and the day of vaccination is examined, detected median time between biological treatment and the frst dose of vaccination is 11.5 days (5-19 IQR), between the frst dose of vaccination and biological treatment is 14 days (7-21 IQR), between treatment and the second dose of vaccine is 14 days (5-23.5 IQR), and between the second dose of vaccine and the next biological treatment is 12.5 days (7-15 IQR). While 25 (8.7%) of the patients had COVID-19 infection before vaccination, 7 (2.4%) patients were found to have COVID-19 after vaccination (p<0.001). While two of the patients who had COVID-19 infection in the pre-vaccination period required hospitalization, none of the patients who had COVID-19 in the post-vaccination period required hospitalization. The rate of patients who developed side effects after the frst dose of the vaccine was 20.6%. The side effects seen, respectively, were detected as pain-redness at the injection site (16%), fatigue (11.8%), headache (8.4%), muscle-joint pain (7.3%) and fever (5.6%). The rate of patients reporting side effects after the second dose of the vaccine was 17.1%. The incidence of side effects after mRNA vaccine was found to be statistically signifcant compared to inactivated virus vaccine in terms of both doses (p=0.011, p<0.001). Major side effects such as myocarditis, ana-phylaxis-angioedema, myocardial infarction, and thrombosis were not observed in any of the patients included in the study. There was no evidence of disease activation in the median follow-up of 209 days (145-280 IQR) after vaccination. Conclusion: During the follow-up of the patients during the study, no major vaccine-related side effects, post-vaccine disease activation and the need for treatment change were not detected. In order to more accurately evaluate the efficacy of the vaccination program in the patient population using biologic agents, larger-scale studies including unvaccinated individuals are needed.

6.
HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI ; 60(3):204-210, 2022.
Article in English | Web of Science | ID: covidwho-1939265

ABSTRACT

Aim: Patients with chronic diseases were forced into lockdown due to the coronavirus disease-2019 pandemic. Extended quarantine could lead to physical inactivity and psychiatric problems. We investigated the effects of quarantine and social isolation during the pandemic on the motor and non-motor symptoms (NMS) of Parkinson's disease (PD) patients with and without deep brain stimulation (DBS). Methods: This study included 168 patients with PD who were in quarantine for 2 months (between April 1, 2020 and May 31, 2020). Eighty-three patients had undergone bilateral subthalamic DBS surgery. A questionnaire with three parts was administered via phone: 1) motor symptoms, 2) NMS, and 3) the reasons for impairment. Results: Of the patients, 54.7% reported impairment in at least one motor symptom and 58.9% reported impairment in at least one NMS. Increased tremors, difficulty with turning in bed, and insomnia were significantly more pronounced in patients without DBS. Patients with DBS complained less of being bored due to staying at home and had less deterioration due to lack of exercise and slower disease progression. Conclusion: Half of the symptoms of patients with PD worsened during quarantine, but patients with DBS tolerated the lockdown better. Telemedicine and online physiotherapy programs should be recommended to prevent rapid disease progression.

7.
Participatory Educational Research ; 9(4):379-395, 2022.
Article in English | Scopus | ID: covidwho-1876271

ABSTRACT

Massive Open Online Courses (MOOCs) are considered learning environments that eliminate many learning barriers. Online courses in MOOCs have become an opportunity for everyone during the lockdown of the COVID-19 outbreak. However, usability issues may cause problems such as high dropout rates and lack of learner's motivation. Therefore, in this study, the usability of Coursera, one of the most known MOOCs in the world, was evaluated. The evaluation was performed with ISO 9241-11 standard. The environment's effectiveness, efficiency, and satisfaction were evaluated with the authentic tasks requested to be done in Coursera. Additionally, the findings were supported by eye-tracking metrics such as fixation duration, fixation counts, heat maps, and gaze plots. Twelve individuals (six females, six males) participated in the authentic tasks, and three individuals (two females, one male) participated in the eye-tracking phase. Results of the study revealed that most participants successfully performed the authentic tasks and are generally satisfied with the usability of the environment. However, considering eye-tracking findings and Coursera Usage Satisfaction Survey, some usability problems such as inadequate language support and the difficulty of using the search feature emerged. In the end, possible reasons were discussed, and the suggestions were presented for usability improvements. © 2022, Ozgen Korkmaz. All rights reserved.

15.
Antimicrobial Resistance and Infection Control ; 10(SUPPL 2), 2021.
Article in English | EMBASE | ID: covidwho-1631640

ABSTRACT

Introduction: Healthcare-associated infections (HAI) are the most frequent adverse event in healthcare. Hand Hygiene (HH) is a crucial intervention to prevent the transmission of HAIs that should be learned in the early years of education by health care workers. Since COVID 19 pandemic hit education systems worldwide and face-to-face (f2f) training stopped, there is a need for innovative and effective distance educational interventions. Objectives: This pre-test, post-test intact group experimental design educational intervention study aims to create a unique online HH training program/competition which motivates students to participate and learn with high satisfaction. Methods: HH training program/competition was developed with the involvement of all 8 health sciences faculties and 11 medical colleges' representatives in one f2f[jc1] and two online meetings. Pre/posttests, skills training guides and WHO guidelines-based ppt presentations were developed. Materials were made accessible at the "flipgrid" application. Students registered and attended 2 h long synchronous pre-test, demonstration sessions through Zoom and Facebook stream followed by a post-test. They then recorded and uploaded their correct handwashing practice. We used Google forms to collect students' feedback (0 very bad-10 very good). Results: The total target students number was 14.180. 812 and 1412 students completed pre and post-test respectively and 1.900 during the stream. All 212 students who uploaded videos were evaluated, ranked between 0 and 100, receiving written feedback. Post-test scores were high (x = 81.0 ± 2.3). There were significant differences between mean total scores (t = 26.5;p < 0.000) of the pre-post test. The mean score of the evaluated videos was found as (x = 72.0 ± 1.4). 842 students provided feedback;general satisfaction was very high (x = 9.57 ± 1.11). Conclusion: This study suggests that the organization of nationwide online HH training/competition for health students is feasible and associated with acceptable participation rates and learning levels, with high satisfaction. Technology,internet access and digital literacy levels remain under-researched in this study to explain nationwide 10% participation.

16.
Annals of Clinical and Analytical Medicine ; 12(8):951-957, 2021.
Article in English | Web of Science | ID: covidwho-1622731

ABSTRACT

Recent data show that no age group is excluded from the possibility of SARS-CoV-2 infection. However, it is more likely to affect the elderly with comorbidities such as cardiovascular and pulmonary diseases, diabetes, and hypertension that can lead to the progression of COVID-19. Dyslipidemia is often found with these comorbid diseases. According to recent findings, lipoproteins, and particularly high-density lipoprotein cholesterol (HDL-C), may play a role in regulating the entry of the SARS-CoV-2 virus into the host cell. In fact, HDL-C has many beneficial properties, including anti-inflammatory, anti-oxidative, anti-thrombotic, anti-infectious, anti-apoptotic, intercellular commu- nication, and pro-vasodilator capacities. HDL-C has an affinity for binding and neutralization of the pathogen. The link between COVID-19 and lipid-dependent pathologies has not yet been fully understood. We draw attention to the molecules and functions involved in HDL-C. Because many therapeutic compounds that regulate HDL-C functions and metabolism can be used in the treatment of COVID-19 recently.

17.
Annals of Clinical and Analytical Medicine ; 12(8):949-955, 2021.
Article in English | EMBASE | ID: covidwho-1377082

ABSTRACT

Recent data show that no age group is excluded from the possibility of SARS-CoV-2 infection. However, it is more likely to affect the elderly with comorbidities such as cardiovascular and pulmonary diseases, diabetes, and hypertension that can lead to the progression of COVID-19. Dyslipidemia is often found with these comorbid diseases. According to recent findings, lipoproteins, and particularly high- density lipoprotein cholesterol (HDL-C), may play a role in regulating the entry of the SARS-CoV-2 virus into the host cell. In fact, HDL-C has many beneficial properties, including anti-inflammatory, anti-oxidative, anti-thrombotic, anti-infectious, anti-apoptotic, intercellular communication, and pro-vasodilator capacities. HDL-C has an affinity for binding and neutralization of the pathogen. The link between COVID-19 and lipid-dependent pathologies has not yet been fully understood. We draw attention to the molecules and functions involved in HDL-C. Because many therapeutic compounds that regulate HDL-C functions and metabolism can be used in the treatment of COVID-19 recently.

18.
Turkiye Klinikleri tip Bilimleri Dergisi ; 41(2):176-188, 2021.
Article in English | CAB Abstracts | ID: covidwho-1352898

ABSTRACT

Viruses invade cells to reproduce, and they require an iron-filled cell for efficient reproduction. Together with other viruses, the coronavirus disease-2019 (COVID-19) virus can alter the expression of proteins involved in iron homeostasis. For example, in COVID-19 patients, an increase in pro-inflammatory cytokines such as interleukin-6 may stimulate the synthesis of hepcidin, the regulatory hormone of iron metabolism, thereby suppressing ferroportin-mediated cellular iron export. Increased serum levels of ferritin in COVID-19 virus infection is associated with a poor prognosis and may be partly due to the virus itself. Some viruses selectively infect iron acceptor cells (e.g. macrophages) by binding to transferrin receptor 1 during cell entry. Moreover, human airway secretions in the major route of entry of COVID-19 include transferrin and lactoferrin, and this glycoproteins can bind iron and maintain a chemically inert form. Understanding how iron metabolism and viral infection interact in the COVID-19 outbreak may suggest new ways to control the disease.

19.
Annals of Clinical and Analytical Medicine ; 12(2):150-152, 2021.
Article in English | Web of Science | ID: covidwho-1239078

ABSTRACT

Aim: In this study, we aimed to research whether the serum lactate of the COVID-19 patients presented to the initial emergency department can be used to make prognosis of the patients. Materials and Methods: A total of 39 COVID-19 patients were included in the study. Fourteen (35.8%) patients were over 65 years old (Group 1). Twenty-five patients (64.2%) were under 65 years old (Group 2). The diagnosis was made via the oro-nasopharyngeal swab PCR test. We noted the demographic data (age, gender, comorbidities), initial (emergency service presentation) complete blood count parameters including WBC, Plt/Lymp ratio, CRP, procalcitonin and serum lactate levels. We also noted the hospitalization unit (clinic/intensive care unit), hospitalization length, and the outcomes. Patients were divided into two groups according to 65 years and the groups' laboratory results with the prognosis. Results: The mean age of the study group was 55 years. Fourteen (35.8%) patients were over 65 years old. Serum lactate levels did not significantly differ between groups. Hospital length of stay was significantly longer in patients over 65 years of age. Age and hospitalization length were positively correlated with age in all patients. Discussion: Serum lactate level measurement has recently become an important parameter especially for critically ill patients. It is beneficial for predicting the severity and prognosis in severe infections. Serum lactate levels in COVID-19 patients did not differ between age groups. Hospitalization length was longer in elderly patients.

20.
Journal of Experimental and Clinical Medicine (Turkey) ; 38(3):255-259, 2021.
Article in English | EMBASE | ID: covidwho-1224457

ABSTRACT

To investigate a possible deterioration of the symptoms of Alzheimer's disease (AD) patients during a quarantine period of 60 days, and the impact on caregiver burden. This study consisted of 54 individuals (36 female, 18 male) aged 60 years and over who had been diagnosed with AD. During the quarantine period, caregivers of the patients (child, spouse, relatives) who were confined to their homes were contacted by phone and administered a survey composed of questions for neuropsychiatric symptoms and caregiver burden. Patients' mean age was 77.18±6.96 years. The most worsening symptom was forgetfulness (35.2%) and agitation (24.1%). Incoherent speech, introversion, sleep disturbance, hallucinations, carry on with hobbies, reduced personal care, changes in appetite, and incontinence were less deteriorated. Of the caregivers, 61.1% thought that something terrible would happen to the patient, and 38.9% felt they could not find time for themselves. Drug rejection increased the burden twofold. Telemedicine methods, providing opportunities for the caregiver and the patient to walk outside, and giving medication that dissolves in the mouth or epidermal patches may be useful to prevent disease progression during the lockdown.

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