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ASAIO J ; 66(6): 603-606, 2020 06.
Article in English | MEDLINE | ID: covidwho-72456


The outbreak of novel coronavirus (SARS-CoV-2) that causes the respiratory illness COVID-19 has led to unprecedented efforts at containment due to its rapid community spread, associated mortality, and lack of immunization and treatment. We herein detail a case of a young patient who suffered life-threatening disease and multiorgan failure. His clinical course involved rapid and profound respiratory decompensation such that he required support with venovenous extracorporeal membrane oxygenation (VV-ECMO). He also demonstrated hyperinflammation (C-reactive protein peak 444.6 mg/L) with severe cytokine elevation (Interleukin-6 peak > 3000 pg/ml). Through treatment targeting hyperinflammation, he recovered from critical COVID-19 respiratory failure and required only 160 hours of VV-ECMO support. He was extubated 4 days after decannulation, had progressive renal recovery, and was discharged to home on hospital day 24. Of note, repeat SARS-CoV-2 test was negative 21 days after his first positive test. We present one of the first successful cases of VV-ECMO support to recovery of COVID-19 respiratory failure in North America.

Betacoronavirus , Coronavirus Infections/complications , Extracorporeal Membrane Oxygenation , Pneumonia, Viral/complications , Respiratory Insufficiency/therapy , Adult , COVID-19 , Cytokines/immunology , Humans , Inflammation/immunology , Male , Pandemics , Patient Discharge , Respiratory Insufficiency/etiology , SARS-CoV-2