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1.
Int J Gynaecol Obstet ; 2021 Nov 11.
Article in English | MEDLINE | ID: covidwho-1525440

ABSTRACT

OBJECTIVE: To evaluate the correlation of maternal and cord blood levels of SARS-CoV-2 antibodies in pregnant women immunized against COVID-19. METHODS: A prospective cohort study was performed of pregnant women who delivered at a single university affiliated tertiary medical center. Women who received the COVID-19 vaccine (BNT162b2 Pfizer©) were approached. The correlation between levels of maternal sera and umbilical cord SARS-CoV-2 specific IgG was assessed. RESULTS: Overall, 58 women were included; of them, 19 had received a single dose and 39 received two doses of the COVID-19 vaccine. Positive levels of umbilical cord IgG were found in 13/19 (68.4%) and 38/39 (97.4%) women after the administration of a single dose and two doses of the vaccine, respectively. The levels of SARS-CoV-2 IgG antibodies in the maternal sera of vaccinated women were positively correlated to their respective concentrations in cord blood sera (ρ = 0.857; R2 linear = 0.719; P < 0.001). Thirteen days after vaccination, the ratio of maternal-to-umbilical cord anti Spike IgG antibodies was approximately 1, indicating relatively similar levels in maternal and cord sera. CONCLUSION: After the SARS-CoV-2 vaccine, levels of maternal and cord blood antibodies were positively correlated, especially when tested after 13 days following administration of the first dose of the vaccine.

2.
Nat Commun ; 12(1): 6222, 2021 10 28.
Article in English | MEDLINE | ID: covidwho-1493103

ABSTRACT

The importance of breastmilk in postnatal life lies in the strong association between breastfeeding and the reduction in the risk of infection and infection-related infant mortality. However, data regarding the induction and dynamics of breastmilk antibodies following administration of the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine is scarce, as pregnant and lactating women were not included in the initial vaccine clinical trials. Here, we investigate the dynamics of the vaccine-specific antibody response in breastmilk and serum in a prospective cohort of ten lactating women who received two doses of the mRNA vaccine. We show that the antibody response is rapid and highly synchronized between breastmilk and serum, reaching stabilization 14 days after the second dose. The response in breastmilk includes both IgG and IgA with neutralization capacity.


Subject(s)
Breast Feeding , COVID-19 Vaccines/genetics , RNA, Messenger/blood , Adult , Animals , Antibody Formation/genetics , Antibody Formation/physiology , Female , Humans , Milk/chemistry , RNA, Messenger/analysis , Vaccines, Synthetic/therapeutic use
3.
Vouga, Manon, Favre, Guillaume, Martinez Perez, Oscar, Pomar, Leo, Forcen Acebal, Laura, Abascal, Alejandra, Vila Hernandez, Maria Rosa, Hcini, Najeh, Lambert, Véronique, Carles, Gabriel, Sichitiu, Joanna, Salomon, Laurent, Stiremann, Julien, Ville, Yves, Martinez de Tejada, Begoña, Goncé, Anna, Hawkins-Villareal, Ameth, Castillo, Karen, Gratacos Solsona, Eduard, Trigo, Lucas, Cleary, Brian, Geary, Michael, Bartels, Helena, Al-Kharouf, Feras, Malone, Fergal, Higgins, Mary, Keating, Niamh, Knowles, Susan, Poncelet, Christophe, Carvalho, Carolina, Ribeiro-do-Valle, Fernanda, Surita, Garanhani, Dantas-Silva, Amanda, Borrelli, Carolina, Gomes Luz, Adriana, Fuenzalida, Javiera, Carvajal, Jorge, Guerra Canales, Manuel, Hernandez, Olivia, Grechukhina, Olga, Ko, Albert I.; Reddy, Uma, Figueiredo, Rita, Moucho, Marina, Viana Pinto, Pedro, De Luca, Carmen, De Santis, Marco, Ayres de Campos, Diogo, Garabedian, Charles, Subtil, Damien, Bohrer, Betania, Da Rocha Oppermann, Maria Lucia, Celeste, Maria, Wender, Osorio, Schuler-Faccini, Lavinia, Vieira Sanseverino, Maria Teresa, Giugliani, Camila, Friedrich, Luciana, Horn Scherer, Mariana, Mottet, Nicolas, Ducarme, Guillaume, Pelerin, Helene, Moreau, Chloe, Breton, Bénédicte, Quibel, Thibaud, Rozenberg, Patrick, Mueller, Doris, Granado, Cristina, Hoesli, Irene, Monod, Cécile, Bassler, Dirk, Heldstab, Sandra, Ochsenbein Kölble, Nicole, Sentilhes, Loïc, Charvet, Melissa, Deprest, Jan, Richter, Jute, Van der Veeken, Lennart, Eggel-Hort, Béatrice, Plantefeve, Gaetan, Derouich, Mohamed, Nieto Calvache, Albaro José, Lopez-Giron, Maria Camila, Burgos-Luna, Juan Manuel, Escobar-Vidarte, Maria Fernanda, Hecher, Kurt, Tallarek, Ann-Christin, Hadar, Eran, Krajden Haratz, Karina, Malinger, Gustavo, Maymon, Ron, Yogev, Yariv, Schäffer, Leonhard, Toussaint, Arnaud, Rossier, Marie-Claude, Moreira de sa, Renato Augusto, Grawe, Claudia, Aebi-Popp, Karoline, Radan, Anda-Petronela, Raio, Luigi, Surbek, Daniel, Böckenhoff, Paul, Strizek, Brigitte, Kaufmann, Martin, Bloch, Andrea, Boulvain, Michel, Johann, Silke, Heldstab, Sandra Andrea, Todesco Bernasconi, Monya, Grant, Gaston, Feki, Anis, Muller Brochut, Anne-Claude, Giral, Marylene, Sedille, Lucie, Papadia, Andrea, Capoccia Brugger, Romina, Weber, Brigitte, Fischer, Tina, Kahlert, Christian, Nielsen Saines, Karin, Cambou, Mary, Kanellos, Panagiotis, Chen, Xiang, Yin, Mingzhu, Haessig, Annina, Baud, David, Panchaud, Alice.
Preprint in English | SSRN | ID: ppcovidwho-2803
4.
Vouga, Manon, Favre, Guillaume, Martinez Perez, Oscar, Pomar, Leo, Forcen Acebal, Laura, Abascal, Alejandra, Vila Hernandez, Maria Rosa, Hcini, Najeh, Lambert, Véronique, Carles, Gabriel, Sichitiu, Joanna, Salomon, Laurent, Stiremann, Julien, Ville, Yves, Martinez de Tejada, Begoña, Goncé, Anna, Hawkins-Villareal, Ameth, Castillo, Karen, Gratacos Solsona, Eduard, Trigo, Lucas, Cleary, Brian, Geary, Michael, Bartels, Helena, Al-Kharouf, Feras, Malone, Fergal, Higgins, Mary, Keating, Niamh, Knowles, Susan, Poncelet, Christophe, Carvalho, Carolina, Ribeiro-do-Valle, Fernanda, Surita, Garanhani, Dantas-Silva, Amanda, Borrelli, Carolina, Gomes Luz, Adriana, Fuenzalida, Javiera, Guerra Canales, Manuel, Hernandez, Olivia, Grechukhina, Olga, Ko, Albert, Reddy, Uma, Figueiredo, Rita, Moucho, Marina, Viana Pinto, Pedro, De Luca, Carmen, De Santis, Marco, Ayres de Campos, Diogo, Garabedian, Charles, Subtil, Damien, Bohrer, Betania, Da Rocha Oppermann, Maria Lucia, Celeste, Maria, Wender, Osorio, Schuler-Faccini, Lavinia, Vieira Sanseverino, Maria Teresa, Giugliani, Camila, Friedrich, Luciana, Horn Scherer, Mariana, Mottet, Nicolas, Ducarme, Guillaume, Pelerin, Helene, Moreau, Chloe, Breton, Bénédicte, Quibel, Thibaud, Rozenberg, Patrick, Mueller, Doris, Granado, Cristina, Hoesli, Irene, Monod, Cécile, Bassler, Dirk, Heldstab, Sandra, Ochsenbein Kölble, Nicole, Sentilhes, Loïc, Charvet, Melissa, Deprest, Jan, Richter, Jute, Van der Veeken, Lennart, Eggel-Hort, Béatrice, Plantefeve, Gaetan, Derouich, Mohamed, Nieto Calvache, Albaro José, Lopez-Giron, Maria Camila, Burgos-Luna, Juan Manuel, Escobar-Vidarte, Maria Fernanda, Hecher, Kurt, Tallarek, Ann-Christin, Hadar, Eran, Krajden Haratz, Karina, Malinger, Gustavo, Maymon, Ron, Yogev, Yariv, Schäffer, Leonhard, Toussaint, Arnaud, Rossier, Marie-Claude, Moreira de sa, Renato Augusto, Grawe, Claudia, Aebi-Popp, Karoline, Radan, Anda-Petronela, Raio, Luigi, Surbek, Daniel, Böckenhoff, Paul, Strizek, Brigitte, Kaufmann, Martin, Bloch, Andrea, Boulvain, Michel, Johann, Silke, Todesco Bernasconi, Monya, Grant, Gaston, Feki, Anis, Muller Brochut, Anne-Claude, Giral, Marylene, Sedille, Lucie, Papadia, Andrea, Capoccia Brugger, Romina, Weber, Brigitte, Fischer, Tina, Kahlert, Christian, Nielsen Saines, Karin, Cambou, Mary, Kanellos, Panagiotis, Chen, Xiang, Yin, Mingzhu, Haessig, Annina, Baud, David, Panchaud, Alice.
Preprint in English | SSRN | ID: ppcovidwho-2498
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