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1.
Kanzo/Acta Hepatologica Japonica ; 61(10):496-503, 2020.
Article in Japanese | EMBASE | ID: covidwho-20243418

ABSTRACT

COVID-19 due to severe acute respiratory syndrome coronavirus 2, which has become a global pandemic, produces elevated liver enzymes, especially in severe cases. The mechanism suggests involvement of an administrated drug, cytokine storm, or hypoxia, etc., as opposed to virus-induced direct damage. If liver enzymes are elevated in COVID-19, we should evaluate for the presence of other liver diseases, and strictly follow-up liver enzyme values. In patients with COVID-19 complicated by chronic liver disease, we will use telemedicine/visits by phone, so as not to interrupt the treatment of the underlying disease, avoid unnecessary outpatient visits, and strive to halt the spread of the infection. Metabolism-associated fatty liver disease, which is often related to obesity, diabetes, and hypertension, may be a risk factor for COVID-19 severity. International academic societies have recommended guidance outlining the evidence to date regarding the management of patients with COVID-19 and liver disorders, and chronic liver disease under the COVID-19 pandemic.Copyright 2020 The Japan Society of Hepatology.

2.
Human and Ecological Risk Assessment ; 2022.
Article in English | Scopus | ID: covidwho-1972865

ABSTRACT

Endocrine disrupting chemicals (EDCs) are a growing global concern due to their widespread use and potential harm to human and animal health. Several EDCs have been linked to cancer, obesity, and diabetes in children and adults. EDCs come from manufacturers or everyday products like cookware, textile, cosmetic, furniture, and plastic. Some EDCs are volatile and may be inhaled by the inhabitants where indoor exposure to EDCs is considered worse than outdoor exposure due to the limited and confined area allowing dermal contact and ingestion of EDCs. During the COVID-19 pandemic in 2020–2021, all Malaysians were confined to their homes, prompting the goal of this study to investigate EDCs in household dust collected from Klang Valley homes. A total of 57 dust samples were collected, filtered, and extracted using methanol. EDCs including perfluoroalkyl and polyfluoroalkyl substances (PFAS), bisphenol and parabens were identified and quantified in dust samples by liquid chromatography mass tandem spectrometry (LCMS/MS). The presence of perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), butylparaben (BuP), methylparaben (MeP), ethylparaben (EtP), and propylparaben (PrP) was detected in 50–100% of dust samples, with range of concentration of 0.31–3693.96 ng/g, indicating that these compounds are common in indoor dust. Methylparaben was the most prevalent EDC in collected dust samples with mean concentration at 148. 18 ng/g, accounting for 54% of the concentration distribution, followed by BuP and PFOA. There were regional differences in EDC profiles, with higher PFAS and paraben levels in urban areas such as Putrajaya, Kuala Lumpur, and Petaling. The estimated daily intake (EDI) of EDCs from indoor dust ingestion varied by age, with infants having a significantly higher EDI (p <.01) than children and adults. Despite safe for consumption (Hazard Quotient, HQ < 1), these findings provide a baseline for assessing PFAS, bisphenol, and paraben in indoor dust from Malaysian homes. © 2022 Taylor & Francis Group, LLC.

3.
10th IEEE CPMT Symposium Japan (ICSJ) ; : 164-167, 2021.
Article in English | Web of Science | ID: covidwho-1759088

ABSTRACT

New coronavirus, SARS-CoV-2, named as COVID-19 was identified and caused the global pandemic in 2020. Recent challenging issues include providing users with non-invasive and easy-to-use diagnostic devices and identifying the infected to prevent the spread of COVID-19 as quick as possible. In this study, a new COVID-19 diagnostic device that integrates porous microneedles (MNs) with a paper-based immunoassay biosensor was developed for the rapid antibody detection. The biodegradable porous MNs made of polylactic acid (PLA) were fabricated and used to extract the interstitial fluid (ISF) in the human skin by capillary effect. The extracted ISF was flowed into the immunoassay biosensor, which results in the detection of SARS-CoV-2 antibodies on site. From In vitro tests, the result demonstrated that human anti-SARS-CoV-2 IgM and IgG could be detected within 2 min. It is expected that COVID-19 can be diagnosed fast and painlessly owing to the porous MNs as well as a paper sensor with the short flow distance between MNs and a sensor. Besides COVID-19, the proposed device has great potential in the fast screening of various kinds of infectious diseases as an effective complementary method with other diagnostic tests.

4.
Journal of Gastroenterology and Hepatology ; 36:171-171, 2021.
Article in English | Web of Science | ID: covidwho-1381722
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