Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 7 de 7
Filter
1.
Clinical and Experimental Rheumatology ; 41(2):470, 2023.
Article in English | EMBASE | ID: covidwho-2301726

ABSTRACT

Background. Viruses are thought to play a role in triggering juvenile idiopathic inflammatory myopathies (JIIM), which include juvenile dermatomyositis (JDM), juvenile polymyositis (JPM), and overlap myositis. There is growing evidence that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can trigger autoimmune diseases in genetically susceptible individuals, including idiopathic inflammatory myopathies (IIM). Studies have shown similarities between SARS-CoV-2 infection and anti-melanoma differentiation-associated gene 5 (MDA5) antibody-related dermatomyositis, suggesting possible shared underlying autoimmune and/or inflammatory mechanisms. To date, there are few studies describing individual cases of JIIM following SARS-CoV-2 infection, and, to our knowledge, none have explored the effects of SARS-CoV-2 on the clinical presentation of JIIM. In this study, we aim to investigate the impact of SARS-CoV-2 on JIIM by comparing the onset of new JIIM cases, as well as clinical and laboratory characteristics at disease onset, in patients diagnosed before and after onset of the Coronavirus Disease 2019 pandemic (COVID 19). Methods. Patients diagnosed with JIIM prior to age 19 at The Children's Hospital at Montefiore were eligible for study inclusion. Demographic, clinical, and laboratory data, as well as evidence of exposure to SARS-CoV-2, were collected retrospectively by manual chart review. Patients were grouped into pre-COVID 19 (defined as prior to January 1, 2020) and post-COVID 19 (defined as January 1, 2020, or later). Descriptive statistics were used to summarize each variable. Given the small sample size, non-parametric testing was performed using Fischer's exact test and Wilcoxon rank sum test. Results. Forty-four patients were included in the analysis (Table I). Thirty-four patients (77.3%) were diagnosed pre-COVID 19 and ten patients (22.7%) were diagnosed post-COVID 19. Of the ten patients diagnosed post-COVID 19, five (50%) had known exposure to or infection with SARS-CoV-2. Patients diagnosed with JIIM post-COVID 19 were more likely to be of non-Hispanic Black or Asian descent (p=0.041), develop disease at an older age (p=0.009), and present with non-classic cutaneous manifestations (as opposed to classic findings of Gottron's papules/sign or Heliotrope rash) (p=0.031), despite similar frequencies of JDM versus overlap myositis. While presence of muscle weakness did not differ between the groups, patients diagnosed post-COVID 19 tended to have more severe weakness, though results were not statistically significant. Interestingly, despite delays to diagnosis reported during the pandemic, there was no difference between time from symptom onset to diagnosis. Conclusion. This is the first study to explore the effects of SARS-CoV-2 on the clinical presentation of JIIM. In our center, we found that patients diagnosed with JIIM after COVID-19 were more likely to be racial minorities, older at onset, and present with non-classic cutaneous manifestations. While there were no significant differences in myositis specific or associated antibodies, patients diagnosed post-COVID 19 did not have complete autoantibody investigation performed at the time of this study. Clinicians should consider JIIM even in the absence of classic cutaneous manifestations, particularly in the post-COVID 19 era. Patients should be followed longitudinally to explore long-term impacts of SARS-CoV-2 on JIIM. Further investigation is warranted to identify the mechanisms by which SARS-CoV-2 impacts JIIM and how these differ from the effects of other viruses.

2.
Data Technologies and Applications ; 2023.
Article in English | Scopus | ID: covidwho-2266421

ABSTRACT

Purpose: This study quantified companies' views on the COVID-19 pandemic with sentiment analysis of US public companies' disclosures. The study aims to provide timely insights to shareholders, investors and consumers by exploring sentiment trends and changes in the industry and the relationship with stock price indices. Design/methodology/approach: From more than 50,000 Form 10-K and Form 10-Q published between 2020 and 2021, over one million texts related to the COVID-19 pandemic were extracted. Applying the FinBERT fine-tuned for this study, the texts were classified into positive, negative and neutral sentiments. The correlations between sentiment trends, differences in sentiment distribution by industry and stock price indices were investigated by statistically testing the changes and distribution of quantified sentiments. Findings: First, there were quantitative changes in texts related to the COVID-19 pandemic in the US companies' disclosures. In addition, the changes in the trend of positive and negative sentiments were found. Second, industry patterns of positive and negative sentiment changes were similar, but no similarities were found in neutral sentiments. Third, in analyzing the relationship between the representative US stock indices and the sentiment trends, the results indicated a positive relationship with positive sentiments and a negative relationship with negative sentiments. Originality/value: Performing sentiment analysis on formal documents like Securities and Exchange Commission (SEC) filings, this study was differentiated from previous studies by revealing the quantitative changes of sentiment implied in the documents and the trend over time. Moreover, an appropriate data preprocessing procedure and analysis method were presented for the time-series analysis of the SEC filings. © 2022, Emerald Publishing Limited.

3.
2022 CHI Conference on Human Factors in Computing Systems, CHI 2022 ; 2022.
Article in English | Scopus | ID: covidwho-1874731

ABSTRACT

Contact tracers assist in containing the spread of highly infectious diseases such as COVID-19 by engaging community members who receive a positive test result in order to identify close contacts. Many contact tracers rely on community member's recall for those identifications, and face limitations such as unreliable memory. To investigate how technology can alleviate this challenge, we developed a visualization tool using de-identified location data sensed from campus WiFi and provided it to contact tracers during mock contact tracing calls. While the visualization allowed contact tracers to find and address inconsistencies due to gaps in community member's memory, it also introduced inconsistencies such as false-positive and false-negative reports due to imperfect data, and information sharing hesitancy. We suggest design implications for technologies that can better highlight and inform contact tracers of potential areas of inconsistencies, and further present discussion on using imperfect data in decision making. © 2022 ACM.

4.
Springer Protocol. Handb. ; : 3-19, 2022.
Article in English | EMBASE | ID: covidwho-1718502

ABSTRACT

Coronaviruses (CoVs) infect diverse animal species and cause respiratory, enteric, hepatic, renal, neurologic, and even systemic diseases. The majority of CoVs have a narrow host specificity, but a few CoVs have a broad range of host specificity. This chapter provides a brief review of animal CoVs, including SARS-CoV-2 of animals for their receptors, host tropism, and pathogenesis in target animals.

5.
Journal of the Architectural Institute of Korea ; 37(9):21-30, 2021.
Article in Korean | Scopus | ID: covidwho-1485392

ABSTRACT

The purpose of this study was to explore the possibilities of the transition to the Rhizome-type Library in post COVID-19 era. The cases and theories were considered to understand the characteristics of the Rhizome-type Spatial Structure. The spatial structure of the Rhizome-type Library has De-centrality, Independence, Diversity and partly De-hierarchicality, De-territorialisation, Nomadic, Ambiguity, Conjunctivity. The results of this study were as follows;First, the Rhizome-type Library will be easy to access the neighborhood, which will facilitate the convenience of users. Second, the Rhizome-type Library can be placed in very small places in the neighborhood and provide variety of services and also personal space for reading, learning, and works. Third, the Rhizome-type Library has flexible and changeable spatial forms and the form can be customized. And lastly, the Rhizome-type Library has the potential to evolve to include the functions of other Public Service Facilities, so the Rhizome-type Library can be used as an alternative to large Public Service Facilities in unexpected disaster situations, such as COVID-19. In conclusion, the Rhizome-type Library could be a way to change the paradigm of library service and space in the post COVID-19 era. © 2021 Architectural Institute of Korea.

7.
Cerebrovascular Diseases ; 49(SUPPL 1):7-8, 2020.
Article in English | Web of Science | ID: covidwho-977963
SELECTION OF CITATIONS
SEARCH DETAIL