Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 43
Filter
1.
Cell Discov ; 8(1):132, 2022.
Article in English | PubMed | ID: covidwho-2160196

ABSTRACT

Current SARS-CoV-2 Omicron subvariants impose a heavy burden on global health systems by evading immunity from most developed neutralizing antibodies and vaccines. Here, we identified a nanobody (aSA3) that strongly cross-reacts with the receptor binding domain (RBD) of both SARS-CoV-1 and wild-type (WT) SARS-CoV-2. The dimeric construct of aSA3 (aSA3-Fc) tightly binds and potently neutralizes both SARS-CoV-1 and WT SARS-CoV-2. Based on X-ray crystallography, we engineered a bispecific nanobody dimer (2-3-Fc) by fusing aSA3-Fc to aRBD-2, a previously identified broad-spectrum nanobody targeting an RBD epitope distinct from aSA3. 2-3-Fc exhibits single-digit ng/mL neutralizing potency against all major variants of concerns including BA.5. In hamsters, a single systemic dose of 2-3-Fc at 10 mg/kg conferred substantial efficacy against Omicron infection. More importantly, even at three low doses of 0.5 mg/kg, 2-3-Fc prophylactically administered through the intranasal route drastically reduced viral RNA loads and completely eliminated infectious Omicron particles in the trachea and lungs. Finally, we discovered that 2(Y29G)-3-Fc containing a Y29G substitution in aRBD-2 showed better activity than 2-3-Fc in neutralizing BA.2.75, a recent Omicron subvariant that emerged in India. This study expands the arsenal against SARS-CoV-1, provides potential therapeutic and prophylactic candidates that fully cover major SARS-CoV-2 variants, and may offer a simple preventive approach against Omicron and its subvariants.

2.
Eur Rev Med Pharmacol Sci ; 26(21): 8129-8143, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2118079

ABSTRACT

OBJECTIVE: A lack of objective biomarkers is preventing the screening and diagnosis of COVID-19 combined with major depression disorder (COVID-19-MDD). The purpose of this study was to identify diagnostic biomarkers and gene regulatory mechanisms associated with autophagy; a crucial process significantly involved in the pathogenesis of COVID-19-MDD. MATERIALS AND METHODS: In this study, differentially expressed genes (DEGs) were screened using GSE98793 from the GEO2R analysis (GEO) database, and intersected with the COVID-19-related gene (CRGs) and autophagy-related genes (ARGs) to obtain common genes involved in. Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of these common genes were performed. Subsequently, the transcription factor (TF)-gene regulatory network and comorbidity network were constructed. In addition, 10 drug candidates were screened using the DSigDB database. To identify diagnostic markers, we used LASSO regression. RESULTS: In total, 13 common genes were screened, which were primarily enriched in lysosomes, endoplasmic reticulum membranes, and other endomembrane systems also associated with autophagy. Additionally, these genes were involved in neurological cell signaling and have a functional role in pathways related to vascular endothelial growth factor, tyrosine kinase, autophagy, inflammation, immunity, and carcinogenesis. Tumors and psychiatric disorders were the most highly linked diseases to COVID-19. Finally, ten drug candidates and eight diagnostic markers (STX17, NRG1, RRAGD, XPO1, HERC1, HSP90AB1, EPHB2, and S1PR3) were screened. CONCLUSIONS: This is the first study to screen eight diagnostic markers and construct a gene regulatory network for COVID-19-MDD from the perspective of autophagy. The findings of our study provide novel insights into the diagnosis and treatment of COVID-19-MDD.


Subject(s)
COVID-19 , Depressive Disorder, Major , Humans , Computational Biology , COVID-19/genetics , Vascular Endothelial Growth Factor A , Biomarkers , Machine Learning , Autophagy/genetics
3.
12th International Conference on Information Communication and Management, ICICM 2022 ; : 45-49, 2022.
Article in English | Scopus | ID: covidwho-2079062

ABSTRACT

With the rapid development of computer technology, the traditional teaching mode has been changed. Computer technology has played a decisive role in promoting teaching reform. This paper mainly discusses the implementation and experience of the mixed teaching mode of preventive medicine course based on the network teaching platform under the epidemic situation of novel coronavirus pneumonia. The mixed teaching mode of "online live teaching + MOOC + TBL"was used for the study on the online course of preventive medicine, and a mixed teaching mode of preventive medicine course based on the network teaching platform was constructed. In the teaching practice for clinical medical students, it was found that this teaching model could help to improve their teaching satisfaction, performance, autonomous learning ability, and ability to obtain information and evaluate information, through which a satisfactory teaching result has been achieved. The results indicate that this teaching mode may be an efficient and innovative teaching mode, and an effective way to improve the quality of education and teaching, worth popularizing. © 2022 Owner/Author.

4.
China Geology ; 5(3):411-420, 2022.
Article in English | Scopus | ID: covidwho-2056987

ABSTRACT

A large number of antibiotics have been discharged into rivers by human activities, posing a threat to aquatic ecosystems. The surface water of the Yellow River Basin also suffers antibiotic pollution, which hinders the improvement in the aquatic ecological environment. This study investigated and analyzed the characteristics and assessed the ecological risks of antibiotic pollution in surface water bodies such as canals, rivers and fish ponds in Kaifeng, Henan Province, which is a key city along the lower reaches of the Yellow River. The test results are as follows. A total of 15 types of antibiotics were detected in the surface water. They had a total antibiotic concentration of 12.2–249.9 μg/L, of which tetracyclines (TCs) and quinolones accounted for the highest percentages. Six types of quinolones had detection rates of up to 100%, and doxycycline (DC) and oxytetracycline (OTC) had average concentrations of 29.52 μg/L1 and 13.71 μg/L, respectively. The major canals with water diverted from the Yellow River had total concentrations of quinolones and TCs of 22. 0 μg/L and 14.9 μg/L, respectively, which were higher than those in previous studies. This phenomenon may be related to the decrease in the water flow of the Yellow River during the dry season and the increase in the antibiotic consumption of residents in the context of the Covid-19 outbreak. The upper reaches of the Huiji River in the Xiangfu District had higher antibiotic content than other districts in Kaifeng. Specifically, TCs accounted for 72.38%–91.84% of all antibiotics, and the DC and OTC concentrations were significantly higher than other antibiotics in the upper reaches. As indicated by the ecological risk assessment results, TCs had the highest ecological risks to green algae. Among them, DC had medium-high risks;TC, OTC, and chlortetracycline (CTC) had medium-high risks;trimethoprim (TMP) and lomefloxacin (LOM) had low risks;other TC antibiotics had no risk. Compared with green algae, most antibiotics showed higher ecological risks to daphnia and lower ecological risks to fish. DC and OTC dominate antibiotic pollutants in the surface water in Kaifeng City, and especially in Xiangfu District, where DC and OTC have medium-high risks. The TCs in the major Yellow River showed medium risks to both green algae and daphnia. It can be speculated that the antibiotic pollution in the Yellow River might pose a certain threat to the ecological security of water in Kaifeng City. ©2022 China Geology Editorial Office. © 2022 Editorial Office of China Geology. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd

5.
2022 IEEE International Conference on Consumer Electronics - Taiwan, ICCE-Taiwan 2022 ; : 377-378, 2022.
Article in English | Scopus | ID: covidwho-2051984

ABSTRACT

This paper proposes an outdoor barbecue restaurant environment control system based on AIoT technology in Penghu, Taiwan, which provides a more convenient restaurant management method for barbecue restaurant service providers and improves the comfort of diners in barbecue restaurants. The proposed system can automatically adjust the temperature and humidity of the restaurant, which uses image processing technology to count the number of diners in the restaurant and set up cameras in the food storage refrigerator to identify whether there are empty plates in time. In response to the COVID-19 epidemic when entering a restaurant, mask identification is carried out using object recognition so that diners who wear masks abnormally can be detected in time, and the virus infection problem can be reduced. All information can be monitored through the proposed IoT monitoring platform. © 2022 IEEE.

6.
Annals of the Rheumatic Diseases ; 81:333-334, 2022.
Article in English | EMBASE | ID: covidwho-2008914

ABSTRACT

Background: Published data suggest no increased rate of fare of autoimmune infammatory rheumatic diseases (AIIRD) after COVID-19 mRNA vaccination;however, the studies are limited by small sample size, short follow up or at risk of selection bias (voluntary physician reports or patient surveys). Objectives: To study fares of AIIRD within three months of the frst dose of an anti-SARS-COV2 mRNA vaccine. Methods: A retrospective cohort study of consecutive AIIRD patients ≥ 12 years old, across six public hospitals in Singapore who received at least one dose of an mRNA (Pfzer/BioNTech or Moderna) vaccine. Data were censored at the frst post-vaccine clinic visit when the patient had fared or if ≥ three months had elapsed since the frst dose of the vaccine, whichever came frst. Predictors of fare were determined by Cox proportional hazards analysis and time to fare was examined using a Nelson Aalen cumulative hazard estimate (Figure 1). Results: 2339 patients (74% Chinese, 72% female) of median (IQR) age 64 (53, 71) years were included in the interim analysis (Table 1). 2112 (90%) had the Pfzer/BioNTech vaccine and 195 (8%) had Moderna, with a median (IQR) interval of 21 (21, 23) days between the two doses. The most common AIIRD diagnoses were Rheumatoid arthritis (1063, 45%), Psoriatic arthritis (296, 12.6%) and Systemic lupus erythematosus (SLE) (288, 12.3%). 186 (8%) were treated with biologics/targeted disease modifying agents. 2125 (91%) patients were in low disease activity or remission. Treatment was interrupted for vaccination in only 18 (0.8%) patients. Seven (0.3%) patients had previous COVID-19 infection. 452 (19%) fares were recorded during 9798.8 patient-months [4.6/100 patient-months, median (IQR) follow up duration 4.2 (3.3, 5.3) months], of which 272 (11.6%) patients fared within the 3-month period of interest and 180 (7.7%) fared outside of the 3-month period (Table 1). Median (IQR) time-to-fare was 40.5 (18, 56.6) days. 60 (22.1%) were mild and self-limiting, 170 (62.5%) were mild-moderate and 42 (15.4%) were severe. 190 (69.8%) of those who fared required escalation of treatment and 15 (5.5%) required hospital admission. 239 (10.2%) had improved disease activity after the vaccine. On multivariate Cox regression analysis, patients in the oldest age tertile [median (IQR) 74 (71, 79) years] were less likely to fare [HR 0.80 (95% CI 0.63, 1.00), p = 0.05] Patients with infammatory arthritis (compared with connective tissue disease, vasculitis and others) and patients with baseline active disease were more likely to fare [HR 1.72 (95% CI 1.35, 2.20), p < 0.001 and 1.82 (95% CI 1.39, 2.39), p < 0.001 respectively] Conclusion: There was a moderately high rate of AIIRD fares after mRNA vaccination;however, there was no clustering of fares in the immediate post-vaccine period to suggest causality. Older patients were less likely to fare, while those with infammatory arthritis and active disease at baseline were more likely to fare.

7.
Dermatologica Sinica ; 40(2):67-70, 2022.
Article in English | EMBASE | ID: covidwho-1957509

ABSTRACT

With the rapid outbreak of the coronavirus disease 2019 (COVID-19) pandemic, considerable concerns about the safety of systemic treatments of immune-mediated dermatologic disorders has been raised by dermatologists and their patients. We aimed to perform a rapid review of latest American and European guidelines on the use of systemic treatments in patients with immune-mediated dermatologic disorders and confirmed COVID-19 infection and to provide recommendations to inform practice. Based on the current limited guidelines and evidence, systemic corticosteroids should not be abruptly discontinued and the lowest effective dose should be continued. Systemic immunosuppressants (including methotrexate, cyclosporine, azathioprine, cyclophosphamide, and leflunomide), biologics, and sulfasalazine should be withheld in patients with confirmed COVID-19 infection. Whether to continue Janus kinase inhibitors should be determined following a shared decision-making process between dermatologists and patients after considering patients' medical conditions and risk for severe COVID.

8.
Indoor and Built Environment ; 31(5):1159-1160, 2022.
Article in English | Scopus | ID: covidwho-1932924
9.
Chinese Physics B ; 31(7):12, 2022.
Article in English | Web of Science | ID: covidwho-1927259

ABSTRACT

Under the background of Covid-19 sweeping the world, safe and reasonable passenger flow management strategy in subway stations is an effective means to prevent the spread of virus. Based on the social force model and the minimum cost model, the movement and path selection behavior of passengers in the subway station are modeled, and a strategy for passenger flow management to maintain a safe social distance is put forward. Take Qingdao Jinggangshan Road subway station of China as the simulation scene, the validity of the simulation model is verified by comparing the measured value and simulation value of the time required for passengers from getting off the train to the ticket gate. Simulation results indicate that controlling the time interval between incoming passengers at the entrance can effectively control the social distance between passengers and reduce the risk of epidemic infection. By comparing the evacuation process of passengers under different initial densities, it is found that the greater the initial density of passengers is, the longer the passengers are at risk social distance. In the process of passenger emergency evacuation, the stairs/escalators and ticket gates are bottleneck areas with high concentration of passenger density, which should be strictly disinfected many times on the basis of strictly checking the health code of incoming passengers and controlling the arrival time interval. The simulation results of this paper verify the harmfulness of passenger emergency evacuation without protective measures, and provide theoretical support for the operation and management of subway station under the epidemic situation.

10.
Reviews in Cardiovascular Medicine ; 23(6), 2022.
Article in English | EMBASE | ID: covidwho-1918320

ABSTRACT

Background: The present study aimed to clarify the impact of the 2020 COVID-19 pandemic on emergency management of acute type A aortic dissection. Methods: We consecutively enrolled 337 acute type A aortic dissection (ATAAD) patients at emergency room in Fuwai Hospital (Beijing, China) from January to June during the 2020 COVID-19 epidemic (n = 148) and the same period in 2019 as the historical control (n = 189). The primary outcome was defined as in-hospital death. Other outcomes included automatic discharge during emergency admission. The factors with significant differences before and after the epidemic were compared and analyzed by stages with the study endpoint to clarify their changes in different stages of the epidemic. Results: There was no significant difference in in-hospital mortality (35 (20.5%) vs. 23 (17.4%), p = 0.472). Compared with year 2019, proportion of patients receiving surgical treatment decreased significantly (74 (50.0%) vs. 129 (68.25%), p < 0.001). The surgery time of ATAAD patients in 2020 was significantly shorter (6.46 [5.52, 7.51] vs. 7.33 [6.00, 8.85] hours, p = 0.01). The length of stay in the emergency department significantly differed at each stage. Conclusions: Our study demonstrated a significant reduction in the number of ATAAD patients and surgical treatment during COVID-19 outbreak. The surgical strategy of patients changed, but the overall mortality was largely the same. Patients undergoing surgery had a trend toward longer interval from the onset to the operating room, but they tended to be normal at the end of the epidemic. Proper epidemic prevention policies may avoid COVID-19 hitting patients who are not infected with the virus to the greatest extent.

11.
Chinese Journal of General Practitioners ; 21(5):471-476, 2022.
Article in Chinese | Scopus | ID: covidwho-1911770

ABSTRACT

Objective To explore the impact of Coronavirus disease 2019 (COVID-19) epidemic on career choosing perspective among medical students and to analyze the related factors. Methods Semi-structured telephone interviews were conducted during March 1-25 2020 among 19 medical students of 8-year program from Peking Union Medical College. The grounded theory and thematic analysis were applied to code the data and identify categories and factors. Results Among the 19 respondents aged 19-26 years, 9 were males and 10 were female;10 were at the clinical stage, and 9 were at the premedical stage;3 respondents had family members involved in medical profession. Thematic analysis identified 6 main categories that affect the variability of medical students' career prospects under the COVID-19 pandemic. The 6 themes were individual characteristics of students;occupational characteristics;systemic factors;COVID-19 events;stressors of physicians and influence of job satisfaction. The outbreak affected everyone's mind of future career to varying degrees. The participants had been exposed to more negative aspects, while only one participant changed her career intention. There were conflicting views on whether to choose some specialties in future, such as respiratory medicine, infectious disease and critical care medicine. The participants feel more pressure as a doctor from the attitude of the public. Almost all participants mentioned feeling unsafe due to the high risk of occupational exposure and doctor-patient relationships. Most valued the support from their family, faculty, classmates, and volunteers. Many participants expressed their hope to improve the medical policies and systems. Conclusions The influence of COVID-19 outbreak on medical students' career choosing can be positive as well as negative in different degrees. However, we found no evidence that it altered their perspectives substantially. © 2022 Chinese Journal of Psychiatry. All rights reserved.

12.
Zhonghua Liu Xing Bing Xue Za Zhi ; 43(6): 791-797, 2022 Jun 10.
Article in Chinese | MEDLINE | ID: covidwho-1903515

ABSTRACT

Rapidly upgraded digital technology has impacted all walks of life, and public health field is also undergoing a digital transformation. The COVID-19 pandemic has accelerated the wide use of digital technology in the prevention and control of infectious diseases, greatly enhancing the capacity of public health system in emergency response and routine disease prevention and control. This article summarizes the definition of digital public health, applications of digital technology in the prevention and control of infectious diseases and chronic non-communicable diseases, as well as in public health surveillance, discusses the challenges in the development of digital public health and introduces the eight principles for digital transformation of public health proposed by the Pan American Health Organization.


Subject(s)
COVID-19 , Pandemics , Delivery of Health Care , Humans , Pandemics/prevention & control , Public Health , Public Health Surveillance
13.
Diabetic Medicine ; 39(SUPPL 1):116-117, 2022.
Article in English | EMBASE | ID: covidwho-1868635

ABSTRACT

Background and Aims: During the covid-19 pandemic revisions were recommended to the gestational diabetes diagnostic criteria. Given the characteristics of our inner city multi-ethnic cohort, we continued with the NICE 2015 criteria. We aimed to determine the incidence of gestational diabetes during the first wave of the covid-19 pandemic. Methods: Women diagnosed with gestational diabetes in March-July 2020 were retrospectively reviewed and compared to two separate historical time-matched cohorts (03-07/ 2018 and 03-07/ 2017). Maternal demographics, gestational diabetes incidence and fetal outcomes were compared. Results: 953 pregnancies were registered in 2020, 963 in 2018 and 1162 in 2017. The highest gestational diabetes incidence was observed in the covid-19 cohort (12.6% (n = 120), 7.3% (n = 70) and 4.4% (n = 52) respectively, p < 0.001). On average, women were diagnosed with GDM later in 2020 (mean gestational age (GA) 28.6 weeks, 27.0 and 27.0 weeks, p < 0.001). Mean ( ± SD) age, height, and early pregnancy weight/ body mass index were similar. Proportional differences in women with gestational diabetes of non-white ethnicity were exhibited, with the lowest proportion in 2020 (77.0%, 86.4% and 82.9% respectively, p < 0.001). Mean ( ± SD) fetal birth weight varied across the groups (3237.5 ( ± 473)g, 3117 ( ± 647)g and 2981 ( ± 845)g, p < 0.001). There were no differences in adjusted fetal birth weight centiles. Mean (SD) GA at birth was higher in 2020 (38.8 ( ± 1.26), 38.4 ( ± 2.38), 37.60 ( ± 5.1) weeks, p = 0.03). Conclusions: A significant increase in the diagnosis of gestational diabetes during the covid-19 epidemic was observed. The implementation of national lockdowns may have resulted in reduced physical activity and excess gestational weight gain, which could explain this.

14.
Annals of Translational Medicine ; : 12, 2022.
Article in English | Web of Science | ID: covidwho-1822668

ABSTRACT

Background: New England Journal of Medicine (NEJM), Lancet, Journal of the American Medical Association (JAMA), and British Medical Journal (BMJ) are collectively known as "the Top Four Medical Journals (TFMJ)" in China. Through the analysis of Chinese scholars' publications in the TFMJ in the recent 10 years, this study aimed to clarify the current situation of high-quality medical research conducted by Chinese scholars and institutions. Methods: Data were retrieved and downloaded manually from PubMed (2011-2020). Information on the publication year, journal, author, affiliation, and citation, etc. were extracted and analyzed using R software. Results: A total of 761 articles were involved in the final analysis. The number of articles published by Chinese scholars in the TFMJ was 135/29,942 (0.45%) in BMJ, 124/14,033 (0.88%) in JAMA, 314/16,117 (1.94%) in Lancet, and 188/15,242 (1.23%) in NEJM (P<0.001). Besides, the letter was the main research type, which was up to 44.54%, and the original research only accounted for 17.47%. The most popular subspecialty and subject were infectious diseases and COVID-19, respectively. The most productive researcher was Chen Wang, and Bin Cao was the most cited Chinese scholar. The most productive institute was Chinese Academy of Medical Sciences and Peking Union Medical College. The most cited study was "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China". Conclusions: The presence of Chinese scholars in the TFMJ has grown, but there is still much room to improve. A Matthew effect in China's high-level scientific research was demonstrated.

16.
International Journal of Public Health Science ; 11(1):195-203, 2022.
Article in English | Scopus | ID: covidwho-1776649

ABSTRACT

In order to curb the depression levels among youth during the coronavirus disease 2019 (COVID-19) outbreak, we examined the recurrent themes of mixed expressive writing among undergraduates during the pandemic. Previous quantitative studies had emphasized on the effectiveness of expressive writing in reducing depressive symptoms, however, less qualitative studies were conducted in evaluating the content within people’s writings. As the pandemic had caused major disruptions among people, we implemented mixed expressive writing in capturing both positive and negative experiences during the pandemic. Ten participants were recruited to perform mixed expressive writing twice per week, for four consecutive weeks. Thematic analysis was used in analyzing their writings and forming the emerged themes. Five themes were formed, which included ‘school’, ‘relationships’, ‘reflection’, ‘work’, and “random incidents’. Future research should examine the effectiveness of expressive writing in writing specific themes on improving its respective psychological constructs. © 2022, Intelektual Pustaka Media Utama. All rights reserved.

17.
Journal of the American College of Cardiology ; 79(9):1088, 2022.
Article in English | EMBASE | ID: covidwho-1768626

ABSTRACT

Background Although the number of patients presenting with non-ST elevation myocardial infarction (NSTEMI) has drastically reduced in the coronavirus-19 pandemic era, increased mortality was reported. A plausible explanation for increased mortality was suggested as the delay of arrival at the hospital due to patients’ reticence of their symptoms. However, evidence to support the suggested explanation is lacking. Methods From the nationwide prospective registry, we evaluated 6,544 patients with NSTEMI. Study patients were categorized into two groups according to their symptom-to-door (StD) time (<24 h or ≥24 h). The primary outcome was 3-year all-cause mortality, and the secondary outcome was 3-year composite of all-cause mortality, recurrent MI, and hospitalization for heart failure. Results Overall, 27.9% patients were classified into the StD time ≥24 h group. The StD time ≥24 h group had higher all-cause mortality (17.0% vs. 10.5%, p<0.001) and incidence of secondary outcome (23.3% vs. 15.7%, p<0.001) than the StD time <24 h group. In the multivariable analysis, independent predictors of delayed arrival at the hospital were the elderly, female, non-specific symptoms such as atypical chest pain or dyspnea, diabetes, and no use of emergency medical services. Conclusion Delayed arrival (StD time ≥24 h) is associated with an increased risk of 3-year all-cause mortality and composite outcomes in patients with NSTEMI. [Formula presented]

18.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ; 57(3): 282-288, 2022 Mar 07.
Article in Chinese | MEDLINE | ID: covidwho-1760874

ABSTRACT

Objective: To analyze the correlation between loss of smell/taste and the number of real confirmed cases of coronavirus disease 2019 (COVID-19) worldwide based on Google Trends data, and to explore the guiding role of smell/taste loss for the COVID-19 prevention and control. Methods: "Loss of smell" and "loss of taste" related keywords were searched in the Google Trends platform, the data were obtained from Jan. 1 2019 to Jul. 11 2021. The daily and newly confirmed COVID-19 case number were collected from World Health Organization (WHO) since Dec. 30 2019. All data were statistically analyzed by SPSS 23.0 software. The correlation was finally tested by Spearman correlation analysis. Results: A total of data from 80 weeks were collected. The retrospective analysis was performed on the new trend of COVID-19 confirmed cases in a total of 186 292 441 cases worldwide. Since the epidemic of COVID-19 was recorded on the WHO website, the relative searches related to loss of smell/taste in the Google Trends platform had been increasing globally. The global relative search volumes of "loss of smell" and "loss of taste" on Google Trends was 10.23±2.58 and 16.33±2.47 before the record of epidemic while 80.25±39.81 and 80.45±40.04 after (t value was 8.67, 14.43, respectively, both P<0.001). In the United States and India, the relative searches for "loss of smell" and "loss of taste" after the record of epidemic were also much higher than before (all P<0.001). The correlation coefficients between the trend of weekly new COVID-19 cases and the Google Trends of "loss of smell" in the global, United States, and India was 0.53, 0.76, and 0.82 respectively (all P<0.001), the correlation coefficients with Google Trends of "loss of taste" was 0.54, 0.78, and 0.82 respectively (all P<0.001). The lowest and highest point of loss of smell/taste search curves of Google Trends in different periods appeared 7 to 14 days earlier than that of the weekly newly COVID-19 confirmed cases curves, respectively. Conclusions: There is a significant positive correlation between the number of newly confirmed cases of COVID-19 worldwide and the amount of keywords, such as "loss of smell" and "loss of taste", retrieved in Google Trends. The trend of big data based on Google Trends might predict the outbreak trend of COVID-19 in advance.


Subject(s)
Ageusia , COVID-19 , Big Data , Disease Outbreaks , Humans , Internet , Retrospective Studies , Smell , United States
19.
American Journal of Translational Research ; 13(12):14157-14167, 2021.
Article in English | EMBASE | ID: covidwho-1610152

ABSTRACT

Background: Previous studies have unveiled the occurrence of re-detectable positive (RP) RNA test result after hospital discharge among recovered COVID-19 patients, but the clinical characteristics of RP patients (RP patients) and the potential features affecting RP RNA test outcome remain unclear. Methods: A total of 742 COVID-19 patients discharged between March 1st, 2020 and March 20th, 2020 were enrolled. All patients were followed-up for SARS-CoV-2 RNA test and RP patents were identified. The clinical characteristics between RP patients and NRP patients were compared, and the potential features affecting re-detectable RNA test outcome were further evaluated. Results: Up to April 9th, 2020, 60 recovered patients (8.09%) had been re-detected to be SARS-CoV-2 RNA positive. Among those 60 RP patients, the median RP time was 12 days from the last negative result of SARS-CoV-2 RNA test or 10 days from hospital discharge. RP patients were prone to be older, having mild/moderate conditions, unilateral lung involvement and fatigue, chills, stuffy or runny nose, with high lymphocyte count. Multivariate logistic analysis and COX regression analysis demonstrated that age, lymphocyte count, urea nitrogen, stuffy or runny nose as well as lung involvement were independently associated with RP RNA test (P<0.05). Conclusions: Older patients accompanied with stuffy or runny nose, low urea nitrogen as well as unilateral lung involvement were more likely to develop RP RNA test result after hospital discharge. Therefore, we strongly suggest using broncho-alveolar lavage fluid for RNA detection, extending quarantine time, and conducting continual follow-up medical examination for those discharged patients.

20.
Gastroenterology ; 160(6):S-613, 2021.
Article in English | EMBASE | ID: covidwho-1599468

ABSTRACT

Introduction: The COVID-19 pandemic prompted a rapid shift to telehealth for care delivery. We aimed to assess satisfaction with and preferences for telehealth to improve care experiences for patients with irritable bowel syndrome (IBS). Methods: We conducted a prospective survey-based cross-sectional study from September 29 to November 9, 2020 in a diverse, community-based integrated healthcare system in Southern California. We included members age 18-90 with an International Classification of Diseases 9, 10 code for IBS from an office-based encounter between June 1, 2018 to June 1, 2020. A specifically developed survey (TIBS-CoV2) was emailed to patients. We collected demographic and clinical data from the electronic medical record. We assessed satisfaction via 5-point Likert scale (“strongly agree and agree” was defined as satisfied;“strongly disagree and disagree” as dissatisfied). Using Chi-square and Wilcoxon Rank Sum tests, we compared demographic and clinical characteristics of those who were satisfied and dissatisfied with telehealth in patients with ROME IV IBS. We used multivariate logistic regression to identify predictors for telehealth satisfaction. Results: Of 44,789 surveys sent, 2598 (5.8%) patients responded, 1473 (56.7%) completed the entire survey (median age 60.0 [42.4-71.2], 80.1% female;66.3% non-Hispanic white, 22.1% Hispanic, 5.0% black, 4.0% Asian) and 744 (28.6%) had ROME IV confirmed IBS. 651 (87.5%) patients with IBS used telehealth for their care: 436 (67.0%) were satisfied, 62 (9.5%) were dissatisfied and 153 (23.5%) felt neutral about their experience. No significant differences were seen in sex, race/ethnicity, BMI, marital status, income, IBS subtype or severity between satisfied and dissatisfied groups (Table 1). Telehealth satisfaction was associated with full-time employment (188, 43.1%, p>0.001), a college degree or higher (244, 56.0%, p=0.01), or daily social media use (338, 77.5%, p=0.01). Dissatisfaction was associated with older age (59.2±17, p<0.01), retirement (26, 41.9%, p=0.02) and low self-perceived health literacy (4, 6.5%, p=0.008). Satisfied patients would consider telehealth over a face-to-face visit for a travel time of 30-59 minutes (170, 39.0%, p=0.01);dissatisfied patients did not consider travel time a factor (23, 37.1%, p>0.001). Multivariate analysis confirmed age, a college degree, daily use of social media and travel time of 30-59 minutes as independent predictors of telehealth satisfaction (Table 2). Conclusions: A majority of patients with IBS are satisfied with telehealth and are more likely to use telehealth since the COVID-19 pandemic. Factors including age, available time, education level, health literacy and comfort with technology likely influence satisfaction with telehealth in IBS and may help to identify patients who would be most responsive to a focused IBS-telehealth program.(Table presented) (Table presented)

SELECTION OF CITATIONS
SEARCH DETAIL