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1.
Acs Es&T Water ; : 10, 2022.
Article in English | Web of Science | ID: covidwho-1927050

ABSTRACT

This study aimed to provide a low-cost technique for virus detection in wastewater by improving an aluminum hydroxide adsorption-precipitation method. The releasing efficiency of viruses trapped by the aluminum hydroxide precipitates was improved by adding ethylenediaminetetraacetic acid disodium salt (EDTA-2Na) to dissolve the precipitates at a Na(2)EDTA center dot 2H(2)O:AlCl3 molar ratio of 1.8-3.6. The recovery rates of the improved method for seven viruses, including SARS-CoV-2-abEN pseudovirus and six animal viruses, were 5.9-22.3% in tap water and 4.9-35.1% in wastewater. Rotavirus A (9.0-4.5 X 10(3) copies/mL), porcine circovirus type 2 (5.8-6.4 X 10(5) copies/mL), and porcine parvovirus (5.6-2.7 X 10(4) copies/mL) were detected in China's pig farm wastewater, while rotavirus A (2.0 X 10(3) copies/mL) was detected in hospital wastewater. SARS-CoV-2 was detected in hospital wastewater (8.4 X 10(2) to 1.4 X 10(4) copies/mL), sewage (6.4 X 10 to 2.3 X 10(3) copies/mL), and river water (6.6 X 10 to 9.3 X 10 copies/mL) in Nepal. The method was automized, with a rate of recovery of 4.8 +/- 1.4% at a virus concentration of 10(2) copies/mL. Thus, the established method could be used for wastewater-based epidemiology with sufficient sensitivity in coping with the COVID-19 epidemic and other virus epidemics.

2.
Ieee Sensors Journal ; 22(7):7231-7239, 2022.
Article in English | Web of Science | ID: covidwho-1868547

ABSTRACT

With the further development of online shopping and the impact of the COVID-19 pandemic, the logistics industry has further increased the demand for unmanned, automated warehousing and logistics handling. To realize intelligent warehousing and logistics handling, reliable positioning navigation technology is indispensable. Therefore, this paper designs a Dual-lidar high-precision natural navigation system based on the ROS (Robot Operating System) platform, which can fulfill the basic warehousing and logistics requirements. The natural navigation system uses the Lidar-SLAM method based on graph optimization to construct the 2D environment map, the PF (Particle Filter) algorithm in MRPT (Mobile Robot Programming Toolkit) is used for system positioning, and the real-time correction algorithm is used for motion control. On the built hardware platform, the navigation system completed the fixed-point cruise navigation task, and finally achieved a navigation accuracy of 4 cm and an average repeatable navigation accuracy of 6 mm. The designed navigation system has reference significance for multi-sensor fusion navigation. In reality, it can be applied to the transportation of warehousing and logistics, and it is expected to be mass-produced in the future.

3.
Vestn Otorinolaringol ; 87(2): 70-75, 2022.
Article in Russian | MEDLINE | ID: covidwho-1863439

ABSTRACT

The pandemic of the new coronavirus infection (COVID-19) has identified new diagnostic and medical tasks before different doctors. As observations show, children have the flow of infection easier than adults. However, in some cases, COVID-19 in children proceeds extremely difficult, with fever and multisystem inflammation, possibly requiring treatment in the resuscitation department. In domestic practice, the term "Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19" is used to indicate the disease. Among the local symptoms of MIS are inflammations of the skin and mucous membranes, as well as various lymphadenopathy. The article presents the results of our clinic's observation of 205 patients with MIS for the period from May 2020 to May 2021. In some patients, the clinical manifestations of MIS-C required differential diagnosis with parapharyngeal abscesses (PPA). For this purpose, the children were consulted by an otorhinolaryngologist and a CT scan of the neck with contrast enhancement was performed. Despite the striking clinical manifestations similar to PPA, in no case was a pharyngeal abscess revealed. Both of these diseases are potentially fatal if treatment is not started on time, and therefore we believe that the awareness of otorhinolaryngologists about the manifestations of MIS-C will be useful in modern clinical practice.


Subject(s)
COVID-19 , Pharyngeal Diseases , Abscess/diagnosis , Abscess/etiology , Abscess/therapy , Adult , COVID-19/complications , COVID-19/diagnosis , Child , Diagnosis, Differential , Humans , Pharyngeal Diseases/diagnosis , SARS-CoV-2 , Systemic Inflammatory Response Syndrome
4.
Embase; 2022.
Preprint in English | EMBASE | ID: ppcovidwho-334805

ABSTRACT

Omicron sub-lineage BA.2 has rapidly surged globally, accounting for over 60% of recent SARS-CoV-2 infections. Newly acquired RBD mutations and high transmission advantage over BA.1 urge the investigation of BA.2's immune evasion capability. Here, we show that BA.2 causes strong neutralization resistance, comparable to BA.1, in vaccinated individuals' plasma. However, BA.2 displays more severe antibody evasion in BA.1 convalescents, and most prominently, in vaccinated SARS convalescents' plasma, suggesting a substantial antigenicity difference between BA.2 and BA.1. To specify, we determined the escaping mutation profiles1,2 of 714 SARS-CoV-2 RBD neutralizing antibodies, including 241 broad sarbecovirus neutralizing antibodies isolated from SARS convalescents, and measured their neutralization efficacy against BA.1, BA.1.1, BA.2. Importantly, BA.2 specifically induces large-scale escape of BA.1/BA.1.1effective broad sarbecovirus neutralizing antibodies via novel mutations T376A, D405N, and R408S. These sites were highly conserved across sarbecoviruses, suggesting that Omicron BA.2 arose from immune pressure selection instead of zoonotic spillover. Moreover, BA.2 reduces the efficacy of S309 (Sotrovimab)3,4 and broad sarbecovirus neutralizing antibodies targeting the similar epitope region, including BD55-5840. Structural comparisons of BD55-5840 in complexes with BA.1 and BA.2 spike suggest that BA.2 could hinder antibody binding through S371F-induced N343-glycan displacement. Intriguingly, the absence of G446S mutation in BA.2 enabled a proportion of 440-449 linear epitope targeting antibodies to retain neutralizing efficacy, including COV2-2130 (Cilgavimab)5. Together, we showed that BA.2 exhibits distinct antigenicity compared to BA.1 and provided a comprehensive profile of SARS-CoV-2 antibody escaping mutations. Our study offers critical insights into the humoral immune evading mechanism of current and future variants.

5.
Journal of Medical Devices-Transactions of the Asme ; 16(1):6, 2022.
Article in English | Web of Science | ID: covidwho-1779290

ABSTRACT

The COVID-19 pandemic created an unprecedented shortage of personal protective equipment (PPE) for healthcare workers-especially respirators. In response to a lack of commercial respirator equipment, a multidisciplinary prototyping hackathon was held and the key components required to develop an inexpensive, scalable "COVID-19 reusable elastomeric respirator" (RER-19) were identified. Available hospital supplies were assessed based on their published technical specifications to meet each of the key component requirements. The fully assembled prototype was then validated through user testing, and volunteers underwent standard fit testing with cardiopulmonary monitoring while wearing the RER-19 in a small pilot study. Multiple social media platforms were then used to disseminate educational information on respirator assembly, use, and maintenance. Here, we present our institution's initial experience with prototyping to meet a specific healthcare challenge, in combination with prompt dissemination of information to educate and empower healthcare workers in the face of a critical PPE shortage during an unprecedented and evolving pandemic.

6.
ACS Applied Polymer Materials ; 2021.
Article in English | Scopus | ID: covidwho-1768763

ABSTRACT

The demand for air filtration products has increased significantly with the aggravation of air pollution and the pandemic of coronavirus disease (COVID-19). It is urgently needed to develop an air filtration membrane that exhibits lasting filtration performance and antibacterial activity. Herein, we report a large-scale blow spinning technique to produce polyvinylidene fluoride (PVDF) nanofiber membranes for highly efficient air mechanical filtration and its antibacterial modification by adding the silver nanoparticles (AgNPs). The PVDF nanofiber membrane with an area density of only 1.0 g/m2 exhibits the highest filtration efficiency of 98.63% for the particle with a size of 0.3 μm. After eliminating static electricity, there is almost no reduction in the filtration efficiency of particulate matter with a size larger than 1 μm and only 4.69% decrease in the particulate matter with a size of 0.5 μm. Hence, the PVDF nanofiber membrane with nanostructures for air filtration works mainly by the means of mechanical filtration. To inhibit the survival or growth of the intercepted bacteria on the membrane, the PVDF/AgNPs nanofiber membrane was fabricated by adding AgNPs to PVDF nanofibers, which exhibits the strongest antibacterial activity of more than 99% and an excellent filtration efficiency similar to that without adding AgNPs. The nanofiber membrane with antibacterial activity is expected to extend the service or storage time or be reused without loss of filtration performance. Additionally, large-scale production of nanofiber filtration membranes has been realized using a multi-needle blow spinning machine. © 2022 American Chemical Society.

7.
Open Public Health Journal ; 14:592-599, 2021.
Article in English | Scopus | ID: covidwho-1745216

ABSTRACT

Aims: The study examines the factors related to the appraisal and adherence of the individual and public health preventive measures. Background: The effectiveness of the measures battling the pandemic was largely determined by the voluntary compliance of the public. Objectives: This study aimed to identify psychological perception factors related to the appraisal of individual measures and endorsement of public health measures during the early stage of the COVID-19 pandemic among Chinese living in Canada. Methods: A convenience sample of 656 participants completed an online survey. Nonparametric Kruskal Wallis tests were used to compare COVID perception variables (e.g., perceived susceptibility, fear, perceived severity, and information confusion) among different sociodemographic subgroups. Bootstrapped regression models were used to assess the association of these variables with outcome measures. Results: Compared to their counterpart groups, lower perceived susceptibility was reported by adults 65 years and older (p = .002) or retired (p = .015);greater fear was reported by females (p = .044), those with lower education (p = .001), and Mainland Chinese (p = .033);greater perceived severity was reported by individuals with lower education and smaller household size (ps = .003). Perceived susceptibility was inversely associated with individual measure appraisal (p = .032). Perceived severity was positively associated with individual measure appraisal (p = .005) and public measure endorsement (p < .001). Conclusion: Individual behaviour measure appraisal was predicted by lower perceived susceptibility and higher perceived severity, whereas public health measure endorsement was related to higher perceived severity. These results inform the public and the policymakers about the critical factors that affect the preventive measure appraisal and endorsement. © 2021 Na et al.

8.
Vopr Pitan ; 91(1): 86-97, 2022.
Article in Russian | MEDLINE | ID: covidwho-1744381

ABSTRACT

The problem of increasing the population antiviral immunity is of particular importance during the third year of the SARS-CoV-2 pandemic. Concomitant intestinal dysbiosis is known to play an significant role in immune cell dysfunction. Therefore, it is very important to take measures to maintain the gut microbiota using the most affordable nutritional remedies, which include fermented milk and probiotic products designed for mass population consumption and capable of enhancing their immune defence when added to the daily diet. The aim of the study was to analyze scientific evidence highlighting the role of intestinal microbiota in maintaining the macro-organism immunological balance, and to evaluate modern fermented milk and probiotic products in terms of their effect on normalising the gut microbiota and their importance in the prevention and treatment of SARS-CoV-2. Material and methods. The presented scientific and analytical review analyzed the data of electronic resources of the Global Health platform, scientific libraries eLIBRARY.RU, Cochrane Library and CyberLeninka, the search system Google Academy¼, specialized sites for scientific publications ScienceDirect and Elsevier, bibliographic databases of articles on medical sciences MEDLINE, CDC infection diseases, Embase and PubMed- NCBI. The structural-logical, analytical and axiomatic methods were used. Results. It has been shown that normal intestinal microbiota takes part in maintaining metabolism in the digestive tract, increases the body's immune reactivity and regulates the functioning of all organs and systems. The severity of dysbiotic disorders can determine susceptibility to SARS-CoV-2, the severity of this infection course, as well as the level of post-infection and post-vaccination anti-COVID-19 immunity. The high prevalence of gut dysbacteriosis indicates the need to strengthen measures of correcting dysbiotic disorders, including the inclusion of fermented and probiotic products in the daily population diet. Conclusion. Fermented milk and probiotic products, as sources of easily digestible macronutrients, essential micronutrients, biologically active substances and beneficial live microorganisms, should be included in the daily diet during the SARS-CoV-2 pandemic to increase the adaptive capacity and immunity of the population.


Subject(s)
COVID-19 , Diet , Gastrointestinal Microbiome , Milk , Probiotics , Animals , COVID-19/immunology , COVID-19/prevention & control , Fermentation , Gastrointestinal Microbiome/immunology , Humans , Milk/microbiology , Pandemics , Probiotics/administration & dosage , SARS-CoV-2
9.
Techne: Research in Philosophy and Technology ; 25(3):503-512, 2021.
Article in English | Scopus | ID: covidwho-1707938

ABSTRACT

Reluctance to adopt mask-wearing as a preventive measure is widely observed in many Western societies since the beginning of the COVID-19 pandemics. This reluctance toward mask adoption, like any other complex social phenomena, will have multiple causes. Plausible explanations have been identified, including political polarization, skepticism about media reports and the authority of public health agencies, and concerns over liberty, amongst others. In this paper, we propose potential explanations hitherto unnoticed, based on the framework of epistemic injustice. We show how testimonial injustice and hermeneutical injustice may be at work to shape the reluctant mask adoption at both the societal and individual levels. We end by suggesting how overcoming these epistemic injustices can benefit the global community in this challenging situation and in the future. © 2021 Philosophy Documentation Center. All rights reserved.

10.
Chinese Journal of New Drugs ; 30(22):2029-2033, 2021.
Article in Chinese | Scopus | ID: covidwho-1589974

ABSTRACT

mRNA-based drug has already become a focus as a potential new type of drug in recent years. With the rapidly evolving technologies, mRNA has been widely applied in various areas of clinical research, such as immune disease, oncological disease, infectious disease, and congenital metabolic disorder. Since the outbreak of COVID-19, there has been a great leap in mRNA vaccine development, forecasting that much more mRNA medicines will enter the market in the near future. In order to meet industrial requirements, this article provides an overview of the product profiles of mRNA-based drugs and their industrial landscape, and further discusses the key considerations in the manufacturing of such medicines. © 2021, Chinese Journal of New Drugs Co. Ltd. All right reserved.

11.
Lancet ; 398(10317):2147-2148, 2021.
Article in English | Web of Science | ID: covidwho-1576530
12.
Chinese Journal of Disease Control and Prevention ; 25(4):421-426, 2021.
Article in Chinese | Scopus | ID: covidwho-1566857

ABSTRACT

Objective To explore the epidemic characteristics of COVID-19 in Lu’an city, so as to provide scientific basis for the prevention and control of COVID-19 in this area. Methods All the confirmed cases of COVID-19 were selected from the Infectious Disease Reporting System from the onset of disease to 24:00 on February 18th, 2020 in Lu’an City. The general demographic, onset and medical information, and epidemiological characteristics of confirmed cases were collected to describe the feature of patients. The spatial and temporal distribution of disease transmission was analyzed by SaTScan 9.6.0.0 software, and Excel 2010 software was used to draw the epidemic curves of all cases. Results A total of 69 confirmed cases were reported in Lu’an City by February 18th, 2020. There were more male cases (44) than female (25), and cases mainly aged 36-45 years old (37.68%). The proportion of workers was the highest (24.64%). The first symptom of conformed cases was fever (50, 72.46%), cough (25, 36.23%) and fatigue (12, 17.40%). The epidemic was more serious in Jinzhai County (23), Huoshan County (17) and Huoqiu County (13). The number of cases in Lu’an showed that the first epidemic peak occurred between January 25th and January 28th, and the largest number of cases occurred on January 27th, then showed a downward trend. A total of 45 aggregate cases were found. Conclusion The COVID-19 epidemic in Lu’an City is generally preventable and controllable. It will be alert to the risk of family clustering, spread of asymptomatic infections and imported cases. Future work should focus on the investigation of close contacts. © 2021, Publication Centre of Anhui Medical University. All rights reserved.

13.
Journal of Alternative and Complementary Medicine ; 27(11):A3, 2021.
Article in English | EMBASE | ID: covidwho-1554546

ABSTRACT

Purpose: To confirm whether self-administered AVNA treatment is effective in improving emotional distress under the COVID-19 pandemic. Methods: A smartphone-based online, randomized, controlled trial was designed from 26 February 2020 to 28 April 2020 in four study sites, including Wuhan, Beijing, Shenyang, and Guangzhou of China. Local residents who had considerable emotional distress with a score of the Hospital Anxiety and Depression Scale (HADS) ≥ 9 were recruited. Participants were randomly assigned to three times of AVNA (n = 191) per day, in morning, around noon, and in evening or usual care (UC, n = 215) once daily for 14 days. The primary outcome was the response rate, which was the proportion of participants whose Hospital Anxiety and Depression Scale (HADS) score reduced from baseline by ≥ 50%. The assessment was conducted at baseline, 3 days, and 14 days. Results: The AVNA group had a markedly higher response rate than the UC group at 3 days (35.6% vs. 24.9%, P = 0.02) and at 14 days (70.7% vs. 60.6%, P = 0.02). The AVNA group showed significantly greater reduction in scores of HADS at the two measurement points and BAI at 3 days (P ≤ 0.03), with average respective effect size of 0.217 and 0.195. Participants with AVNA spent less time falling asleep and rated their sleep quality being remarkably higher than those with UC at endpoint. Conclusion: During COVID-19 pandemic period, treatment with self-administrated AVNA was more effective than UC in reducing emotional distress of isolated populations. These findings support self-administered AVNA as a treatment option for patients with emotional distress under the COVID-19 pandemic or other emergent events.

14.
2nd International Conference on Public Health and Data Science, ICPHDS 2021 ; : 139-147, 2021.
Article in English | Scopus | ID: covidwho-1537746

ABSTRACT

The outbreak of novel coronavirus puts China at risk of economic downturn. In addition, with the concentrated outbreak of the epidemic in the world, especially in developed economies, there is still a lot of uncertainty about global economic growth. International public health emergencies and their responses, especially the impact of global infectious diseases, are not limited to the medical sector. Therefore, this paper will focus on and explore its impact on the international free trade system, supply-side, supply chain security and efficiency, and international finance. And the author finds that infectious diseases may promote the accelerated rise of non-contact commerce and trade in services, and promote the transformation and upgrading of China's foreign trade. This paper quantitatively analyzes the use of e-commerce platform of college students during the epidemic through SPSS statistical software, and finds that international public health emergency response measures not only have an impact on the trade supply side, but also have an asymmetric impact on the demand side. The epidemic will also boost China's e-commerce platform new business type. At last, through the above analysis, the paper puts forward measures and suggestions that can reduce the impact of such incidents on China's economy, and improve the control system of international public health emergencies in China. © 2021 IEEE.

15.
Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities ; 42(11):3509-3518, 2021.
Article in English | Scopus | ID: covidwho-1524547

ABSTRACT

Rapid detection of body fluid severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) antibody is an effective strategy for infection therapeutic effect of coronavirus disease(COVID-19). Most detection methods require relatively large equipment, which limited their on-site application. Lateral flow immunoassay(LFIA) can be used to qualitative antibody detection based on the aggregation of gold nanoparticles (Au NPs), which exhibits just one-color change and cannot realize rapid quantitative detection without the help of additional equipment. In this study, a high-resolution multicolor colorimetric strategy was developed and applied to assessing antibody concentration at a glance based on etching of gold nanorods(Au NRs). Firstly, SARS-CoV-2 recombinant antigen was immobilized on the surface of the 96-wells. Then, horseradish peroxidase(HRP)-labeled second antibody combined with antibody to form an antigen-antibody-secondary antibody complex on the well surface, which has direct relationship with antibody concentration in the sample and can be used to oxidize 3, 3', 5, 5'-tetramethylbenzidine(TMB) to form TMB2+ at the presence of HRP. The generation of TMB2+ efficiently etch Au NRs to produce multicolor solution. The etching result in vivid color changes in the system has a relationship with the amount of SARS-CoV-2 IgM antibody. Under the optimal conditions, the proposed strategy exhibited a linear response in the 5.00―200 IU concentration range, and a detection limit of 1.29 IU for SARS-CoV-2 IgM antibody, with high sensitivity and specificity. This assay is prospective for the on-site semi-quantitative visual detection of SARS-CoV-2 IgM antibody concentration in the COVID-19 therapeutic process. © 2021, Editorial Department of Chem. J. Chinese Universities. All right reserved.

16.
Kexue Tongbao/Chinese Science Bulletin ; 66(31):3925-3931, 2021.
Article in Chinese | Scopus | ID: covidwho-1523391

ABSTRACT

Left unmitigated, climate change poses a catastrophic risk to human health, demanding an urgent and concerted response from every country. The 2015 Lancet Commission on Health and Climate Change and The Lancet Countdown: Tracking Progress on Health and Climate Change have been initiated to map out the impacts of climate change and the necessary policy responses. To meet these challenges, Tsinghua University, partnering with the University College London and 17 Chinese and international institutions, has prepared the Chinese Lancet Countdown report, which has a national focus and builds on the work of the global Lancet Countdown: Tracking Progress on Health and Climate Change. Drawing on international methodologies and frameworks, this report aims to deepen the understanding of the links between public health and climate change at the national level and track them with 23 indicators. This work is part of the Lancet's Countdown broader efforts to develop regional expertise on this topic, and coincides with the launch of the Lancet Countdown Regional Centre in Asia, based at Tsinghua University. The data and results of this report are presented at the provincial level, where possible, to facilitate targeted response strategies for local decision-makers. Based on the data and findings of the 2020 Chinese Lancet Countdown report, five recommendations are proposed to key stakeholders in health and climate change in China: (1) Enhance inter-departmental cooperation. Climate change is a challenge that demands an integrated response from all sectors, urgently requiring substantial inter-departmental cooperation among health, environment, energy, economic, financial, and education authorities. (2) Strengthen health emergency preparedness. Knowledge and findings on current and future climate-related health threats still lack the required attention and should be fully integrated into the emergency preparedness and response system. (3) Support research and raise awareness. Additional financial support should be allocated to health and climate change research in China to enhance health system adaptation, mitigation measures, and their health benefits. At the same time, media and academia should be fully motivated to raise the public and politicians' awareness of this topic. (4) Increase climate change mitigation. Speeding up the phasing out of coal is necessary to be consistent with China's pledge to be carbon neutral by 2060 and to continue to reduce air pollution. Fossil fuel subsidies must also be phased out. (5) Ensure the recovery from COVID-19 to protect health now and in the future. China's efforts to recover from COVID-19 will shape public health for years to come. Climate change should be a priority in these interventions. © 2021, Science Press. All right reserved.

17.
Kardiologiia ; 61(10): 99-103, 2021 Oct 30.
Article in Russian | MEDLINE | ID: covidwho-1515681

ABSTRACT

The article presents recent data on possibilities of a broader use of mineralocorticoid receptor antagonists for existing indications and of expanding indications for the use of this pharmaceutical group in the context of the novel coronavirus infection COVID-19. The authors discussed prospects for expanded detection of aldosteronism using a new diagnostic approach, including an additional evaluation of blood pressure response to spironolactone.


Subject(s)
COVID-19 , Hypertension , Expert Testimony , Humans , Mineralocorticoid Receptor Antagonists , SARS-CoV-2 , Spironolactone
18.
TrAC - Trends in Analytical Chemistry ; 144, 2021.
Article in English | EMBASE | ID: covidwho-1466938

ABSTRACT

Decorating liquid crystals (LCs) with stimuli-responsive materials provides a bridge between the LCs and the biochemical interactions. The alignments of the LC molecules are particularly sensitive. Even small perturbations to the LC interface can substantially direct the orientation of bulk LC phases, which results in transduction and amplification of the chemical and biological events into readily detectable optical outputs. These characteristics make the LCs extremely alluring for the development of biosensors that allow highly sensitive and label-free detection of biomarkers at the aqueous/LC interface. In this review, we organize the LC-based sensing systems into six groups, including monolayer formation, monolayer removal, monolayer disruption, floating LC droplets, sessile LC droplets, and LC elastomer microspheres. The principle, utilization, advancement, and limitations of each platform for the detection of various biomarkers are discussed in detail, which will help expand our understanding of the development of LC-based sensors for advanced diagnostic and therapeutic approaches.

19.
Chest ; 160(4):A1095, 2021.
Article in English | EMBASE | ID: covidwho-1466128

ABSTRACT

TOPIC: Critical Care TYPE: Original Investigations PURPOSE: Ventilator weaning protocols rely in part on objective indices to best predict extubation failure in the critically ill. In this study, we investigated static lung compliance (LC) as a predictor of extubation failure, in comparison to extubation readiness using rapid shallow breathing index (RSBI). METHODS: A cross-sectional, multi-institutional study of 2,334 mechanically ventilated patients admitted from 12/01/2017-12/01/2019. We included all older than 18 years with a documented spontaneous breathing trial and extubation trial. Static lung compliance and RSBI were calculated prior to extubation trial. The primary outcome was extubation failure - defined as need for reintubation within 24 hours from time of extubation. RESULTS: Of the 2,334 patients, 55.6% were males with a mean age of 66-years. The population consisted mostly of Caucasians (74%) and African Americans (20%). 183 of 2,334 (7.84%) patients required reintubation within 24 hours. There was a negative correlation between RSBI and lung compliance at time of extubation trial. The logLC of patients requiring reintubation was significantly lower than those who remained extubated with a mean of 3.58 ± 0.43 vs. 3.69 ± 0.49 (95% CI in difference:0.041 -0.17;p = 0.001). Whereas, log RSBI was not significant for 24-hour reintubation (p = 0.521). Patients were then dichotomized to a compliance of less or greater than 50 and RSBI of less or greater than 104. LC < 50 remained a significant predictor for extubation failure (OR 1.54;95% CI: 1.07-2.22;p = 0.019) whereas, RSBI >104 was not associated with extubation failure (OR 1.53;98% CI:0.20 -11.57;p = 0.674). On multivariate logistic regression after adjusting for age, mode of ventilation, ventilator days, and P/F ratio, LC remained the strongest predictor for 24-hr reintubation (OR 1.56;95% CI: 1.14-2.13). CONCLUSIONS: Static lung compliance measured at the day of extubation is a promising physiological discriminant to evaluate extubation readiness. We recommend further validation studies in prospective cohorts. CLINICAL IMPLICATIONS: Static lung compliance may potentially be used as a discriminant to risk stratify patients with acute respiratory failure for extubation success. DISCLOSURES: No relevant relationships by Lauren Abplanalp, source=Web Response No relevant relationships by Girish Balachandran Nair, source=Admin input No relevant relationships by Enrique Calvo Ayala, source=Web Response No relevant relationships by Limin Yu, source=Web Response

20.
2021 IEEE International Conference on Intelligent Reality, ICIR 2021 ; : 39-48, 2021.
Article in English | Scopus | ID: covidwho-1413624

ABSTRACT

The COVID-19 pandemic has motivated a shift from physical interaction, approaches, or procedures due to social distancing. More people are at home using digital displays for real-time communication and engagement. With recent innovations in computational hardware for spatial applications, such as extended reality technologies, entry barriers for hosting intimate, interpersonal, virtual events continue to fall. The barrier falls at such a rate that the production or manufacturing of an extended reality system for different and simultaneous, practical scenarios may be built to solve communication issues resulting from COVID-19. This paper aims to describe a low-cost networked holographic system that can be used for various purposes such as communication, education, and gaming. We created three different applications to show the cross-compatibility, effectiveness, and usability of our system. © 2021 IEEE.

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