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1.
17th Annual ACM/IEEE International Conference on Human-Robot Interaction, HRI 2022 ; 2022-March:870-874, 2022.
Article in English | Scopus | ID: covidwho-2097606

ABSTRACT

The use of social robots has recently been investigated in various areas, including STEM (Science, Technology, Engineering, and Mathematics) education and artistic performances. To inform children of the seriousness of climate change and awareness that they can make change, we created the Robot Musical Theater performance. In this project, natural elements (wind, earth, fire, and water) were anthropomorphized and represented by humanoid robots (Pepper, Milo, and Nao). The robots were designed to motivate audience to participate in the action to prevent climate change. Because of COVID, only fourteen visitors as a single group were allowed to participate in real-time and posted to YouTube, where at the time of submission, 141 people have viewed the performance. The participants provided positive comments on the performance and showed their willingness to participate in the movement to prevent climate change, and expressed their further interest in STEM learning. This performance is expected to contribute to enhancing informal STEM and robotics learning, as well as advancing robotic arts. © 2022 IEEE.

2.
Bull Exp Biol Med ; 173(6): 734-739, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2094660

ABSTRACT

IgM and IgG antibodies to the SARS-CoV-2 virus are detected in subjects who have recovered from COVID-19; IgM antibodies persist in a 1/3 of infected subjects up to 12 months from the moment of the disease, while IgG antibodies are present in the vast majority of cases (97%; medium and high levels antibodies were registered in 85% of cases). By the 12th month, 40% of those who recovered still have a very high level of IgG antibodies to the S-protein (>500 BAU/ml). In the feces, urine, and blood serum of patients with long-term persistent IgM antibodies, no coronavirus antigens were detected. After vaccination with the Gam-COVID-Vac vaccine, IgG antibodies to the S-protein are detected in 100% of cases and remain at a high level for 4 months, by the 5-6th month, the level of antibodies decreases. During revaccination, the level of IgG antibodies to S-protein reaches high values earlier than during primary vaccination, and remains high for 4 months (observation period). The blood sera of recovered and vaccinated patients have a high virus-neutralizing activity (at least 1:80), while its level is somewhat higher in recovered patients.


Subject(s)
Antibodies, Viral , COVID-19 , Humans , Immunization, Secondary , COVID-19/prevention & control , SARS-CoV-2 , Vaccination , Immunoglobulin M , Immunoglobulin G
3.
Russian Journal of Anesthesiology and Reanimatology /Anesteziologiya i Reanimatologiya ; 2022(5):71-78, 2022.
Article in Russian | Scopus | ID: covidwho-2091094

ABSTRACT

The review is devoted to cellular and molecular mechanisms of the course and progression of new coronavirus disease, in particular, the role of hypoxia and hypoxia-induced factor 1α (HIF-1α). Literature searching was performed in the PubMed, Medline and Web of Science databases for the period 2019—2022. Hypoxia is a direct consequence of lung damage due to COVID-19 infection. In the areas of SARS-CoV-2-induced damage, focal inflammation occurs, and tissue microenvironment becomes hypoxic («inflammatory hypoxia»). Possible causes of «silent», «happy» or «apathetic» hypoxia in patients with COVID-19 and no symptoms of respiratory discomfort are discussed. HIF-1α activated by hypoxia is generally considered to be the main regulator of cellular response to oxygen deficiency. There is no consensus regarding the role of its activation in pathogenesis of COVID-19. As a transcriptional factor, HIF-1α can reduce penetration of SARS-CoV-2 via proteins controlling its entry into cells. This protein also reduces angiotensin-converting enzyme 2 receptor (ACE2) and serine protease expression, as well as increases expression of ADAM17 enzyme, which cleaves ACE2 from surface membrane of alveolocyte. The reverse side of HIF-1α activation may be fulminant cytokine storm as a result of expression of immune cells releasing pro-inflammatory cytokines. Possible HIF-dependent approaches to the treatment and prevention of COVID-19 are considered. These approaches are aimed at either suppressing HIF-1α activity using HIF-1α suppressor drugs or activating and stabilizing HIF-1α using HIF prolyl hydroxylase inhibitors. © E.V. VOLCHKOVA1, N.A. KUZUBOVA2, YU.S. ALEKSANDROVICH1, E.S. LEBEDEVA2.

4.
American Journal of Cancer Research ; 12(8):4040-4049, 2022.
Article in English | EMBASE | ID: covidwho-2084307

ABSTRACT

The outbreak of the COVID-19 pandemic has greatly impacted patients with non-small cell lung cancer (NSCLC), making the fear of cancer recurrence (FCR) more pronounced. We explored the effects of FCR on immunotherapy efficacy and quality of life during the COVID-19 pandemic in China among the 124 NSCLC patients enrolled in this study. Quality of life and immunotherapy efficacy were compared between high- and low-FCR groups after completing 4-6 courses of treatment or cancer progression. Worse immunotherapy efficacy and quality of life were reported for the high-FCR group than for the low-FCR group. These findings emphasize the need to pay close attention to the level of FCR in NSCLC patients. Efforts should be taken to alleviate FCR levels among NSCLC patients. Moreover, research is needed to investigate the possible link between immunotherapy efficacy and FCR. Copyright © 2022 E-Century Publishing Corporation. All rights reserved.

5.
Statistica Sinica ; 32:2119-2146, 2022.
Article in English | Web of Science | ID: covidwho-2083013

ABSTRACT

With increasingly abundant data that relate to both space and time becoming available, spatiotemporal modeling is receiving much attention in the literature. This paper study develops a class of spatiotemporal autoregressive par-tially linear varying-coefficient models that are sufficiently flexible to simultaneously capture the spatiotemporal dependence and nonstationarity often encountered in practice. When spatial observations are observed over time and exhibit dynamic and nonstationary behaviors, our models become particularly useful. We develop a numerically stable and computationally efficient estimation procedure, using the tensor-product splines over triangular prisms to approximate the coefficient func-tions. The estimators of both the constant coefficients and the varying coefficients are consistent. We also show that the estimators of the constant coefficients are asymptotically normal, which enables us to construct confidence intervals and make inferences. The method's performance is evaluated using Monte Carlo experiments, and applied to model and forecast the spread of COVID-19 at the county level in the United States.

6.
23rd International Conference on Electronic Packaging Technology, ICEPT 2022 ; 2022.
Article in English | Scopus | ID: covidwho-2078212

ABSTRACT

Along with the COVID-19 pandemic and the large-scale application of 5G, IoT has become more critical for our daily lives. GaAs is a promising semiconductor for field effect transistors in IoT applications. Due to the high electron mobility of GaAs, n-type FinFET based on GaAs is expected with a higher conductance and electron velocity than Silicon. FinFET based on GaAs has a lower subthreshold swing (SS) and higher Ion/Ioff than FinFET based on Silicon, particularly at high temperatures.Negative Capacitance FinFET(NC-FinFET) is an important emerging technology for low-power applications. To further enhance the performance of the GaAs FinFET, we incorporate Hf0.5Zr0.5O2 films in the gate to achieve Negative Capacitance (NC). The NC effect brings a higher Ion/Ioff and a negative coefficient to reduce the SS of the FinFET. Our simulation research proves the GaAs-NC-FinFET has the slightest SS variation in 300K-400K and maximum Ion/Ioff compared with other FinFETs. © 2022 IEEE.

7.
Journal of Food and Drug Analysis ; 30(3):440-453, 2022.
Article in English | EMBASE | ID: covidwho-2067698

ABSTRACT

The jelly from achenes of Ficus pumila var. awkeotsang (FPAA) is a famous beverage ingredient in Taiwan. In this work, ficumarin (1), a new compound was obtained from its twigs (FPAT) and elucidated with comprehensive spectroscopic data. The biosynthetic origin was proposed from the p-coumaroyl-CoA pathway. Alloxanthoxyletin, betulinic acid, and catechin were identified as the major and active constituents responsible for relieving neutrophilic inflammation by FPAT. Among them, the most potent alloxanthoxyletin was found to interact with PRO350 and GLU377 of human INOSOX. Further, Nrf2 activating capacity of the FPAT fraction and its coumarins was confirmed. With the analysis of LC-MS/MS data and feature-based molecular networking, coumarins were found as the dominant and responsible components. Notably, alloxanthoxyletin increased Nrf2 expression by up to 816.8 +/- 58% due to the interacting with the VAL561, THR560 and VAL420 residues of 5FNQ protein. COVID-19 Docking Server simulation indicated that pyranocoumarins would promisingly interfere with the life cycle of SARS-CoV-2. FPAT was proven to exert. Copyright © 2022 Taiwan Food and Drug Administration.

8.
Russian Journal of Anesthesiology and Reanimatology /Anesteziologiya i Reanimatologiya ; 2022(4):78-84, 2022.
Article in Russian | Scopus | ID: covidwho-2056578

ABSTRACT

Intensive therapy of severe COVID-19 is one of the most difficult problems of modern intensive care. Objective. To assess the effectiveness of clinical guidelines in the treatment of severe forms of a new coronavirus infection in children. Material and methods. A retrospective controlled non-randomized multiple-center study enrolled 111 ICU children from 40 hospitals. Specialists of the Federal Remote Intensive Care Counselling Centre counseled all patients. Children were divided into 2 groups («recovery» and «death») depending on the outcome. Results. pSOFA score 2 (1—5) at admission was associated with 19.5-fold increase of mortality risk (OR 19.5, 95% Cl 2.3—165.7). We found higher score «respiratory distress» item in all patients regardless the outcome. Antibacterial, corticosteroid therapy and vasopressor support significantly affected the outcome of disease (X2=18.202;df=3, p=0.000), while infusion, respiratory, anticoagulant therapy and enteral nutrition were less significant, especially in pSOFA score ≤4 points (X2=15.521;df=5, p=0.008). Mortality risk decreased in no need for increase of initial doses of catecholamines (OR 0.2, 95% 0=0.1—0.7). Less compliance with recommendations for correction of antibacterial and corticosteroid therapy was followed by higher mortality (OR 5.2, 95% Cl 1.4—18.9 and OR 3.4, 95% Cl 1.1—10.8, respectively). Conclusion. Timely strict implementation of clinical guidelines, adequate catecholamine support, antibacterial and corticosteroid therapy in children with COVID-19 significantly reduce the likelihood of mortality. © 2022, Media Sphera Publishing Group. All rights reserved.

9.
2022 International Symposium on Educational Technology, ISET 2022 ; : 221-223, 2022.
Article in English | Scopus | ID: covidwho-2052037

ABSTRACT

The outbreak of COVID-19 promotes the development of online learning. Micro-video course has become the mainstream learning resource of online learning because of its concise theme, strong pertinence and vivid content. However, there are few researches on feedback strategy of micro-video course in basic education. Based on the principles of multi-media design and ADDIE instructional design model, a micro-video course of robot knowledge was designed in this study. Different feedback strategies(i.e., descriptive feedback (DF), evaluative feedback (EF), suggestive feedback(SF), guiding feedback (GF)) were embedded in the micro-video course. The effects of four feedback strategies on students' learning outcome, cognitive load, and learning motivation were explored through experiment. The results provide some suggestions for the production of basic education micro-video course. © 2022 IEEE.

10.
11.
Journal of General Internal Medicine ; 37:S207, 2022.
Article in English | EMBASE | ID: covidwho-1995868

ABSTRACT

BACKGROUND: The COVID-19 pandemic brought unforeseen challenges and had many unfortunate consequences. The unprecedented uncertainty and other drastic changes that were driven by the pandemic illuminated some of the existing flaws in our healthcare system and in medical education. Numerous articles have been published discussing the impact of COVID-19;however, relatively few focus on its relation to medical education, specifically regarding communication, health equity, and uncertainty in medicine. We aim to explore these challenges as opportunities to guide improvements in medical education curriculum in these areas. METHODS: Physicians across Colorado from various medical specialties and unique practice environments were interviewed. We developed a standard set of interview questions that focused on the impact of the pandemic in the context of physicians' practices, the effect on patient care, adaptations, and the impact on trainees' education. Audio files of the interviews were transcribed, analyzed, and tallied according to a list of systematically established themes. The final data was reviewed to identify common and critical themes that could be used as an opportunity to create a positive transformation to medical education. RESULTS: Thirty-one physicians across 20 different medical specialties and sub-specialties were interviewed within the month of April 2020. Analysis of the interviews identified a number of common themes including significant mental health impact, a lack of data to drive clinical decisions, challenges in communication with patients and their families, and a disproportionate impact of the pandemic on underserved communities. Next steps include the administration and analysis of a follow-up survey of proposed innovative solutions for all interviewed physicians. CONCLUSIONS: The pandemic illuminated gaps in our healthcare system that were already present but not readily apparent. These identified themes impact all specialties, demonstrating that many of these gaps are universal in the field of medicine, and we believe that the best way to effect change is to incorporate these topics into medical education. Challenging trainees to navigate complex cases that may lack absolute answers would emphasize critical thinking and better prepare physicians for the uncertainties and complexities of medicine. As telehealth has transformed healthcare delivery, students must learn to navigate the nuances of virtual care without sacrificing the quality of care. Also, the increased prevalence of anxiety has highlighted the importance of being adequately trained to identify and address mental health disorders regardless of medical specialty. Lastly, the pandemic's disproportionate impact on underserved populations emphasizes the importance for students to be well-versed on topics such as health equity, policy reform and advocacy, and economics in ways that allow for actionable change.

12.
Sustainability ; 14(14):13, 2022.
Article in English | Web of Science | ID: covidwho-1979365

ABSTRACT

The COVID-19 pandemic impacts our lives significantly;people have changed their daily lives in response to the unprecedented epidemic which not only awakened the arrival of a new normal in business, but also new lifestyles. For example, the adaptation of contactless mobile payment has grown in the past two years to avoid unnecessary contact and possible infections. In this study, we intend to examine behavioral intentions that made consumers shift from traditional cash payment to mobile payment during the COVID-19 period. Our research framework and hypotheses were developed and examined through the push (dissatisfaction)-pull (alternative attractiveness)-mooring (perceived fear) model. We used structural equation modeling (SEM) to validate our model and corresponding hypotheses. The results of this study showed that dissatisfaction with tradition-al payments and customer's perceived fears positively and significantly affected switching intentions. However, alternative attractiveness had no significant impact on consumers' switching intentions from cash to mobile payments during the pandemic. Moreover, this study shows how perceived fear has a mediating effect that motivates people to change their payment behaviors. Implications and future research directions about consumers changing in such a dynamic time are also discussed.

13.
Psychiatria Danubina ; 34:S31-S31, 2022.
Article in English | Web of Science | ID: covidwho-1976148
14.
JOURNAL OF GENERAL INTERNAL MEDICINE ; 37(SUPPL 2):207-207, 2022.
Article in English | Web of Science | ID: covidwho-1935360
15.
Developments in Marketing Science: Proceedings of the Academy of Marketing Science ; : 149-150, 2022.
Article in English | Scopus | ID: covidwho-1930271

ABSTRACT

The rapid development of social media and influencer marketing has tremendously changed the way in which consumers collect information, make purchase decisions, and communicate with brands (Lou and Yuan 2019;Neal 2017;Scott 2015). Marketing practitioners, especially those from luxury brands, are explosively increasing their budget on influencer marketing more than ever for its payoff in sales performance (Lou and Yuan 2019). During the worldwide quarantine and social distancing due to the breakout of COVID-19 pandemic, influencer marketing has become one of the most prevailing marketing approaches. Researchers have revealed a variety of impacts of influencer marketing on both consumer behaviors and branding performance (Blackwell et al. 2017;Hollebeek et al. 2016;Schivinski et al. 2016;Vanmeter and Grisaffe 2015). However, there is a lack of evidence to answer whether consumers develop emotional attachment and to what extent towards the influencer and the brand involved in the brand-influencer collaboration. This research, founded on social attachment theory (Mawson 2005), adopts a mixed methodology approach to investigate the relationship between consumer satisfaction derived from influencer promoted purchases, influencer attachment, and luxury band attachment. In the context of influencer marketing, our research reveals positive relationships between consumer satisfaction, influencer attachment and luxury brand attachment respectively;furthermore, the positive impact of consumer satisfaction on influencer attachment is stronger than on luxury brand attachment. This research also identifies a positive moderating role of brand sponsorship on the relationship between consumer satisfaction and luxury brand attachment. Although the COVID-19 crisis has caused severe social and business isolation, it brings some exceptional opportunities for brands to bond with their target consumers through social media and influencer marketing. Our results show that consumers more autonomously engage in behaviors that enhance the development of attachment due to the social isolation under quarantine. This finding qualifies social attachment theory (Mawson 2005) to explain the occurrence of affiliation in the context of influencer marketing and identifies influencers as attachment figures to their online communities. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

16.
2022 IEEE International Memory Workshop, IMW 2022 ; 2022.
Article in English | Scopus | ID: covidwho-1901470

ABSTRACT

Hyperdimensional computing (HDC) is a promising paradigm for large-scale genome sequencing. In this work, we explore the feasibility of the in-memory HDC on 3D NAND Flash for genome sequencing. We investigate the HDC engine with geographical region classification of SARS-CoV-2 genome sequences. The simulation results indicate the robustness of the classification accuracy despite the 3D NAND Flash non-idealities. The system performance is evaluated and it achieves 1.21× improvement on energy efficiency compared to PCM-based HDC engine. The area efficiency is also improved by 3.79×. © 2022 IEEE.

17.
Immunologiya ; 43(2):174-187, 2022.
Article in English | EMBASE | ID: covidwho-1897332

ABSTRACT

Introduction. In severe cases of coronavirus disease 2019 (COVID-19) pulmonary infiltration is accompanied by cytokine storm syndrome (CSS) development. Besides COVID-19, CSS can be triggered by the range of pathologies, which include hemophagocytic lymphohistiocytosis (sHLH) and septic shock (SS). The aim of this study was to compare immunological profiles in fatal cases of COVID-19, sHLH and SS. Material and methods. Serum levels of IL-1β, IL-2, IL-6, IL-8, IL-10, IL-17A, IL-18, IFN-γ, TNF-α, procalcitonin, neopterin, ferritin with percent of glycosylated fraction (% GF) were measured in 37 COVID-19 fatal cases, collected during 2020 year prospectively;and in 39 sHLH and 47 SS fatal cases, collected within 2018–2019 years retrospectively. Comparison groups also included 194 non-fatal COVID-19 cases and 20 healthy donors, collected during 2020 year. Cytokine concentrations, procalcitonin and neopterin were measured by enzyme-linked immunosorbent assay;the ferritin level was determined by the turbidimetry method. The percent of glycosylated ferritin fraction (% GF) was calculated by the modified method of M. Worwood et al. Results. Deceased patients with COVID-19 had higher IL-6, IL-8, IL-10, IL-18, procalcitonin median levels compared to the survived. Meanwhile IL-8, IL-18, IFN-γ, TNFα and ferritin concentrations were significantly lower in deceased COVID-19 patients compared to sHLH and SS. The levels of IL-6 and procalcitonin in fatal COVID-19 were comparable to SS, but significantly higher than in sHLH. Leucocytes were higher in COVID-19 compared to both SS and sHLH. Conclusion. Each fatal condition was accompanied by specific features of the cytokine profile: high IL-6 combined with low IFN-γ, TNFα in COVID-19;high IL-8, IL-6 with low IL-17A, IL-2 in SS;high IL-18, ferritin, IFN-γ with low IL-6, procalcitonin, % GF in sHLH.

18.
Pediatric Infection and Vaccine ; 29(1):28-36, 2022.
Article in Korean | EMBASE | ID: covidwho-1887350

ABSTRACT

Purpose: To evaluate the efficacy and safety of coronavirus disease 2019 (COVID-19) vaccines in children aged 5–11 years, a rapid systematic review was conducted on published clinical trials of COVID-19 vaccines and studies that analyzed real-world data on adverse events after COVID-19 vaccination. Methods: A systematic search was conducted on medical literature in international (Ovid-MEDLINE) and pre-published literature databases (medRxiv), followed by handsearching up to January 4, 2022. We used terms including COVID-19, severe acute respiratory syndrome coronavirus 2, and vaccines, and the certainty of evidence was graded using the GRADE approach. Results: A total of 1,675 studies were identified, of which five were finally selected. Among the five studies, four consisted of data from clinical trials of each of the four types of COVID-19 vaccines (BNT162b2, mRNA-1273, CoronaVac, and BBIBP-CorV). The remaining study consisted of real-world data on the safety of the BNT162b2 vaccine in children aged 5–11 years. This systematic review identified that COVID-19 vaccines in recipients aged 5–11 years produced a favorable immune response, and were vaccines were effective against COVID-19. The safety findings for the BNT162b2 vaccine in children and early adolescents aged 5–11 years were similar to those data noted in the clinical trial. Conclusions: There is limited data on COVID-19 vaccines in children aged 5–11 years. Consequently continuous and comprehensive monitoring is necessary for the evaluation of the safety and effectiveness of the COVID-19 vaccines.

19.
American Journal of Respiratory and Critical Care Medicine ; 205:2, 2022.
Article in English | English Web of Science | ID: covidwho-1880564
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