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Quantitative Imaging in Medicine and Surgery ; 10(11):2208-2211, 2020.
Article | WHO COVID | ID: covidwho-854851
BMC Infect Dis ; 20(1): 647, 2020 Sep 03.
Article in English | MEDLINE | ID: covidwho-744977


BACKGROUND: The family cluster is one of most important modes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission throughout China, and more details are needed about how family clusters cause the spread of coronavirus disease 2019 (COVID-19). CASE PRESENTATION: We retrospectively reviewed 7 confirmed cases from one family cluster. Both clinical features and laboratory examination results were described. Patient 1 had been in close contact with someone who was later confirmed to have COVID-19 in Wuhan City before he returned back to his hometown. He had dinner with 6 other members in his family. All the persons developed COVID-19 successively except for one older woman who neither had dinner with them nor shared a sleeping room with her husband. Six patients had mild or moderate COVID-19 but one older man with underlying diseases progressed into the severe type. After general and symptomatic treatments, all the patients recovered. CONCLUSIONS: In a family cluster, having dinner together may be an important mode for the transmission of SARS-CoV-2. In this setting, most cases are mild with a favorable prognosis, while elderly patients with underlying diseases may progress into the severe type. For someone who has close contact with a confirmed case, 14-day isolation is necessary to contain virus transmission.

Betacoronavirus/isolation & purification , Coronavirus Infections/physiopathology , Coronavirus Infections/transmission , Family Health , Pneumonia, Viral/physiopathology , Pneumonia, Viral/transmission , Adolescent , Adult , Aged , Betacoronavirus/pathogenicity , Child , China/epidemiology , Coronavirus Infections/epidemiology , Coronavirus Infections/virology , Female , Humans , Male , Pandemics , Pneumonia, Viral/epidemiology , Pneumonia, Viral/virology , Retrospective Studies
Annals of translational medicine ; 8(12):747-747, 2020.
Article | WHO COVID | ID: covidwho-640177


Background: The coronavirus disease 2019 (COVID-19) virus has a high incidence rate and strong infectivity The diagnosis and evaluation of familial outbreaks requires a collective consideration of epidemiological history, molecular detection methods, chest computed tomography (CT), and clinical symptoms Methods: A group of family patients with COVID-19 diagnosed in Guizhou, China, in February 2020, was retrospectively analyzed As of March 1, all patients in the group have been discharged from hospital This study tracked all patients in the group We report the epidemiology, radiological characteristics, treatment, and clinical outcomes of these patients Results: We collected a group of 8 clustered cases (3 men and 5 women) from a family with confirmed COVID-19 infection In the first admission diagnosis, according to the degree of clinical symptoms, the 8 patients were defined as mild type (4/8) or moderate type (4/8) They were also divided according to the CT findings into early period (1/8), progressive period (3/8), and negative on CT scan (4/8);for the first 4 patients, the corresponding CT image scores were 1, 4, 5, and 5 respectively In this group of COVID-19 patients, half of the patients showed occult clinical manifestations and negative CT performance We defined these patients as COVID-19-infected patients, or asymptomatic carriers Conclusions: The family cluster analysis indicated that COVID-19-infected patients (asymptomatic carriers) and symptomatic COVID-19 patients are distinct but coexistent This may indicate that the infectivity and virulence of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) has decreased In order to block the transmission pathway of this virus before it spreads, we need to identify the presence of asymptomatic carriers as early as possible

Ann Palliat Med ; 2020 Apr 20.
Article in English | MEDLINE | ID: covidwho-101323


The coronavirus disease 2019 (COVID-19) is a new infectious disease, firstly appeared in Wuhan city and has rapidly spread to 114 countries outside China, which is receiving worldwide attention. As two important means of examination, computed tomography (CT) and real-time reverse transcription polymerase chain reaction (RT-PCR) have always been controversial in the clinical diagnosis of COVID-19 pneumonia. Here, we report a family cluster case of a father and a son diagnosed as COVID-19 at our hospital, and described the clinical manifestations, laboratory results, CT changes, diagnosis and treatment strategy of these two patients. Focus on the value of these two methods in the diagnosis and treatment of diseases, as well as their respective deficiencies. For patient 1 (father), the efficacy of RT-PCR is not satisfactory either in terms of diagnosis or follow-up, which may cause misdiagnosis and delay treatment. For patient 2 (son), the clinical symptoms were not obvious, but CT imaging clearly displayed dynamic changes of the lung lesions. Meanwhile, the two patients respectively underwent five chest CT examinations during their hospitalization and discharge follow-up, showing the potential harm of radiation. Therefore, in clinical work, doctors should make full use of the advantages of CT and RT-PCR, and take other measures to make up for their disadvantages.