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1.
RESEARCH IN TRANSPORTATION BUSINESS AND MANAGEMENT ; 43, 2022.
Article in English | Web of Science | ID: covidwho-1907745

ABSTRACT

COVID-19 has hit our society hard, with more than 242 million cases reported worldwide and more than 4.9 million directly related fatalities. The role of Africa throughout the pandemic has been puzzling, since the African continent seems to have gone through the pandemic better than other continents;clearly better than predicted by the public during the emergence of COVID-19 one year ago. While several factors have been proposed in the literature to explain the unexpected role of Africa, including a relatively young population, more historical driven preparedness to other types of coronavirus and diseases, and a limited amount of testing, the puzzle is not considered to be solved. In this study, we aim to answer the question whether air transportation indicators can support us in explaining the evolution of COVID-19 in Africa? Using flight data for the year 2020, we explore how changes in the air transportation system correlate with evolution of epidemiological indicators. Our results suggest that air transportation could indeed play a critical role for the spread of COVID-19 in Africa as well. Overall, we hope that our analysis contributes towards a better understanding of COVID-19 and the role air transportation plays in an under-researched region of the world.

2.
Epidemiology ; 70(SUPPL 1):S279, 2022.
Article in English | EMBASE | ID: covidwho-1854007

ABSTRACT

Background: As nutritional requirements change with age, registered dietitian nutritionists (RDNs) play a critical role in maintaining older adults' quality of life. Preclinical medical students infrequently have opportunities to engage with and learn the roles and responsibilities of interprofessional (IP) team members. This study evaluated the effectiveness of a nutrition clinical experience to increase first-year medical students' (M1s') understanding of the roles of RDNs on the IP healthcare team. Methods: M1s at a tertiary care center participated in a required 1.5 or 2 hour IP clinical observation experience with an outpatient or inpatient RDN. Due to the COVID-19 pandemic, virtual, in-person, and hybrid experiences were offered. M1s and participating RDNs completed post-experience surveys. Results: Ninety M1s participated in the experience;89% completed a post-experience survey. Overall, 96% of responding M1s enjoyed the experience, 96% agreed the experience helped them understand RDN's roles, and 99% agreed they were more likely to involve a RDN in patient care following the experience. Of respondents, 35, 33, and 10 participated via a virtual, in-person, or hybrid experience, respectively. Although not statistically significant, there was a trend toward more agreement with in-person vs. virtual experiences related to experience enjoyment (100% vs 94%), experience helpfulness (100% vs 91%), and intentions to incorporate RDNs into future care (100% vs 97%). A significantly greater proportion of M1s discussed a real patient case when participating in-person compared to participating virtually (100% vs 71%, p<.05). Half of RDNs (6/12) completed a post-experience survey;all agreed the experience allowed them to clearly convey their roles and responsibilities. Conclusions: An IP clinical experience via virtual or in-person modalities is an effective pedagogical tool to improve M1s' understanding of RDN's roles. More work should be done to evaluate students' attitudes regarding in-person vs. virtual experiences. In-person experiences may provide greater opportunity for learning engagement through real-life patient case discussion.

3.
Clinical Cancer Research ; 27(6 SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1816891

ABSTRACT

Background: Serology tests for detecting the antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can identify previous infection and help to confirm the presence of current infection. Objective: The aim of this study was to evaluate the performances of a newly developed high throughput immunoassay for anti-SARS-CoV-2 IgG antibody detection. Results: Clinical agreement studies were performed in 77 COVID-19 patient serum samples and 226 negative donor serum/plasma samples. Positive percent agreement (PPA) was 46.15% (95% CI: 19.22% ∼74.87%), 61.54% (95% CI: 31.58% ∼86.14%), and 97.53% (95% CI: 91.36% ∼99.70%) for samples collected on 0-7 days, 8-14 days, and ≥15 days from symptom onset, respectively. Negative Percent Agreement (NPA) was 98.23% (95% CI: 95.53% ∼99.52%). No cross-reactivity was observed to patient samples positive for IgG antibodies against the following pathogens: HIV, HAV, HBV, RSV, CMV, EBV, Rubella, Influenza A, and Influenza B. Hemoglobin (200 mg/dL), bilirubin (2 mg/dL) and EDTA (10 mM) showed no significant interfering effect on this assay. Conclusion: An anti-SARS-CoV-2 IgG antibody assay with high sensitivity and specificity has been developed. With the high throughput, this assay will speed up the anti-SARS-CoV-2 IgG testing.

4.
Clinical Cancer Research ; 27(6 SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1816890

ABSTRACT

Objectives Sensitive and high throughput molecular testing availability is essential during the COVID-19 pandemic. The vast majority of the SARS-CoV-2 molecular assays use nasopharyngeal or oropharyngeal swab specimens collected from suspected individuals. However, collecting these specimens has apparent drawbacks, including discomfort to patients and exposure risk to healthcare workers. Methods We developed and validated of QuantiVirus™ SARS-CoV-2 multiplex test using saliva as the testing specimens with pooling. Results The analytical sensitivity (LOD) was confirmed to be 100-200 copies/mL. For clinical evaluation, 85 known positive and 90 knowns negative NPS specimens were showed a positive predictive agreement of 100% and a negative predictive agreement of 98.9%. Twenty paired NPS and saliva samples were tested and showed overall 80% concordance rate without significant difference between NPS and saliva specimens by Wilcoxon signed-rank test (p=0.13). On a large scale of saliva-based population screening, the positive test rate was 1.79% among 389 saliva specimens. Furthermore, saliva sample pooling up to 6 samples for SARS-CoV-2 detection is feasible with sensitivity of 94.8% and specificity of 100%. Conclusions These results demonstrated that the clinical performance of saliva-based testing is comparable to that of NPS-based testing, and that pooling of saliva specimens for SARS-CoV-2 detection is feasible.

5.
IEEE International Conference on Robotics and Automation (ICRA) ; : 12282-12288, 2021.
Article in English | Web of Science | ID: covidwho-1799302

ABSTRACT

Driven by the SARS-CoV-2 pandemic, demand for oropharyngeal swab sampling (OP-swabs) is surging. However, medical staff can easily become infected by the virus during the sampling process. In an effort to combat this, we developed a novel, intrinsically safe rigid-flexible coupling (RFC) manipulator to improve the safety and reliability of OP-swab sampling to test for COVID-19, which is presented herein. Suitable sampling areas and the necessary contact force for OP-swab sampling tasks are carefully investigated, and three typical sampling paths outlined that could be performed by a robotic system. This is followed by a detailed description of an intrinsically safe bionic micro-pneumatic actuator (MPA) that was designed and fabricated as the main component of the RFC manipulator. The developed RFC manipulator's kinematic modeling, motion planning, and force control capacities were designed for OP-swab sampling scenarios. The system was then validated using both an oral cavity phantom and human volunteers, with comparative experiments on the swab quality of the OP-swab sampling approach conducted in both robotic and manual modes. The results indicate that fully-automated sampling based on this design would be feasible.

6.
Environ. Sci.-Wat. Res. Technol. ; : 14, 2022.
Article in English | Web of Science | ID: covidwho-1795655

ABSTRACT

As a class of endocrine disrupting compounds (EDCs), corticosteroids (CSs) have attracted increasing attention due to their large excretion masses and toxic effects. However, compared to the very well-studied estrogens and androgens, few studies have been made dealing with the removal of CSs at environmentally relevant concentrations using advanced water and wastewater treatment processes. In this study, degradation performances of 26 natural and synthetic CSs in secondary effluent at environmentally relevant concentrations were comparatively investigated during UV/free chlorine (UV/Cl-2), UV/monochloramine (UV/NH2Cl) and UV/hydrogen peroxide (UV/H2O2) treatments. The 26 CSs could be divided into two groups: UV sensitive CSs, which have two double bonds in ring A (Delta(1,4)), and UV insensitive CSs, which have only one double bond in ring A (Delta(4)). The UV sensitive CSs could be effectively removed (removal efficiency >60%) by a UV dose of 100 mJ cm(-2) while the UV insensitive CSs could be removed (removal efficiency >40%) by a UV dose of 800 mJ cm(-2). The removal efficiencies of UV insensitive CSs increased with the increase of UV dose. Most of the CSs were poorly removed by sole Cl-2, NH2Cl, or H2O2 treatment (removal efficiency <40%). However, the addition of Cl-2, NH2Cl, and H2O2 promoted the UV degradation of CSs, especially for UV-insensitive CSs. UV photolysis would be the predominant mechanism in the UV/Cl-2, UV/NH2Cl, and UV/H2O2 processes for removing CSs in water. Besides the UV photolysis, HO radicals also functioned for CS removal. Compared with the insignificant effects of reactive chlorine species (RCS), the reactive nitrogen species (RNS) showed obvious selectivity in CS degradation. This study expanded the UV induced oxidation performances of CSs, which lays a foundation for exploring degradation mechanisms and eliminating the pollution from CSs.

7.
Psycho-Oncology ; 31:53-53, 2022.
Article in English | Web of Science | ID: covidwho-1756178
8.
2021 IEEE International Conference on Robotics and Automation, ICRA 2021 ; 2021-May:12282-12288, 2021.
Article in English | Scopus | ID: covidwho-1730973

ABSTRACT

Driven by the SARS-CoV-2 pandemic, demand for oropharyngeal swab sampling (OP-swabs) is surging. However, medical staff can easily become infected by the virus during the sampling process. In an effort to combat this, we developed a novel, intrinsically safe rigid-flexible coupling (RFC) manipulator to improve the safety and reliability of OP-swab sampling to test for COVID-19, which is presented herein. Suitable sampling areas and the necessary contact force for OP-swab sampling tasks are carefully investigated, and three typical sampling paths outlined that could be performed by a robotic system. This is followed by a detailed description of an intrinsically safe bionic micro-pneumatic actuator (MPA) that was designed and fabricated as the main component of the RFC manipulator. The developed RFC manipulator's kinematic modeling, motion planning, and force control capacities were designed for OP-swab sampling scenarios. The system was then validated using both an oral cavity phantom and human volunteers, with comparative experiments on the swab quality of the OP-swab sampling approach conducted in both robotic and manual modes. The results indicate that fully-automated sampling based on this design would be feasible. © 2021 IEEE

9.
Embase;
Preprint in English | EMBASE | ID: ppcovidwho-326873

ABSTRACT

A comparison of SARS-CoV-2 wild-type and the beta variant virus neutralization capacity between 2 and 3 mRNA vaccine series in nursing home residents, and between nursing home and assisted living residents strongly supports 3rd dose vaccine recommendations, and equivalent polices for nursing homes and assisted living settings. Findings suggest that residents mount a robust humoral response to a 3rd mRNA vaccination, and have greater neuralization capacity compared to a 2 dose series.

10.
Journal of Real Estate Finance and Economics ; : 30, 2022.
Article in English | Web of Science | ID: covidwho-1681462

ABSTRACT

With unique datasets, this paper studies the effects of dockless bike sharing on house prices. We find that in neighborhoods relatively far from subway stations, house prices increase with the usage intensity of shared bikes. This indicates a positive value of bike sharing as a complement to the subway network. Meanwhile, shared bike usage intensity also has a negative impact on house prices. The negative effect is mitigated for luxury neighborhoods and neighborhoods near City Management Teams, suggesting that the negative effect is related to bike misplacement. Since the breakout of COVID-19, both the positive and negative price impacts have become more evident. This is consistent with the fact that the user base of shared bikes, which allow for social distancing in an open space, has increased during the pandemic. This may enhance people's confidence in the long survival of the bike sharing industry.

11.
2nd International Symposium on Artificial Intelligence for Medicine Sciences, ISAIMS 2021 ; : 307-311, 2021.
Article in English | Scopus | ID: covidwho-1613109

ABSTRACT

This paper is to investigate the impact of meteorological factors and ozone on the COVID-19 epidemic in the United States, and to analyze the annual change patterns of the major influencing factors. Random forest modeling was performed for the correlation between the meteorological factors including relative humidity, 2-meter temperature, ultraviolet (UV) radiation, surface pressure, total precipitation, and total cloud cover, as well as ozone variations, and the daily new cases of COVID-19 in 497 counties in the US, so as to obtain the ranking of the impact of the above factors on the COVID-19 epidemic in the US. Statistical processing and K-means cluster analysis were performed on the modeling results. The modeling results showed that 73.6% of the counties were related to the modeling factors, while 26.4% were not significantly related to the modeling factors. Counties with R2 less than 0.3 were mainly distributed in Connecticut, Louisiana, Michigan, North Carolina, and Texas;In the models with R2 greater than 0.3, the most important influencing factors were 2-meter temperature, UV radiation, and ozone variations. K-means cluster analysis showed that when the number of clusters K=3, the contour coefficient was the largest, and the clustering results at this point presented more obvious characteristics of geographic spatial distribution. Natural factors including relative humidity, 2-meter temperature, UV radiation, surface pressure, total precipitation, total cloud cover, and ozone could not fully explain the changes in the COVID-19 epidemic in the US. Temperature, UV radiation, and ozone were the most significant natural factors that affect the epidemic in the US. Higher 2-meter temperature and stronger UV radiation would help to curb the COVID-19 spread in the US. Lower temperatures and less ultraviolet radiation might be the cause of the epidemic surges in winter in the country. © 2021 ACM.

12.
J Infect ; 84(2): 158-170, 2022 02.
Article in English | MEDLINE | ID: covidwho-1603797

ABSTRACT

BACKGROUND: Data on the long-term impact of SARS-CoV-2 infection in children and young people (CYP) are conflicting. We assessed evidence on long-term post-COVID symptoms in CYP examining prevalence, risk factors, type and duration. METHODS: Systematic search of published and unpublished literature using 13 online databases between 01/12/2019 and 31/07/2021. Eligible studies reported CYP ≤19 years with confirmed or probable SARS-CoV-2 with any symptoms persisting beyond acute illness. Random effects meta-analyses estimated pooled risk difference in symptom prevalence (controlled studies only) and pooled prevalence (uncontrolled studies also included). Meta-regression examined study characteristics hypothesised to be associated with symptom prevalence. Prospectively registered: CRD42021233153. FINDINGS: Twenty two of 3357 unique studies were eligible, including 23,141 CYP. Median duration of follow-up was 125 days (IQR 99-231). Pooled risk difference in post-COVID cases compared to controls (5 studies) were significantly higher for cognitive difficulties (3% (95% CI 1, 4)), headache (5% (1, 8)), loss of smell (8%, (2, 15)), sore throat (2% (1, 2)) and sore eyes (2% (1, 3)) but not abdominal pain, cough, fatigue, myalgia, insomnia, diarrhoea, fever, dizziness or dyspnoea. Pooled prevalence of symptoms in post-COVID participants in 17 studies ranged from 15% (diarrhoea) to 47% (fatigue). Age was associated with higher prevalence of all symptoms except cough. Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms. INTERPRETATION: The frequency of the majority of reported persistent symptoms was similar in SARS-CoV-2 positive cases and controls. This systematic review and meta-analysis highlights the critical importance of a control group in studies on CYP post SARS-CoV-2 infection.


Subject(s)
COVID-19 , Adolescent , Child , Fatigue , Fever/etiology , Headache/complications , Headache/etiology , Humans , SARS-CoV-2
13.
24th ACM Conference on Computer-Supported Cooperative Work and Social Computing, CSCW 2021 ; : 347-351, 2021.
Article in English | Scopus | ID: covidwho-1515327

ABSTRACT

The COVID-19 pandemic has been uniquely challenging for the Asian diaspora. The virus has directly devastated Asian communities around the world, most notably across India. Its indirect effects have also been crushing: violent hate crimes against elders, the dissolution of once-thriving businesses, and the trauma of pandemic-enforced disconnect from transnational family networks have all weighed heavily on Asian people. Publicly grappling with these difficulties, through hashtags and GoFundMes across social media, has raised awareness of the issues that Asian people have dealt with long before COVID. But doing so amidst isolation has illuminated a need for space to build relationships, confront intra- and inter-community biases, and envision a more hopeful future. This workshop looks to create that space. By convening social computing researchers with ties to Asian diaspora identities, we aim to foster discussion of how social platforms enable identity formation and online activism unique to the Asian diasporic experience. We will consider what it means to be an Asian diaspora researcher, challenge CSCW's notion of what it means to be Asian, and explore how Asianness can work in alliance with other marginalized identities to ultimately concretize a research agenda for CSCW to more meaningfully engage with Asian diaspora experiences. © 2021 ACM.

14.
Microbiol Spectr ; 9(2): e0053721, 2021 10 31.
Article in English | MEDLINE | ID: covidwho-1476396

ABSTRACT

UV light, more specifically UV-C light at a wavelength of 254 nm, is often used to disinfect surfaces, air, and liquids. In early 2020, at the cusp of the COVID-19 pandemic, UV light was identified as an efficient means of eliminating coronaviruses; however, the variability in published sensitivity data is evidence of the need for experimental rigor to accurately quantify the effectiveness of this technique. In the current study, reliable and reproducible UV techniques have been adopted, including accurate measurement of light intensity, consideration of fluid UV absorbance, and confirmation of uniform dose delivery, including dose verification using an established biological target (T1UV bacteriophage) and a resistant recombinant virus (baculovirus). The experimental results establish the UV sensitivity of SARS-CoV-2, HCoV-229E, HCoV-OC43, and mouse hepatitis virus (MHV) and highlight the potential for surrogate viruses for disinfection studies. All four coronaviruses were found to be easily inactivated by 254 nm irradiation, with UV sensitivities of 1.7, 1.8, 1.7, and 1.2 mJ/cm2/log10 reduction for SARS-CoV-2, HCoV-229E, HCoV-OC43, and MHV, respectively. Similar UV sensitivities for these species demonstrate the capacity for HCoV-OC43, HCoV-229E, and MHV to be considered surrogates for SARS-CoV-2 in UV-inactivation studies, greatly reducing hazards and simplifying procedures for future experimental studies. IMPORTANCE Disinfection of SARS-CoV-2 is of particular importance due to the global COVID-19 pandemic. UV-C irradiation is a compelling disinfection technique because it can be applied to surfaces, air, and water and is commonly used in drinking water and wastewater treatment facilities. UV inactivation depends on the dose received by an organism, regardless of the intensity of the light source or the optical properties of the medium in which it is suspended. The 254 nm irradiation sensitivity was accurately determined using benchmark methodology and a collimated beam apparatus for four coronaviruses (SARS-CoV-2, HCoV-229E, HCoV-OC43, and MHV), a surrogate indicator organism (T1UV), and a resistant recombinant virus (baculovirus vector). Considering the light distribution across the sample surface, the attenuation of light intensity with fluid depth, the optical absorbance of the fluid, and the sample uniformity due to mixing enable accurate measurement of the fundamental inactivation kinetics and UV sensitivity.


Subject(s)
Coronavirus 229E, Human/radiation effects , Coronavirus OC43, Human/radiation effects , Murine hepatitis virus/radiation effects , SARS-CoV-2/radiation effects , Ultraviolet Rays , Animals , Baculoviridae/radiation effects , COVID-19/prevention & control , Cell Line , Chlorocebus aethiops , Disinfection/methods , Humans , Vero Cells
15.
Chinese Journal of New Drugs ; 30(19):1768-1774, 2021.
Article in Chinese | EMBASE | ID: covidwho-1473128

ABSTRACT

As the first mRNA-based COVID-19 vaccine received Emergency Use Authorization (EUA) in 2020, its great safety profile and high protection efficacy has been well demonstrated. As a result of its unique advantage in the mechanism of action, mRNA can effectively trigger strong humoral and cellular immune response. Of note, many other prophylactic or therapeutic mRNA vaccines developed for preventing different infectious diseases or treatment of cancer are under clinical trial investigations. mRNA-based protein supplementation and gene therapy also begin to emerge. There will be bigger stage for the development of mRNA technology-based products, posing a revolutionary effect in the field of biopharmaceuticals.

16.
Nano Biomedicine and Engineering ; 13(3):225-228, 2021.
Article in English | EMBASE | ID: covidwho-1403981

ABSTRACT

The novel coronavirus pneumonia, a global pandemic disease named as coronavirus disease 2019, has caused enormous losses on the health and economies of people all over the world, while there is still a lack of quick and sensitive diagnostic method and effective therapy. Developing rapid diagnostic method for coronavirus disease 2019 has become exceptional urgent. Herein we report a rapid diagnostic method for the novel coronavirus through monitoring the volatile biomarkers in human exhaled breath. The breath volatile biomarkers are derived from the metabolism of novel coronavirus, including acetoin, 2,4,6-trimethylpyridine, 3-methyl tridecane, tetradecane, isooctyl alcohol, pentadecane, hexadecane, 1-methylene-1H-indene. By comparing the types and concentrations of the volatile biomarkers in human exhaled breath combined with SERS sensor, we could distinguish between the healthy person and the patients with coronavirus disease 2019. This work confirms that various volatile organic compounds metabolized by novel coronavirus can be employed for rapidly screening of patients with coronavirus disease 2019, and has broad application prospects in the prevention and control of the epidemic.

17.
Investigative Ophthalmology and Visual Science ; 62(8), 2021.
Article in English | EMBASE | ID: covidwho-1378657

ABSTRACT

Purpose : Due to the Coronavirus Disease 2019 (COVID-19) pandemic, the AAO announced guidelines which recommended the cessation and postponement of all routine and nonurgent clinic visits and elective surgeries. While this decision was important for the public health effort to mitigate the COVID-19 pandemic, the effect this decision had on patients with exudative age-related macular degeneration (AMD) requiring frequent visits for treatment and monitoring is unknown. This retrospective observational study evaluates the effect that the delay in these visits and treatments had on this patient population.Methods : This study identified patients with exudative AMD undergoing active treatment who had at least one appointment rescheduled due to the COVID-19 pandemic from March to May 2020 at a single institution. Data was collected from the last appointment prior to March 2020, and the first appointment following delay, and compared to agematched controls from 2019 with the same diagnosis. Average length of time from postponement to follow-up was calculated. Patient demographics, visual acuity (LogMAR), and central macular thickness (CMT) on spectral-domain optical coherence tomography (OCT) were documented. Statistical analysis was conducted using t-tests with a two-tailed hypothesis. Results : 69 patients (96 eyes) with exudative AMD met inclusion criteria. The mean (SD) age was 83.7 (8.3) years and 74% of patients were female. The mean (SD) number of days of treatment delay was 45.9 (38.6) days. Mean (SD) increase in CMT was 23.84 (82.71) μm for the eye that had delayed treatment, which was statistically significant (t=2.49, p=0.01). Mean (SD) change in visual acuity was +0.11 (0.32) LogMAR, which was significantly worse (t=3.42, p=0.001). Conclusions : Central macular thickness and visual acuity of treatment eyes were significantly worse as a result of the delay secondary to the COVID-19 pandemic. Further data collection over time is required to determine whether changes in CMT and VA are reversible over time. Further analyses of sequelae of delayed injections may reveal unique insights into subgroups which may be more tolerant of extended injection schedules.

18.
Medical Journal of Wuhan University ; 42(5):718-723, 2021.
Article in Chinese | Scopus | ID: covidwho-1350551

ABSTRACT

Objective: To investigate the characteristics of disease transmission, diagnosis, and treatment of COVID‑19 in children. Methods: We retrospectively studied 20 children with COVID‑19 from 4 medical centers in Hubei, China. Results: Among the 20 children, 18 (90.0%) were contaminated by close contact and characterized by family clustering. Seven cases (35.0%) had all family members infected, and 11 cases (55.0%) were confirmed by either of the parents infected. Twelve cases (60.0%) had fever, which was the primary symptom in 10 cases (50.0%). Only one child was in severe degree and combined with severe underlying disease (congenital heart disease). Seven cases (35.0%) presented typical ground‑glass opacity in CT. All patients were confirmed to be infected with SARS‑CoV‑2. Eleven cases (55.0%) had normal white blood cell counts, and one case (5.0%) with severe COVID‑19 showed a continuous decline in T cells subsets. Conclusion: COVID‑19 in children is transmitted by close contact and characterized by family clustering. Fever is the most common symptom or initial symptom. However, the sustained low levels of T cells and underlying diseases are risk factors for severe COVID‑19 children. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.

20.
Medical Journal of Wuhan University ; 42(4):608-614, 2021.
Article in Chinese | Scopus | ID: covidwho-1299713

ABSTRACT

Objective: To investigate the gastrointestinal (GI) manifestations of COVID-19 and retrospectively analyze the clinical characteristics of COVID-19 patients with GI symptoms. Methods: Data of 137 COVID-19 inpatients treated in Renmin Hospital of Wuhan University from February 1 to February 29, 2020 were collected. Patients were divided into GI group and Non-GI group according to the presence of digestive system abnormalities and gastrointestinal symptoms before and during admission. General data, clinical data, and relevant laboratory examination results of 137 patients were collected. SPSS 23.0 software was used for statistical analysis to compare the differences of various indicators between the two groups. Results: There was no statistically significant difference between the clinical data and the clinical manifestations of fever and dry cough between the GI group and the Non-GI group (P>0.05). The proportion of patients with fatigue in the GI group was higher than that in the Non-GI group (P<0.001). The proportion of critically ill patients was greater than that of the Non-GI group (P=0.011), and the proportion of GI combined with hypertension, diabetes, cardiovascular disease and chronic liver disease was higher than that of the Non-GI group (all P<0.05). GI group mortality rate was much higher than that of Non-GI group (P<0.001). Patients with GI group had higher white blood cell count and neutrophil count than Non-GI (P<0.001). The proportion of neutrophils, lymphocytes as well as lymph between the two groups had no statistical difference (P>0.05). The proportion of monocytes in the GI group was lower than that in the Non-GI group (P=0.033). There was no statistical difference in platelet count and C-reactive protein level between the two groups (P>0.05). LDH, TBIL, and Urea levels of GI group were higher than those of Non-GI group (P<0.05). There was no statistical difference in other cardiac, liver and kidney function tests, PT and APTT values between the two groups (P>0.05), but D-dimer in GI group was higher than in Non-GI group (P<0.001). Conclusion: Gastrointestinal symptoms are common in COVID-19 patients, and patients with other underlying diseases are at greater risk for developing gastrointestinal symptoms. COVID-19 patients with gastrointestinal symptoms progress more rapidly, have a higher mortality rate, and exhibit certain concomitant symptoms and laboratory tests that are specific to COVID-19. Therefore, more attention should be paid to the digestive system abnormalities and gastrointestinal symptoms in COVID-19 patients during clinical work. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.

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