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1.
Zhonghua Yu Fang Yi Xue Za Zhi ; 56(12): 1795-1802, 2022 Dec 06.
Article in Chinese | MEDLINE | ID: covidwho-2201072

ABSTRACT

Objective: To trace and characterize the whole genome of SARS-CoV-2 of confirmed cases in the outbreak of COVID-19 on July 31, 2021 in Henan Province. Method: Genome-wide sequencing and comparative analysis were performed on positive nucleic acid samples of SARS-CoV-2 from 167 local cases related to the epidemic on July 31, 2021, to analyze the consistency and evolution of the whole genome sequence of virus. Results: Through high-throughput sequencing, a total of 106 cases of SARS-CoV-2 whole genome sequences were obtained. The results of genome analysis showed that the whole genome sequences of 106 cases belonged to the VOC/Delta variant strain (B.1.617.2 clade), and the whole genome sequences of 106 cases were shared with the genomes of 3 imported cases from Myanmar admitted to a hospital in Zhengzhou. On the basis of 45 nucleotide sites, 1-5 nucleotide variation sites were added, and the genome sequence was highly homologous. Conclusion: Combined with the comprehensive analysis of viral genomics, transmission path simulation experiments and epidemiology, it is determined that the local new epidemic in Henan Province is caused by imported cases in the nosocomial area, and the spillover has caused localized infection in the community. At the same time, it spills over to some provincial cities and results in localized clustered epidemics.


Subject(s)
COVID-19 , Epidemics , Humans , SARS-CoV-2/genetics , Genome, Viral , Phylogeny
2.
Fudan University Journal of Medical Sciences ; 47(2):179-183 and 191, 2020.
Article in Chinese | Scopus | ID: covidwho-831370

ABSTRACT

Since the occurrence of coronavirus disease 2019 (COVID-19) in Wuhan, Hubei Province of China in December 2019, the epidemic has developed rapidly and has now spread to the whole country. The pediatric hospital affiliated to Fudan University, as a designated hospital for treating children with infectious diseases in Shanghai, must be responsible for the treatment in children. The standardized hospital outpatient screening process management can improve the efficiency of diagnosis and treatment, reduce nosocomial infection, and control the spread of the epidemic. In order to deal with the epidemic situation, we carefully studied a series of laws and regulations, as well as instructions documents issued by the National Health and Health Commission, we reviewed and referenced recently published domestic and foreign literature, we also combined with the characteristics of children's specialist hospital, then formulated this screening process and management strategy of COVID-19 in outpatient and emergency departments. © 2020, Editorial Department of Fudan University Journal of Medical Sciences. All right reserved.

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