Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 6 de 6
Filter
1.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-310370

ABSTRACT

Objective: To identify the willingness of medical undergraduates to work as volunteers for fighting COVID-19 and effect factors of willingness to volunteer. Methods: A cross-sectional online questionnaire survey which consisted of three sections with 26 items was conducted. The primary outcome was the willingness to volunteer. Descriptive analysis was used for the results of characteristics, a univariant analysis was performed by chi-square test and a multivariate analysis was performed by multivariate logistic regression. Results: A total of 5499 questionnaires were issued and 5379 effective questionnaires were finally recovered. There were 1797 males (33.4%) and 3582 females (66.6%), with an average age of 20±1.5 years old. 3553(66.1%) students wanted to volunteer. Male was associated with less adjusted OR (0.68, 0.56 to 0.81) for willingness. The undergraduates in school of public health was most (3.81, 2.26 to 6.40) willing to work. The undergraduates who had often participated in voluntary activities but not regularly was 3.23(2.03-5.16) times more willing than those that never participate. Conclusion: It suggested that medical educators should emphasize voluntary activities in undergraduate medical education and continue to insistence of medical humanities and public health education to improve the social responsibility and professional identity of medical undergraduates.

2.
Hum Mol Genet ; 29(6): 955-966, 2020 04 15.
Article in English | MEDLINE | ID: covidwho-1455300

ABSTRACT

γ-secretase is a macromolecular complex that catalyzes intramembranous hydrolysis of more than 100 membrane-bound substrates. The complex is composed of presenilin (PS1 or PS2), anterior pharynx defect-1 (APH-1), nicastrin (NCT) and PEN-2 and early-onset; autosomal dominant forms of Alzheimer's disease (AD) are caused by inheritance of mutations of PS. No mutations in genes encoding NCT, or PEN-2 have been identified to date that cause AD. In this regard, a large genetic meta-analysis of four cohorts consisting of more than 600 000 individuals identified a common missense variant, rs117618017 in the APH1B gene that results in a T27I mutation, as a novel genome-wide significant locus. In order to confirm the findings that rs117618017 is associated with risk of AD, we performed a genetic screen from deep whole genome sequencing of the large NIMH family-based Alzheimer's Disease (AD) dataset. In parallel, we sought to uncover potential molecular mechanism(s) by which APH-1B T27I might be associated with AD by generating stable HEK293 cell lines, wherein endogenous APH-1A and APH-1B expression was silenced and into which either the wild type APH-1B or the APH-1B T27I variant was stably expressed. We then tested the impact of expressing either the wild type APH-1B or the APH-1B T27I variant on γ-secretase processing of human APP, the murine Notch derivative mNΔE and human neuregulin-1. We now report that we fail to confirm the association of rs1047552 with AD in our cohort and that cells expressing the APH-1B T27I variant show no discernable impact on the γ-secretase processing of established substrates compared with cells expressing wild-type APH-1B.


Subject(s)
Alzheimer Disease/pathology , Amyloid Precursor Protein Secretases/metabolism , Endopeptidases/genetics , Membrane Proteins/genetics , Polymorphism, Single Nucleotide , Alzheimer Disease/genetics , HEK293 Cells , Humans , Mutation , Protein Binding
3.
Chin J Acad Radiol ; : 1-9, 2021 Jun 28.
Article in English | MEDLINE | ID: covidwho-1286228

ABSTRACT

BACKGROUND: Coronary artery calcification (CAC) is an independent risk factor of major adverse cardiovascular events; however, the impact of CAC on in-hospital death and adverse clinical outcomes in patients with coronavirus disease 2019 (COVID-19) remains unclear. OBJECTIVE: To explore the association between CAC and in-hospital mortality and adverse events in patients with COVID-19. METHODS: This multicenter retrospective cohort study enrolled 2067 laboratory-confirmed COVID-19 patients with definitive clinical outcomes (death or discharge) admitted from 22 tertiary hospitals in China between January 3, 2020 and April 2, 2020. Demographic, clinical, laboratory results, chest CT findings, and CAC on admission were collected. The primary outcome was in-hospital death and the secondary outcome was composed of in-hospital death, admission to intensive care unit (ICU), and requiring mechanical ventilation. Multivariable Cox regression analysis and Kaplan-Meier plots were used to explore the association between CAC and in-hospital death and adverse clinical outcomes. RESULTS: The mean age was 50 years (SD,16) and 1097 (53.1%) were male. A total of 177 patients showed high CAC level, and compared with patients with low CAC, these patients were older (mean age: 49 vs. 69 years, P < 0.001) and more likely to be male (52.0% vs. 65.0%, P = 0.001). Comorbidities, including cardiovascular disease (CVD) ([33.3%, 59/177] vs. [4.7%, 89/1890], P < 0.001), presented more often among patients with high CAC, compared with patients with low CAC. As for laboratory results, patients with high CAC had higher rates of increased D-dimer, LDH, as well as CK-MB (all P < 0.05). The mean CT severity score in high CAC group was also higher than low CAC group (12.6 vs. 11.1, P = 0.005). In multivariable Cox regression model, patients with high CAC were at a higher risk of in-hospital death (hazard ratio [HR], 1.731; 95% CI 1.010-2.971, P = 0.046) and adverse clinical outcomes (HR, 1.611; 95% CL 1.087-2.387, P = 0.018). CONCLUSION: High CAC is a risk factor associated with in-hospital death and adverse clinical outcomes in patients with confirmed COVID-19, which highlights the importance of calcium load testing for hospitalized COVID-19 patients and calls for attention to patients with high CAC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s42058-021-00072-4.

4.
Comput Stand Interfaces ; 77: 103520, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1071236

ABSTRACT

The current pandemic situation due to COVID-19 is seriously affecting our daily work and life. To block the propagation of infectious diseases, an effective contact tracing mechanism needs to be implemented. Unfortunately, existing schemes have severe privacy issues that jeopardize the identity-privacy and location-privacy for both users and patients. Although some privacy-preserving systems have been proposed, there remain several issues caused by centralization. To mitigate this issues, we propose a Privacy-preserving contact Tracing scheme in 5G-integrated and Blockchain-based Medical applications, named PTBM. In PTBM, the 5G-integrated network is leveraged as the underlying infrastructure where everyone can perform location checking with his mobile phones or even wearable devices connected to 5G network to find whether they have been in possible contact with a diagnosed patient without violating their privacy. A trusted medical center can effectively trace the patients and their corresponding close contacts. Thorough security and performance analysis show that the proposed PTBM scheme achieves privacy protection, traceability, reliability, and authentication, with high computation & communication efficiency and low latency.

5.
SciFinder; 2020.
Preprint | SciFinder | ID: ppcovidwho-4411

ABSTRACT

A review on proper selection of disinfectants in new coronavirus prevention and control.

6.
Theranostics ; 10(14): 6372-6383, 2020.
Article in English | MEDLINE | ID: covidwho-494062

ABSTRACT

Background: The risk factors for adverse events of Coronavirus Disease-19 (COVID-19) have not been well described. We aimed to explore the predictive value of clinical, laboratory and CT imaging characteristics on admission for short-term outcomes of COVID-19 patients. Methods: This multicenter, retrospective, observation study enrolled 703 laboratory-confirmed COVID-19 patients admitted to 16 tertiary hospitals from 8 provinces in China between January 10, 2020 and March 13, 2020. Demographic, clinical, laboratory data, CT imaging findings on admission and clinical outcomes were collected and compared. The primary endpoint was in-hospital death, the secondary endpoints were composite clinical adverse outcomes including in-hospital death, admission to intensive care unit (ICU) and requiring invasive mechanical ventilation support (IMV). Multivariable Cox regression, Kaplan-Meier plots and log-rank test were used to explore risk factors related to in-hospital death and in-hospital adverse outcomes. Results: Of 703 patients, 55 (8%) developed adverse outcomes (including 33 deceased), 648 (92%) discharged without any adverse outcome. Multivariable regression analysis showed risk factors associated with in-hospital death included ≥ 2 comorbidities (hazard ratio [HR], 6.734; 95% CI; 3.239-14.003, p < 0.001), leukocytosis (HR, 9.639; 95% CI, 4.572-20.321, p < 0.001), lymphopenia (HR, 4.579; 95% CI, 1.334-15.715, p = 0.016) and CT severity score > 14 (HR, 2.915; 95% CI, 1.376-6.177, p = 0.005) on admission, while older age (HR, 2.231; 95% CI, 1.124-4.427, p = 0.022), ≥ 2 comorbidities (HR, 4.778; 95% CI; 2.451-9.315, p < 0.001), leukocytosis (HR, 6.349; 95% CI; 3.330-12.108, p < 0.001), lymphopenia (HR, 3.014; 95% CI; 1.356-6.697, p = 0.007) and CT severity score > 14 (HR, 1.946; 95% CI; 1.095-3.459, p = 0.023) were associated with increased odds of composite adverse outcomes. Conclusion: The risk factors of older age, multiple comorbidities, leukocytosis, lymphopenia and higher CT severity score could help clinicians identify patients with potential adverse events.


Subject(s)
Betacoronavirus , Coronavirus Infections/diagnosis , Pneumonia, Viral/diagnosis , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , COVID-19 , Child , Child, Preschool , China/epidemiology , Comorbidity , Coronavirus Infections/epidemiology , Coronavirus Infections/mortality , Female , Hospital Mortality , Humans , Infant , Kaplan-Meier Estimate , Male , Middle Aged , Pandemics , Pneumonia, Viral/epidemiology , Pneumonia, Viral/mortality , Prognosis , Proportional Hazards Models , Retrospective Studies , Risk Factors , SARS-CoV-2 , Theranostic Nanomedicine , Thorax/diagnostic imaging , Tomography, X-Ray Computed , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL