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1.
BMC Pediatr ; 22(1): 53, 2022 Jan 20.
Article in English | MEDLINE | ID: covidwho-1643121

ABSTRACT

BACKGROUND: After the outbreak of COVID-19, many families equip with 75% ethanol to inactivate the SARS-CoV-2, which increases the risk of exposure to ethanol. CASE PRESENTATION: We reported a 25-day-old newborn who was diagnosed with neonatal acute ethanol intoxication with a presenting complaint of accidental consumption about 15 ml formula milk containing 75% ethanol. His main clinical manifestations were irritability, flushed skin, tachycardia, tachypnea, and toxicology analysis detected ethanol. After timely gastric lavage and intravenous fluid replacement, he was cured and discharged. CONCLUSIONS: During the COVID-19 epidemic, high concentration ethanol used for inactivating SARS-COV-2 should be placed reasonably and neonatal feeding safety should be emphasized. Timely diagnosis and symptomatic treatment are essential for the prevention and management of acute ethanol intoxication in newborns.

2.
Preprint in English | EuropePMC | ID: ppcovidwho-292741

ABSTRACT

The δ- and λ-variants of COVID-19 are blowing to globle economy, human life and health. The variants put the world in a harsher state. Lockdown is powerful in stopping the spread and infection. We evaluate the lockdown impact on NO 2 , SO 2 , O 3 , PM 2.5 and PM 10 in Wuhan, which reported the first COVID-19 case. Data before, during and after blokade in year 2020 were all analyzed. Lockdown significantly decreased four of the five pollutants. The decreasing reasons are discussed in social policies, people's living habits and Chinese characters. Wuhan is a transportation hub in central China. Viruses spread through it to all over the country. Although COVID-19 mainly bring bad social effects, people get chance to rethink the value of life: We should sustainablely develop and pursuing spiritual instead of excessive material enjoyment. These ultimately built more stable societies and benefit mankind itself.

3.
Sci Rep ; 11(1): 7334, 2021 04 01.
Article in English | MEDLINE | ID: covidwho-1500696

ABSTRACT

To identify the risk factors of mortality for the coronavirus disease 19 (COVID-19) patients admitted to intensive care units (ICUs) through a retrospective analysis. The demographic, clinical, laboratory, and chest imaging data of patients admitted to the ICU of Huoshenshan Hospital from February 10 to April 10, 2020 were retrospectively analyzed. Student's t-test and Chi-square test were used to compare the continuous and categorical variables, respectively. The logistic regression model was employed to ascertain the risk factors of mortality. This retrospective study involved 123 patients, including 64 dead and 59 survivors. Among them, 57 people were tested for interleukin-6 (IL-6) (20 died and 37 survived). In all included patients, the oxygenation index (PaO2/FiO2) was identified as an independent risk factor (odd ratio [OR] = 0.96, 95% confidence interval [CI]: 0.928-0.994, p = 0.021). The area under the curve (AUC) was 0.895 (95% CI: 0.826-0.943, p < 0.0001). Among the patients tested for IL-6, the PaO2/FiO2 (OR = 0.955, 95%CI: 0.915-0.996, p = 0.032) and IL-6 (OR = 1.013, 95%CI: 1.001-1.025, p = 0.028) were identified as independent risk factors. The AUC was 0.9 (95% CI: 0.791-0.964, p < 0.0001) for IL-6 and 0.865 (95% CI: 0.748-0.941, p < 0.0001) for PaO2/FiO2. PaO2/FiO2 and IL-6 could potentially serve as independent risk factors for predicting death in COVID-19 patients requiring intensive care.


Subject(s)
COVID-19/mortality , Interleukin-6/analysis , Aged , Area Under Curve , COVID-19/pathology , COVID-19/virology , Comorbidity , Female , Humans , Intensive Care Units , Logistic Models , Male , Middle Aged , Oxygen Consumption , ROC Curve , Retrospective Studies , Risk Factors , SARS-CoV-2/isolation & purification
4.
Int J Environ Res Public Health ; 18(20)2021 10 10.
Article in English | MEDLINE | ID: covidwho-1463678

ABSTRACT

COVID-19 and its variants have been changing the world. The spread of variants brings severe effects to the global economy and to human's lives and health, as well as to society. Lockdown is proven to be effective in stopping the spread. It also provides a chance to study natural environmental changes with humanity's limited interference. This paper aims to evaluate the impact of lockdown on five major airborne pollutants, i.e., NO2, SO2, O3, PM2.5 and PM10, in the three different functional regions of Chongming, Xuhui and Jinshan of Shanghai. Changes in the same pollutants from the three regions over the same/different periods were all studied and compared. Overall, the COVID-19 lockdown has changed pollutant concentrations in the long and short terms. Concentrations of four pollutants decreased, except for that of earth surface O3, which increased. SO2 had significant correlations with all other pollutants. PM2.5 and PM10 are more externally input than locally produced. NO2, SO2 and PM levels sharply reduced in Jinshan and Xuhui due to the limited usage of fossil fuel. Lockdown improved the air quality. People now have a chance to rethink the value of life and the harmony between economic progress and environmental protection. This is helpful to establish sustainable societies.


Subject(s)
Air Pollutants , Air Pollution , COVID-19 , Air Pollutants/analysis , Air Pollution/analysis , China , Cities , Communicable Disease Control , Environmental Monitoring , Humans , Particulate Matter/analysis , SARS-CoV-2
5.
J Med Syst ; 45(4): 42, 2021 Feb 19.
Article in English | MEDLINE | ID: covidwho-1092039

ABSTRACT

In confronting the sudden epidemic of COVID-19, China and other countries have been under great deal of pressure to block virus transmission and reduce death cases. Fangcang shelter hospital, which is converted from large-scale public venue, is proposed and proven to be an effective way for administering medical care and social isolation. This paper presents the practice in information technology support for a Fangcang shelter hospital in Wuhan, China. The experiences include the deployment strategy of IT infrastructure, the redesign of function modules in the hospital information system (HIS), equipment maintenance and medical staff training. The deployment strategy and HIS modules have ensured smoothness and efficiency of clinical work. The team established a quick response mechanism and adhered to the principle of nosocomial infection control. Deployment of network and modification of HIS was finished in the 48 hours before patient admittance. A repair hotline and remote support for equipment and software were available whenever medical workers met with any questions. No engineer ever entered the contaminated areas and no one was infected by the coronavirus during the hospital operation. Up to now, Fangcang shelter hospital is adopted by many regions around the world facing the collapse of their medical systems. This valuable experience in informatization construction and service in Wuhan may help participators involving in Fangcang shelter hospital get better information technology support, and find more practical interventions to fight the epidemic.


Subject(s)
COVID-19/therapy , Emergency Shelter/organization & administration , Hospitals, Special/organization & administration , Mobile Health Units/organization & administration , Patient Isolation/statistics & numerical data , COVID-19/epidemiology , China , Emergencies , Facility Design and Construction , Hospitals, Isolation , Humans , Information Technology , Risk Factors
6.
Preprint | SciFinder | ID: ppcovidwho-4204

ABSTRACT

Objective To investigate the prevention and control measures for reprocessing of surgical instruments used in patients with SARS-CoV-2 infection. Methods By formulating the process for treatment of SARS-CoV-2-contaminated surgical instruments, the prevention and control measures in the reprocessing of contaminated surgical instruments were stand- ardized and their effectiveness was evaluated. Results The recycling and cleaning staffs operated according to this standard procedure. After processing SARS-CoV-2-contaminated surgical instruments, no medical staff was infected and no cross - infections among patients appeared. Conclusion Through the implementation of the treatment process of SARS-CoV-2 contaminted surgical instruments, the nosocomial infection of SARS-CoV-2 was effectively prevented and controlled, and no infection was achieved.

7.
Front Psychiatry ; 11: 598712, 2020.
Article in English | MEDLINE | ID: covidwho-1000154

ABSTRACT

Background: The COVID-19 pandemic is a major public health issue and challenge to health professionals. In similar epidemics, nurses experienced more distress than other providers. Methods: We surveyed both on-duty nurses caring for infected patients and second-line nurses caring for uninfected patients from Hubei and other provinces throughout China. Results: We received completed surveys from 1,364 nurses from 22 provinces: 658 front-line and 706 second-line nurses. The median (IQR) GHQ-28 score of all nurses was 17 (IQR 11-24). The overall incidence of mild-to-moderate distress (GHQ score > 5) was 28%; that for severe distress (GHQ score > 11) was 6%. The incidence of mild-to-moderate distress in the second-line nurses was higher than that in the front-line nurses (31 vs. 25%; OR, 0.74; 95 CI, 0.58-0.94). Living alone (OR, 0.62; 95% CI, 0.44-0.86) and feeling supported (OR, 0.82, 95% CI, 0.74-0.90) independently predicted lower anxiety. Conclusions: During the COVID-19 pandemic, the psychological problems of all nurses were generally serious. The interviewed second-line nurses face more serious issues than the front-line nurses.

8.
Ann Transl Med ; 8(18): 1158, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-875041

ABSTRACT

Background: To evaluate the role of high-resolution computed tomography (HRCT) in the diagnosis of 2019 novel coronavirus (2019-nCoV) pneumonia and to provide experience in the early detection and diagnosis of 2019-nCoV pneumonia. Methods: Seventy-two patients confirmed to be infected with 2019-nCoV from multiple medical centers in western China were retrospectively analyzed, including epidemiologic characteristics, clinical manifestations, laboratory findings and HRCT chest features. Results: All patients had lung parenchymal abnormalities on HRCT scans, which were mostly multifocal in both lungs and asymmetric in all patients, and were mostly in the peripheral or subpleural lung regions in 52 patients (72.22%), in the central lung regions in 16 patients (22.22%), and in both lungs with "white lung" manifestations in 4 patients (5.56%). Subpleural multifocal consolidation was a predominant abnormality in 38 patients (52.78%). Ground-glass opacity was seen in 34 patients (47.22%). Interlobular septal thickening was found in 18 patients, 8 of whom had only generally mild thickening with no zonal predominance. Reticulation was seen in 8 patients (11.11%), and was mild and randomly distributed. In addition, both lungs of 28 patients had 2 or 3 CT imaging features. Out of these 72 patients, 36 were diagnosed as early stage, 32 patients as progressive stage, and 4 patient as severe stage pneumonia. Moreover, the diagnostic accuracy of HRCT features combined with epidemiological history was not significantly different from the detection of viral nucleic acid (all P >0.05). Conclusions: The HRCT features of 2019-nCoV pneumonia are characteristic to a certain degree, which when combined with epidemiological history yield high clinical value in the early detection and diagnosis of 2019-nCoV pneumonia.

9.
Gen Psychiatr ; 33(5): e100288, 2020.
Article in English | MEDLINE | ID: covidwho-808787

ABSTRACT

Background: Medical staff fighting the COVID-19 pandemic are experiencing stress from high occupational risk, panic in the community and the extreme workload. Maintaining the psychological health of a medical team is essential for efficient functioning, but psychological intervention models for emergency medical teams are rare. Aims: To design a systematic, full-coverage psychological health support scheme for medical teams serving large-scale emergent situations, and demonstrate its effectiveness in a real-world study in Leishenshan Hospital during the COVID-19 epidemic in Wuhan, China. Methods: The scheme integrates onsite and online mental health resources and features team-based psychosocial support and evidence-based interventions. It contained five modules, including a daily measurement of mood, a daily mood broadcast that promotes positive affirmation, a daily online peer-group activity with themes based on the challenges reported by the team, Balint groups and an after-work support team. The daily mood measurement provides information to the other modules. The scheme also respects the special psychological characteristics of medical staff by promoting their strengths. Results: The scheme economically supported a special medical team of 156 members with only one onsite psychiatrist. Our data reflected that the entire medical team maintained an overall positive outlook (7-9 out of 10 in a Daily Mood Index, DMI) for nearly 6 weeks of continuous working. Since the scheme promoted self-strengths and positive self-affirmation, the number of self-reports of life-related gains were high and played a significant effect on the DMI. Our follow-up investigations also revealed that multiple modules of the scheme received high attention and evaluation levels. Conclusion: Our quantitative data from Leishenshan hospital, Wuhan, China, show that the programme is adequate to support the continuous high workload of medical teams. This scheme could be applied to medical teams dealing with emergent situations.

10.
Gen Psychiatr ; 33(3): e100292, 2020.
Article in English | MEDLINE | ID: covidwho-618920

ABSTRACT

Background: Facing the social panic and substantial shortage of medical resources during the coronavirus disease 2019 (COVID-19) outbreak, providing psychological first-aid to inpatients is essential for their rehabilitation and the orderly operating of medical systems. However, the closed-ward environment and extreme shortage of onsite mental health workers have limited the use of traditional face-to-face diagnosis and psychological interventions. Aim: To develop a mental health intervention model for inpatients that can be applied during a widespread epidemic, such as COVID-19. Methods: In a medical team stationed in Leishenshan Hospital, Wuhan, China, we integrated onsite and online psychological support resources to implement a graded psychological intervention system. The onsite psychiatrist established trust with the patients and classified them into categories according to their symptom severity. While face-to-face evaluation and intervention are critical for effective online support, the online team effectively extended the scope of the 'first-aid' to all patients. Conclusion: This integrated onsite and online approach was effective and efficient in providing psychological interventions for inpatients during the crisis. Our model provides a realistic scheme for healthcare systems in or after the COVID-19 epidemic and also could be adopted in areas of the world with insufficient mental healthcare resources.

11.
Zhongguo Zhong Yao Za Zhi ; 45(10): 2265-2274, 2020 May.
Article in Chinese | MEDLINE | ID: covidwho-398790

ABSTRACT

In December 2019, an outbreak of viral pneumonia began in Wuhan, Hubei Province, which caused the spread of infectious pneumonia to a certain extent in China and neighboring countries and regions, and triggered the epidemic crisis. The coronavirus disease 2019(COVID-19) is an acute respiratory infectious disease listed as a B infectious disease, which is managed according to standards for A infectious disease. Traditional Chinese medicine and integrated traditional Chinese and Western medicine have played an active role in the prevention and control of this epidemic. China's ethnomedicine has recognized infectious diseases since ancient times, and formed a medical system including theory, therapies, formula and herbal medicines for such diseases. Since the outbreak of the COVID-19 epidemic, Tibet Autonomous Region, Qinghai Province, Inner Mongolia Autonomous Region, Xinjiang Uygur Autonomous Region and Chuxiong Autonomous Prefecture of Yunnan, Qiandongnan Autonomous Prefecture of Guizhou have issued the prevention and control programs for COVID-19 using Tibetan, Mongolian, Uygur, Yi and Miao medicines. These programs reflect the wisdom of ethnomedicine in preventing and treating diseases, which have successfully extracted prescriptions and preventive measures for the outbreak of the epidemic from their own medical theories and traditional experiences. In this paper, we summarized and explained the prescriptions and medicinal materials of ethnomedicine in these programs, and the origin of Tibetan medicine prescriptions and Mongolian medicine prescriptions in ancient books were studied. These become the common characteristics of medical prevention and treatment programs for ethnomedicine to formulate therapeutic programs under the guidance of traditional medicine theories, recommend prescriptions and prevention and treatment methods with characteristics of ethnomedicine, and focus on the conve-nience and standardization. However, strengthening the support of science and technology and the popularization to the public, and improving the participation of ethnomedicine in national public health services and the capacity-building to deal with sudden and critical diseases are key contents in the development of ethnomedicine in the future.


Subject(s)
Betacoronavirus , Coronavirus Infections/drug therapy , Pneumonia, Viral/drug therapy , COVID-19 , China , Humans , Medicine, Traditional , Pandemics , SARS-CoV-2 , Tibet
12.
J Med Virol ; 92(10): 1890-1901, 2020 10.
Article in English | MEDLINE | ID: covidwho-60287

ABSTRACT

The discovery of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the outbreak of coronavirus disease 2019 (COVID-19) are causing public health emergencies. A handful pieces of literature have summarized its clinical and radiologic features, whereas therapies for COVID-19 are rather limited. To evaluate the efficacy of convalescent plasma therapy in COVID-19 patients, we did this timely descriptive study. Six laboratory-confirmed COVID-19 patients were enrolled and received the transfusion of ABO-compatible convalescent plasma. The efficacy of this intervention was determined by the alleviation of symptoms, changes in radiologic abnormalities and laboratory tests. No obvious adverse effect observed during the treatment. Transfusion of convalescent plasma led to a resolution of ground-glass opacities and consolidation in patients #1, #2, #3, #4, and #6. In patients #1 and #5 who presented with SARS-CoV-2 in throat swab, convalescent plasma therapy elicited an elimination of the virus. Serologic analysis indicated an immediate increase in anti-SARS-CoV-2 antibody titers in patients #2 and #3, but not in patient #1. This study indicates that convalescent plasma therapy is effective and specific for COVID-19. This intervention has a special significance for eliminating SARS-CoV-2 and is believed to be a promising state-of-the-art therapy during COVID-19 pandemic crisis.


Subject(s)
COVID-19/therapy , Adult , Aged , Antibodies, Viral/blood , China , Female , Humans , Immunization, Passive , Immunoglobulin G/blood , Immunoglobulin M/blood , Male , Middle Aged
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