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1.
Small Methods ; : e2200932, 2022 Oct 27.
Article in English | MEDLINE | ID: covidwho-2085203

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies are shown to be effective therapeutics for providing coronavirus disease 2019 (COVID-19) protection. However, recurrent variants arise and facilitate significant escape from current antibody therapeutics. Bispecific antibodies (bsAbs) represent a unique platform to increase antibody breadth and to reduce neutralization escape. Herein, a novel immunoglobulin G-variable domains of heavy-chain-only antibody (IgG-VHH) format bsAb derived from a potent human antibody R15-F7 and a humanized nanobody P14-F8-35 are rationally engineered. The resulting bsAb SYZJ001 efficiently neutralizes wild-type SARS-CoV-2 as well as the alpha, beta, gamma, and delta variants, with superior efficacy to its parental antibodies. Cryo-electron microscopy structural analysis reveals that R15-F7 and P14-F8-35 bind to nonoverlapping epitopes within the RBD and sterically hindered ACE2 receptor binding. Most importantly, SYZJ001 shows potent prophylactic and therapeutic efficacy against SARS-CoV-2 in three established mouse models. Collectively, the current results demonstrate that the novel bsAb format is feasible and effective, suggesting great potential as an inspiring antiviral strategy.

2.
Chemosphere ; : 136670, 2022 Oct 21.
Article in English | MEDLINE | ID: covidwho-2082820

ABSTRACT

Energy crisis and increasing rigorous management standards pose significant challenges for solid waste management worldwide. Several emerging diseases such as COVID-19 aggravated the already complex solid waste management crisis, especially sewage sludge and food waste streams, because of the increasingly large production year by year. As mature waste disposal technologies, landfills, incineration, composting, and some other methods are widespread for solid wastes management. This paper reviews recent advances in key sewage sludge disposal technologies. These include incineration, anaerobic digestion, and valuable products oriented-conversion. Food waste disposal technologies comprised of thermal treatment, fermentation, value-added product conversion, and composting have also been described. The hot topic and dominant research foci of each area are summarized, simultaneously compared with conventional technologies in terms of organic matter degradation or conversion performance, energy generation, and renewable resources production. Future perspectives of each technology that include issues not well understood and predicted challenges are discussed with a positive effect on the full-scale implementation of the discussed disposal methods.

3.
Radiat Res ; 198(3): 306-317, 2022 09 01.
Article in English | MEDLINE | ID: covidwho-2079878

ABSTRACT

COVID-19 is a challenge to biosecurity and public health. The speed of vaccine development lags behind that of virus evolution and mutation. To date, no agent has been demonstrated to be fully effective against COVID-19. Therefore, it remains of great urgency to rapidly develop promising therapeutic and diagnostic candidates. Intriguingly, mounting evidence hints at parallel etiologies between SARS-CoV-2 infection and radiation injury. Herein, from the perspectives of immunogenic pathway activation and metabolic alterations, we provide novel evidence of commonalities between these two pathological conditions based on the most recent findings. Since numerous agents have been developed to prevent or reverse radiation injury in the past 70 years to ensure nuclear safety, we also advocate investigating the promising function of radioprotectors and radiomitigators against COVID-19 in clinical settings.


Subject(s)
COVID-19 , Radiation Injuries , Humans , SARS-CoV-2
4.
Frontiers in public health ; 10, 2022.
Article in English | EuropePMC | ID: covidwho-2057655

ABSTRACT

Background The COVID-19 pandemic has lasted more than 2 years, and the global epidemic prevention and control situation remains challenging. Scientific decision-making is of great significance to people's production and life as well as the effectiveness of epidemic prevention and control. Therefore, it is all the more important to explore its patterns and put forward countermeasures for the pandemic of respiratory infections. Methods Modeling of epidemiological characteristics was conducted based on COVID-19 and influenza characteristics using improved transmission dynamics models to simulate the number of COVID-19 and influenza infections in different scenarios in a hypothetical city of 100,000 people. By comparing the infections of COVID-19 and influenza in different scenarios, the impact of the effectiveness of vaccination and non-pharmaceutical interventions (NPIs) on disease trends can be calculated. We have divided the NPIs into three levels according to the degree of restriction on social activities (including entertainment venues, conventions, offices, restaurants, public transport, etc.), with social controls becoming progressively stricter from level 1 to level 3. Results In the simulated scenario where susceptible individuals were vaccinated with three doses of COVID-19 coronaVac vaccine, the peak number of severe cases was 26.57% lower than that in the unvaccinated scenario, and the peak number of infection cases was reduced by 10.16%. In the scenario with level three NPIs, the peak number of severe cases was reduced by 7.79% and 15.43%, and the peak number of infection cases was reduced by 12.67% and 28.28%, respectively, compared with the scenarios with NPIs intensity of level 2 and level 1. For the influenza, the peak number of severe cases in the scenario where the entire population were vaccinated was 89.85%, lower than that in the unvaccinated scenario, and the peak number of infections dropped by 79.89%. Conclusion The effectiveness of COVID-19 coronaVac vaccine for preventing severe outcomes is better than preventing infection;for the prevention and control of influenza, we recommend influenza vaccination as a priority over strict NPIs in the long term.

5.
Financ Res Lett ; : 103372, 2022 Sep 22.
Article in English | MEDLINE | ID: covidwho-2041760

ABSTRACT

We examine the resilience of Chinese banks during the COVID-19 pandemic by investigating non-performing loan (NPL) ratios. We find that despite the reduction in the growth rate of total bank lending, bank NPL ratios significantly increase during the COVID-19 crisis. Banks with high-quality capital are more effective in controlling their NPL ratios during the Crisis. Big Five banks, state-owned banks and domestic banks have lower NPL ratios than their counterparts during the Crisis.

6.
Earth's Future ; 10(8), 2022.
Article in English | ProQuest Central | ID: covidwho-2016569

ABSTRACT

Global food security is directly linked to human health and sustainable development. It is critical to comprehensively twig future changes in global food demand and progress in implementing the United Nations Sustainable Development Goals (SDGs), considering the transition of dietary patterns. We presented a global‐scale analysis quantifying the status of national food consumption and SDG performance in 2017, and the food demands and SDG index scores in 2030 were predicted under three healthy dietary patterns using 11 SDG indicators. High‐income nations scored well on most SDG indicators but poorly on food waste and the environment. Total global food demand was projected to be the highest under the national dietary guidelines pattern (12.69–13.37 million ton/d) and the lowest under the WHO healthy diet pattern (10.55–11.18 million ton/d). However, food demand under different dietary patterns varied among regions. Transitioning from current diets to healthy diets was projected to gain SDG index score for most countries. Strategies for shifts in dietary patterns to determine the tradeoff between global food security and sustainable development should be tailored to local conditions. The EAT‐Lancet dietary pattern is an optimal choice for determining the tradeoff between food security and sustainable development on a global scale. Given the current status of food access and nutrition, the National and the WHO dietary patterns are recommended for Asia and Africa, respectively.

7.
Int J Appl Earth Obs Geoinf ; 112: 102905, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1991102

ABSTRACT

Coronavirus disease 2019 (COVID-19) has crucially influenced anthropogenic activities, which in turn impacts upon the environment. In this study, we investigated the variations on aerosol optical depth (AOD) at 550 nm over the Bohai Sea and Yellow Sea during the COVID-19 lockdown (from February to March in 2020) of China mainland based on Moderate-resolution Imaging Spectroradiometer (MODIS) observation by comparing with historical AOD records (2011-2019). Our results show that with the lockdown implementation, the decade-low AOD levels are achieved in February and March 2020 (0.39 ± 0.18 and 0.37 ± 0.19, respectively), which are 22% and 28% (p < 0.01) lower than the average AOD between 2011 and 2019 (0.50 ± 0.08 and 0.52 ± 0.05, respectively). After the lockdown restrictions were relaxed and industrial production gradually resumed, the AOD in April 2020 rebounded to the historical average level. Besides, compared with historical observations (2011-2019), the AOD temporal variability from February to April 2020 showed different pattern, with the decade-high increase from March to April (+0.11) and decade-low increase from February to March (-0.01). Independent observations and simulation, including fine particulate matter (PM2.5) from ground-based measurements, wind field from Cross-Calibrated Multi-Platform, satellite-derived aerosol type, and back trajectories calculation by Hybird Single Paricle Lagrangian Intergrated Trajectory (HYSPLIT) model, indicated that the above abnormal AOD variation can be attributed to reduction of anthropogenic emissions during the COVID-19 lockdown period. The results of this paper, therefore, indicate that aerosols over the Bohai and Yellow Seas are strongly influenced by human activities, and the public health events such as the epidemic may alter the intensity of human activities and thus the spatio-temporal pattern of aerosol over ocean. With the global spread of the epidemic and the corresponding significant changes in human behavior patterns (restrictions on human activities, etc.), more studies should be carried out in the future about the aerosol variability and its potential impact on the marine environment.

8.
Children (Basel) ; 9(8)2022 Aug 16.
Article in English | MEDLINE | ID: covidwho-1987675

ABSTRACT

BACKGROUND: The outbreak of COVID-19 has seriously threatened the health of people around the world. To prevent the spread of the epidemic, Chinese universities have implemented closed management of campuses. The implementation of restrictive measures has gradually caused changes in the quality of sleep and the psychological state of college students. In addition, college students are faced with the dual pressure of employment and study, and the psychological pressure is huge. Therefore, it is necessary to investigate sleep and depressive symptoms among college students. METHODS: Using the method of stratified cluster sampling, 6695 college students were selected from three universities in Jiangxi, Anhui, and Xinjiang provinces from April to May 2022. The Chinese version of the Pittsburgh sleep quality index (PSQI) and the self-rating depression scale (SDS) were used for the survey. Hierarchical logistic regression analysis was used to analyze the relationship between the PSQI and the SDS. RESULTS: Overall, during the outbreak of COVID-19, 69.0% of males and 73.5% of females had poor sleep quality among Chinese college students and the detection rate of depressive symptoms was 43.6% for males and 47.8% for females, respectively. Taking students with good sleep quality as references, after controlling for covariates, hierarchical logistic regression shows that Chinese college students with poor sleep quality have a higher OR value (OR = 12.0, 95%CI: 10.2~14.1, p < 0.001), especially in males (OR = 43.8, 95%CI:30.2~63.6, p < 0.001). For both males and females, the OR value of college students with the following characteristics was higher: rural college students (males, OR = 50.32, 95%CI: 32.50-77.93; females, OR = 8.03, 95%CI: 6.45-9.99), overweight college students (males, OR = 62.17, 95%CI: 19.47-198.53; females, OR = 16.67, 95%CI: 6.48-42.88), and college students drinking sugar-sweetened beverages (males, OR = 59.00, 95%CI: 36.96-94.18; females, OR = 8.16, 95%CI: 6.63-10.05) (p < 0.001). CONCLUSIONS: Poor sleep quality is associated with depressive symptoms among Chinese college students, especially college males. Our research suggests that it is necessary to consider the improvement of sleep quality and depressive symptoms among college students during the COVID-19 epidemic.

9.
Angew Chem Int Ed Engl ; 61(37): e202203706, 2022 09 12.
Article in English | MEDLINE | ID: covidwho-1981567

ABSTRACT

Serological assay for coronavirus 2019 (COVID-19) patients including asymptomatic cases can inform on disease progression and prognosis. A detection method taking into account multiplex, high sensitivity, and a wider detection range will help to identify and treat COVID-19. Here we integrated color-size dual-encoded beads and rolling circle amplification (RCA) into a bead-based fluorescence immunoassay implemented in a size sorting chip to achieve high-throughput and sensitive detection. We used the assay for quantifying COVID-19 antibodies against spike S1, nucleocapsid, the receptor binding domain antigens. It also detected inflammatory biomarkers including interleukin-6, interleukin-1ß, procalcitonin, C-reactive protein whose concentrations range from pg mL-1 to µg mL-1 . Use of different size beads integrating with RCA results in a tunable detection range. The assay can be readily modified to simultaneously measure more COVID-19 serological molecules differing by orders of magnitude.


Subject(s)
COVID-19 , Antibodies, Viral , COVID-19/diagnosis , Humans , Immunoassay/methods , Procalcitonin
10.
Ann Palliat Med ; 10(7): 8003-8014, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1390183

ABSTRACT

BACKGROUND: Infectious disease is ubiquitous and can represent a major threat to human health. Procalcitonin (PCT) is mainly used to identify the severity of bacterial infections, which can be secondary to many non-bacterial infectious diseases. The purpose of this study was to evaluate current research in the field of infectious diseases and to suggest directions for further investigation. METHODS: The Science Citation Index Expanded (SCI-E) database in the Web of Science Core Collection (WOSCC) was used as the search data source. The search parameters including the search scope were limited to "infectious disease" and the search term was "procalcitonin". The time range of the target literature was 1900 to the final search date of this research (May 7, 2021), and the language was limited to English. The full records of the search results and cited references were exported in plain text format, and Citespace software was used to analyze the documents. RESULTS: A total of 996 related research documents were found, and the number increased significantly in 2020. The United States, Germany, and the United Kingdom were the main sources of research, and the main research institutions were Aarhus University Hospital and Harvard University. The main journals are publishing material were Clin Infect Dis, Lancet, and Crit Care Med. Analysis of key words showed that the most common current research topics were sepsis and biomarkers of disease monitoring. CONCLUSIONS: Research on infectious disease and the role of PCT is increasing. The main research topics are sepsis and biomarkers for disease monitoring.


Subject(s)
Communicable Diseases , Procalcitonin , Bibliometrics , Humans , Publishing , United Kingdom , United States
12.
J Adv Nurs ; 78(12): 4071-4081, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-1937946

ABSTRACT

AIM: The aim was to examine the subgroups of work engagement in frontline nurses during the COVID-19 pandemic. BACKGROUND: The pandemic may affect the work engagement of nurses who have direct contact with infected patients and lead to a poor quality of care. Identifying classification features of work engagement and tailoring interventions to support frontline nurses is imperative. DESIGN: This study utilized a cross-sectional study design. METHODS: Three hundred fifty-five nurses were enrolled in this cross-sectional study from 14 February to 15 April 2020. A latent profile analysis was performed to identify classification features of work engagement. Multiple logistic regression analyses were used to examine predictors of profile membership. RESULTS: A four-profile model provided the best fit. The four profiles were titled 'low work engagement' (n = 99), 'high vigour-low dedication and absorption' (n = 58), 'moderate work engagement' (n = 63) and 'high work engagement' (n = 135). A regression analysis suggested that young nurses and nurses who were the only children of their family were more likely to be in the 'low work engagement' and 'high vigour-low dedication and absorption' groups. CONCLUSION: This study highlights the importance of tailoring interventions for frontline supporting nurses by considering their distinct work engagement patterns, especially during the COVID-19 pandemic, to improve the promotion of work satisfaction and quality of care. IMPACT: This was the first study to explore the latent profiles of work engagement in frontline nurses during the COVID-19 pandemic. Over 40% of nurses were in the 'low work engagement' and 'high vigour-low dedication and absorption' groups and reported low levels of work engagement. Understanding different patterns of work engagement in frontline nurses can help nursing managers provide emotional, material and organizational support based on the features of each latent profile, which may improve the quality of care and patient safety.


Subject(s)
COVID-19 , Nurses , Child , Humans , Work Engagement , COVID-19/epidemiology , Pandemics , Cross-Sectional Studies , Job Satisfaction
13.
Sustain Cities Soc ; 85: 104061, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-1926897

ABSTRACT

The COVID-19 pandemic led to a sharp economic contraction. A comprehensive understanding of the relationship between the spatial composition of production factor (SCPF) and socioeconomic recovery is still missing. Here, we applied the contrasting status of nitrogen dioxide (NO2) concentrations in cities in central and eastern China as natural laboratories. From the perspective of the spatial composition of land (SCL) and the dependence on the inflow population (DIP), four quantifiable indicators (resilience, impact, sensitivity, recovery speed) were used to analyze the adaptability of SCPF to the epidemic lockdown. The results indicate that appropriate SCPF is a prerequisite for a complete "land-population-industry" nexus. The built-up area proportion is below 74.38%, with higher adaptability to epidemic shocks. The range of rural built-up proportion conducive to economic recovery is 10.18%-15.18%. The proportions of various land types inside the city's defense unit should also be constrained. Similarly, DIP is advocated to be maintained below 17.5%. For urban-rural fringe areas, the response to epidemic prevention and socioeconomic recovery are rapid. This observation-driven study indicated that COVID-19 is a shocking reminder for policymakers, to improve the socioeconomic recovery ability from the spatial composition of production factor perspective in the post-COVID-19 era.

14.
International Journal of Islamic and Middle Eastern Finance and Management ; 15(3):527-568, 2022.
Article in English | ProQuest Central | ID: covidwho-1922508

ABSTRACT

Purpose>This paper aims to analyze the impact of price-limit hits by hit type and when such hits start and stop using intraday trades and quotes at a one-second frequency for firms included in the BIST-50 index during the 13-months starting with March 2008. Like the recent COVID-19 period, this period includes the heightened stress in global financial markets in September 2008.Design/methodology/approach>Using intra-day trades and quotes at a one-second frequency, the authors examine the market effects of price limits for firms included in the BIST-50 index during the global financial crisis. The authors compare the values of various metrics for 60 min centered on price-limit hit periods. The authors conduct robustness tests using auto regressive integrated moving average (ARIMA) models with trade-by-trade and with 3-min returns.Findings>The findings are supportive of the following hypotheses: magnet price effects, greater informational asymmetric effects of market quality and each version of price discovery. Results are robust using samples differentiated by cross-listed status, same-day quotes instead of transaction prices and equidistant and trade-by-trade returns.Originality/value>The authors use intraday data to reduce measurement error that is particularly pronounced when daily data are used to assess price limits that start and/or stop during a trading session. The authors contribute to the micro-structure literature by using ARIMA models with trade-by-trade and 3-min returns to alleviate some bias due to the autocorrelations in returns around price-limit hits in the presence of a magnet effect. The authors include some recent regulation changes in various countries to illustrate the importance of circuit breakers using price limits during COVID-19.

15.
J Infect Dev Ctries ; 16(6): 1009-1015, 2022 06 30.
Article in English | MEDLINE | ID: covidwho-1924339

ABSTRACT

INTRODUCTION: To investigate the effects and influencing factors of the COVID-19 epidemic on the employment intention of resident physicians in China. METHODOLOGY: 409 questionnaires were statistically analyzed after removing the missing values. We used the Chi-Square test for single-factor analysis and logistic regression analysis for multivariate analysis. The questions include the residents' employment intention and their willingness to engage in epidemic-related subspecialties and participate in epidemic-related work. RESULTS: Residents of severe and high-risk epidemic regions had much lower employment intentions than those of stable epidemic regions (OR = 1.917, 95% CI: 1.024, 3.591, p = 0.042). The higher the Center for Epidemiologic Studies Depression Scale (CES-D) score, the more susceptible was the resident's employement intention (OR = 1.085, 95% CI: 1.044, 1.128, p < 0.001). Residents from severe and high-risk epidemic regions were more willing to participate in clinical work (OR = 4.263, 95% CI: 1.892, 9.604, p < 0.001), and the higher the CES-D score, the lower was the proportion of residents willing to choose clinical work (OR = 0.941, 95% CI: 0.893, 0.992, p = 0.023). Residents from severe epidemics and high-risk provinces were less willing to participate in respiratory medicine (χ2 = 5.070, p = 0.027) and critical care medicine (χ2 = 7.046, p = 0.011). Compared to residents with bachelor's degrees, residents with master's and doctoral degrees were less willing to participate in isolation wards (OR = 1.831, 95% CI: 1.122, 2.990, p = 0.016). Residents in epidemic-related current rotation departments were less willing to go to Wuhan as volunteers (OR = 2.197, 95% CI: 1.110, 4.347, p = 0.024). CONCLUSIONS: The COVID-19 outbreak had a negative impact on the job intentions of Chinese residents in general.


Subject(s)
COVID-19 , Epidemics , Physicians , COVID-19/epidemiology , China/epidemiology , Employment , Humans , Intention , Surveys and Questionnaires
17.
Information Technology & People ; 35(4):1364-1382, 2022.
Article in English | ProQuest Central | ID: covidwho-1878903

ABSTRACT

Purpose>Most students are considered digital natives and are presumably equipped to handle extensive technology use. However, online learning turns students into involuntary telecommuters when it is the primary modality. The prevailing trends of online learning, digital socialization, telehealth and other online services, combined with remote work has increased students' reliance on information and communications technologies (ICTs) for all purposes, which may be overwhelming. We examine how technology overload strains the ability of online learning to meet students' basic psychological needs (BPNs), which can decrease positive outcomes such as academic enjoyment and personal performance.Design/methodology/approach>Data was collected via an online survey of 542 university students and the proposed model was tested using partial least squares (PLS) regression.Findings>We find that technology overload can diminish the positive relationship between online learning intensity and BPNs satisfaction, which is alarming because BPNs satisfaction is critical to students' positive experiences. Moreover, we find that technology overload and lack of technology experience can directly drive BPNs frustration, which decreases positive outcomes and increases academic anxiety.Originality/value>We extend a theoretical framework for telecommuting to examine online learning. Additionally, we consider the role of technology overload and experience both as drivers and as moderators of students' BPNs satisfaction and frustration in online learning. Our results provide valuable insights that can inform efforts to rebalance the deployment of ICTs to facilitate online educational experiences.

18.
Genes Genomics ; 2022 Jun 07.
Article in English | MEDLINE | ID: covidwho-1877981

ABSTRACT

BACKGROUND: Ralstonia solanacearum causes bacterial wilt of Pogostemon cablin which is an important aromatic herb and also the main materials of COVID-19 therapeutic traditional drugs. However, we are lacking the information on the genomic sequences of R. solanacearum isolated from P. cablin. OBJECTIVE: The acquisition and analysis of this whole-genome sequence of the P. cablin bacterial wilt pathogen. METHODS: An R. solanacearum strain, named SY1, was isolated from infected P. cablin plants, and the complete genome sequence was sequenced and analyzed. RESULTS: The SY1 strain contains a 3.70-Mb chromosome and a 2.18-Mb megaplasmid, with GC contents of 67.57% and 67.41%, respectively. A total of 3308 predicted genes were located on the chromosome and 1657 genes were located in the megaplasmid. SY1 strain has 273 unique genes compared with five representative R. solanacearum strains, and these genes were enriched in the plant-pathogen interaction pathway. SY1 possessed a higher syntenic relationship with phylotype I strains, and the arsenal of type III effectors predicted in SY1 were also more closely related to those of phylotype I strains. SY1 contained 14 and 5 genomic islands in its chromosome and megaplasmid, respectively, and two prophage sequences in its chromosome. In addition, 215 and 130 genes were annotated as carbohydrate-active enzymes and antibiotic resistance genes, respectively. CONCLUSION: This is the first genome-scale assembly and annotation for R. solanacearum which isolated from infected P. cablin plants. The arsenal of virulence and antibiotic resistance may as the determinants in SY1 for infection of P. cablin plants.

19.
J Int Med Res ; 50(5): 3000605221103525, 2022 May.
Article in English | MEDLINE | ID: covidwho-1874964

ABSTRACT

OBJECTIVE: To identify factors associated with high-flow nasal cannula (HFNC) therapy failure in patients with severe COVID-19. METHODS: We retrospectively examined clinical and laboratory data upon admission, treatments, and outcomes of patients with severe COVID-19. Sequential Organ Failure Assessment (SOFA) scores were also calculated. RESULTS: Of 54 patients with severe COVID-19, HFNC therapy was successful in 28 (51.9%) and unsuccessful in 26 (48.1%). HFNC therapy failure was more common in patients aged ≥60 years and in men. Compared with patients with successful HFNC therapy, patients with HFNC therapy failure had higher percentages of fatigue, anorexia, and cardiovascular disease; a longer time from symptom onset to diagnosis; higher SOFA scores; a higher body temperature, respiratory rate, and heart rate; more complications, including acute respiratory distress syndrome, septic shock, myocardial damage, and acute kidney injury; a higher C-reactive protein concentration, neutrophil count, and prothrombin time; and a lower arterial partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2). However, male sex, a low PaO2/FiO2, and a high SOFA score were the only independent factors significantly associated with HFNC therapy failure. CONCLUSIONS: Male sex, a low PaO2/FiO2, and a high SOFA score were independently associated with HFNC therapy failure in patients with severe COVID-19.


Subject(s)
COVID-19 , Respiratory Insufficiency , COVID-19/therapy , Cannula/adverse effects , Humans , Male , Oxygen , Respiratory Insufficiency/etiology , Respiratory Insufficiency/therapy , Retrospective Studies
20.
Sotsiologicheskie Issledovaniia ; - (5):133, 2022.
Article in English | ProQuest Central | ID: covidwho-1872002

ABSTRACT

The study is aimed at identifying features of the COVID-2019 pandemic impact on urbanization in China. The objects of the study were the cities of Shanghai, Beijing and Guangzhou. The choice is determined by their representativeness and the possibility to apply the results of the study to other large urban agglomerations in China. The methodology is based on an integrated methodological approach that combines elements of descriptive statistical and sociological research. To assess relationship between the spread of the pandemic in the metropolitan areas of Shanghai, Beijing and Guangzhou, correlation and regression analysis was used. The study of the impact of the pandemic on the quality of life of the urban population was carried out through a survey using a structured questionnaire. The data obtained were processed and analyzed using the SPSS26.0 software, which made it possible to identify the degree of connection between urbanization and aspects of the urban people life, including their employment, well-being, access to health services, and the transformation of life values. It was found that there is a strong link between the level of urbanization and the pandemic, therefore, with the development of urbanization, the number of cases of infection (if other conditions remain unchanged) increases, and vice versa. As a result of a survey of urban residents and an assessment of the frequencies and correlations of responses, it was revealed that the impact of the pandemic on the daily life of urban people was most pronounced on the level of well-being among informally employed people, increasing the availability of health care, and only then on the values of citizens. These results should be taken into account for improving the quality of urbanization.

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