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1.
Zhonghua Er Ke Za Zhi ; 60(11): 1158-1162, 2022 Nov 02.
Article in Chinese | MEDLINE | ID: covidwho-2099939

ABSTRACT

Objective: To analyze the clinical characteristics of the neonates infected with SARS-CoV-2 during the Omicron outbreak in Shanghai 2022. Methods: In this retrospective case series study, all the 16 neonates with SARS-CoV-2 Omicron infection who were admitted to the neonatal unit in Shanghai Public Health Clinical Center from March 1st to May 31st, 2022 were enrolled. Their epidemiological history, clinical manifestations, nucleic acid cycle threshold (Ct) value and outcomes were analyzed. Based on maternal vaccination, they were divided into vaccinated group and unvaccinated group. Rank sum test and Chi-square test were used for the comparison between the groups. Results: Among the 16 neonates, 10 were male, and 6 were female. All the infants were full-term. The infection was confirmed at the age of 12.5 (8.0, 20.5) days. All the neonates had a history of exposure to infected family members, and thus horizontal transmission was the primary mode. Four infants were asymptomatic, 12 were symptomatic, and there were no severe or critical cases. The most common clinical manifestation was fever (11 cases), with the highest temperature of 38.1 (37.9, 38.3) ℃ and a course of 1-5 days. Other clinical manifestations included nasal obstruction (3 cases), runny nose (2 cases), cough (2 cases), poor feeding (2 cases), vomiting (1 case), and mild tachypnea (1 case). The complete blood counts of all neonates were within the normal range, and the C-reactive protein increased slightly in 1 infant. Chest imaging was performed in 2 infants, showing mild focal exudative changes. Nucleic acid turned negative (Ct value ≥35) within 7-15 days after diagnosis. All neonates fully recovered after supportive treatment, and the length of hospitalization was 13 (10, 14) days. In the telephone follow-up 2 weeks after discharge for all 16 cases, no infant showed reoccurrence of clinical manifestations or nucleic acid reactivation. Maternal vaccination was not significantly correlated with symptomatic infection or the persistence of positive nucleic acid result in neonates (all P>0.05). Conclusions: Horizontal transmission is the primary mode for neonatal SARS-CoV-2 Omicron infection. Neonatal infections are usually mild or asymptomatic, with good short-term outcomes. And their clinical manifestations and laboratory examinations are nonspecific.


Subject(s)
COVID-19 , Nucleic Acids , Infant, Newborn , Male , Female , Humans , SARS-CoV-2 , Retrospective Studies , China/epidemiology , Fever , Disease Outbreaks
2.
Zhonghua Er Ke Za Zhi ; 60(11): 1163-1167, 2022 Nov 02.
Article in Chinese | MEDLINE | ID: covidwho-2099938

ABSTRACT

Objective: To summarize the management and short-term outcomes of neonates delivered by mothers infected with SARS-CoV-2 Omicron variant. Methods: A retrospective study was performed on 158 neonates born to mothers infected with SARS-CoV-2 Omicron variant admitted to the isolation ward of Children's Hospital of Fudan University from March 15th, 2022 to May 30th, 2022. The postnatal infection control measures for these neonates, and their clinical characteristics and short-term outcomes were analyzed. They were divided into maternal symptomatic group and maternal asymptomatic group according to whether their mothers had SARS-CoV-2 symptoms. The clinical outcomes were compared between the 2 groups using Rank sum test and Chi-square test. Results: All neonates were under strict infection control measures at birth and after birth. Of the 158 neonates, 75 (47.5%) were male. The gestational age was (38+3±1+3) weeks and the birth weight was (3 201±463)g. Of the neonates included, ten were preterm (6.3%) and the minimum gestational age was 30+1 weeks. Six neonates (3.8%) had respiratory difficulty and 4 of them were premature and required mechanical ventilation. All 158 neonates were tested negative for SARS-COV-2 nucleic acid by daily nasal swabs for the first 7 days. A total of 156 mothers (2 cases of twin pregnancy) infected with SARS-CoV-2 Omicron variant, the time from confirmed SARS-CoV-2 infection to delivery was 7 (3, 12) days. Among them, 88 cases (56.4%) showed clinical symptoms, but none needed intensive care treatment. The peripheral white blood cell count of the neonates in maternal symptomatic group was significantly higher than that in maternal symptomatic group (23.0 (18.7, 28.0) × 109 vs. 19.6 (15.4, 36.6) × 109/L, Z=2.44, P<0.05). Conclusions: Neonates of mothers infected with SARS-CoV-2 Omicron variant during third trimester have benign short-term outcomes, without intrauterine infection through vertical transmission. Strict infection control measures at birth and after birth can effectively protect these neonates from SARS-CoV-2 infection.


Subject(s)
COVID-19 , Pregnancy Complications, Infectious , Female , Humans , Infant , Infant, Newborn , Male , Pregnancy , Mothers , Pregnancy Complications, Infectious/diagnosis , Pregnancy Complications, Infectious/prevention & control , Retrospective Studies , SARS-CoV-2
3.
Annals of Allergy, Asthma & Immunology ; 129(5):S52-S52, 2022.
Article in English | CINAHL | ID: covidwho-2075892
4.
Frontiers in Environmental Science ; 10, 2022.
Article in English | Web of Science | ID: covidwho-2071079

ABSTRACT

This study investigates the motives behind the degrees of molecular pollution during the COVID-19 pandemic, which persisted from first walk 1 January 2020 to 31 December 2020. A spatial Durbin file model is used linked to an edge backslide model in this article to find the widely inclusive and nearby consequences of present-day plan and urbanization on nonrenewable energy source by things. The outcomes are discussed next: both were available in modern-day plan and urbanization from a generally inclusive standpoint. The geological consequences of CO2 emissions were concentrated on utilizing information from 22 European countries somewhere in the range of 1990-2020, and all through the examination cycle, the Durbin spatial model was discovered. Although factors such as gross domestic product per capita, urbanization, and energy power impact CO2 emissions, exchange receptivity stays unaltered. The findings will fill in as critical repercussions for state-run administrations, wellbeing experts, and regulators in the war against the return of COVID-19 in Europe. The great number of suggestions were worthless since the concept integrated six money-connected creation assessments into a coordinated arrangement. There is information to indicate that CO2 emissions are associated with money-related events in neighboring nations.

5.
Sci Total Environ ; 2022.
Article in English | PubMed Central | ID: covidwho-2061858

ABSTRACT

To avoid the spread of COVID-19, China implemented strict prevention and control measures, resulting in dramatic variations in urban and regional air quality. With the complex effect from long-term emission mitigation and meteorology variation, an accurate evaluation of the net effect from lockdown on air quality changes has not been fully quantified. Here, we combined machine learning algorithm and Theil–Sen regression technique to eliminate meteorological and long-term trends effects on air pollutant concentrations and precisely detect concentrations changes those ascribed to lockdown measures in North China. Our results showed that, compared to the same period in 2015–2019, the adverse meteorology during the lockdown period (January 25th to March 15th) in early 2020 increased PM2.5 concentration in North China by 9.8 %, while the reduction of anthropogenic emissions led to a 32.2 % drop. Stagnant meteorological conditions have a more significant impact on the ground-level air quality in the Beijing-Tianjin-Hebei Region than that in Shanxi and Shandong provinces. After further striping out the effect of long-term emission reduction trend, the lockdown-derived NO2, PM2.5, and O3 shown variety change trend, and at −30.8 %, −27.6 %, and +10.0 %, respectively. Air pollutant changes during the lockdown could be overestimated up to 2-fold without accounting for the influences of meteorology and long-term trends. Further, with pollution reduction during the lockdown period, it would avoid 15,807 premature deaths in 40 cities. If with no deteriorate meteorological condition, the total avoided premature should increase by 1146.

6.
10th International Symposium on Project Management, ISPM 2022 ; : 418-423, 2022.
Article in English | Scopus | ID: covidwho-2046998

ABSTRACT

Anti-epidemic emergency engineering refers to the engineering response and construction project that must be timely implemented in the event of an epidemic event or hidden danger, which plays a decisive role in ensuring the prevention and control of the epidemic in the epidemic-stricken areas. Based on the initial development of COVID-19 epidemic and the anti-epidemic emergency engineering construction in Wuhan City, this paper analyzes the research significance of construction community in the anti-epidemic emergency engineering construction management, and presents a method of anti-epidemic emergency engineering management based on construction community, including the members composition and management contents of the construction community. Finally, a study of practical example is carried out based on the emergency engineering construction project of Huoshenshan Hospital. © Conference Proceedings of the 10th International Symposium on Project Management, China, ISPM 2022.

7.
Frontiers in Genetics ; 13, 2022.
Article in English | EMBASE | ID: covidwho-2043442

ABSTRACT

Since the occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, SARS-CoV-2 has led to a global coronavirus disease 2019 (COVID-19) pandemic. A better understanding of the SARS-CoV-2 receptor ACE2 at the genetic level would help combat COVID-19, particularly for long COVID. We performed a genetic analysis of ACE2 and searched for its common potential single nucleotide polymorphisms (SNPs) with minor allele frequency >0.05 in both European and Chinese populations that would contribute to ACE2 gene expression variation. We thought that the variation of the ACE2 expression would be an important biological feature that would strongly affect COVID-19 symptoms, such as “brain fog”, which is highlighted by the fact that ACE2 acts as a major cellular receptor for SARS-CoV-2 attachment and is highly expressed in brain tissues. Based on the human GTEx gene expression database, we found rs2106809 exhibited a significant correlation with the ACE2 expression among multiple brain and artery tissues. This expression correlation was replicated in an independent European brain eQTL database, Braineac. rs2106809*G also displays significantly higher frequency in Asian populations than in Europeans and displays a protective effect (p = 0.047) against COVID-19 hospitalization when comparing hospitalized COVID-19 cases with non-hospitalized COVID-19 or SARS-CoV-2 test-negative samples with European ancestry from the UK Biobank. Furthermore, we experimentally demonstrated that rs2106809*G could upregulate the transcriptional activity of ACE2. Therefore, integrative analysis and functional experiment strongly support that ACE2 SNP rs2106809 is a functional brain eQTL and its potential involvement in long COVID, which warrants further investigation.

8.
Journal of Humanistic Psychology ; 2022.
Article in English | Web of Science | ID: covidwho-2005555

ABSTRACT

The City of Brownsville was made vulnerable to the COVID-19 pandemic due to high rates of obesity and diabetes, high rates of poverty, and adverse social determinants of health. To address the unique challenges faced by the community, Brownsville's COVID-19 response brought together the skills of academia with the local understanding and health expertise of the city's public health department to craft a pandemic response that addressed the specific needs and unique challenges of the residents. This article explores the response partnerships formed and the data-driven, community-oriented campaigns that were designed by the Brownsville Public Health Department. The collaborative partnership of the COVID-19 working group and the innovative dissemination strategies designed by the health department provided an effective method of disease mitigation among the city's most vulnerable residents. The article demonstrates the impact of the response campaigns by including a resident's perspective on the impact of the response, specifically how the health department tailored their efforts to meet the needs of the Brownsville community.

11.
Environmental Science-Nano ; : 10, 2022.
Article in English | Web of Science | ID: covidwho-1978025

ABSTRACT

Since the emergence of coronavirus disease 2019 (COVID-19), this highly contagious disease has ravaged the world, cumulatively causing millions of deaths and huge economic losses. As the culprit of COVID-19, severe acute respiratory syndrome beta-coronavirus 2 (SARS-CoV-2) is highly infectious and pathogenic, which has caused extreme panic worldwide. Early and rapid monitoring of SARS-CoV-2 has a significant role in suppressing the pandemic and reducing the virus's lethality. In our work, we prepared a self-enhanced ruthenium complex linked to zeolitic imidazole framework-8 (ZIF-8) and used it as an electrochemiluminescence (ECL) emitter. Additionally, a double-stranded specific nuclease (DSN)-assisted target RNA cycling with catalytic hairpin assembly (CHA) signal amplification technology was used to achieve the conversion of target RNA concentration to double-stranded DNA (dsDNA) output which significantly improved the detection sensitivity of target RNA under environmental conditions and in real human serum samples. In addition, we also combined the trans-cleavage property of CRISPR-Cas12a with the adsorption property of C3N4 on a ferrocene (Fc)-labeled DNA probe and obtained target RNA-dependent ECL signals. The reliable detection protocol achieved the transformation of SARS-CoV-2 RNA concentration to ECL responses, obtaining a limit of detection (LOD) of 0.67 fM with high specificity and reproducibility, which was of guiding significance for current detection methods of mutant SARS-CoV-2 and universal RNA.

12.
Frontiers in Environmental Science ; 10, 2022.
Article in English | Scopus | ID: covidwho-1952299

ABSTRACT

The recent outbreak of epidemic disease (COVID-19) has dramatically changed the socio-economic and environmental dynamics of the world. In particular, it affects human movement, travel intentions, and ambient air pollution amid rising stringency measures. Therefore, this study examines the influence of tourism knowledge, environmental vulnerability, and risk knowledge on travelers’ intentions in China’s tourism industry during COVID-19. To address the study objectives, an online survey questionnaire was created, through which a valid sample of 402 respondents was achieved. The direct and indirect relationship between variables was tested through structural equation modeling, the outcomes confirm that both tourism knowledge and risk knowledge in terms of COVID-19 significantly and negatively define the travelers’ intention toward tourism. Moreover, environmental vulnerability moderately affected tourism behavior and augmented with COVID-19 stringency disclosures. The mediating effect of risk perception and attitude towards the relationship between exogenous and endogenous constructs was tested. It shows a significant mediating impact of risk perception, environmental hazards and attitude towards risk on the nexus between tourism knowledge and travelers’ intention. The study offers valuable recommendations for policymakers to understand tourist intentions and climate vulnerability. Copyright © 2022 Yang, Fang, Ramirez-Asis, Alashker, Abourehab and Zhang.

13.
OPEN CHEMISTRY ; 20(1):570-582, 2022.
Article in English | Web of Science | ID: covidwho-1938472

ABSTRACT

Xinguan No. 3 has been recommended for the treatment of coronavirus disease 2019 (COVID-19);however, its potential mechanisms are unclear. This study aims to explore the mechanisms of Xinguan No. 3 against COVID-19 through network pharmacology and molecular docking. We first searched the ingredients of Xinguan No. 3 in three databases (Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, Traditional Chinese Medicines Integrated Database, and The Encyclopedia of Traditional Chinese Medicine). The active components and their potential targets were predicted through the SwissTargetPrediction website. The targets of COVID-19 can be found on the GeneCards website. Protein interaction analysis, screening of key targets, functional enrichment of key target genes, and signaling pathway analysis were performed through Search Tool for the Retrieval of Interacting Genes databases, Metascape databases, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway databases. Finally, the affinity of the key active components with the core targets was verified by molecular docking. The results showed that five core targets had been screened, including MAPK1, NF-kappa B1, RELA, AKT1, and MAPK14. Gene ontology enrichment analysis revealed that the key targets were associated with inflammatory responses and responses to external stimuli. KEGG enrichment analysis indicated that the main pathways were influenza A, hepatitis B, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, and TNF signaling pathway. Therefore, Xinguan No. 3 might play a role in treating COVID-19 through anti-inflammatory, immune responses, and regulatory responses to external stimuli.

14.
Journal of China Pharmaceutical University ; 52(5):547-554, 2021.
Article in Chinese | EMBASE | ID: covidwho-1897186

ABSTRACT

Remdesivir-loaded liposomes for inhalation were prepared and the in vitro properties were evaluated. Firstly, preparation methods of remdesivir-loaded liposomes were screened, and single-factor experiments were conducted to optimize the prescription and preparation process. Then the physical property, deposition ratio and aerodynamic particle size distribution of remdesivir-loaded liposomes suspension for inhalation were comprehensively evaluated. As a result, the optimal liposomes were prepared by the thin-film dispersion method with pH 6. 5 phosphate-buffered saline as the hydration medium. In the prescription, the ratio of drug to DPPC was 1:20;the cholesterol accounted for 10% of total lipids;and 20% DSPE-mPEG 2000 was added as stabilizer. 4% trehalose was added as lyoprotectant when lyophilizing to obtain ideal appearance, good stability and a small particle size change after reconstitution. Remdesivir-loaded liposomes were spherical with smooth surface and uniform particle size distribution under transmission electron microscope. In vitro release tests showed no significant change for release curves of remdesivir-loaded liposomes suspension before and after nebulization. Deposition experiments indicated that the fine particles fraction of liposomes was 51. 4%, and the mass median aerodynamic diameter was less than 5 μm measured by next generation impactor. To sum up, remdesivir-loaded liposomes for inhalation with high encapsulation efficiency and stability can achieve a suitable particle size distribution to effectively deposit in the lung after nebulization, which provides a new approach for the treatment of COVID-19.

15.
American Journal of Respiratory and Critical Care Medicine ; 205:3, 2022.
Article in English | English Web of Science | ID: covidwho-1880948
16.
SAGE Open ; 12(2), 2022.
Article in English | Scopus | ID: covidwho-1840926

ABSTRACT

The outbreak of COVID-19 in late 2019 had soon become a pandemic, leading to the lockdown of schools all around the world. To mitigate the negative impacts brought by COVID-19, the educational institutions of all levels have inevitably shifted from face-to-face teaching to online teaching. For English language teaching, fully synchronous online learning has been implemented worldwide, posing a great challenge for both instructors and learners. This study reports on findings of Chinese university English as a foreign language students’ perspectives’ on synchronous online language learning during the pandemic, with a special focus on their encountered difficulties. Drawing on the qualitative interview method, the study investigated 14 EFL learners at a public comprehensive university in a coastal city in southern China. Using thematic analysis, there are four main difficulties identified in the interviews, namely the lack of learning climate, the cultivation of learner autonomy, changes of interaction patterns, and the adaptation to remote assessment. The paper ends with a discussion of findings and implications for English learning and teaching in the “new normal”. © The Author(s) 2022.

17.
Chinese Journal of Disease Control and Prevention ; 26(3):343-346 and 356, 2022.
Article in Chinese | EMBASE | ID: covidwho-1822640

ABSTRACT

Objective To analyze the utilization of HIV testing services and related influencing factors among men who have sex with men (MSM) on COVID-19. Methods From September to November 2020, an electronic questionnaire survey was conducted on MSM in the AIDS Vct of Longhua CDC and the Third People's Hospital of Shenzhen, The rank sum test was used to compare the changes in the utilization of HIV testing services in different situations of various factors, and ordinal multinomial logistic regression model was established to analyze the influencing factors of the utilization of HIV testing services. Results A total of 30.4% MSM were reported reduction in the use of HIV testing services. Logistic regression analysis showed that highly panic of COVID-19 reducing the frequency of anal sex (OR=0.056, 95% CI: 0.021-0.150, P < 0.001), being advised not going to testing agency (OR=0.538, 95% CI: 0.297-0.975, P=0.041), and being infected of COVID-19 (OR=21.979, 95% CI: 4.369-110.559, P < 0.001) had higher chance of reduction in the used of HIV testing services. Conclusion The HIV testing service utilization is decreased in MSM during COVID-19. It is necessary to pay more attention to this convenience when formulating and implementing epidemic prevention and control measures.

18.
Construction Research Congress (CRC) on Project Management and Delivery, Contracts, and Design and Materials ; : 59-68, 2022.
Article in English | Web of Science | ID: covidwho-1790151

ABSTRACT

The COVID-19 pandemic has increased contractual concerns under contingencies for public- private partnership (P3) projects. Conventional manual contract extraction is time-consuming and error-prone. Devising a method for automatic contract extraction can support contract management in this aspect. This research proposes a rule-based natural language processing (NLP) approach to extracting contingency liabilities allocated between the public sector and the private sector in the contract. The model consists of a domain-specific lexicon developed based on 21 US transportation P3 concession agreements and a set of matching rules to identify target sentences which fall into five classes, namely remedy entitlement, remedy obligation, liability waiver, mitigation, and termination. This automatic process can reduce the time and cost of the contract review process and help identify issues that the contracting parties should consider going forward in drafting new contracts or in amending existing contracts to avoid potential disputes, in response to consequences of contingencies, including the COVID-19 pandemic.

19.
Chinese Journal of Disease Control and Prevention ; 26(1):112-115, 2022.
Article in Chinese | EMBASE | ID: covidwho-1771919

ABSTRACT

Objective An epidemic of COVID-19 caused by an imported Delta variant strain in Guangzhou was investigated, and the transmission chain, transmission characteristics and infection of each case were analyzed, so as to provide a theoretical basis for predicting disease development and epidemic prevention and control. Methods By collecting the information released by Guangzhou government, the confirmed cases with a clear transmission chain were selected, and the infectious disease indicators such as serial interval (SI), basic reproduction number (Rq) and time-dependent reproduction number (Rt) were calculated to analyze the epidemiological characteristics. Results From May 21 to June 20, 2021, a total of 144 cases of indigenous COVID-19 were confirmed in Guangzhou, among which 67 pairs of cases with a clear transmission chain were selected. SI was calculated to follow the Gamma distribution, with a mean of 4. 27 d and a standard deviation of 2.65 d. Rq = 3. 18 (95% CI: 2. 1974.428), and Rt showed an obvious decreasing trend over time. On June 10, Rt = 0.97 (95% CI: 0. 751 -1. 214), which was lower than 1. Since then Rt had been less than 1, and it got smaller and smaller over time. Conclusion In this COVID-19 epidemic, the SI was shorter and the Rq was larger, which indicated that the Delta variant strain had a faster transmission rate and stronger transmissibility than the COVID-19 infected in Wuhan in 2020.

20.
10th International Conference on Design, User Experience, and Usability held as Part of the 23rd International Conference on Human-Computer Interaction (HCII) ; 12780:548-561, 2021.
Article in English | Web of Science | ID: covidwho-1763311

ABSTRACT

The arrival of the 2019 novel coronavirus (COVID-19) has accelerated the replacement of old lifestyles by new lifestyles. In the post-COVID-19 era, the various behavioral changes, emotional and psychological problems caused by the COVID-19 epidemic may not yet be over, forcing the public to face a variety of experiential changes. Therefore, the purpose of this paper is to summarize the influence of COVID-19 on the psychology, emotion, behavior and experience of the public through literature review, and analyze the causal relationship between them. Then this paper looks for a usability design strategy to solve the user experience from the perspective of design and 'creation of cure'. Finally, the logical framework of the design strategy is summarized to deal with the realistic needs of the post-COVID-19 era. Based on the analysis of the existing literature, this paper proposes: 1) the potential design strategies of mental models and art therapy for psychological and emotional experience, 2) the potential design strategy of behavioral model and art therapy is proposed for behavioral experience, and 3) user experience models in different fields are proposed for the change of user experience.

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