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1.
Chinese Journal of Virology ; 37(4):950-956, 2021.
Article in Chinese | GIM | ID: covidwho-2145387

ABSTRACT

Against the background of the outbreak of coronavirus disease 2019 (COVID-19) . in order to further understand and clarify the current global status and hotspots of the COVID-19, this paper is based on the Web of Science database to search for this topic. As of April 30, 2020, the SCI literature in the field of SARS-CoV-2 will be subjected to a metrological analysis to discuss the research focus and research status of SARS-CoV-2. This research analyzed the research situation of this research field through the information acquisition, processing and analysis of SARS - CoV - 2 related literature, and the application of bibliometrics methods. Statistical analysis data and visual data analysis results showed that a total of 1, 523 documents had been searched with "COVID - 19" as the subject term;at the current stage of research, China ranked first in the number of articles published in this field;University of London, Harvard University and Huazhong University of Science and Technology were among the top three institutions in the world in terms of publication volume;sorting out high-frequency key words to identify the research hotspots as COVID-19, SARS and public health. It is found that Chinese scholars have achieved rapid development in the field of "COV ID-19", and they are at the forefront of the world in terms of the influence of articles and the amount of articles published.

2.
Sustainability ; 14(14):8694, 2022.
Article in English | MDPI | ID: covidwho-1938985

ABSTRACT

Due to the massive global impact of the current COVID-19 pandemic, the call for social and environment responsibility has grown stronger, and discussion regarding responsible leadership has been aroused. Agreement on the antecedents of responsible leadership has not yet been reached, however, and most studies are theoretical and focus on the personal characteristics of leaders. In this paper, we explore the antecedents of responsible leadership behavior at the organizational and situational level, through case studies of companies in China. Based on the organizational strategy, organizational ownership, mass media, crisis, local community, and other influencing factors, we determine two types of responsible leadership behaviors: Proactive responsible leadership behavior, which involves leaders showing initiative in dealing with relationships with stakeholders both inside and outside the organization, as well as voluntarily striving to assume relevant responsibilities in order to achieve economic and/or social development goals;and passive responsible leadership behavior, which involves acts of being responsible to some stakeholders under pressure from external circumstances or when unexpected events occur, even though this behavior may go against the actor's original intention. We further explore the influence mechanism of these factors on responsible leadership and discuss the development trend from passive to proactive responsible leadership behavior.

3.
Frontiers in public health ; 10, 2022.
Article in English | EuropePMC | ID: covidwho-1787530

ABSTRACT

Background The COVID-19 pandemic is a public health emergency of international concern. This study aimed to describe the cognition and social behaviors related to COVID-19 among medical college students in China and to explore the relevant factors that have affected individual social behaviors. The study could enrich practical research on the social behaviors of college students during the COVID-19 pandemic. Methods From February to April 2020, online questionnaire survey was conducted meticulously. Based on their majors, the students were divided into a medical student group (249 cases) and a near-peer medical student group (397 cases). Descriptive statistics was used to elaborate the cognition related to the pandemic and the status quo of social behaviors among these students. A multiple linear regression model was established to analyze the relevant factors affecting individual social behaviors from various perspectives during the pandemic. Results Regarding the cognition situation: 76.32% of those surveyed had good pandemic awareness, and the average general cognition score was 30.55 ± 3.17 points. In terms of social behaviors, the average scores for purposive rational actions and affective actions during the outbreak were relatively high, scoring 8.85 ± 1.72 points (>10 points) and 4.32 ± 1.41 points (>6 points), respectively, while the average value rational actions score was relatively low at 5.95 ± 1.90 points (>10 points). The results of the multiple linear regression model showed that urban college students had higher scores for purposive rational actions;college students with the CCP membership had higher value rational actions scores;school and major were also significant factors affecting affective actions scoring. The COVID-19 cognition score had a significant effect on the social behavior score in all dimensions (P < 0.001). Conclusions The cognition of COVID-19 among students in Chinese medical colleges was good, and pandemic cognition was an important factor that affected individual social behaviors. Universities and colleges should strengthen the publicity and education of knowledge related to COVID-19, guide students to internalize their knowledge of the pandemic into positive behaviors, and help to win the battle of pandemic prevention and control.

4.
Angew Chem Int Ed Engl ; 60(44): 23756-23762, 2021 10 25.
Article in English | MEDLINE | ID: covidwho-1375593

ABSTRACT

The longevity and reusability of N95-grade filtering facepiece respirators (N95 FFRs) are limited by consecutive donning and disinfection treatments. Herein, we developed stable N97 nanofibrous respirators based on chemically modified surface to enable remarkable filtration characteristics via polarity driven interaction. This was achieved by a thin-film coated polyacrylonitrile nanofibrous membrane (TFPNM), giving an overall long-lasting filtration performance with high quality factor at 0.42 Pa-1 (filtration efficiency: over 97 %; pressure drop: around 10 Pa), which is higher than that of the commercial N95 FFRs (0.10-0.41 Pa-1 ) tested with a flow rate of 5 L min-1 and the 0.26 µm NaCl aerosol. A coxsackie B4 virus filtration test demonstrated that TFPNM also had strong virus capture capacity of 97.67 %. As compared with N95 FFRs, the TFPNM was more resistant to a wider variety of disinfection protocols, and the overall filtration characteristics remained N97 standard.


Subject(s)
Enterovirus B, Human/metabolism , Nanofibers/chemistry , Ventilators, Mechanical/virology
5.
Vaccines (Basel) ; 9(7)2021 Jun 27.
Article in English | MEDLINE | ID: covidwho-1289043

ABSTRACT

Surveys showed that vaccine hesitancy may influence the acceptance of COVID-19 vaccines in healthcare workers (HCWs) and the general population. Currently, the actual acceptance of COVID-19 vaccination in HCWs has rarely been reported. In the present survey, we investigated the real-world acceptance of COVID-19 vaccination in HCWs in perinatal medicine during the first three-month period of vaccination in China and to identify the main reason for the decline of vaccination. HCWs (1087) who participated in a Chinese national symposium on perinatal medicine during 16-18 April 2021 were invited to answer a 27-question questionnaire online. A total of 1051 HCWs completed the questionnaire. Of them, 86.2% (906/1051) accepted the COVID-19 vaccination and 13.8% (145/1051) declined the vaccination. Because of the vaccine hesitancy, one-fourth of the vaccinated participants did not accept the vaccination until consulted with others or requested by employers. The main reason for the decline of vaccination in 145 unvaccinated HCWs was the concern about vaccine safety. The results indicate that vaccination request by employers may promote vaccine acceptance. More convincing data on the safety of COVID-19 vaccines appears to be important to increase the acceptance of vaccination.

6.
One Health ; 12: 100224, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1062536

ABSTRACT

BACKGROUND: Coronavirus-Disease-2019 (COVID-19) caused by Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2) is rapidly spreading worldwide causing a pandemic. To control the pandemic, the One Health approach (https://www.who.int/news-room/q-a-detail/one-health) is very important. We herein provide a real-world example of efficient COVID-19 control in Anhui Province, China with outbreak originating from imported cases through implementation of a series of measures as part of the One Health approach and describe the stratified cases features. METHODS: Since the identification of the first imported COVID-19 case on Jan 22, 2020, Anhui immediately initiated a sequence of systematic and forceful interventions. We detailed the control measures and analyzed the effects as demonstrated by the corresponding temporal changes of overall epidemiology data on confirmed, cured, and hospitalized cases and contacts. An accumulated number of 991 cases were confirmed, with a total number of 29,399 contacts traced. We further retrieved individual-level data of confirmed cases and compared them across stratifications by sex, age group, linkage to Wuhan, and period of diagnosis. RESULTS: With a series of interventions including active field investigation, case tracing, quarantine, centralization, education, closed management, and boundary control implemented, number of hospitalized COVID-19 cases peaked, new case disappeared, and all cases were discharged 21, 36, and 46 days after the identification of the initial case, respectively. Male patients were younger, more often had linkage to Wuhan, and received timelier care, but less often had infected cohabitants. Patients aged 25-44 years most often had linkage to Wuhan, while such frequency was lowest in those ≥65 years. Cases <25 years most often had a known contact with COVID-19 patients and any infected family member and cohabitant and were beforehand quarantined, and received fastest management. Patients with linkage to Wuhan were younger, less often had infected family member, had longer incubation period, and received earlier quarantine and timelier care. With more recent periods, the proportion of cases with linkage to Wuhan markedly decreased while the proportion of cases with known contact with COVID-19 cases dramatically increased; the proportions of patients with any infected family member or cohabitant, those beforehand quarantined, and those taking drugs before admission increased; incubation period lengthened, and patients received timelier professional care. Nonspecific systemic symptoms were most common, whose proportion decreased in more recent periods. CONCLUSIONS: Timely and powerful measures as part of the One Health approach (https://www.who.int/news-room/q-a-detail/one-health) effectively and efficiently controlled the COVID-19 outbreak in Anhui, which can be a good real-world example strongly demonstrating the usefulness of such measures in places with outbreaks originating from imported cases. Precise and dynamic prevention and control measures should be implemented and based on features including sex, age group, exposure history, and phase of outbreak.

7.
J Cell Physiol ; 235(12): 9884-9894, 2020 12.
Article in English | MEDLINE | ID: covidwho-574652

ABSTRACT

Coronavirus disease-2019 (COVID-19) is a global pandemic with high infectivity and pathogenicity, accounting for tens of thousands of deaths worldwide. Recent studies have found that the pathogen of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), shares the same cell receptor angiotensin converting enzyme II (ACE2) as SARS-CoV. The pathological investigation of COVID-19 deaths showed that the lungs had characteristics of pulmonary fibrosis. However, how SARS-CoV-2 spreads from the lungs to other organs has not yet been determined. Here, we performed an unbiased evaluation of cell-type-specific expression of ACE2 in healthy and fibrotic lungs, as well as in normal and failed adult human hearts, using published single-cell RNA-seq data. We found that ACE2 expression in fibrotic lungs mainly locates in arterial vascular cells, which might provide a route for bloodstream spreading of SARS-CoV-2. Failed human hearts have a higher percentage of ACE2-expressing cardiomyocytes, and SARS-CoV-2 might attack cardiomyocytes through the bloodstream in patients with heart failure. Moreover, ACE2 was highly expressed in cells infected by respiratory syncytial virus or Middle East respiratory syndrome coronavirus and in mice treated by lipopolysaccharide. Our findings indicate that patients with pulmonary fibrosis, heart failure, and virus infection have a higher risk and are more susceptible to SARS-CoV-2 infection. The SARS-CoV-2 might attack other organs by getting into the bloodstream. This study provides new insights into SARS-CoV-2 blood entry and heart injury and might propose a therapeutic strategy to prevent patients from developing severe complications.


Subject(s)
Betacoronavirus/pathogenicity , Coronavirus Infections/virology , Heart Injuries/virology , Lung/virology , Pneumonia, Viral/virology , Animals , COVID-19 , Gene Expression Profiling/methods , Heart Failure/metabolism , Lung/metabolism , Mice , Pandemics , RNA/metabolism , SARS-CoV-2 , Severe Acute Respiratory Syndrome/genetics , Severe Acute Respiratory Syndrome/metabolism
8.
J Infect ; 80(6): e1-e13, 2020 06.
Article in English | MEDLINE | ID: covidwho-47490

ABSTRACT

BACKGROUND: The outbreak of coronavirus-disease-2019 (COVID-19) has rapidly spread to many places outside Wuhan. Previous studies on COVID-19 mostly included older hospitalized-adults. Little information on infectivity among and characteristics of youngsters with COVID-19 is available. METHODS: A cluster of 22 close-contacts of a 22-year-old male (Patient-Index) including youngsters with laboratory-confirmed COVID-19 and hospitalized close-contacts testing negative for severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) in Anhui Province, China was prospectively-traced. RESULTS: Since January 23, 2020, we enrolled a cluster of eight youngsters with COVID-19 (median age [range], 22 [16-23] years; six males) originating from Patient-Index returning from Wuhan to Hefei on January 19. Patient-Index visited his 16-year-old female cousin in the evening on his return, and met 15 previous classmates in a get-together on January 21. He reported being totally asymptomatic and were described by all his contacts as healthy on January 19-21. His very first symptoms were itchy eyes and fever developed at noon and in the afternoon on January 22, respectively. Seven youngsters (his cousin and six classmates) became infected with COVID-19 after a-few-hour-contact with Patient-Index. None of the patients and contacts had visited Wuhan (except Patient-Index), or had any exposure to wet-markets, wild-animals, or medical-institutes within three months. For affected youngsters, the median incubation-period was 2 days (range, 1-4). The median serial-interval was 1 day (range, 0-4). Half or more of the eight COVID-19-infected youngsters had fever, cough, sputum production, nasal congestion, and fatigue on admission. All patients had mild conditions. Six patients developed pneumonia (all mild; one bilateral) on admission. As of February 20, four patients were discharged. CONCLUSIONS: SARS-CoV-2-infection presented strong infectivity during the incubation-period with rapid transmission in this cluster of youngsters outside Wuhan. COVID-19 developed in these youngsters had fast onset and various nonspecific atypical manifestations, and were much milder than in older patients as previously reported.


Subject(s)
Asymptomatic Diseases/epidemiology , Contact Tracing , Coronavirus Infections/epidemiology , Coronavirus Infections/transmission , Infectious Disease Incubation Period , Pneumonia, Viral/epidemiology , Pneumonia, Viral/transmission , Adolescent , Adult , Betacoronavirus/isolation & purification , COVID-19 , China/epidemiology , Coronavirus Infections/diagnosis , Coronavirus Infections/pathology , Female , Humans , Male , Pandemics , Pneumonia, Viral/diagnosis , Pneumonia, Viral/pathology , Prospective Studies , SARS-CoV-2 , Young Adult
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