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1.
Journal of China Pharmaceutical University ; 52(5):547-554, 2021.
Article in Chinese | EMBASE | ID: covidwho-1897186

ABSTRACT

Remdesivir-loaded liposomes for inhalation were prepared and the in vitro properties were evaluated. Firstly, preparation methods of remdesivir-loaded liposomes were screened, and single-factor experiments were conducted to optimize the prescription and preparation process. Then the physical property, deposition ratio and aerodynamic particle size distribution of remdesivir-loaded liposomes suspension for inhalation were comprehensively evaluated. As a result, the optimal liposomes were prepared by the thin-film dispersion method with pH 6. 5 phosphate-buffered saline as the hydration medium. In the prescription, the ratio of drug to DPPC was 1:20;the cholesterol accounted for 10% of total lipids;and 20% DSPE-mPEG 2000 was added as stabilizer. 4% trehalose was added as lyoprotectant when lyophilizing to obtain ideal appearance, good stability and a small particle size change after reconstitution. Remdesivir-loaded liposomes were spherical with smooth surface and uniform particle size distribution under transmission electron microscope. In vitro release tests showed no significant change for release curves of remdesivir-loaded liposomes suspension before and after nebulization. Deposition experiments indicated that the fine particles fraction of liposomes was 51. 4%, and the mass median aerodynamic diameter was less than 5 μm measured by next generation impactor. To sum up, remdesivir-loaded liposomes for inhalation with high encapsulation efficiency and stability can achieve a suitable particle size distribution to effectively deposit in the lung after nebulization, which provides a new approach for the treatment of COVID-19.

2.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 34(1): 36-40, 2022 Feb 23.
Article in Chinese | MEDLINE | ID: covidwho-1893447

ABSTRACT

OBJECTIVE: To evaluate the diagnostic efficiency of four anti-cysticercus IgG, IgG4 or IgM antibody test kits (enzyme-linked immunosorbent assay, ELISA) by different manufacturers, so as to provide insights into the epidemiological investigation and clinical detection of cysticercosis. METHODS: Forty serum samples from cerebral cysticercosis patients, 100 serum samples from healthy volunteers, 30 serum samples from paragonimiasis skrjabini patients, 17 serum samples from cystic echinococcosis and 19 serum samples from subcutaneous or cerebral sparganosis patients were collected and detected using anti-cysticercus IgG, IgG4 or IgM antibody test kits (brand A) and the anti-cysticercus IgG antibody test kit (brand B). The sensitivity, specificity and false negative rate of the four kits for detection of cysticercosis were estimated. RESULTS: The anti-cysticercus IgG, IgG4 or IgM antibody test kits (brand A) showed 95.00% (38/40), 87.50% (35/40), 7.50% (3/40) sensitivities and 98.00% (98/100), 100.00% (100/100) and 100.00% (100/100) for detection of cysticercosis, while the anti-cysticercus IgG antibody test kit (brand B) presented a 75.00% (30/40) sensitivity and 100.00% (100/100) specificity for detection of cysticercosis. The sensitivity for detection of cysticercosis was significantly higher by the anti-cysticercus IgG antibody test kit (brand A) than by the anti-cysticercus IgG antibody test kit (brand B) (χ2 = 6.28, P < 0.05); however, no significant difference was seen in the specificity by two kits (χ2 = 2.01, P > 0.05). The four ELISA kits showed overall false positive rates of 37.88% (25/66), 22.73% (15/66), 62.12% (41/66) and 15.15% (10/66) for detection of paragonimiasis, echinococcosis and sparganosis (χ2 = 37.61, P < 0.05), and the anti-cysticercus IgG antibody test kit (brand A) presented the highest overall false positive rate for detection of paragonimiasis, echinococcosis and sparganosis (χ2 = 7.56, P' < 0.008), while a higher overall false positive rate was seen for detection of paragonimiasis, echinococcosis and sparganosis by the anti-cysticercus IgG antibody test kit (brand A) than by the anti-cysticercus IgG antibody test kit (brand B) (χ2 = 8.75, P' < 0.008). The four ELISA kits showed false positive rates of 40.00% (12/30), 16.67% (5/30), 76.67% (23/30) and 13.33% (4/30) for detection of paragonimiasis (χ2 = 32.88, P < 0.05) and 21.05% (4/19), 26.32% (5/19), 73.68% (14/19) and 15.79% (3/19) for detection of sparganosis (χ2 = 19.97, P < 0.05), and the highest false positive rates were found by the anti-cysticercus IgM antibody test kit (brand A) for detection of paragonimiasis and sparganosis (all P' < 0.008). However, the four ELISA kits showed comparable false positive rates of 52.94% (9/17), 29.41% (5/17), 23.53% (4/17) and 17.65% (3/17) for detection of echinococcosis (χ2 = 8.24, P > 0.05). In addition, the anti-cysticercus IgM anti-body test kit (brand A) showed false positive rates of 76.67% (23/30), 23.53% (4/17) and 73.68% (14/19) for detection of paragonimiasis, echinococcosis and sparganosis (χ2 = 14.537, P < 0.05), with the lowest false positive rate seen for detection of echinococcosis (χ2 = 14.537, P' < 0.014), while no significant differences were seen in the false positive rate for detection of paragonimiasis, echinococcosis and sparganosis by other three ELISA kits (all P > 0.05). CONCLUSIONS: The four anti-cysticercus IgG, IgG4 or IgM antibody test kits exhibit various efficiencies for serodiagnosis of cysticercosis. The anti-cysticercus IgG antibody test kit (brand A) has a high sensitivity for serodiagnosis of cysticercosis; however, it still needs to solve the problems of cross-reaction with other parasitic diseases and stability.


Subject(s)
Cysticercosis , Cysticercus , Animals , Antibodies, Helminth , Cysticercosis/diagnosis , Enzyme-Linked Immunosorbent Assay , Humans , Reagent Kits, Diagnostic , Sensitivity and Specificity , Serologic Tests
3.
Embase; 2022.
Preprint in English | EMBASE | ID: ppcovidwho-334805

ABSTRACT

Omicron sub-lineage BA.2 has rapidly surged globally, accounting for over 60% of recent SARS-CoV-2 infections. Newly acquired RBD mutations and high transmission advantage over BA.1 urge the investigation of BA.2's immune evasion capability. Here, we show that BA.2 causes strong neutralization resistance, comparable to BA.1, in vaccinated individuals' plasma. However, BA.2 displays more severe antibody evasion in BA.1 convalescents, and most prominently, in vaccinated SARS convalescents' plasma, suggesting a substantial antigenicity difference between BA.2 and BA.1. To specify, we determined the escaping mutation profiles1,2 of 714 SARS-CoV-2 RBD neutralizing antibodies, including 241 broad sarbecovirus neutralizing antibodies isolated from SARS convalescents, and measured their neutralization efficacy against BA.1, BA.1.1, BA.2. Importantly, BA.2 specifically induces large-scale escape of BA.1/BA.1.1effective broad sarbecovirus neutralizing antibodies via novel mutations T376A, D405N, and R408S. These sites were highly conserved across sarbecoviruses, suggesting that Omicron BA.2 arose from immune pressure selection instead of zoonotic spillover. Moreover, BA.2 reduces the efficacy of S309 (Sotrovimab)3,4 and broad sarbecovirus neutralizing antibodies targeting the similar epitope region, including BD55-5840. Structural comparisons of BD55-5840 in complexes with BA.1 and BA.2 spike suggest that BA.2 could hinder antibody binding through S371F-induced N343-glycan displacement. Intriguingly, the absence of G446S mutation in BA.2 enabled a proportion of 440-449 linear epitope targeting antibodies to retain neutralizing efficacy, including COV2-2130 (Cilgavimab)5. Together, we showed that BA.2 exhibits distinct antigenicity compared to BA.1 and provided a comprehensive profile of SARS-CoV-2 antibody escaping mutations. Our study offers critical insights into the humoral immune evading mechanism of current and future variants.

4.
2021 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2021 ; : 2456-2462, 2021.
Article in English | Scopus | ID: covidwho-1722872

ABSTRACT

Given the huge amount of data from diverse sources and involving various conceptual fields in heterogeneous formats, researchers have encountered challenges in their effort to process, search for, and access knowledge about coronavirus disease 2019 (COVID-19). In this paper, we built COVID19-OBKG, an ontology-based knowledge graph and web service for COVID-19, to enable the access and retrieval of knowledge. First, we built the schema of COVID19-OBKG based on biomedical ontologies to guide the construction of the instance layer of COVID19-OBKG from top to bottom. Secondly, we collected data sources related to COVID-19, including structured databases and web pages. We acquired entities and relationships from data sources through named entity recognition and relation extraction algorithms and merged them with knowledge in biomedical ontologies. Thirdly, we modeled our data in the form of an attribute graph and stored it in Dgraph. Finally, we built a web service to support the retrieval and visualization of COVID19-OBKG, which verified the effectiveness of our approach to constructing a knowledge graph, and the usability of COVID19-OBKG. © 2021 IEEE.

5.
Medical Journal of Wuhan University ; 43(2):179-183, 2022.
Article in Chinese | Scopus | ID: covidwho-1687523

ABSTRACT

Objective: To analyze the clinical characteristics of COVID‑19 in the patients with predominant digestive symptoms and to discuss related clinical issues. Methods: A retrospective clinical analysis was performed on 638 discharged patients with confirmed COVID‑19 from January 30, 2020 to March 10, 2020, to collect their basic information, first symptoms, laboratory results, nucleic acid test, disease severity, and outcomes. Results: Of the 638 patients with COVID‑19, fever was the most common first symptom. There were 87 cases (13.6%) with obvious digestive symptoms and 551 cases (86.4%) without digestive symptoms, of which, diarrhea was the most common (67.8%) one. As compared with those without predominant digestive symptoms, these COVID cases were younger in age, had higher rate of cough (65.5%), higher maximum body temperature, and higher proportion of WBC counts <4.0×109/L. However, patients without gastrointestinal symptoms had a higher level of ultra‑troponin I. There was no significant difference between the two groups in terms of gender composition, fever, sputum, chest pain, chest tightness, dyspnea, and basic diseases. Meanwhile, no statistical difference was found between the two groups in most laboratory results, duration of viral shedding, the production of specific antibodies, characteristics of chest CT imaging, disease severity, and death rate. Conclusion: The diarrhea‑mainly digestive symptoms were the first‑episode symptoms in some patients with COVID‑19, their clinical characteristics and the courses were generally similar to those without obvious digestive symptoms. In view of the fact that some patients have positive nucleic acid test on anal swab and there is a risk of gastrointestinal transmission, the clinical care requirements and difficulties have increased for such patients. © 2022, Editorial Board of Medical Journal of Wuhan University. All right reserved.

6.
4th International Symposium on Power Electronics and Control Engineering, ISPECE 2021 ; 12080, 2021.
Article in English | Scopus | ID: covidwho-1621986

ABSTRACT

With the outbreak of COVID-19, the phenomenon of crowds has attracted much attention. To study the impact of fire on evacuation density of teaching building under epidemic situation, a university teaching building was simulated by FDS. The influence of smoke exhaust window opening on fire development was studied by analyzing the law of smoke, temperature and CO concentration, and the allowable evacuation time ASET of teaching building was obtained. Evacuation simulation using Pathfinder determines the required evacuation time RSET and analyzes congestion points, making evacuation improvements from two aspects: reducing the proportion of people and planning evacuation. The results show that CO concentration is an important factor affecting the ASET of teaching buildings, and it can extend the ASET of teaching buildings when the top smoke exhaust window is open;The evacuation congestion points of teaching buildings are mostly concentrated in the classroom exit, the east corner of the passage, the corner of the stair platform and the corner of the west exit. Although reducing the proportion of people can achieve safe evacuation, it can not meet the needs of the evacuation density under the epidemic situation. Through further evacuation planning, it can not only meet the requirements of safe evacuation, but also reduce the evacuation density, which provides a reference for the safe evacuation of teaching buildings under the epidemic situation. © COPYRIGHT SPIE. Downloading of the is permitted for personal use only.

7.
American Journal of Translational Research ; 13(11):12875-12886, 2021.
Article in English | EMBASE | ID: covidwho-1567794

ABSTRACT

Objective: To explore the risk factors for early clinical recurrence of inflammatory bowel disease (IBD) after fecal microbiota transplantation (FMT). Methods: A retrospective study was conducted on 192 patients with IBD who received FMT treatment in the Colorectal Disease Specialty/Intestinal Microecology Treatment Center of the Tenth People’s Hospital Affiliated to Tongji University from February 2017 to June 2020. Univariate and multivariate logistic regression models were used to analyze the risk factors for early recurrence of inflammation. Feces from all participants were collected to extract the total bacterial genomic DNA. The V6-8 regions of the bacterial 16S rDNA gene were amplified by polymerase chain reaction (PCR), the PCR products were detected by the denaturing gradient gel electrophoresis (DGGE) method, and the intestinal flora was analyzed by DNA fingerprinting. Stool samples from all patients were tested for 9 bacteria, white blood cells (WBC) and platelet (PLT) counts, as well as the erythrocyte sedimentation rate (ESR) and serum C-reactive protein (CRP) level. Results: Of the 192 patients, 15 cases had inflammation recurrence during FMT and within one week after treatment, including 11 cases of ulcerative colitis (UC) and 4 cases of Crohn’s disease (CD), with a total recurrence rate of 7.8%. High Mayo inflammatory activity score, Mayo endoscopic sub-item score (MES) =3 points, CRP>10 mg/L, anemia, albumin <30 g/L, absolute value of peripheral blood lymphocytes (PBL) <500/mm3, and intolerance to enteral full nutrition were independent risk factors for recurrence during and after FMT in UC patients (P<0.05). Albumin <30 g/L and simultaneous use of immunosuppressive agents were associated with disease recurrence during and after FMT in CD patients. WBC, PLT, and CRP were all negatively correlated with Enterococcus (EC), and ESR was positively correlated with Saccharomyces boulardii (SB) (P<0.01). Conclusion: The low recurrence rate of IBD after FMT indicates the safety of FMT, but this procedure should be cautiously used in patients with severe intestinal barrier dysfunction and/or severe intestinal dysfunction.

8.
Macromolecular Materials and Engineering ; 2021.
Article in English | Scopus | ID: covidwho-1513915

ABSTRACT

Paper-based flexible pressure sensors have received extensive attention owing to their recoverability and accessibility. This study, proposes a graphical pressure sensor array with a multilayered structure. A simple writing method is adopted to realize the adsorption of sensitive materials on the fiber structure of cellulose paper. Pressure sensors with 1, 3, 5, and 7 stacked layers are fabricated and compared. The results show that the seven-layer sensor achieves a high sensitivity (44 kPa–1) and fast time response (less than 150 ms). The highly sensitive stacked paper-based sensor array realizes the pressure detection in objects and special-shaped surfaces. A pressure sensor based on a commercial corrugated box is also fabricated for comparison. The corrugated carton array is used to switch the reminder devices for convenience and accessibility. Because many scenarios require a safe distance to be maintained, particularly under the influence of COVID-19, the writable paper-based sensor array is used to realize graphical distance perception and provide warnings. © 2021 Wiley-VCH GmbH

9.
Chinese Journal of Applied Clinical Pediatrics ; 36(18):1368-1372, 2021.
Article in Chinese | Scopus | ID: covidwho-1481061

ABSTRACT

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection is still worldwide.As a vulnerable group, severe and dead pediatric cases are also reported.Under this severe epidemic situation, children should be well protected.With the widespread vaccination of SARS-CoV-2 vaccine in adults, the infection rate have decreased.Therefore, SARS-CoV-2 vaccine inoculation for children groups step by step is of great significance to the protection of children and the prevention and control of corona virus disease 2019(COVID-19) as a whole.But the safety of children vaccinated with SARS-CoV-2 vaccine is a main concern of parents.Therefore, in order to ensure the safety of vaccination and the implementation of vaccination work, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health and the Society of Pediatrics, Chinese Medical Association organized experts to interpret the main issue of parents about SARS-CoV-2 vaccine for children, in order to answer the doubts of parents. Copyright © 2021 by the Chinese Medical Association.

10.
Chinese Journal of Applied Clinical Pediatrics ; 36(18):1361-1367, 2021.
Article in Chinese | Scopus | ID: covidwho-1481060

ABSTRACT

At present, severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection is still rampant worldwide.As of September 10, 2021, there were about 222 million confirmed cases of corona virus disease 2019(COVID-19)and more than 4.6 million deaths worldwide.With the development of COVID-19 vaccines and the gradual vaccination worldwide, the increasing number of cases in children and unvaccinated young people has drawn attention.According to World Health Organization surveillance data, the proportion of COVID-19 infection cases in children gradually increased, and the proportion of cases in the age groups of under 5 years and 5-14 years increased from 1.0% and 2.5% in January 2020 to 2.0% and 8.7% in July 2021, respectively.At present, billions of adults have been vaccinated with various COVID-19 vaccines worldwide, and their protective effects including reducing infection and transmission, reducing severe disease and hospitalization, and reducing death, as well as high safety have been confirmed.Canada, the United States, Europe and other countries have approved the emergency COVID-19 vaccination in children and adolescents aged 12 to 17 years, and China has also approved the phased vaccination of COVID-19 vaccination in children and adolescents aged 3 to 17 years. For smooth advancement and implementation of COVID-19 vaccination in children, academic institutions, including National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, and The Society of Pediatrics, Chinese Medical Association organized relevant experts to reach this consensus on COVID-19 vaccination in children. Copyright © 2021 by the Chinese Medical Association.

11.
Journal of Public Economics ; 203:1, 2021.
Article in English | Web of Science | ID: covidwho-1466729
13.
Laplage Em Revista ; 7:238-249, 2021.
Article in English | Web of Science | ID: covidwho-1292198

ABSTRACT

This article is devoted to a comparative analysis of the effectiveness of measures to support the economy during the COVID-19 pandemic in the People's Republic of China. A network description of economic and social support measures in China and other countries was made, and the relative amounts of support as a percentage of the gross domestic product produced were disclosed. The structure of economic support measures is analyzed. It was found that the relative size of the economy's aid does not affect the growth of the real gross product. On the example of China, the effectiveness of administrative actions to localize the pandemic and support the economy is revealed, while the role of educating the appropriate civil initiative is noted. During a pandemic, the key factor in the subsequent recovery of the economy is not the amount of cash injections and benefits provided, but the discipline and responsibility of the authorities and society.

14.
Laplage Em Revista ; 7:349-364, 2021.
Article in English | Web of Science | ID: covidwho-1292197

ABSTRACT

The presented article aims to identify the key factors that can influence the success of sustainable management of corporate structures in a pandemic and post-pandemic state of the business environment. In the practical sphere, the authors set tasks to develop practical methods that can increase the efficiency of cost management in the strategic horizon and form a system of key performance indicators that allows to adequately assess the results of the corporation's activities. According to the authors, this should be done in advance and consider the lessons learned from cost management in the context of the COVID-19 pandemic. The results were obtained while testing the hypothesis about the relationship between the strategic cost management system and the quality of corporate business. This hypothesis is rejected by the external approach to business quality but confirmed by the internal approach to business quality.

15.
2021 World Wide Web Conference, WWW 2021 ; : 2590-2600, 2021.
Article in English | Scopus | ID: covidwho-1280481

ABSTRACT

Since late December 2019, it has been reported an outbreak of atypical pneumonia, now known as COVID-19 caused by the novel coronavirus. Cases have spread to more than 200 countries and regions internationally. World Health Organization (WHO) officially declares the coronavirus outbreak a pandemic and the public health emergency has caused world-wide impact to daily lives: people are advised to keep social distance, in-person events have been moved online, and some function facilitates have been locked-down. Alternatively, the Web becomes an active venue for people to share information. With respect to the on-going topic, people continuously post questions online and seek for answers. Yet, sharing global information conveyed in different languages is challenging because the language barrier is intrinsically unfriendly to monolingual speakers. In this paper, we propose a multilingual COVID-QA model to answer people's questions in their own languages while the model is able to absorb knowledge from other languages. Another challenge is that in most cases, the information to share does not have parallel data in multiple languages. To this end, we propose a novel framework which incorporates (unsupervised) translation alignment to learn as pseudo-parallel data. Then we train multilingual question-answering mapping and generation. We demonstrate the effectiveness of our proposed approach compared against a series of competitive baselines. In this way, we make it easier to share global information across the language barriers, and hopefully we contribute to the battle against COVID-19. © 2021 ACM.

16.
Chinese Journal of Applied Clinical Pediatrics ; 36(10):721-732, 2021.
Article in Chinese | Scopus | ID: covidwho-1278526

ABSTRACT

2019 novel coronavirus(2019-nCoV) outbreak is one of the public health emergency of international concern.Since the 2019-nCoV outbreak, China has been adopting strict prevention and control measures, and has achieved remarkable results in the initial stage of prevention and control.However, some imported cases and sporadic regional cases have been found, and even short-term regional epidemics have occurred, indicating that the preventing and control against the epidemic remains grim.With the change of the incidence proportion and the number of cases in children under 18 years old, some new special symptoms and complications have appeared in children patients.In addition, with the occurrence of virus mutation, it has not only attracted attention from all parties, but also proposed a new topic for the prevention and treatment of 2019-nCoV infection in children of China.Based on the second edition, the present consensus further summarizes the clinical characteristics and experience of children's cases, and puts forward recommendations on the diagnostic criteria, laboratory examination, treatment, prevention and control of children's cases for providing reference for further guidance of treatment of 2019-nCoV infection in children. © 2021 Chinese Medical Association

17.
2021 5th International Conference on Advances in Energy, Environment and Chemical Science, AEECS 2021 ; 245, 2021.
Article in English | Scopus | ID: covidwho-1233733

ABSTRACT

Objective: To evaluate the teaching method based DingTalk combined PBL teaching method and CBL teaching method in the teaching of pathogenic biology under novel coronavirus pneumonia enviroment. Methods: 48 undergraduates of grade 2018 were selected as the experimental group, and 48 undergraduates of grade 2017 were selected as the control group. After class, the theory test and microbiological test knowledge test and questionnaire were as the assessment index. Results: the scores of mastering microbial inspection knowledge and satisfaction in the experimental group were significantly higher than those in the control group, and the difference was statistically significant (P < 0.05). Conclusion: compared with the traditional teaching method, PBL + CBL teaching method based on DingTalk platform is more popular with students, which can mobilize their learning initiative and improve their ability. © The Authors, published by EDP Sciences, 2021.

18.
Journal of Public Economics ; 196, 2021.
Article in English | Scopus | ID: covidwho-1144843

ABSTRACT

We examine Chinese cities’ COVID-19 reopening plans as a window into governments’ economic and social priorities. We measure reopenings based on official government news announcements, and show that these are predicted by citizen discontent, as captured by Baidu searches for terms such as “unemployment” and “protest” in the prior week. The effects are particularly strong early in the epidemic, indicating a priority on initiating economic recovery as early as possible. These results indicate that even a non-democratic government may respond to citizen concerns, possibly to minimize dissent. © 2021 Elsevier B.V.

19.
Frontiers in Physics ; 8, 2021.
Article in English | Scopus | ID: covidwho-1133953

ABSTRACT

COVID-19 has infected millions of people, with deaths in more than 200 countries. It is therefore essential to understand the dynamic characteristics of the outbreak and to design effective strategies to restrain the large-scale spread of the epidemic. In this paper, we present a novel framework to depress the epidemic spreading, by leveraging the decentralized dissemination of information. The framework is equivalent to finding a special minimum dominating set for a duplex network which is a general dominating set for one layer and a connected dominating set for another layer. Using the spin glass and message passing theory, we present a belief-propagation-guided decimation (BPD) algorithm to construct the special minimum dominating set. As a consequence, we could immediately recognize the epidemic as soon as it appeared, and rapidly immunize the whole network at minimum cost. © Copyright © 2021 Wang, Zhang, Zhu, Jiang, Wu, Xu and Zhao.

20.
Medical Journal of Wuhan University ; 42(2):233-236, 2021.
Article in Chinese | Scopus | ID: covidwho-1115573

ABSTRACT

Objective: To investigate the value of D-dimer, C-reactive protein (CRP), Procalcitonin (PCT) and blood routine test in evaluating the prognosis of patients with severe coronavirus disease 2019 (COVID-19). Methods: A total of 54 severe COVID-19 patients were retrospectively studied, and were divided into death group (n=54) and survival group (n=31) according to the outcomes. The plasma D-dimer, CRP, PCT, and blood routine test of the two groups were analyzed and compared in order to clarify their relationship to the prognosis of severe COVID-19. Results: The time to initiation of disease days, age and proportion of comorbidity in death group were significantly longer or higher than in survival group (all P<0.05). The white blood cell counts and neutrophil counts levels in death group were significantly higher than in survival group (both P<0.05), while the lymphocyte counts levels in dead group were significantly lower than in survival group (P<0.05). D-dimer, CRP and PCT in death group were significantly higher than in survival group (all P<0.05). D-dimer was positively correlated to CRP (r=0.426, P<0.05), and negatively correlated with PCT (r=-0.217, P>0.05). Conclusion: D-dimer, CRP, white blood cell counts, and lymphocyte counts are valuable for prognosis evaluation of patients with severe COVID-19, and PCT also has certain prognostic value. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.

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