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1.
Frontiers in pharmacology ; 13, 2022.
Article in English | EuropePMC | ID: covidwho-1876649

ABSTRACT

Acute lung injury (ALI) or its aggravated stage acute respiratory distress syndrome (ARDS) is a common severe clinical syndrome in intensive care unit, may lead to a life-threatening form of respiratory failure, resulting in high mortality up to 30–40% in most studies. Nanotechnology-mediated anti-inflammatory therapy is an emerging novel strategy for the treatment of ALI, has been demonstrated with unique advantages in solving the dilemma of ALI drug therapy. Artesunate (ART), a derivative of artemisinin, has been reported to have anti-inflammatory effects. Therefore, in the present study, we designed and synthesized PEGylated ART prodrugs and assessed whether ART prodrugs could attenuate lipopolysaccharide (LPS) induced ALI in vitro and in vivo. All treatment groups were conditioned with ART prodrugs 1 h before challenge with LPS. Significant increased inflammatory cytokines production and decreased GSH levels were observed in the LPS stimulated mouse macrophage cell line RAW264.7. Lung histopathological changes, lung W/D ratio, MPO activity and total neutrophil counts were increased in the LPS-induced murine model of ALI via nasal administration. However, these results can be reversed to some extent by treatment of ART prodrugs. The effectiveness of mPEG2k-SS-ART in inhibition of ALI induced by LPS was confirmed. In conclusion, our results demonstrated that the ART prodrugs could attenuate LPS-induced ALI effectively, and mPEG2k-SS-ART may serve as a novel strategy for treatment of inflammation induced lung injury.

2.
Disease Surveillance ; 37(2):154-158, 2022.
Article in Chinese | GIM | ID: covidwho-1855883

ABSTRACT

Objective: To assess the global epidemic of Coronavirus disease 2019(COVID-19)in January 2022 and the risk of importation.

3.
Am J Public Health ; 112(6): 913-922, 2022 06.
Article in English | MEDLINE | ID: covidwho-1817598

ABSTRACT

We analyzed COVID-19 influences on the design, implementation, and validity of assessing the quality of primary health care using unannounced standardized patients (USPs) in China. Because of the pandemic, we crowdsourced our funding, removed tuberculosis from the USP case roster, adjusted common cold and asthma cases, used hybrid online-offline training for USPs, shared USPs across provinces, and strengthened ethical considerations. With those changes, we were able to conduct fieldwork despite frequent COVID-19 interruptions. Furthermore, the USP assessment tool maintained high validity in the quality checklist (criteria), USP role fidelity, checklist completion, and physician detection of USPs. Our experiences suggest that the pandemic created not only barriers but also opportunities to innovate ways to build a resilient data collection system. To build data system reliance, we recommend harnessing the power of technology for a hybrid model of remote and in-person work, learning from the sharing economy to pool strengths and optimize resources, and dedicating individual and group leadership to problem-solving and results. (Am J Public Health. 2022;112(6):913-922. https://doi.org/10.2105/AJPH.2022.306779).


Subject(s)
Acacia , COVID-19 , China/epidemiology , Humans , Pandemics , Quality of Health Care
4.
PLoS One ; 17(4): e0262426, 2022.
Article in English | MEDLINE | ID: covidwho-1817470

ABSTRACT

With the tendency toward economic and strategy decoupling between China and the United States and amidst the anti-globalization trend, enterprises are facing unprecedented challenges and opportunities. In this study, we reveal how the agile intuition (AI) of top managers with respect to the external environment affects enterprise innovation behavior (IB) based on the cognition-behavior framework. Strategic learning (SL) is considered a moderator, and knowledge sharing (KS) is considered a mediator. The survey sample consists of 305 managers from 47 enterprises in China during the COVID-19 period. The empirical results show that top management agile intuition significantly promotes enterprise IB; knowledge sharing (KS) partially mediates the relationship between top manager AI and enterprise IB; and SL suppresses the promotion effect of top manager AI on enterprise IB to a certain extent, hindering blind innovation. In a surprising result, we find that strategic guidance by an external consultant does not significantly affect the enterprise IB in China.


Subject(s)
COVID-19 , Intuition , China , Humans , Knowledge , Surveys and Questionnaires
5.
Disease Surveillance ; 37(1):12-16, 2022.
Article in Chinese | CAB Abstracts | ID: covidwho-1789473

ABSTRACT

Objective: To assess the global epidemic of Coronavirus disease 2019(COVID-19)in December 2021 and the risk of importation.

6.
Disease Surveillance ; 36(12):1235-1239, 2021.
Article in Chinese | GIM | ID: covidwho-1771274

ABSTRACT

Objective: To assess the global epidemic of Coronavirus disease 2019(COVID-19) in November 2021 and the risk of importation.

7.
Front Plant Sci ; 13: 866282, 2022.
Article in English | MEDLINE | ID: covidwho-1753403

ABSTRACT

Scutellaria baicalensis, is one of the most traditional medicinal plants in the Lamiaceae family, and has been widely used to treat liver and lung complaints and as a complementary cancer treatment in traditional Chinese medicine. The preparation from its roots, called "Huang Qin," is rich in specialized flavones such as baicalein, wogonin, and their glycosides which lack a 4'-hydroxyl group on the B ring (4'-deoxyflavones), with anti-tumor, antioxidant, and antiviral activities. Baicalein has recently been reported to inhibit the replication of the COVID-19 virus. These 4'-deoxyflavones are found only in the order Lamiales and were discovered in the genus Scutellaria, suggesting that a new metabolic pathway synthesizing 4'-deoxyflavones evolved recently in this genus. In this review, we focus on the class of 4'-deoxyflavones in S. baicalensis and their pharmacological properties. We also describe the apparent evolutionary route taken by the genes encoding enzymes involved in the novel, root-specific, biosynthetic pathway for baicalein and wogonin, which provides insights into the evolution of specific flavone biosynthetic pathways in the mint family.

8.
Disease Surveillance ; 36(11):1112-1116, 2021.
Article in Chinese | GIM | ID: covidwho-1726093

ABSTRACT

Objective: To assess the global epidemic of Coronavirus disease 2019(COVID-19) in October 2021 and the risk of importation.

9.
Disease Surveillance ; 36(10):985-989, 2021.
Article in Chinese | CAB Abstracts | ID: covidwho-1726087

ABSTRACT

Objective: To assess the global epidemic of Coronavirus disease 2019(COVID-19) in September 2021 and the risk of importation.

10.
Disease Surveillance ; 36(9):864-868, 2021.
Article in Chinese | GIM | ID: covidwho-1575232

ABSTRACT

Objective: To assess the global epidemic of Coronavirus disease 2019(COVID-19) in August 2021 and the risk of importation.

11.
Disease Surveillance ; 36(8):751-755, 2021.
Article in Chinese | GIM | ID: covidwho-1524242

ABSTRACT

Objective: To assess the global epidemic of Coronavirus disease 2019(COVID-19) in July 2021 and the risk of importation.

12.
Neurobiol Stress ; 15: 100377, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1454587

ABSTRACT

Accumulating evidence shows that Coronavirus Disease 19 (COVID-19) survivors may encounter prolonged mental issues, especially post-traumatic stress symptoms (PTSS). Despite manifesting a plethora of behavioral or mental issues in COVID-19 survivors, previous studies illustrated that static brain functional networks of these survivors remain intact. The insignificant results could be due to the conventional statistic network analysis was unable to reveal information that can vary considerably in different temporal scales. In contrast, time-varying characteristics of the dynamic functional networks may help reveal important brain abnormalities in COVID-19 survivors. To test this hypothesis, we assessed PTSS and collected functional magnetic resonance imaging (fMRI) with COVID-19 survivors discharged from hospitals and matched controls. Results showed that COVID-19 survivors self-reported a significantly higher PTSS than controls. Tapping into the moment-to-moment variations of the fMRI data, we captured the dynamic functional network connectivity (dFNC) states, and three discriminative reoccurring brain dFNC states were identified. First of all, COVID-19 survivors showed an increased occurrence of a dFNC state with heterogeneous patterns between sensorimotor and visual networks. More importantly, the occurrence rate of this state was significantly correlated with the severity of PTSS. Finally, COVID-19 survivors demonstrated decreased topological organizations in this dFNC state than controls, including the node strength, degree, and local efficiency of the supplementary motor area. To conclude, our findings revealed the altered temporal characteristics of functional networks and their associations with PTSS due to COVID- 19. The current results highlight the importance of evaluating dynamic functional network changes with COVID-19 survivors.

13.
Disease Surveillance ; 36(7):645-649, 2021.
Article in Chinese | CAB Abstracts | ID: covidwho-1436124

ABSTRACT

Objective: To assess the global epidemic of Coronavirus disease 2019(COVID-19) in June 2021 and the risk of importation.

14.
Disease Surveillance ; 36(6):521-525, 2021.
Article in Chinese | GIM | ID: covidwho-1374561

ABSTRACT

Objective: To assess the global epidemic of Coronavirus disease 2019(COVID-19) in May 2021 and the risk of importation.

15.
Disease Surveillance ; 36(5):406-410, 2021.
Article in Chinese | GIM | ID: covidwho-1352843

ABSTRACT

Objective: To assess the global epidemic of Coronavirus disease 2019(COVID-19) in April 2021 and the risk of importation.

16.
Int J Clin Health Psychol ; 21(3): 100252, 2021.
Article in English | MEDLINE | ID: covidwho-1345341

ABSTRACT

This cross-sectional study aims to record post-traumatic stress (PTS) and post-traumatic growth (PTG) of the general population of China during the first wave of COVID-19 spread. Method: An online survey was distributed in China during February and March 2020 to record the general population's PTS (using the Post-traumatic Stress Disorder Checklist-Civilian Version, PCL-C) and PTG (using the Post-traumatic Growth Inventory, PTGI) due to COVID-19. Confirmatory Factor Analyses (CFAs) and a Two-Part Model (TPM) of regression analysis were conducted. Results: In total, 29,118 Chinese participants completed the survey (54.20% were in their 20s, 68% were males, and 60.30% had a university education). CFA results illustrated that bifactor models described the Chinese psychometric traits of PTS and PTG over the default models. Results of TPM suggested that female, low-educated, and middle-aged individuals were more vulnerable to PTS. Remarkably, mutual and positive correlations between the PTS and the PTG, though small in statistics, were observed through regression analyses. Conclusions: The current results presented new best-fit structural models, potential predictors, and valuable baseline information on the PTS and the PTG of the Chinese population in the context of COVID-19.


Este estudio transversal se realizó para registrar el estrés postraumático (EPT) y el crecimiento de estrés postraumático (CPT) de la población general de China durante la primera ola de la extensión del COVID-19. Método: Se realizó una encuesta en línea en China durante febrero y marzo del año 2020 para registrar EPT de la población (utilizando el Post-traumatic Stress Disorder Checklist-Civilian Version, PCL-C) y CPT (utilizando el Post-traumatic Growth Inventory, PTGI). Se llevaron a cabo Análisis Factorial Confirmatorio (AFC) y Modelo de Dos Partes (MDP) de análisis de regresión. Resultados: En total, 29.118 chinos completaron la encuesta (54,2% de ellos tenían 20~29 años, 68,0% eran hombres, y 60,3% tenían una Educación Universitaria). Los resultados de AFC ilustraron que los modelos de bifactoriales eran mejores para descubrir los rasgos psicométricos de EPT y CPT de los participantes chinos que los modelos predeterminados. Los resultados de MDP sugirieron que las mujeres, las personas con bajo nivel educativo y de mediana edad eran más vulnerables a EPT. Se observaron correlaciones mutuas y positivas entre EPT y CPT, aunque pequeñas. Conclusiones: Los resultados actuales presentaron nuevos modelos estructurales de mejor ajuste, predictores potenciales e información de referencia valiosa de EPT y CPT de la población China en el contexto de COVID-19.

17.
ACS Cent Sci ; 7(7): 1156-1165, 2021 Jul 28.
Article in English | MEDLINE | ID: covidwho-1337094

ABSTRACT

As the COVID-19 pandemic continues to spread, investigating the processes underlying the interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report the identification of CD209L/L-SIGN and the related protein CD209/DC-SIGN as receptors capable of mediating SARS-CoV-2 entry into human cells. Immunofluorescence staining of human tissues revealed prominent expression of CD209L in the lung and kidney epithelia and endothelia. Multiple biochemical assays using a purified recombinant SARS-CoV-2 spike receptor-binding domain (S-RBD) or S1 encompassing both N termal domain and RBD and ectopically expressed CD209L and CD209 revealed that CD209L and CD209 interact with S-RBD. CD209L contains two N-glycosylation sequons, at sites N92 and N361, but we determined that only site N92 is occupied. Removal of the N-glycosylation at this site enhances the binding of S-RBD with CD209L. CD209L also interacts with ACE2, suggesting a role for heterodimerization of CD209L and ACE2 in SARS-CoV-2 entry and infection in cell types where both are present. Furthermore, we demonstrate that human endothelial cells are permissive to SARS-CoV-2 infection, and interference with CD209L activity by a knockdown strategy or with soluble CD209L inhibits virus entry. Our observations demonstrate that CD209L and CD209 serve as alternative receptors for SARS-CoV-2 in disease-relevant cell types, including the vascular system. This property is particularly important in tissues where ACE2 has low expression or is absent and may have implications for antiviral drug development.

18.
Mol Psychiatry ; 26(12): 7475-7480, 2021 12.
Article in English | MEDLINE | ID: covidwho-1319020

ABSTRACT

Previous coronavirus pandemics were associated elevated post-traumatic stress symptoms (PTSS), but the self-report and neurological basis of PTSS in patients who survived coronavirus disease 2019 (COVID-19) are largely unknown. We conducted a two-session study to record PTSS in the COVID-19 survivors discharged from hospitals for a short (i.e., about 3 months, Session 1) to a medium period (i.e., about 6 months, Session 2), as well as brain imaging data in Session 2. The control groups were non-COVID-19 locals. Session 1 was completed for 126 COVID-19 survivors and 126 controls. Session 2 was completed for 47 COVID-19 survivors and 43 controls. The total score of post-traumatic stress disorder (PTSD) checklist for DSM-5 (PCL-5) score was significantly higher in COVID-19 survivors compared with controls in both sessions. The PCL-5 score in COVID-19 survivors was positively correlated with the duration after discharge (r = 0.27, p = 0.003 for Session 1), and increased by 20% from Session 1 to Session 2 for the survivors who participated both sessions. The increase was positively correlated with individual's test-retest duration (r = 0.46, p = 0.03). Brain structural volume and functional activity in bilateral hippocampus and amygdala were significantly larger in COVID-19 survivors compared with controls. However, the volumes of the left hippocampus and amygdala were negatively correlated with the PCL-5 score for the COVID-19 survivors. Our study suggests that COVID-19 survivors might face possible PTSS deteriorations, and highlights the importance of monitoring mental wellness of COVID-19 survivors.


Subject(s)
COVID-19 , Stress Disorders, Post-Traumatic , Follow-Up Studies , Hippocampus , Humans , Neuroimaging , SARS-CoV-2 , Self Report , Stress Disorders, Post-Traumatic/diagnostic imaging , Survivors
19.
Hum Pathol ; 116: 49-62, 2021 10.
Article in English | MEDLINE | ID: covidwho-1309235

ABSTRACT

Severe COVID-19 results in a glucocorticoid responsive form of acute respiratory distress (ARDS)/diffuse alveolar damage (DAD). Herein we compare the immunopathology of lung tissue procured at autopsy in patients dying of SARS-CoV-2 with those dying of DAD prior to the COVID-19 pandemic. Autopsy gross and microscopic features stratified by duration of illness in twelve patients who tested positive for SARS-CoV-2 viral RNA, as well as seven patients dying of DAD prior to the COVID-19 pandemic were evaluated with multiplex (5-plex: CD4, CD8, CD68, CD20, AE1/AE3) and SARS-CoV immunohistochemistry to characterize the immunopathologic stages of DAD. We observed a distinctive pseudopalisaded histiocytic hyperplasia interposed between the exudative and proliferative phase of COVID-19 associated DAD, which was most pronounced at the fourth week from symptom onset. Pulmonary macrothrombi were seen predominantly in cases with pseudopalisaded histiocytic hyperplasia and/or proliferative phase DAD. Neither pseudopalisaded histiocytic hyperplasia nor pulmonary macrothrombi was seen in non-COVID-19 DAD cases, whereas microthrombi were common in DAD regardless of etiology. The inflammatory pattern of pseudopalisaded histiocytic hyperplasia may represent the distinctive immunopathology associated with the dexamethasone responsive form of DAD seen in severe COVID-19.


Subject(s)
COVID-19/pathology , Histiocytes/pathology , Lung/pathology , Pulmonary Alveoli/pathology , Adult , Aged , Aged, 80 and over , Cell Proliferation/physiology , Female , Humans , Hyperplasia/pathology , Male , Middle Aged
20.
Disease Surveillance ; 36(4):307-311, 2021.
Article in Chinese | GIM | ID: covidwho-1302609

ABSTRACT

Objective: To assess the global epidemic of Coronavirus disease 2019(COVID-19) in March 2021 and the risk of importation.

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