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1.
International Journal of Economics and Financial Issues ; 12(3):60-67, 2022.
Article in English | ProQuest Central | ID: covidwho-2100976

ABSTRACT

During dramatic public health shocks, the impact of anti-epidemic policies on public sentiment is uncertain, and public sentiment has a significant impact on the stock market. But the relationship between the three is not clear. This paper uses government information release to reflect anti-epidemic policies, uses personal weibo to calculate public sentiment, and analyzes the relationship between Government information release, public sentiment and stock market. Through the Bi-LSTM classification model analysis about 200,000 microblog data during COVID-19, and build panel data regression model. The results show that: public sentiment have a significant positive impact on stock returns;Government information release have a significant positive impact on public sentiment;public sentiment play a intermediating role between government information release and stock market;Influenced by the enterprise size and the industry it belongs to, there is heterogeneity in public sentiment's impact.

2.
PLoS One ; 17(8): e0270953, 2022.
Article in English | MEDLINE | ID: covidwho-1968864

ABSTRACT

Microblog has become the "first scenario" under which the public learn about the epidemic situation and express their opinions. Public sentiment mining based on microblog data can provide a reference for the government's information disclosure, public sentiment guidance and formulation of epidemic prevention and control policy. In this paper, about 200,000 pieces of text data were collected from Jan. 1 to Feb. 26, 2020 from Sina Weibo, which is the most popular microblog website in China. And a public sentiment analysis framework suitable for Chinese-language scenarios was proposed. In this framework, a sentiment dictionary suitable for Chinese-language scenarios was constructed, and Baidu's Sentiment Analysis API was used to calculate the public sentiment indexes. Then, an analysis on the correlation between the public sentiment indexes and the COVID-19 case indicators was made. It was discovered that there is a high correlation between public sentiments and incidence trends, in which negative sentiment is of statistical significance for the prediction of epidemic development. To further explore the source of public negative sentiment, the topics of the public negative sentiment on Weibo was analyzed, and 20 topics in five categories were got. It is found that there is a strong linkage between the hot spots of public concern and the epidemic prevention and control policies. If the policies cover the hot spots of public concern in a timely and effective manner, the public negative sentiment will be effectively alleviated. The analytical framework proposed in this paper also applies to the public sentiment analysis and policy making for other major public events.


Subject(s)
COVID-19 , Epidemics , Social Media , Attitude , COVID-19/epidemiology , COVID-19/prevention & control , Epidemics/prevention & control , Humans , Policy
3.
Front Public Health ; 10: 841770, 2022.
Article in English | MEDLINE | ID: covidwho-1779970

ABSTRACT

Background: COVID-19 has been listed as an international public health emergency. During the pandemic, the nurses were affected physically and mentally when in contact with and caring for patients infected with COVID-19, especially those in intensive care units (ICUs). Objective: To summarize and evaluate the actual psychological experience of nurses caring for patients with severe pneumonia in the ICUs during the COVID-19 pandemic. Methods: Relevant publications were identified by systematic searches across 11 databases in December 2021. All qualitative and mixed-method studies in English and Chinese from 2019 that explored the experiences of nurses who cared for severe COVID-19 patients in ICUs were included. The qualitative meta-synthesis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Two independent reviewers selected the studies and assessed the quality of each study. Meta-synthesis was performed to integrate the results. Results: A total of 12 studies revealed 9 sub-themes and 3 descriptive themes: physical reactions and psychological changes, the need for support from multiple sources, and increased adaptation and resilience. Conclusion: Nurses who treated severe COVID-19 patients have experienced severe work trials and emotional reactions during the pandemic. They have also developed personally in this process. Managers should develop strategies that address the nurse's needs for external support, reasonably respond to public health emergencies, and improve nursing care outcomes.


Subject(s)
COVID-19 , Humans , Intensive Care Units , Pandemics
4.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-316032

ABSTRACT

Despite widespread interest in the pathophysiology of COVID-19 in respiratory and cardiovascular systems, little is known about the morphologic and molecular changes in the testis of patients with COVID-19 and the effects of SARS-CoV-2 infection on male fertility. We report here on the pathophysiology and molecular feature of testes obtained at autopsy from six men with COVID-19, as compared with those of testes from three men with age-matched, uninfected SARS-CoV-2. Our histopathological results showed that all COVID-19 patients had severe spermatogenesis damages compared with controls. Importantly, we detected the nuclear acid of the SARS-CoV-2 virus, viral particles, and SARS-CoV-2 spike S1 protein in COVID-19 patient testes, and we also found ACE2 and TMPRSS2 significantly elevated in the testes from COVID-19 patients. Furthermore, we observed a prominent leukocyte infiltration, including CD3+ T lymphocytes, CD20+ B lymphocytes, CD68+ macrophages, HLA-DR+ myeloid cells, and CD38+ plasma cells in the testes of COVID-19 patients. RNA-Seq analyses further revealed SARS-CoV-2 infection could lead to dysfunction of the genes that regulate the spermatogenesis and inflammation response-related pathways. Collectively, our pathological and molecular examination findings indicate that SARS-CoV-2 could directly attack testicular cells, thereby inducing the damage of testicular immune privilege and spermatogenesis defects.

5.
Brain Commun ; 4(1): fcab295, 2022.
Article in English | MEDLINE | ID: covidwho-1672135

ABSTRACT

Recent studies indicate that COVID-19 infection can lead to serious neurological consequences in a small percentage of individuals. However, in the months following acute illness, many more suffer from fatigue, low motivation, disturbed mood, poor sleep and cognitive symptoms, colloquially referred to as 'brain fog'. But what about individuals who had asymptomatic to moderate COVID-19 and reported no concerns after recovering from COVID-19? Here, we examined a wide range of cognitive functions critical for daily life (including sustained attention, memory, motor control, planning, semantic reasoning, mental rotation and spatial-visual attention) in people who had previously suffered from COVID-19 but were not significantly different from a control group on self-reported fatigue, forgetfulness, sleep abnormality, motivation, depression, anxiety and personality profile. Reassuringly, COVID-19 survivors performed well in most abilities tested, including working memory, executive function, planning and mental rotation. However, they displayed significantly worse episodic memory (up to 6 months post-infection) and greater decline in vigilance with time on task (for up to 9 months). Overall, the results show that specific chronic cognitive changes following COVID-19 are evident on objective testing even amongst those who do not report a greater symptom burden. Importantly, in the sample tested here, these were not significantly different from normal after 6-9 months, demonstrating evidence of recovery over time.

6.
Frontiers in public health ; 9, 2021.
Article in English | EuropePMC | ID: covidwho-1651356

ABSTRACT

Aim: To explore the knowledge and attitudes of newly graduated registered nurses, who have undergone standardized training in the intensive care unit, about the early mobilization of mechanically ventilated patients and identify perceived barriers to the application of early mobilization. Background: Early mobilization of mechanically ventilated patients has been gradually gaining attention, and its safety and effectiveness have also been verified. Nurses in intensive care units are the implementers of early mobilization, and the quality of their care is closely related to patient prognosis. However, the knowledge and attitude of newly graduated registered nurses undergoing standardized training, in intensive care units, on the early mobilization of mechanically ventilated patients and the obstacles they face in clinical implementation are still unclear. Methods: This qualitative study utilized the phenomenological method to explore the experiences of 15 newly graduated registered nurses undergoing standardized training in intensive care units in a 3rd hospital in Shanghai, China. Semi-structured face-to-face interviews were conducted in June 2020. The Colaizzi seven-step framework was used for data analysis. Findings: A total of 15 new nurses comprised the final sample after data saturation. Three main themes emerged from the analysis and seven subthemes: perceived importance, low implementation rate, and perceived barriers. Conclusions: Newly graduated registered nurses undergoing standardized training in intensive care units have a high level of awareness of the importance of early mobilization of mechanically ventilated patients and are willing to implement it. However, there is a lack of relevant knowledge and other obstacles that restrict clinical implementation. Early mobilization should be included in the standardized training of new nurses in intensive care units.

7.
Front Immunol ; 12: 631044, 2021.
Article in English | MEDLINE | ID: covidwho-1094169

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic has been raging around the world since January 2020. Pregnancy places the women in a unique immune scenario which may allow severe COVID-19 disease. In this regard, the potential unknown effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on mothers and fetuses have attracted considerable attention. There is no clear consistent evidence of the changes in the immune status of pregnant women after recovery from COVID-19. In this study, we use multiparameter flow cytometry and Luminex assay to determine the immune cell subsets and cytokines, respectively, in the peripheral blood and umbilical cord blood from pregnant women recovering from COVID-19 about 3 months (n=5). Our results showed decreased percentages of Tc2, Tfh17, memory B cells, virus-specific NK cells, and increased percentages of naive B cells in the peripheral blood. Serum levels of IL-1ra and MCP-1 showed a decreased tendency in late recovery stage (LRS) patients. Meanwhile, there was no significant difference in immune cell subsets in the umbilical cord blood. The placentas from LRS patients showed increased CD68+ macrophages infiltration and mild hypoxic features. The inflammatory damage of the placenta may be related to the antiviral response. Since the receptors, ACE2 and TMPRSS2, utilized by SARS-CoV-2 are not co-expressed in the placenta, so it is extremely rare for SARS-CoV-2 to cause infection through this route and the impact on the fetus is negligible.


Subject(s)
B-Lymphocytes/immunology , COVID-19/immunology , Fetal Blood/immunology , Germinal Center/immunology , Placenta/immunology , SARS-CoV-2/physiology , Th17 Cells/immunology , Angiotensin-Converting Enzyme 2/metabolism , Autoantigens/metabolism , Female , Flow Cytometry , Humans , Immunologic Memory , Immunophenotyping , Killer Cells, Natural , Pregnancy , Receptors, Interleukin-1/metabolism , Serine Endopeptidases/metabolism
9.
Am J Reprod Immunol ; 84(5): e13304, 2020 11.
Article in English | MEDLINE | ID: covidwho-960753

ABSTRACT

Caused by a novel type of virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) constitutes a global public health emergency. Pregnant women are considered to have a higher risk of severe morbidity and even mortality due to their susceptibility to respiratory pathogens and their particular immunologic state. Several studies assessing SARS-CoV-2 infection during pregnancy reported adverse pregnancy outcomes in patients with severe conditions, including spontaneous abortion, preterm labor, fetal distress, cesarean section, preterm birth, neonatal asphyxia, neonatal pneumonia, stillbirth, and neonatal death. However, whether these complications are causally related to SARS-CoV-2 infection is not clear. Here, we reviewed the scientific evidence supporting the contributing role of Treg/Th17 cell imbalance in the uncontrolled systemic inflammation characterizing severe cases of COVID-19. Based on the recognized harmful effects of these CD4+ T-cell subset imbalances in pregnancy, we speculated that SARS-CoV-2 infection might lead to adverse pregnancy outcomes through the deregulation of otherwise tightly regulated Treg/Th17 ratios, and to subsequent uncontrolled systemic inflammation. Moreover, we discuss the possibility of vertical transmission of COVID-19 from infected mothers to their infants, which could also explain adverse perinatal outcomes. Rigorous monitoring of pregnancies and appropriate measures should be taken to prevent and treat early eventual maternal and perinatal complications.


Subject(s)
COVID-19/immunology , Pregnancy Complications, Infectious/immunology , Pregnancy/immunology , SARS-CoV-2/physiology , T-Lymphocytes, Regulatory/immunology , Th17 Cells/immunology , COVID-19/transmission , Female , Humans , Infectious Disease Transmission, Vertical , Pandemics , Pregnancy Outcome
10.
J Reprod Immunol ; 139: 103122, 2020 06.
Article in English | MEDLINE | ID: covidwho-27137

ABSTRACT

The 2019 novel coronavirus disease (COVID-19) was first detected in December 2019 and became epidemic in Wuhan, Hubei Province, China. COVID-19 has been rapidly spreading out in China and all over the world. The virus causing COVID-19, SARS-CoV-2 has been known to be genetically similar to severe acute respiratory syndrome coronavirus (SARS-CoV) but distinct from it. Clinical manifestation of COVID-19 can be characterized by mild upper respiratory tract infection, lower respiratory tract infection involving non-life threatening pneumonia, and life-threatening pneumonia with acute respiratory distress syndrome. It affects all age groups, including newborns, to the elders. Particularly, pregnant women may be more susceptible to COVID-19 since pregnant women, in general, are vulnerable to respiratory infection. In pregnant women with COVID-19, there is no evidence for vertical transmission of the virus, but an increased prevalence of preterm deliveries has been noticed. The COVID-19 may alter immune responses at the maternal-fetal interface, and affect the well-being of mothers and infants. In this review, we focused on the reason why pregnant women are more susceptible to COVID-19 and the potential maternal and fetal complications from an immunological viewpoint.


Subject(s)
Betacoronavirus/immunology , Coronavirus Infections/complications , Coronavirus Infections/immunology , Disease Susceptibility/immunology , Pneumonia, Viral/complications , Pneumonia, Viral/immunology , Pregnancy Complications, Infectious/immunology , COVID-19 , China , Coronavirus Infections/pathology , Female , Humans , Pandemics , Pneumonia, Viral/pathology , Pregnancy , Pregnancy Complications, Infectious/virology , Premature Birth/etiology , SARS-CoV-2
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