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1.
Front Vet Sci ; 9, 2022.
Article in English | PubMed Central | ID: covidwho-2163206

ABSTRACT

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can be transmitted from human to companion animals. The national wide serological surveillance against SARS-CoV-2 was conducted among pet animals, mainly in cats and dogs, 1 year after the first outbreak of COVID-19 in China. All sera were tested for SARS-CoV-2 IgG antibodies using an indirect enzyme linked immunosorbent assay (ELISA) based on the receptor binding domain (RBD) of spike protein. This late survey takes advantage of the short duration of the serological response in these animals to track recent episode of transmission. A total of 20,592 blood samples were obtained from 25 provinces across 7 geographical regions. The overall seroprevalence of SARS-CoV-2 infections in cats was 0.015% (2/13397;95% confidence intervals (CI): 0.0, 0.1). The virus infections in cats were only detected in Central (Hubei, 0.375%) and Eastern China (Zhejiang, 0.087%) with a seroprevalence estimated at 0.090 and 0.020%, respectively. In dogs, the seroprevalence of SARS-CoV-2 infections was 0.014% (1/7159;95% CI: 0.0, 0.1) in the entire nation, seropositive samples were limited to Beijing (0.070%) of Northern China with a prevalence of 0.054%. No seropositive cases were discovered in other geographic regions, nor in other companion animals analyzed in this study. These data reveal the circulation of SARS-CoV-2 in companion animals, although transmission of the virus to domestic cats and dogs is low in China, continuous monitoring is helpful for the better understand of the virus transmission status and the effect on animals.

2.
Cell Discov ; 8(1):132, 2022.
Article in English | PubMed | ID: covidwho-2160196

ABSTRACT

Current SARS-CoV-2 Omicron subvariants impose a heavy burden on global health systems by evading immunity from most developed neutralizing antibodies and vaccines. Here, we identified a nanobody (aSA3) that strongly cross-reacts with the receptor binding domain (RBD) of both SARS-CoV-1 and wild-type (WT) SARS-CoV-2. The dimeric construct of aSA3 (aSA3-Fc) tightly binds and potently neutralizes both SARS-CoV-1 and WT SARS-CoV-2. Based on X-ray crystallography, we engineered a bispecific nanobody dimer (2-3-Fc) by fusing aSA3-Fc to aRBD-2, a previously identified broad-spectrum nanobody targeting an RBD epitope distinct from aSA3. 2-3-Fc exhibits single-digit ng/mL neutralizing potency against all major variants of concerns including BA.5. In hamsters, a single systemic dose of 2-3-Fc at 10 mg/kg conferred substantial efficacy against Omicron infection. More importantly, even at three low doses of 0.5 mg/kg, 2-3-Fc prophylactically administered through the intranasal route drastically reduced viral RNA loads and completely eliminated infectious Omicron particles in the trachea and lungs. Finally, we discovered that 2(Y29G)-3-Fc containing a Y29G substitution in aRBD-2 showed better activity than 2-3-Fc in neutralizing BA.2.75, a recent Omicron subvariant that emerged in India. This study expands the arsenal against SARS-CoV-1, provides potential therapeutic and prophylactic candidates that fully cover major SARS-CoV-2 variants, and may offer a simple preventive approach against Omicron and its subvariants.

3.
Journal of Applied Polymer Science ; 2022.
Article in English | Scopus | ID: covidwho-2148268

ABSTRACT

Antibacterial fabric with high thermal stability and mechanical strength is important for personalized protection, especially under the background of coronavirus pandemic (COVID-19). This paper presents a facile approach toward high-efficient antibacterial polypropylene spunbonded nonwoven fabrics (SNFs), which are decorated by a composite of graphene oxide embedded with silver nanoparticles (AgNPs/GO) through dip-coating and in situ reduction effect of pre-introduced amino-terminated hyperbranched polymer (HBP-NH2). Typically, HBP-NH2 was grafted onto the GO nanosheets, then silver ions were trapped and self-reduced by the HBP-NH2 to generate silver nanoparticles decorated GO. The produced AgNPs are uniformly dispersed on the GO with a size of 13 nm. As an antibacterial coating, the Ag/GO composite could tightly wrap the SNFs fibers through the dip-padding method, capable of enhancing the thermal stability and mechanical property of SNFs. The treated SNFs exhibited excellent antibacterial activities (~99.9%) against both Echerisia coli and Staphylococcus aureus, promising important potential for biomedical and personal protection applications. © 2022 Wiley Periodicals LLC.

4.
J Infect Dev Ctries ; 16(11):1696-1702, 2022.
Article in English | PubMed | ID: covidwho-2143899

ABSTRACT

INTRODUCTION: Research on the association between albumin (ALB) level and clinical outcomes of coronavirus disease 2019 (COVID-19) are limited. This study aimed to investigate the relationship between albumin level at the time of admission and adverse outcomes in patients with COVID-19. METHODOLOGY: This was a retrospective cohort study with 199 COVID-19 patients from five designated hospitals in Fujian Province who were enrolled between 22 January and 27 February, 2020. Clinical characteristics and laboratory values at the time of admission were collected. Adverse outcomes were defined as meeting at least one of the following criteria: development of acute respiratory distress syndrome (ARDS), respiratory failure, shock, multiple organ failure (MOF), intensive care unit (ICU) admission and in-hospital mortality event. The univariate and multivariate linear regression models and generalized additive models (GAM) were used to analyze the relationship between ALB and adverse outcomes. RESULTS: A non-linear relationship with an inflection point of 32.6g/L was detected between ALB and adverse outcomes after adjusting for potential confounders. The odds ratio and the confidence intervals on the left and right sides of the inflection point were 0.204 (0.061-0.681) and 0.908 (0.686-1.203), respectively. This suggested that ALB was negatively correlated with adverse outcomes when ALB was less than 32.6 g/L, and for every 1 unit increase in ALB, the risk of adverse outcomes was reduced by 79.6%. CONCLUSIONS: The relationship between ALB and adverse outcomes of COVID-19 is non-linear. ALB level is an independent predictive factor for adverse outcomes in COVID-19 patients.

5.
Current Topics in Medicinal Chemistry ; 22(21):1729-1730, 2022.
Article in English | EMBASE | ID: covidwho-2141243
6.
10th International Conference on Traffic and Logistic Engineering, ICTLE 2022 ; : 28-34, 2022.
Article in English | Scopus | ID: covidwho-2136336

ABSTRACT

In order to objectively evaluate the international status and level of China's transport development under the background of building a transport power, this paper selects major countries in the world to carry out international benchmarking analysis from the perspective of international comparison. Firstly, the evaluation index system of transport power construction suitable for international comparison is proposed by focusing on the positioning of indicators and construction principles, and the definition, statistical caliber, calculation formula, data source and other basic elements of indicators are further clarified. Secondly, by determining the evaluation scope, standardizing treatment, and setting weights, the two methods of cluster analysis and index weighting are used for calculation and analysis and mutual comparison. Finally, the results of the two methods show that: China's transport development level is generally in the third echelon, higher than the main BRICS countries, but there is still a significant gap compared with the United States, Japan, Germany, Britain, France, and other countries. China is speeding up its efforts to build into a transport power. In recent years, China's transport development has been at the forefront and at a high speed, with a good momentum of development. During the COVID-19 pandemic, the transport growth rate in China was significantly faster than that of other countries, and the gap between China and the world's transport power is narrowing at a faster pace. © 2022 IEEE.

7.
The Lancet Regional Health - Western Pacific ; 30, 2023.
Article in English | Scopus | ID: covidwho-2131791

ABSTRACT

Background: With the outbreak of the coronavirus disease 2019 (COVID-19), nurses have won well-deserved recognition for their indispensable roles in providing humane and professional healthcare for patients. However, by the nature of their role working at the forefront of patient care, nurses are prone to experiencing mental health consequences. Therefore, we pay attention to measuring the magnitude of psychological symptoms and identifying associated factors among nurses in China. Methods: We launched a nationwide, cross-sectional survey of nurses who worked in secondary or tertiary hospitals and public or private hospitals from 30 provinces in China. The prevalence and severity of symptoms of burnout, depression, and anxiety were investigated, respectively. Multivariable logistic regression analyses were performed to identify factors associated with each psychological symptom. Findings: A total of 138 279 respondents who worked in 243 hospitals completed this survey. A substantial proportion of nurses reported symptoms of burnout (34%), depression (55·5%), and anxiety (41·8%). In line with the disproportionality of economic development, we noted that the middle or western region was an independent risk factor for depression and anxiety. Compared with those working in the secondary hospital, nurses who worked in tertiary hospitals were associated with a higher likelihood of burnout and depression. Interpretation: Nurses are experiencing emotional, physical, and mental exhaustion during the COVID-19 epidemic. Governments and health policymakers need to draw attention to reinforcing prevention and ameliorating countermeasures to safeguard nurses' health. Funding: The strategic consulting project of the Chinese Academy of Engineering [2021-32-5]. Advanced Institute of Infomation Technology, Peking University, Zhejiang Province [2020-Z-17] © 2022 The Author(s)

8.
Chinese Journal of Pharmacology and Toxicology ; 36(4):241-252, 2022.
Article in Chinese | EMBASE | ID: covidwho-2115577

ABSTRACT

OBJECTIVE To find out whether 2811 will cause toxic reactions in animals, and determine the safe dose of without any toxic reactions and the relationship between the dose, time of administration and results of the toxicity test. METHODS Thirty healthy rhesus monkeys were selected and randomly divided into 3 groups, 1 O in each group (half males and half females), namely, the solvent control group, 2811 100 and 400 mg* kg-1 groups, respectively. The solvent control group was iv given 0.9% sodium chloride injection, while the experimental groups were iv given 2811 100 and 400 mg* kg-1 , respectively, once every 6 days, 3 times in 2 weeks, and allowed to recover for 9 weeks after drug withdrawal. During the test, the body weight, food intakes, body temperatures, ophthalmology, blood pressure, electrocardiograms, blood routine, anticoagulation, blood biochemistry, electrolytes, urine, systemic anatomy, organ weight and coefficient were observed, while histopathology and immunology tests were performed. At the same time, the anti-drug antibody (ADA) and plasma concentrations were determined, and toxikinetic parameters were analyzed. RESULTS During the experiment, the observation of general symptoms, body mass, food intakes, body temperatures, ophthalmology, blood pressure, electrocardiograms, blood routine, anticoagulation, blood biochemistry, electrolytes, urine, organ weight and coefficient, histopathology and immunology of animals in each dose group showed no significant changes related to the tested animals. ADA was not detected in any of the groups. Plasma drug concentrations in 2B11 100 and 400 mg* kg-1 groups were basically consistent and proportional to the dose, so was the ratio of peak concentration and exposure. 2B11 injection showed linear kinetics in vivo. CONCLUSION Under the conditions set in this test, the 2-week repeated administration toxicity test of 2B11 in rhesus monkeys is safe, and no clinical adverse reactions are observed at the dose level of 400 mg*kg-1, which provides reference for the follow-up clinical study of 2B11. Copyright © 2022 Chinese Journal of Pharmacology and Toxicology. All rights reserved.

9.
Annals of the Academy of Medicine Singapore ; 49(7):456-461, 2020.
Article in English | EMBASE | ID: covidwho-2115576

ABSTRACT

Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 and was declared a global pandemic by the World Health Organization on 11 March 2020. A definitive diagnosis of COVID-19 is made after a positive result is obtained on reverse transcription-polymerase chain reaction assay. In Singapore, rigorous contact tracing was practised to contain the spread of the virus. Nasal swabs and chest radiographs (CXR) were also taken from individuals who were suspected to be infected by COVID-19 upon their arrival at a centralised screening centre. From our experience, about 40% of patients who tested positive for COVID-19 had initial CXR that appeared "normal". In this case series, we described the temporal evolution of COVID-19 in patients with an initial "normal" CXR. Since CXR has limited sensitivity and specificity in COVID-19, it is not suitable as a first-line diagnostic tool. However, when CXR changes become unequivocally abnormal, close monitoring is recommended to manage potentially severe COVID-19 pneumonia. Copyright © 2020 Annals, Academy of Medicine, Singapore.

10.
Current Topics in Medicinal Chemistry ; 22(1):1-2, 2022.
Article in English | EMBASE | ID: covidwho-2114519
11.
Zhonghua Er Ke Za Zhi ; 60(11): 1103-1106, 2022 Nov 02.
Article in Chinese | MEDLINE | ID: covidwho-2099940

Subject(s)
COVID-19 , Child , Humans , SARS-CoV-2
12.
Zhonghua Er Ke Za Zhi ; 60(11): 1163-1167, 2022 Nov 02.
Article in Chinese | MEDLINE | ID: covidwho-2099938

ABSTRACT

Objective: To summarize the management and short-term outcomes of neonates delivered by mothers infected with SARS-CoV-2 Omicron variant. Methods: A retrospective study was performed on 158 neonates born to mothers infected with SARS-CoV-2 Omicron variant admitted to the isolation ward of Children's Hospital of Fudan University from March 15th, 2022 to May 30th, 2022. The postnatal infection control measures for these neonates, and their clinical characteristics and short-term outcomes were analyzed. They were divided into maternal symptomatic group and maternal asymptomatic group according to whether their mothers had SARS-CoV-2 symptoms. The clinical outcomes were compared between the 2 groups using Rank sum test and Chi-square test. Results: All neonates were under strict infection control measures at birth and after birth. Of the 158 neonates, 75 (47.5%) were male. The gestational age was (38+3±1+3) weeks and the birth weight was (3 201±463)g. Of the neonates included, ten were preterm (6.3%) and the minimum gestational age was 30+1 weeks. Six neonates (3.8%) had respiratory difficulty and 4 of them were premature and required mechanical ventilation. All 158 neonates were tested negative for SARS-COV-2 nucleic acid by daily nasal swabs for the first 7 days. A total of 156 mothers (2 cases of twin pregnancy) infected with SARS-CoV-2 Omicron variant, the time from confirmed SARS-CoV-2 infection to delivery was 7 (3, 12) days. Among them, 88 cases (56.4%) showed clinical symptoms, but none needed intensive care treatment. The peripheral white blood cell count of the neonates in maternal symptomatic group was significantly higher than that in maternal symptomatic group (23.0 (18.7, 28.0) × 109 vs. 19.6 (15.4, 36.6) × 109/L, Z=2.44, P<0.05). Conclusions: Neonates of mothers infected with SARS-CoV-2 Omicron variant during third trimester have benign short-term outcomes, without intrauterine infection through vertical transmission. Strict infection control measures at birth and after birth can effectively protect these neonates from SARS-CoV-2 infection.


Subject(s)
COVID-19 , Pregnancy Complications, Infectious , Female , Humans , Infant , Infant, Newborn , Male , Pregnancy , Mothers , Pregnancy Complications, Infectious/diagnosis , Pregnancy Complications, Infectious/prevention & control , Retrospective Studies , SARS-CoV-2
13.
ACS ES T Water ; 2022.
Article in English | PubMed Central | ID: covidwho-2096629

ABSTRACT

Ruili and Longchuan, two border counties in southwestern China, are facing epidemic control challenges due to the high rate of COVID-19 infections originating from neighboring Myanmar. Here, we aimed to establish the applicability of wastewater and environmental water surveillance of SARS-CoV-2 and conduct whole-genome sequencing (WGS) to trace the possible infection origin. In August 2021, total 72 wastewater and river water samples were collected from 32 sampling sites. SARS-CoV-2 ORF1ab and N genes were measured by RT-qPCR. We found that 19 samples (26.39%) were positive, and the viral loads of ORF1ab and N genes were 6.62 × 102–2.55×105 and 1.86 × 103–2.32 × 105 copies/L, respectively. WGS further indicated the sequences in two transboundary river samples, and one hospital wastewater sample belonged to the delta variant, suggesting that the infection source might be areas with high COVID-19 delta variant incidence in Southeast Asia (e.g., Myanmar). We reported for the first time the detection and quantification of SARS-CoV-2 RNA in the transboundary rivers of Myanmar–China. Our findings demonstrate that wastewater and environmental water may provide independent and nonintrusive surveillance points to monitor the global spread of emerging COVID-19 variants of concern, particularly in high-risk regions or border areas with considerable epidemic challenges and poor wastewater treatment facilities.

14.
Satellite Workshops on AIBlock, AIHWS, AIoTS, CIMSS, Cloud S and P, SCI, SecMT, SiMLA 2022, held in conjunction with the 20th International Conference on Applied Cryptography and Network Security, ACNS 2022 ; 13285 LNCS:36-52, 2022.
Article in English | Scopus | ID: covidwho-2094437

ABSTRACT

The impact of COVID-19, shortage of chips and external factors has made a flurry demand, increased costs and significant delays in supply chains despite technological advancements in the supply chain management process. The blockchain technology is constantly being explored and attracts supply chains in adopting them to allow businesses to scale rapidly. In our work, we identify gaps between existing blockchain implementations and cybersecurity standards. We introduce a framework and show how we can implement secure and trusted blockchains onto the supply chains. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

15.
Advances in Science, Technology and Innovation ; : 287-292, 2022.
Article in English | Scopus | ID: covidwho-2094263

ABSTRACT

With the widespread of the COVID-19 pandemic, the popularity of live streaming and Internet celebrity endorsements have surged the demand for innovative production and the technology of the Internet of Things (IoT). Nonetheless, limited studies have addressed the impact of Internet celebrity economy on physical production and operations with smart digital applications in the context of Industry 4.0. The paper aims to examine how Internet celebrity facilitates manufacturing behaviours and incentivize logistics network upgrading under the epidemic. The empirical results show that the interactions between celebrity and consumer will contribute to the transformation to smart management manufacture and sustainable socio-economic development. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

16.
23rd Annual Conference of the International Speech Communication Association, INTERSPEECH 2022 ; 2022-September:2168-2172, 2022.
Article in English | Scopus | ID: covidwho-2091312

ABSTRACT

A fast, efficient and accurate detection method of COVID-19 remains a critical challenge. Many cough-based COVID-19 detection researches have shown competitive results through artificial intelligence. However, the lack of analysis on vocalization characteristics of cough sounds limits the further improvement of detection performance. In this paper, we propose two novel acoustic features of cough sounds and a convolutional neural network structure for COVID-19 detection. First, a time-frequency differential feature is proposed to characterize dynamic information of cough sounds in time and frequency domain. Then, an energy ratio feature is proposed to calculate the energy difference caused by the phonation characteristics in different cough phases. Finally, a convolutional neural network with two parallel branches which is pre-trained on a large amount of unlabeled cough data is proposed for classification. Experiment results show that our proposed method achieves state-of-the-art performance on Coswara dataset for COVID-19 detection. The results on an external clinical dataset Virufy also show the better generalization ability of our proposed method. Copyright © 2022 ISCA.

17.
Information Processing and Management ; 60(1), 2023.
Article in English | Scopus | ID: covidwho-2086325

ABSTRACT

Information asymmetry in different service products is lacking research. Tourism e-commerce as a dynamic financial market driven by advanced information technology deepens the concern for asymmetry brought to hotel consumers. COVID-19 provides a natural intervention on market asymmetry in the hotel price information, which effects are worth evaluating. This study therefore evaluates the degree of information asymmetry in terms of the lodging price of international tourist hotels (ITHs). Through applying the concept of stochastic frontier approach (SFA), this study estimates the degree of information asymmetry and the inefficiencies. The estimation results indicate that the hotel location, traveler type, operation type may cause different information asymmetry. By comparing with the asymmetry before the pandemic, it is found that the asymmetry in lodging price information decreased since the outbreak of the COVID-19 pandemic. Among the six regions studied, the mean range of information equity degree increased from the original 0.634-0.832 to 0.7633-0.866. It indicates that the outbreak of COVID-19 changed the structure of the consumer groups in hotel operations and then affect the hotelier's pricing strategy. © 2022

18.
19.
2022 Ieee World Ai Iot Congress (Aiiot) ; : 337-343, 2022.
Article in English | Web of Science | ID: covidwho-2070282

ABSTRACT

Since the outbreak of the coronavirus pandemic in December 2019, there has been increased interest in developing better facial recognition systems. This stems from the need to protect everyone from the spread of the virus. However, the measures taken to prevent the spread of the virus pose a challenge to security and surveillance systems as existing systems are unable to match faces with masks more efficiently. For this study, a custom dataset was generated due to the unavailability of a large face dataset for masked face recognition, and the existing datasets focused on Caucasians (white race faces) while Aethiopians (black race faces) were neglected. In this study, a comparative analysis was conducted between the AlexNet, ResNet-50, and Inception-V3 models to recognize faces with surgical masks, fabric masks, and N95 masks. The results of the study showed that the CNN models achieve excellent recognition accuracy for masked and unmasked faces. Analysis of the models' performance showed that the AlexNet model achieved 95.7%, ResNet-50 achieved 97.5%, and Inception-V3 also achieved 95.5%. From the study, ResNet-50 performed better than Inception-V3 and AlexNet models in recognizing masked faces.

20.
Annals of Oncology ; 33:S958, 2022.
Article in English | EMBASE | ID: covidwho-2041540

ABSTRACT

Background: Surufatinib (a small-molecule inhibitor of VEGFR1-3, FGFR1, and CSF-1R) has exhibited encouraging antitumor activity for the treatment of advanced neuroendocrine tumors (including NEN and NEC) in multiple registration studies. Here, we report the preliminary results of advanced neuroendocrine tumors of an ongoing, multicenter, real-world study of surufatinib + MDT (ChiCTR2100049999). Challenges in tumor clinical trials management in the face of the COVID-19 resurgence period in Shanghai. Methods: In this multicenter, single-arm real-world study, adults (18-80) with advanced neuroendocrine tumors (including NEN and NEC) were eligible and received surufatinib (300mg orally, QD) with MDT(multidisciplinary collaborative diagnosis and treatment). The primary endpoint was progression-free survival (PFS) per RECIST 1.1. We minimized the interruptions caused by the pandemic using telemedicine platforms for all patients. This included online consultations, follow-up drug distributions, and health management services. Results: Twenty-three pts were enrolled, with 20 NEN and 3 NEC. At the data cutoff date (April 10, 2022), 15 pts had at least one post-baseline tumor assessment;of them, the confirmed ORR (95%CI) was 20% (4.3-48.1), and DCR (95%CI) was 93.33% (68.1-99.8). Median PFS (mPFS) (95%CI): 10.640 mo (3.796-17.484);median OS: not reached and median duration of follow up was 6.870 mo (6.797-6.943). A pNET patient (NO. 010007) was interrupted by asymptomatic COVID-19 infection 9 mo after enrollment. There are no interruptions caused by COVID-19 for other patients. An NEC patient treated with single agent had a 5.85 mo PFS, evaluated as NE, in whom target lesion resected after baseline. In overall pts (n=23), most commonly (≥3 pts) with hemorrhage, anemia, hypertension, proteinuria, and abdominal pain. Three pts had TRAEs that led to treatment discontinuation. Conclusions: Surufatinib + MDT exhibited promising efficacy and manageable toxicity in pts with advanced neuroendocrine tumors. Now and in the future, it is necessary to design regulatory changes in telehealth adoption for clinical trial design in the pandemic era. Clinical trial identification: ChiCTR2100049999. Legal entity responsible for the study: The authors. Funding: Hutchison MediPharma Limited. Disclosure: All authors have declared no conflicts of interest.

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