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1.
HemaSphere ; 6:2024-2025, 2022.
Article in English | EMBASE | ID: covidwho-2032143

ABSTRACT

Background: MZL is the second most common lymphoma in older pts. Choosing an optimal treatment can be challenging because of patient-or disease-related risk factors and treatment-related toxicities (Curr Opin Oncol. 2019;31(5):386-393). Zanubrutinib is a potent, irreversible next-generation Bruton tyrosine kinase (BTK) inhibitor designed to maximize BTK occupancy and minimize off-target kinase inhibition, which may improve efficacy outcomes and minimize toxicities, such as cardiac arrythmias and bleeding events. Zanubrutinib received accelerated approval from the United States FDA for the treatment of pts with R/R MZL (Haematologica . 2022;107(1):35-43). Aims: We aim to present a subgroup analysis of efficacy and safety of zanubrutinib in pts aged ≥65 years with R/R MZL enrolled in MAGNOLIA (BGB-3111-214;NCT03846427). Methods: MAGNOLIA is a phase 2, multicenter, single-arm study of adults with R/R MZL who had received ≥1 line of therapy including ≥1 CD20-directed regimen. All were treated with zanubrutinib 160 mg twice daily until disease progression or unacceptable toxicity. Use of long-term antiplatelet and anticoagulation agents was permitted. The primary endpoint was overall response rate (ORR;complete response [CR] and partial response [PR]) determined by an independent review committee (IRC) in accordance with the Lugano classification. Secondary endpoints include ORR by investigator assessment (INV), duration of response (DOR), progression-free survival (PFS), and safety. All pts gave informed consent. Results: As of 18 January 2021, a total of 68 pts were enrolled (Table). Forty (61%) pts were ≥65 years old with a median age of 73 (range, 65-85);18 pts were ≥75 years old. Median number of prior therapies was 2 (range, 1-6) and 10 (25%) pts were refractory to last therapy. Most pts received prior rituximab + cyclophosphamide + vincristine + prednisone (48%) or bendamustine + rituximab (30%), while 5 (13%) pts received rituximab monotherapy. MZL subtypes included extranodal (n=17, 43%), nodal (n=14, 35%), and splenic (n=8, 20%). Median duration of treatment was 14.4 months (mo;range, 0.9-19.6). At a median follow-up of 15.8 mo (range, 2.8-21.8), ORR by IRC was 75% (CR 25%, PR 50%;Table). Responses were observed in all subtypes, with an ORR of 71%, 86%, and 75% in extranodal, nodal, and splenic subtypes, respectively (CR 41%, 21%, and 0%, respectively). Median DOR and PFS were not reached;15-month PFS was 87% and 12-month DOR was 93%. Most (63%) pts are continuing zanubrutinib. Treatment discontinuation due to disease progression was 28% by INV. Most common treatmentemergent adverse events (AEs) observed in ≥20% of pts include contusion (28%), diarrhea (25%), and constipation (20%). Grade ≥3 neutropenia occurred in 5% of pts. The most common infection was upper respiratory tract infection (10%). Two (5%) pts discontinued zanubrutinib due to unrelated fatal AEs (COVID-19 pneumonia and myocardial infarction in a patient with pre-existing coronary artery disease). Atrial fibrillation/flutter and hypertension occurred in 2 (5%) pts each and did not lead to treatment discontinuation. No pts required dose reductions, or experienced major or serious hemorrhage. Image: Summary/Conclusion: The safety profile of zanubrutinib observed in older pts was consistent with previously published results (Clin Cancer Res . 2021;27(23):6323-6332). Zanubrutinib was well tolerated and effective, as demonstrated by a high response rate and durable disease control in older pts with R/R MZL.

2.
Journal of Chemical Education ; : 9, 2022.
Article in English | Web of Science | ID: covidwho-1977966

ABSTRACT

Under the threat of the COVID-19 pandemic, an interdisciplinary project about the brewing and analysis of traditional Chinese rice wine was performed at home by junior students of the chemistry major at Huanggang Normal University under the remote guidance of teachers during the spring lockdown semester of 2020. Students were exposed to the concepts of yeast metabolism, analytical testing, and sensory evaluation in terms of real project study and completed a series of hands-on activities at home using readily available materials, utensils, and self-made devices. In the spring semester of 2021, experiments were conducted in the general lab with other students in the same program to compare the results of the two groups of students. The results were that the "home" results were credible, the students were trained not only in laboratory skills but also in analytical and communication skills, and, significantly, the majority of students enjoyed the content and activities. This paper illustrates an effective experimental design procedure that can be conducted at home or in the laboratory in response to uncertain changes, such as a pandemic lockdown.

3.
5th IEEE Conference on Energy Internet and Energy System Integration, EI2 2021 ; : 3025-3030, 2021.
Article in English | Scopus | ID: covidwho-1806894

ABSTRACT

The COVID-19 pandemic has forced many governments around the world to implement strict lockdown measures and order citizens to stay at home, which has caused a major change in travel patterns. This study leveraged electric vehicle charging big data in Hefei, Anhui Province, China to estimate electric vehicle charging demand in the absence of the COVID-19 pandemic using multi-layer perceptron model, which quantified the impact of the COVID-19 pandemic. In addition, we employed the vector autoregressive model to investigate the dynamic relationships between the changes in charging demand and various explanatory factors. The results suggest that the daily average charging demand in Hefei decreased by 78.3% compared to the predicted value during the pandemic. Furthermore, according to the variance decomposition and impulse response function analysis, national confirmed COVID-19 cases play a dominant role in reducing charging demand. The number of daily hospitalizations and Migration Scale Index also have significant and robust effect on the decrease in charging demand. The Air Quality Index and Baidu Index are susceptible to external factors and do not have a direct impact on the change in charging demand. Findings support a better understanding of changes in travel behavior during the pandemic and provide policy makers with references to deal with similar events. © 2021 IEEE

4.
IEEE Pervasive Computing ; 2022.
Article in English | Scopus | ID: covidwho-1731035

ABSTRACT

While current meeting tools are able to capture key analytics (e.g., transcript and summarization), they do not often capture nuanced emotions (e.g., disappointment and feeling impressed). Given the high number of meetings that were held online during the COVID-19 pandemic, we had an unprecedented opportunity to record extensive meeting data with a newly developed meeting companion application. We analyzed 72 h of conversations from 85 real-world virtual meetings and 256 self-reported meeting success scores. We did so by developing a deep-learning framework that can extract 32 nuanced emotions from meeting transcripts, and by then testing a variety of models predicting meeting success from the extracted emotions. We found that rare emotions (e.g., disappointment and excitement) were generally more predictive of success than more common emotions. This demonstrates the importance of quantifying nuanced emotions to further improve productivity analytics, and, in the long term, employee well-being. IEEE

5.
Chemistry of Materials ; 2021.
Article in English | Scopus | ID: covidwho-1713093

ABSTRACT

Owing to the pandemic of Coronavirus disease 2019 (COVID-19), the demands on ultracold-chain logistics have rapidly increased for the storage and transport of mRNA vaccines. Herein, we report a soluble luminescent thermometer based on thermally activated dual-emissions of Mn2+-alloyed 2D perovskite quantum wells (QWs). Owing to the Mn2+ alloying, the binding energy of perovskite QW exciton is reduced from 291 to 100 meV. It facilitates the dissociation of excitons into free charge carriers, which are then transferred and trapped on Mn2+. The temperature-dependent charge transfer efficiency can be tuned from 8.8% (-93 °C) to 30.6% (25 °C), leading to continuous ratiometrical modulation from exciton-dominated violet emission to Mn2+-dominated orange emission. The highest sensitivity (1.44% per K) is approximately twice that of the Mn2+-doped chalcogenide quantum dots. Taking advantage of highly reversible color switching, Mn2+-alloyed QWs provide an economical solution to monitor the ultracold-chain logistics of the COVID-19 vaccine. © 2022 American Chemical Society.

6.
21st COTA International Conference of Transportation Professionals: Advanced Transportation, Enhanced Connection, CICTP 2021 ; : 691-702, 2021.
Article in English | Scopus | ID: covidwho-1628028

ABSTRACT

In 2020, the outbreak of COVID-19 pneumonia has had a great impact on China's economic and social life. The construction and transportation industries have been greatly impacted and suffered from its high mobility. This paper studies the big data of migration between Xi'an and Chengdu from January 1, 2020 to March 15, 2020 and divides the epidemic situation into four stages according to the introduction of the elastic coefficient according to the development of the epidemic situation. In each stage, the elastic coefficient of index change is introduced in combination with the decreasing impact of epidemic prevention and control measures on transportation. Finally, a modified moving average method is formed, which is compared with the ordinary moving average method. The results show that the modified moving average method combined with Hadoop big data platform can improve the accuracy and efficiency of the intercity transportation flow prediction under the epidemic situation. © 2021 CICTP 2021: Advanced Transportation, Enhanced Connection - Proceedings of the 21st COTA International Conference of Transportation Professionals. All rights reserved.

7.
Ieee Transactions on Industrial Informatics ; 17(9):6528-6538, 2021.
Article in English | Web of Science | ID: covidwho-1307656

ABSTRACT

Automatic segmentation of lung lesions from COVID-19 computed tomography (CT) images can help to establish a quantitative model for diagnosis and treatment. For this reason, this article provides a new segmentation method to meet the needs of CT images processing under COVID-19 epidemic. The main steps are as follows: First, the proposed region of interest extraction implements patch mechanism strategy to satisfy the applicability of 3-D network and remove irrelevant background. Second, 3-D network is established to extract spatial features, where 3-D attention model promotes network to enhance target area. Then, to improve the convergence of network, a combination loss function is introduced to lead gradient optimization and training direction. Finally, data augmentation and conditional random field are applied to realize data resampling and binary segmentation. This method was assessed with some comparative experiment. By comparison, the proposed method reached the highest performance. Therefore, it has potential clinical applications.

8.
China Review-an Interdisciplinary Journal on Greater China ; 21(1):37-53, 2021.
Article in English | Web of Science | ID: covidwho-1158755

ABSTRACT

When COVID-19 broke out, local governments in China were expected to deal with the pandemic efficiently and effectively due to their rich experience in tackling the SARS in 2003. However, provincial governments have taken divergent measures in the fight against COVID-19. This research note disentangles the differences and similarities in virus containment policies based on a five-dimensional framework, namely starting early preparation, activation of first-level response, disclosure of epidemic information, resumption of work and production, and utilization of digital tools. Our analysis demonstrates that the government responses are uneven and that there are indeed front-runners in handling the COVID-19 pandemic. Building upon exiting theories on local government behaviors, we suggest that "conformity tendency" in policy diffusion might be helpful to explain the varied responses. During public emergencies, while any provincial government can take the initiative in a particular policy dimension, others need to quickly handle peer pressure or take the political risk of being left behind. Gradually, local governments tend to accept and adopt similar responses and strategies in the national epidemic.

9.
Proc. - IEEE Int. Conf. Bioinform. Biomed., BIBM ; : 491-494, 2020.
Article in English | Scopus | ID: covidwho-1075709

ABSTRACT

Biomedical named entity recognition (BioNER) is a fundamental step for mining COVID-19 literature. Existing BioNER datasets cover a few common coarse-grained entity types (e.g., genes, chemicals, and diseases), which cannot be used to recognize highly domain-specific entity types (e.g., animal models of diseases) or emerging ones (e.g., coronaviruses) for COVID-19 studies. We present CORD-NER, a fine-grained named entity recognized dataset of COVID-19 literature (up until May 19, 2020). CORD-NER contains over 12 million sentences annotated via distant supervision. Also included in CORD-NER are 2,000 manually-curated sentences as a test set for performance evaluation. CORD-NER covers 75 fine-grained entity types. In addition to the common biomedical entity types, it covers new entity types specifically related to COVID-19 studies, such as coronaviruses, viral proteins, evolution, and immune responses. The dictionaries of these fine-grained entity types are collected from existing knowledge bases and human-input seed sets. We further present DISTNER, a distantly supervised NER model that relies on a massive unlabeled corpus and a collection of dictionaries to annotate the COVID-19 corpus. DISTNER provides a benchmark performance on the CORD-NER test set for future research. © 2020 IEEE.

10.
Eur Rev Med Pharmacol Sci ; 25(1): 541-548, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-1052581

ABSTRACT

OBJECTIVE: List the clinical data of the role of remdesivir in COVID-19, and try to make an objective evaluation and analyze its feasibility. MATERIALS AND METHODS: The keywords of "remdesivir", "COVID-19" and "SARS-CoV-2" were systematically searched in PubMed and Web of Science. After removing the repetitions, we summarize articles, letters, and comments on remdesivir in the treatment of COVID-19. RESULTS: In this review, we summarize clinical case of using remdesivir in the treatment of COVID-19, analyzed the final treatment results, and judged whether the drug was effective for the treatment of COVID-19. Also, attention was paid to the side effects of the drug. CONCLUSIONS: According to the clinical results, it was found that remdesivir was effective in the treatment of COVID-19. The drug has side effects, but the symptoms were mild and disappeared immediately after discontinuation of medication.


Subject(s)
Adenosine Monophosphate/analogs & derivatives , Alanine/analogs & derivatives , Antiviral Agents/therapeutic use , COVID-19/drug therapy , SARS-CoV-2 , Adenosine Monophosphate/administration & dosage , Adenosine Monophosphate/adverse effects , Adenosine Monophosphate/therapeutic use , Alanine/administration & dosage , Alanine/adverse effects , Alanine/therapeutic use , Antiviral Agents/administration & dosage , Antiviral Agents/adverse effects , Humans , Treatment Outcome
11.
Hong Kong Med J ; 28(1): 54-63, 2022 02.
Article in English | MEDLINE | ID: covidwho-921303

ABSTRACT

INTRODUCTION: The outbreak of coronavirus disease 2019 (COVID-19) has exerted a heavy burden on public health worldwide. We aimed to investigate the epidemiological and clinical characteristics of patients with COVID-19 in a designated hospital in Hangzhou, China. METHODS: This was a retrospective study that included laboratory-confirmed cases of COVID-19 in XiXi Hospital of Hangzhou from 15 January 2020 to 30 March 2020. We reviewed and analysed the epidemiological, demographic, clinical, radiological, and laboratory features involving these cases. Age-tratification analysis was also implemented. RESULTS: We analysed 96 confirmed cases. The patients had a mean age of 43 years, with six patients younger than 18 years and 14 patients older than 60 years. No significant gender difference was discovered. Co-morbidities were commonly observed in patients aged over 40 years. Twenty eight of the patients had travelled from Wuhan City, and 51 patients were infected through close contact. Familial clusters accounted for 48 of the cases. The mean incubation time was 7 days, and the symptoms were mainly fever, cough, fatigue, and sore throat. Lymphocytopenia was observed predominantly in patients aged over 60 years. Fifty five patients presented with bilateral pulmonary lesions. The radiological changes were typically distributed in the subpleural area, and pleural effusion rarely occurred. All patients were discharged successfully. CONCLUSION: During the early stage of the COVID-19 outbreak, half of the patients from a designated hospital in Hangzhou City were discovered as familial clusters. Therefore, strict prevention and control measures during self-isolation should be implemented. Patients aged over 60 years who had underlying co-morbidities were prone to lymphocytopenia and severe infection.


Subject(s)
COVID-19 , Adult , Aged , COVID-19/epidemiology , China/epidemiology , Cough/etiology , Hospitals , Humans , Retrospective Studies , SARS-CoV-2
12.
Zhonghua Liu Xing Bing Xue Za Zhi ; 41(5): 662-666, 2020 May 10.
Article in Chinese | MEDLINE | ID: covidwho-20702

ABSTRACT

Objective: To collect the current status and healthcare needs of people living with HIV (PLHIV) in China during the COVID-19 outbreak to inform quick response from government and communities. Methods: During February 5(th) to 10(th), 2020, a national anonymous survey was conducted using an online questionnaire among PLHIV at least 18 years of age and had started antiretroviral treatment (ART) to collect the information on COVID-19 prevention, HIV-related health services and the needs on psychosocial support. Current status and needs of people living with HIV were analyzed in Hubei and other regions. Results: A total of 1 014 valid questionnaires were collected, with PLHIV respondents cross the country. The survey revealed that 93.79% of the respondents could obtain information regarding the prevention of COVID-19 from their communities or villages. Respondents were concerned with HIV-specific protective measures and personal protective equipment shortage. 32.64% of all respondents were not carrying sufficient antiretroviral medicines (ARVs) to meet the needs under traffic and travel restrictions, and some could face stock-outs in the coming month. In Hubei province where 53 respondents needed ARV refill, 64.15% reported difficulty accessing ARV due to the "blockage" . 28.93% respondents were in need of sociopsychological support, and 85.31% anticipated further improvement of the out-of-town ARV refill process from the government. Conclusion: PLHIV wants to know HIV-specific protective measures against COVID-19 outbreak. PLHIV who returned to their home-towns and affected by the lock-downs reported challenges with refills. We should undertake a more systematic study on impacts of the COVID-19 on PLHIV to develop preparedness capacity for future public health emergency.


Subject(s)
Coronavirus Infections/epidemiology , Disease Outbreaks , HIV Infections/therapy , Pneumonia, Viral/epidemiology , Anti-Retroviral Agents/supply & distribution , COVID-19 , China/epidemiology , Health Services Accessibility , Humans , Pandemics , Surveys and Questionnaires
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