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1.
World J Gastroenterol ; 28(15): 1526-1535, 2022 Apr 21.
Article in English | MEDLINE | ID: covidwho-1818246

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 has brought serious challenges for the medical field. Patients with COVID-19 usually have respiratory symptoms. However, liver dysfunction is not an uncommon presentation. Additionally, the degree of liver dysfunction is associated with the severity and prognosis of COVID-19. Prevention, diagnosis, and treatment of malnutrition should be routinely recommended in the management of patients with COVID-19, especially in those with liver dysfunction. Recently, a large number of studies have reported that nutrition therapy measures, including natural dietary supplements, vitamins, minerals and trace elements, and probiotics, might have potential hepatoprotective effects against COVID-19-related liver dysfunction via their antioxidant, antiviral, anti-inflammatory, and positive immunomodulatory effects. This review mainly focuses on the possible relationship between COVID-19 and liver dysfunction, nutritional and metabolic characteristics, nutritional status assessment, and nutrition therapy to provide a reference for the nutritionists while making evidence-based nutritional decisions during the COVID-19 pandemic.


Subject(s)
COVID-19 , Liver Diseases , Nutritionists , Humans , Liver Diseases/diagnosis , Liver Diseases/therapy , Pandemics , SARS-CoV-2
2.
Cell Insight ; : 100029, 2022.
Article in English | ScienceDirect | ID: covidwho-1814234

ABSTRACT

The emergence of the SARS-CoV-2 Omicron variant poses a striking threat to human society. More than 30 mutations in the Spike protein of the Omicron variant severely compromised the protective immunity elicited by either vaccination or prior infection. The persistent viral evolutionary trajectory generates Omicron-associated lineages, such as BA.1 and BA.2. Moreover, the virus recombination upon Delta and Omicron co-infections has been reported lately, although the impact remains to be assessed. This minireview summarizes the characteristics, evolution and mutation control, and immune evasion mechanisms of SARS-CoV-2 variants, which will be helpful for the in-depth understanding of the SARS-CoV-2 variants and policy-making related to COVID-19 pandemic control.

3.
World J Crit Care Med ; 11(2): 112-114, 2022 Mar 09.
Article in English | MEDLINE | ID: covidwho-1791994

ABSTRACT

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 has become a worldwide public health crisis. Studies have demonstrated that diabetes and dyslipidaemia are common comorbidities and could be high-risk factors for severe COVID-19. Vitamin D, a group of fat-soluble compounds responsible for intestinal absorption of calcium, magnesium, and phosphate, has been widely used as a dietary supplement for the prevention and treatment of numerous diseases, including infectious and non-infectious diseases, due to its high cost-effectiveness; safety; tolerability; and anti-thrombotic, anti-inflammatory, antiviral, and immunomodulatory properties. In this letter to the editor, we mainly discuss the potential role of vitamin D in patients with diabetes, dyslipidaemia, and COVID-19.

4.
Front Psychiatry ; 13: 806149, 2022.
Article in English | MEDLINE | ID: covidwho-1785423

ABSTRACT

Objective: During the COVID-19 pandemic, face-to-face intervention services for families of children with autism spectrum disorder (ASD) were limited. This study aimed to evaluate the effectiveness of an 8-week, online-delivered Project ImPACT program for children with ASD and their parents in China during the COVID-19 pandemic. Methods: A pilot non-randomized study with a waitlist control group was conducted in 68 children with ASD and their parents in the Department of Developmental and Behavioral Pediatrics between April 15, 2020 and March 19, 2021. Participants were allocated to either the intervention (IG) or the waitlist group (WLG) according to their order of recruitment. Parents in the IG immediately received 8 weeks of the online-delivered Project ImPACT program, and the WLG received the same program with a delay when the IG had completed all sessions. Participants in both groups received treatment as usual during the research period. Results: The online-delivered Project ImPACT program significantly improved the parent-reported social communication skills of children with ASD. Furthermore, parent's involvement in the training program produced a collateral reduction in parenting stress and an increase in perceived competence in the parental role. Parents rated the program acceptable in terms of curriculum schedule, session content, homework assignments, and therapist feedback. Conclusions: The 8-week, online-delivered Project ImPACT program is a feasible and effective social skill training program for families of children with ASD in China during the COVID-19 pandemic. Due to the methodological limitations, randomized controlled studies with larger sample sizes are suggested to provide more solid evidence.

5.
Sage Open ; 12(1), 2022.
Article in English | ProQuest Central | ID: covidwho-1775287

ABSTRACT

Characterized with in-depth interactions and self-reflections, slow tourism has been gaining growing popularity in recent years thanks to the importance attached to quality of life and self-actualization of tourists in the post modern era, which has all been necessitated by the challenges wrought by the Covid-19 pandemic. In response to the current research lacuna of competitiveness analyses of specialized small-scale destinations, this study comprehensively proposes and empirically evaluates the competitiveness of slow tourism destinations as indicated by the values perceived by the slow tourists, and explores the mechanism of competitiveness of slow tourism destinations with investigation of the interrelationships between competitiveness and tourist attitude, consumption emotion and behavioral intentions through Structural Equation Modeling (SEM). The Gaochun District, which was the first accredited Cittàslow in China, was selected as the research site. Findings yielded four major competitiveness dimensions of community ambiance and service, tourist, and comprehensive management, cultural resources and values and natural resources and protection, and confirmed that perceived values are positively related to attitude, consumption emotion, and behavioral intentions. In addition to offering a valid scale measuring the competitiveness of slow tourism destinations, this study suggests the integration of cultural components in better planning and management of slow tourism destinations.

6.
EuropePMC; 2022.
Preprint in English | EuropePMC | ID: ppcovidwho-331563

ABSTRACT

The COVID-19 pandemic and its corresponding preventive and control measures have increased the mental burden on the public. Social media serve as important platforms to timely track public mental status. In this study, we conducted social-media-based analyses on temporal, geographical and occupational distributions of public mental health status during the pandemic, and how the public reacted to the lock-down policy from the perspective of mental health. We extracted 2,973,319 mental health-related tweets of 1,778,140 users from February 1, 2020 to September 30, 2021. We found that, compared to the general public, healthcare workers had higher concerns on three types of mental health problems (depression, insomnia, addiction) (P<0.001) and focused more on clinical topics while the public worried more about daily life issues. The lockdown policy in New York was correlated with a proportional decrease of mental health-related tweets, while Florida had an opposite correlation (both P<0.05). Our findings indicated that the mental burden brought by the pandemic varied across occupations and locations and changed over time.

7.
BMC Health Serv Res ; 22(1): 284, 2022 Mar 02.
Article in English | MEDLINE | ID: covidwho-1724482

ABSTRACT

BACKGROUND: The present study aimed 1) to examine the effects of epidemic-related job stressors, perceived social support and organizational support on the burnout and well-being of Chinese healthcare workers in the period of COVID-19 regular epidemic prevention and control and 2) to investigate the moderating effects of social support and organizational support on the relationship between job stressors and burnout and well-being within the theoretical framework of the Job Demands-Resources (JD-R) model. METHODS: A sample of healthcare workers (N = 3477) from 22 hospitals in Beijing, China participated in the cross-sectional investigation in October 2020 and reported epidemic-related job stressors, perceived social support, organizational support, burnout, anxiety and depression symptoms. RESULTS: 1) Medical doctors, females, people aged from 30 to 50, and those who worked in the second line during the pandemic reported higher scores of psychological symptoms and burnout in the period of regular epidemic prevention and control; 2) Epidemic-related job stressors positively predicted burnout, anxiety, and depression among healthcare workers; 3) Perceived social support and organizational support were negatively related to reported burnout, anxiety and depression symptoms; 4) Social support reduced the adverse effects of epidemic-related job stressors on anxiety and depression but enhanced the association between stressors and burnout; 5) Organizational support mitigated the adverse effects of epidemic-related job stressors on depression. CONCLUSION: The results shed light on preventing burnout and enhancing the psychological well-being of healthcare workers under epidemic prevention and control measures by reducing epidemic-related job stressors and strengthening personal and organizational support systems.


Subject(s)
Burnout, Professional , COVID-19 , Aged , Burnout, Professional/epidemiology , Burnout, Professional/psychology , Burnout, Psychological , COVID-19/epidemiology , Cross-Sectional Studies , Female , Health Personnel/psychology , Humans , Job Satisfaction , Pandemics , SARS-CoV-2 , Surveys and Questionnaires
8.
BMC Psychiatry ; 22(1): 156, 2022 03 01.
Article in English | MEDLINE | ID: covidwho-1724452

ABSTRACT

BACKGROUND: The outbreak of the COVID-19 pandemic has caused extensive public health concerns, posing significant challenges to healthcare services. One particular area of concern is the mental health of patients with mental disorder, who are often a neglected group. The aim of this study was to investigate the prevalence of, and associated factors for symptoms of post-traumatic stress disorder (PTSD) among patients with mental disorder in China during the COVID-19 pandemic. METHODS: Self-reported questionnaires were distributed to patients in four psychiatric hospitals in Beijing, China, between April 28th and May 30th, 2020. Information regarding sociodemographic characteristics, COVID-19 related factors, support, psychosomatic factors, and PTSD symptoms were collected using a series of scales, such as the Impact of Event Scale-Revised, the 7-item Generalized Anxiety Disorder Scale, the 9-item Patient Health Questionnaire depression scale, and so on. Multivariate regression was used to identify factors related to PTSD symptoms. RESULTS: A total of 1,055 patients with mental disorder were included in the final sample. The prevalence of PTSD symptoms was 41.3%. Hierarchical linear regression demonstrated that fear of the pandemic and anxiety were shared associated factors for both symptoms of PTSD and their subscales. Additionally, age was an associated factor for the total PTSD (ß = 0.12, p < 0.01), intrusion (ß = 0.18, p < 0.001), and avoidance (ß = 0.1, p < 0.05) symptoms; depression was an associated factor for the total PTSD (ß = 0.13, p < 0.001), intrusion (ß = 0.11, p < 0.01), and hyperarousal (ß = 0.19, p < 0.001) symptoms. CONCLUSIONS: The prevalence of PTSD symptoms was high among patients with mental disorder during the COVID-19 pandemic in China. This study found that age, fear of the pandemic, anxiety and depression are significant associated factors of PTSD symptoms in patients with mental disorder during the pandemic. We call for higher awareness and introduction of PTSD interventions to relieve the psychological stress in these patients.


Subject(s)
COVID-19 , Stress Disorders, Post-Traumatic , Anxiety/epidemiology , COVID-19/epidemiology , Cross-Sectional Studies , Depression/epidemiology , Humans , Pandemics , Prevalence , SARS-CoV-2 , Stress Disorders, Post-Traumatic/psychology
9.
Comput Methods Programs Biomed ; 218: 106715, 2022 May.
Article in English | MEDLINE | ID: covidwho-1702300

ABSTRACT

INTRODUCTION: Currently, several countries are facing severe public health and policy challenges when designing their COVID-19 screening strategy. A quantitative analysis of the potential impact that combing the Rapid Antigen Test (RAT; Wet screening) and digital checker (Dry screening) can have on the healthcare system is lacking. METHOD: We created a hypothetical COVID-19 cohort for the analysis. The population size was set as 10 million with three levels of disease prevalence (10%, 1%, or 0.1%) under the assumption that a positive test result will lead to quarantine. A digital checker and two RATs are used for analysis. We further hypothesized two scenarios: RAT only and RAT plus digital checker. We then calculated the number of quarantined in both scenarios and compared the two to understand the benefits of sequential coupling of a digital checker with a RAT. RESULT: Sequential coupling of the digital checker and RAT can significantly reduce the number of individuals quarantined to 0.95-1.33M, 0.86-1.29M, and 0.86-1.29M, respectively, under the three different prevalence levels. CONCLUSION: Sequential coupling of digital checker and RAT at a population level for COVID-19 positive test to reduce the number of people who require quarantine and alleviating stress on the overburdened healthcare systems during the COVID-19 pandemic.


Subject(s)
COVID-19 , COVID-19/epidemiology , Humans , Mass Screening , Pandemics/prevention & control , Quarantine , SARS-CoV-2
10.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-324688

ABSTRACT

Background: There is an increased global outbreak of diseases caused by coronaviruses affecting respiratory tracts of birds and mammals. Recent particularly dangerous coronaviruses are MERS-CoV, SARS-CoV and SARS-CoV-2, causing respiratory illness and even failure of several organs. However, profound impact of coronavirus on host cells remains elusive. Results: : Here, we go deep into transcriptome of MERS-CoV, SARS-CoV and SARS-CoV-2 infected human lung-derived cells, and observed that infection of these coronaviruses all induced increase of retrotransposon expression through upregulation of TET genes. Similar upregulation of retrotransposon was also observed in SARS-CoV-2 infected human intestinal organoids. Retrotransposon upregulation will lead to increased genome instability and more frequent readthrough from retrotransposon to dysregulate gene expression. People with higher basal level of retrotransposon like cancer patients and aged people will have increased risk of symptomatic infection. Additionally, we show evidence supporting long-term epigenetic inheritance of retrotransposon upregulation. We also observed significant amount of chimeric transcripts of retrotransposon and SARS-CoV-2 RNA for potential human genome invasion of viral fragments, with the front and the rear part of SARS-CoV-2 genome being easier to form chimeric RNA, and this may apply for other coronaviruses. Here we suggest that primers and probes for nucleic acid detection should be designed in the middle of virus genome to identify live virus with higher probability. Conclusions: : In summary, we propose that infection of coronaviruses especially SARS-CoV-2 induce retrotransposon activation, formation of chimeric coronavirus-retrotransposon RNA, and elicits more severe symptoms in patients with underlying diseases. More attention may need to be paid to potential harm contributed by retrotransposon dysregulation in treatment of coronavirus-infected patients.

11.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-315674

ABSTRACT

Objective: ACE2, TMPRSS2 and NRP1 are key factors for SARS-CoV-2 infection. Here, we used immunofluorescence to examine the expression patterns of ACE2, TMPRSS2 and NRP1 in human oocytes and different stages of preimplantation embryos to investigated the susceptibility to be infected by SARS-CoV-2.Methods We collected human GV oocytes and different stages of early embryos donated by patients and then performed immunofluorescence followed by confocal microscopy for signals of ACE2, TMPRSS2 and NRP1 proteins in these oocytes and embryos.Results We found that ACE2 was abundant in both inner cell mass and trophectoderm at blastocyst stage, while TMPRSS2 was mainly enriched in trophectoderm. Both of the two factors had faint signal in cleavage embryos and oocytes. In contrast, NRP1 was barely detectable in oocytes or any stage of early embryos. Conclusion Taken together, we propose that human blastocysts, instead of human oocytes and other stages of early embryos, are susceptible to be infected by SARS-CoV-2. Therefore, specific attention should be paid to manipulation of human blastocysts in assisted reproductive technology.

12.
EuropePMC;
Preprint in English | EuropePMC | ID: ppcovidwho-327593

ABSTRACT

Advanced mRNA vaccines play vital roles against SARS-CoV-2. However, due to the poor stability, most current mRNA delivery platforms need to be stored at -20 °C or -70 °C. Here we present lyophilized thermostable mRNA loaded lipid nanoparticles, which could be stored at room temperature with long-term stability. We demonstrate the applicability of lyophilization techniques to different mRNA sequences and lipid components. Three lyophilized vaccines targeting wild-type, Delta and Omicron SARS-CoV-2 variant were prepared and demonstrated to be able induce high-level of IgG titer and neutralization response. In the Delta challenge in vivo experiment, the lyophilized mRNA vaccine successfully protected the mice from infection and clear the virus. This lyophilization platform could significantly improve the accessibility of mRNA vaccine or therapeutics, particularly in remote regions.

13.
EuropePMC;
Preprint in English | EuropePMC | ID: ppcovidwho-327273

ABSTRACT

Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop less severe coronavirus disease 2019 (COVID-19) than adults. The mechanisms for the age-specific differences and the implications for infection-induced immunity are beginning to be uncovered. We show by longitudinal multimodal analysis that SARS-CoV-2 leaves a small footprint in the circulating T cell compartment in children with mild/asymptomatic COVID-19 compared to adult household contacts with the same disease severity who had more evidence of systemic T cell interferon activation, cytotoxicity and exhaustion. Children harbored diverse polyclonal SARS-CoV-2-specific naive T cells whereas adults harbored clonally expanded SARS-CoV-2-specific memory T cells. More naive interferon-activated CD4+ T cells were recruited into the memory compartment and recovery was associated with the development of robust CD4+ memory T cell responses in adults but not children. These data suggest that rapid clearance of SARS-CoV-2 in children may compromise their cellular immunity and ability to resist reinfection.

14.
Front Public Health ; 9: 757113, 2021.
Article in English | MEDLINE | ID: covidwho-1648939

ABSTRACT

Background: To investigate the prevalence of burnout syndrome among Chinese female nurses during the controlled coronavirus disease 2019 (COVID-19) period and explore its associated socio-demographic factors and job characteristics. Methods: With the multistage, stratified sampling method, a cross-sectional online survey was conducted from September to October 2020 in China. The survey tool included revised Maslach Burnout Inventory (MBI) with 15 items, socio-demographic and job characteristics. Univariate logistic regression analysis and multivariate factor logistic regression analysis were used to identify the risk factors for burnout of female nurses. Results: During controlled COVID-19 period in China, the overall prevalence of burnout symptoms among Chinese female nurses was 60.2% with a breakdown in severity as follows: 451 (39.8 %) mild, 163 (14.4%) moderate, and 68 (6.0%) severe burnout. Little variance was reported for burnout symptoms according to job tenure (Waldχ 2 = 14.828, P < 0.05,odds ratio [OR] <1), monthly salary income (Waldχ 2 = 12.460, P < 0.05, OR <1), and night shift (Waldχ 2 = 3.821, P < 0.05, OR > 1). Conclusion: Burnout symptoms among Chinese female nurses were prevalent and associated with job tenure, monthly salary income, and night shift. Female nurses who were with shorter job tenure, worked at night shifts, and had lower monthly salaries tended to exhibit increasing high-level burnout than their counterparts. This study serves as an implication for administrators and policy-makers to improve the work conditions of nurses for promoting overall healthcare service quality.


Subject(s)
Burnout, Professional , COVID-19 , Burnout, Professional/epidemiology , Burnout, Psychological , Cross-Sectional Studies , Female , Humans , Prevalence , SARS-CoV-2
15.
Emerg Microbes Infect ; 11(1): 567-572, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-1642256

ABSTRACT

Global concern has been raised by the emergence and rapid transmission of the heavily mutated SARS-CoV-2 Omicron variant (B.1.1.529). So far, the infection features and immune escape ability of the Omicron variant have not been extensively studied. Here, we produced the Omicron pseudovirus and compared its entry, membrane fusion, and immune escape efficiency with the original strain and the dominating Delta variant. We found the Omicron variant showed slightly higher infectivity than the Delta variant and a similar ability to compete with the Delta variant in using Angiotensin-converting enzyme 2 (ACE2) in a BHK21-ACE2 cell line. However, the Omicron showed a significantly reduced fusogenicity than the original strain and the Delta variant in both BHK21-ACE2 and Vero-E6 cells. The neutralization assay testing the Wuhan convalescents' sera one-year post-infection showed a more dramatic reduction (10.15 fold) of neutralization against the Omicron variant than the Delta variant (1.79 fold) compared with the original strain with D614G. Notably, immune-boosting through three vaccine shots significantly improved the convalescents' immunity against the Omicron variants. Our results reveal a reduced fusogenicity and a striking immune escape ability of the Omicron variant, highlighting the importance of booster shots against the challenge of the SARS-CoV-2 antigenic drift.


Subject(s)
COVID-19 , SARS-CoV-2/immunology , Animals , COVID-19/immunology , Chlorocebus aethiops , Humans , Immune Evasion , Immunization, Secondary , Vero Cells
16.
Cell Mol Immunol ; 19(2): 210-221, 2022 02.
Article in English | MEDLINE | ID: covidwho-1608557

ABSTRACT

Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy. Here, we show that ACE2-overexpressing A549 cell-derived microparticles (AO-MPs) are a potential therapeutic agent against SARS-CoV-2 infection. Intranasally administered AO-MPs dexterously navigate the anatomical and biological features of the lungs to enter the alveoli and are taken up by alveolar macrophages (AMs). Then, AO-MPs increase the endosomal pH but decrease the lysosomal pH in AMs, thus escorting bound SARS-CoV-2 from phago-endosomes to lysosomes for degradation. This pH regulation is attributable to oxidized cholesterol, which is enriched in AO-MPs and translocated to endosomal membranes, thus interfering with proton pumps and impairing endosomal acidification. In addition to promoting viral degradation, AO-MPs also inhibit the proinflammatory phenotype of AMs, leading to increased treatment efficacy in a SARS-CoV-2-infected mouse model without side effects. These findings highlight the potential use of AO-MPs to treat SARS-CoV-2-infected patients and showcase the feasibility of MP therapies for combatting emerging respiratory viruses in the future.


Subject(s)
Angiotensin-Converting Enzyme 2/administration & dosage , Angiotensin-Converting Enzyme 2/metabolism , COVID-19/metabolism , COVID-19/therapy , Cell- and Tissue-Based Therapy/methods , Cell-Derived Microparticles/metabolism , Cholesterol/metabolism , Endosomes/chemistry , Macrophages, Alveolar/metabolism , SARS-CoV-2/metabolism , A549 Cells , Angiotensin-Converting Enzyme 2/genetics , Animals , COVID-19/virology , Chlorocebus aethiops , Disease Models, Animal , Female , Humans , Hydrogen-Ion Concentration , Lysosomes/chemistry , Mice , Mice, Inbred ICR , Mice, Transgenic , Oxidation-Reduction , RAW 264.7 Cells , Treatment Outcome , Vero Cells
17.
Innovation (N Y) ; 3(1): 100181, 2022 Jan 25.
Article in English | MEDLINE | ID: covidwho-1595417

ABSTRACT

Most COVID-19 convalescents can build effective anti-SARS-CoV-2 humoral immunity, but it remains unclear how long it can maintain and how efficiently it can prevent the reinfection of the emerging SARS-CoV-2 variants. Here, we tested the sera from 248 COVID-19 convalescents around 1 year post-infection in Wuhan, the earliest known epicenter. SARS-CoV-2 immunoglobulin G (IgG) was well maintained in most patients and potently neutralizes the infection of the original strain and the B.1.1.7 variant. However, varying degrees of immune escape was observed on the other tested variants in a patient-specific manner, with individuals showing remarkably broad neutralization potency. The immune escape can be largely attributed to several critical spike mutations. These results suggest that SARS-CoV-2 can elicit long-lasting immunity but this is escaped by the emerging variants.

19.
Chin J Nat Med ; 19(9): 693-699, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1576003

ABSTRACT

A chemical investigation on the fermentation products of Sanghuangporus sanghuang led to the isolation and identification of fourteen secondary metabolites (1-14) including eight sesquiterpenoids (1-8) and six polyphenols (9-14). Compounds 1-3 were sesquiterpenes with new structures which were elucidated based on NMR spectroscopy, high resolution mass spectrometry (HRMS) and electronic circular dichroism (ECD) data. All the isolates were tested for their stimulation effects on glucose uptake in insulin-resistant HepG2 cells, and cellular antioxidant activity. Compounds 9-12 were subjected to molecular docking experiment to primarily evaluate their anti-coronavirus (SARS-CoV-2) activity. As a result, compounds 9-12 were found to increase the glucose uptake of insulin-resistant HepG2 cells by 18.1%, 62.7%, 33.7% and 21.4% at the dose of 50 µmol·L-1, respectively. Compounds 9-12 also showed good cellular antioxidant activities with CAA50 values of 12.23, 23.11, 5.31 and 16.04 µmol·L-1, respectively. Molecular docking between COVID-19 Mpro and compounds 9-12 indicated potential SARS-CoV-2 inhibitory activity of these four compounds. This work provides new insights for the potential role of the medicinal mushroom S. sanghuang as drugs and functional foods.


Subject(s)
Agaricales , COVID-19 , Polyphenols , Sesquiterpenes , Antioxidants/pharmacology , Basidiomycota , COVID-19/drug therapy , Glucose , Humans , Molecular Docking Simulation , Polyphenols/pharmacology , SARS-CoV-2 , Sesquiterpenes/pharmacology
20.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-296121

ABSTRACT

Background: The outbreak of the COVID-19 pandemic has caused extensive public health concerns, posing significant challenges to healthcare services. One particular area of concern is the mental health of psychiatric patients, who are often a neglected group. The aim of this study was to investigate the prevalence of, and associated factors for symptoms of post-traumatic stress disorder (PTSD) among psychiatric patients in China during the COVID-19 pandemic. Methods: : Self-reported questionnaires were distributed to patients in four psychiatric hospitals in Beijing, China, between April 28 th and May 30 th , 2020. Information regarding sociodemographic characteristics, COVID-19 related factors, support, psychosomatic factors, and PTSD symptoms was collected data using a series of scales, such as the Impact of Event Scale-Revised, the 7-item Generalized Anxiety Disorder Scale, the 9-item Patient Health Questionnaire depression scale, and so on. Multivariate regression was used to identify factors related to PTSD symptoms. Results: : A total of 1,055 psychiatric patients were included in the final sample. The prevalence of PTSD symptoms was 41.3%. Hierarchical linear regression demonstrated that fear of the pandemic and anxiety were shared associated factors for both symptoms of PTSD and its subscales. Additionally, age was an associated factor for the total PTSD ( β = 0.12, p < 0.01), intrusion ( β = 0.18, p < 0.001), and avoidance ( β = 0.1, p < 0.05) symptoms;depression was an associated factor for the total PTSD s ( β = 0.13, p < 0.001), intrusion ( β = 0.11, p < 0.01), and hyperarousal ( β = 0.19, p < 0.001) symptoms. Conclusions: : The prevalence of PTSD symptoms was high among psychiatric patients during the COVID-19 pandemic in China. This study found that age, fear of the pandemic, anxiety and depression are significant associated factors of PTSD symptoms in psychiatric patients during the pandemic. We call for higher awareness and introduction of PTSD interventions to relieve the psychological stress in these patients.

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