Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 36
Filter
1.
EuropePMC; 2022.
Preprint in English | EuropePMC | ID: ppcovidwho-331896

ABSTRACT

Background: China's economic structure is changing from labor-intensive to technology-intensive due to the emergence of low fertility and the increasingly serious aging problem, so it is of great importance to improve the health status of the working age population. Meanwhile, with the accelerated integration of digital technology and real economy, the Internet has increasingly become an important driving force for economic growth and social development in China and has also played a big role in health care, especially under the COVID-19. Therefore, it is worth further exploring how Internet use affects the health of the working age population. Method We used data from China Family Panel Studies (CFPS) in 2018 and applied the Ordered-Probit model to study the relationship between Internet use and the health status of working age population Results The Internet use was significantly and positively related to the health status of the working age population;there was an inverted U-shaped relationship between the intensity of Internet use and individual health;the Internet use affected individual health through information acquisition. The heterogeneity analysis showed that the health promotion of Internet use was stronger for people aged from 32 to 50 years old/ in rural areas/ at low education level/ in the eastern region. Further analysis showed that the Internet use can reduce health inequalities caused by different levels of socioeconomic status. Conclusions Internet, as an information media, has a significantly positive impact on individual health, but excessive use is not conducive to the improvement of health status. However, due to the large base of netizens in China and the unbalanced development among regions, Internet use can have a differential impact on the health status of different groups. In addition, the Internet enhances the accessibility of health care knowledge and compensates for the lack of access to information for low socioeconomic groups, thus improving their health status and reduce health inequalities among different classes.

2.
J Infect Dis ; 2022 Jan 29.
Article in English | MEDLINE | ID: covidwho-1758749

ABSTRACT

BACKGROUND: A protective SARS-COV-2 (SARS2) antibody response is crucial to decrease morbidity and mortality from severe COVID-19 disease and for vaccine efficacy. The effects of pre-existing anti-human coronavirus (HCoV) antibodies on the SARS2-specific IgG responses and severity of disease are currently unclear. METHODS: We profiled anti-spike (S), S1, S2, RBD IgG antibodies against SARS2 and six HCoVs using a multiplex assay (mPLEX-CoV) with serum samples from SARS2 infection (155 patients) and pre-COVID-19 (188 subjects) cohorts. RESULTS: Anti-S SARS2 IgG levels were significantly increased and highly correlated with IgG antibodies that recognized OC43 and HKU1 S proteins in COVID-19 patients. However, OC43 and HKU1 anti-S antibodies in sera collected pre-COVID-19 did not cross-react to SARS2 S. Moreover, these "uni-directional" cross-reactive antibodies elicited by the SARS2 infection were distinct from the "bi-directional" cross-reactive antibodies that recognized the homologous antigen strains, RaTG13 and SARS-CoV-1 (SARS1). Notably, high OC43 and anti-S2 antibodies were associated with a rapid and robust anti-SARS2 antibody response and increased disease severity. In addition, a higher ratio of S2/S1-reactive antibodies developed over time in severe ICU patients. CONCLUSIONS: Our study suggested that early and rapid OC43 S- and S2-reactive antibodies emerging after SARS2 infection may correlate with COVID-19 disease severity.

3.
EuropePMC; 2022.
Preprint in English | EuropePMC | ID: ppcovidwho-330355

ABSTRACT

It is currently unclear if SARS-CoV-2 infection or mRNA vaccination can also induce IgG and IgA against common human coronaviruses (HCoVs) in lactating parents. Here we prospectively analyzed human milk (HM) and blood samples from lactating parents to measure the temporal patterns of anti-SARS-CoV-2 specific and anti-HCoV cross-reactive IgA and IgG responses. Two cohorts were analyzed: a vaccination cohort (n=30) who received mRNA-based vaccines for COVID-19 (mRNA-1273 or BNT162b2), and an infection cohort (n=45) with COVID-19 disease. Longitudinal HM and fingerstick blood samples were collected pre- and post-vaccination or, for infected subjects, at 5 time-points 14 - 28 days after confirmed diagnosis. The anti-spike(S) and anti-nucleocapsid(N) IgA and IgG antibody levels against SARS-CoV-2 and HCoVs were measured by multiplex immunoassay (mPlex-CoV). We found that vaccination significantly increased the anti-S IgA and IgG levels in HM. In contrast, while IgG levels increased after a second vaccine dose, blood and HM IgA started to decrease. Moreover, HM and blood anti-S IgG levels were significantly correlated, but anti-S IgA levels were not. SARS2 acute infection elicited anti-S IgG and IgA that showed much higher correlations between HM and blood compared to vaccination. Vaccination and infection were able to significantly increase the broadly cross-reactive IgG recognizing HCoVs in HM and blood than the IgA antibodies in HM and blood. In addition, the broader cross-reactivity of IgG in HM versus blood indicates that COVID-19 vaccination and infection might provide passive immunity through HM for the breastfed infants not only against SARS-CoV-2 but also against common cold coronaviruses.

4.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-315220

ABSTRACT

The outbreak of the novel SARS-CoV-2 has swiftly spread worldwide. Rapid genome sequencing of the SARS-CoV-2 strains has become a helpful tool for better understanding of virus genomic characteristics and the origin. To obtain the virus whole-genome sequence directly from the clinical specimens, we performed the nanopore sequencing using a modified ARTIC protocol on portable nanopore sequencer, and validated the routine 8 hours workflow and 5 hours rapid pipeline. We had made some optimizations to improve the genome sequencing workflow. The sensitivity of the workflow was also tested by serially diluting RNA from clinical samples. The optimized pipeline was finally applied to obtain the whole genomes from 17 clinical specimens in Hangzhou from January 2020 to March 2020. In the obtained 17 complete genomes of SARS-CoV-2, 12 variations were found and analyzed. The genomic variations and phylogenetic analysis hinted the multiple sources and different transmission pattern during the COVID-19 epidemic in Hangzhou, China. In conclusion, the genomic characteristics and the origin of the virus could be quickly determined by nanopore sequencing following our workflows.

5.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-325363

ABSTRACT

Background: Appropriate hand hygiene behavior is much crucial during COVID-19 pandemic, which is influenced by workload, mental health and professional quality of life. The increasing workload, worse mental health and negative professional quality of life are severe challenges for healthcare workers, whereas the evidence of mechanism between them and hand hygiene behavior are limited. This study aimed to understand and model how HCWs’ hand hygiene behaviors were influenced by workload, mental health and professional quality of life. Methods: A total of 1,734 healthcare workers were investigated, covering self-reported hand hygiene behavior, mental health, workload, professional quality of life and socio-demographic characteristics. Structural equation modelling was conducted to confirm interrelationships and parameters among the variables. Findings: The final model had a good fit (CFI=0.980;TLI=0.941;RMSEA=0.055). Higher workload was linked to worse mental health (β = 0.165, p < 0.001) and higher burnout (β = 0.183, p < 0.001). Worse mental health was linked to higher burnout (β = 0.339, p < 0.001). The higher burnout was associated with worse self-reported hand hygiene behavior (β = -0.302, p < 0.001). Conclusion: Workload is positively associated with mental health and burnout;mental health is positively related to burnout;burnout is negatively associated with hand hygiene behavior. Thus, hand hygiene behavior can be promoted by the strategy to decrease the workload, burnout and enhance mental health.

6.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-325361

ABSTRACT

Background: Healthcare workers suffered mental burden, especially in the period of COVID-19. Professional quality of life quality is suitable to measure how healthcare workers feel in medical aid team. Current evidence of impact of professional quality of life on hand hygiene behavior or even IPC measures was limited, especially in emerging infectious disease period. This study aimed to assess the prevalence of burnout, secondary traumatic stress and compassion satisfaction and explore their impact on self-reported hand hygiene behavior among medical aid team in Wuhan, China, where strict management was conducted to prevent COVID-19 spread and guarantee healthcare workers’ health. Results A cross-sectional study was conducted using online questionnaire covering professional quality of life and self-reported hand hygiene behavior based on COVID-19 guideline. A total of 1,734 healthcare workers were surveyed. The prevalence of burnout, secondary trauma and compassion satisfaction were low and average levels (69.61 and 30.39%), low and average levels (33.33 and 66.21%), average and high levels (49.65 and 49.71%), respectively. Burnout was negatively associated with overall hand hygiene (Coef. =-0.088, p<0.001), low hand hygiene (Coef. =-0.109, p<0.001), medium hand hygiene (Coef. =-0.088, p<0.001) and high hand hygiene (Coef. =-0.065, p<0.001). Conclusions Healthcare workers with higher compassion satisfaction reported higher hand hygiene compared to the lower. Healthcare workers in medical aid team experience lower level burnout, and higher level of compassion satisfaction during COVID-19 pandemic compared to the general period. The lower burnout and higher compassion satisfaction are associated with higher self-reported hand hygiene behavior. Burnout and compassion satisfaction in healthcare workers should be emphasize and need interventions targeting. The management of healthcare workers in Wuhan, China may be constructive for the future medical aid team.

7.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-323805

ABSTRACT

Background: Coronavirus disease 2019 is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is highly transmissible. Early and rapid testing is necessary to effectively prevent and control the outbreak. Detection of SARS-CoV-2 antibodies with lateral flow immunoassay can achieve this goal. Antibody detection is especially effective for the detection of asymptomatic infection. Methods: In this study, SARS-CoV-2 nucleoprotein was expressed by E. coli and purified by affinity chromatography. We used the highly stable and sensitive selenium nanoparticle as the labeling probe coupled with the SARS-CoV-2 nucleoprotein to prepare a new SARS-CoV-2 antibody (IgM and IgG) detection kit. The sensitivity and specificity of the kit were verified by plasma of COVID-19 patients and health persons. Separate detection of IgM and IgG, such as in this assay, was performed in order to reduce mutual interference and improve the accuracy of the test results. Results: The SARS-CoV-2 nucleoprotein was purified on a nickel column, and the final purity was greater than 90%. The sensitivity of the kit was 94.74% and the specificity was 95.12% by 41 negative plasma samples and 19 positive plasma samples detection. Conclusions: The assay kit does not require any special device for reading the results and the readout is a simple color change that can be evaluated with the naked eye. This kit is suitable for rapid and real-time detection of the SARS-CoV-2 antibody.

8.
Pathogens ; 11(2)2022 Jan 29.
Article in English | MEDLINE | ID: covidwho-1667262

ABSTRACT

Infection with the ß-coronavirus SARS-CoV-2 typically generates strong virus-specific antibody production. Antibody responses against novel features of SARS-CoV-2 proteins require naïve B cell activation, but there is a growing appreciation that conserved regions are recognized by pre-existing memory B cells (MBCs) generated by endemic coronaviruses. The current study investigated the role of pre-existing cross-reactive coronavirus memory in the antibody response to the viral spike (S) and nucleocapsid (N) proteins following SARS-CoV-2 infection. The breadth of reactivity of circulating antibodies, plasmablasts, and MBCs was analyzed. Acutely infected subjects generated strong IgG responses to the S protein, including the novel receptor binding domain, the conserved S2 region, and to the N protein. The response included reactivity to the S of endemic ß-coronaviruses and, interestingly, to the N of an endemic α-coronavirus. Both mild and severe infection expanded IgG MBC populations reactive to the S of SARS-CoV-2 and endemic ß-coronaviruses. Avidity of S-reactive IgG antibodies and MBCs increased after infection. Overall, findings indicate that the response to the S and N of SARS-CoV-2 involves pre-existing MBC activation and adaptation to novel features of the proteins, along with the potential of imprinting to shape the response to SARS-CoV-2 infection.

9.
Cell Discov ; 8(1): 10, 2022 Feb 01.
Article in English | MEDLINE | ID: covidwho-1661960

ABSTRACT

SARS-CoV-2 inactivated vaccines have shown remarkable efficacy in clinical trials, especially in reducing severe illness and casualty. However, the waning of humoral immunity over time has raised concern over the durability of immune memory following vaccination. Thus, we conducted a nonrandomized trial among the healthcare workers (HCWs) to investigate the long-term sustainability of SARS-CoV-2-specific B cells and T cells stimulated by inactivated vaccines and the potential need for a third booster dose. Although neutralizing antibodies elicited by the standard two-dose vaccination schedule dropped from a peak of 29.3 arbitrary units (AU)/mL to 8.8 AU/mL 5 months after the second vaccination, spike-specific memory B and T cells were still detectable, forming the basis for a quick recall response. As expected, the faded humoral immune response was vigorously elevated to 63.6 AU/mL by 7.2 folds 1 week after the third dose along with abundant spike-specific circulating follicular helper T cells in parallel. Meanwhile, spike-specific CD4+ and CD8+ T cells were also robustly elevated by 5.9 and 2.7 folds respectively. Robust expansion of memory pools by the third dose potentiated greater durability of protective immune responses. Another key finding in this trial was that HCWs with low serological response to two doses were not truly "non-responders" but fully equipped with immune memory that could be quickly recalled by a third dose even 5 months after the second vaccination. Collectively, these data provide insights into the generation of long-term immunological memory by the inactivated vaccine, which could be rapidly recalled and further boosted by a third dose.

10.
Vaccines (Basel) ; 9(12)2021 Nov 25.
Article in English | MEDLINE | ID: covidwho-1542824

ABSTRACT

The outbreak of coronavirus disease 2019 (COVID-19) has led to numerous tragic deaths all over the world. Great efforts have been made by worldwide nations for COVID-19 targeted vaccine development since the disease outbreak. In January 2021, the Chinese government started to provide free vaccination among nationwide communities, which was optional for citizens. As no evidence has been provided so far regarding COVID-19 vaccination acceptance since the initiation of nationwide vaccination, this study aims to investigate COVID-19 vaccination acceptance among Chinese citizens as well as its associated factors as an attempt to bridge such gap embedded in the current literature. An anonymous cross-sectional study was conducted online in March and April 2021 among adults, with the survey questionnaire designed based on the framework of the health belief model (HBM). Information on socio-demographics, risk perception, past pandemic-related experience, awareness of vaccination as well as acceptance of COVID-19 vaccination were collected. Chi-squared test and multi-level regression were performed to distinguish the acceptance between different groups as well as to identify the significant predictors. A total of 3940 participants completed the survey, with 90.6% of the participants reporting strong willingness to get vaccinated. A list of factors were found to be significantly associated with individuals' acceptance of vaccination, including the region of residence, ethnicity, annual income, whether or not they had experienced a major pandemic event in the past, risk perception of the COVID-19 as well as the awareness of receiving vaccination. Safety concerns about the vaccine (27.7%), concerns about receiving vaccination immediately after newly developed vaccines were released into the market (22.4%) as well as concerns about the potential side effects induced by vaccination (22.1%) were identified as the primary reasons of residents' resistance against vaccination. Overall, residents demonstrated strong willingness to receive vaccination against COVID-19 in China. However, the improvement of vaccination-related knowledge among Chinese residents should be highlighted as a critical strategy to facilitate the penetration of nationwide vaccination in order to ultimately achieve the establishment of herd immunity in China.

11.
Front Public Health ; 9: 758529, 2021.
Article in English | MEDLINE | ID: covidwho-1518578

ABSTRACT

Objective: Public trust in physicians and public health literacy (HL) are important factors that ensure the effectiveness of health-care delivery, particularly that provided during the SARS-CoV-2 pandemic. This study investigates HL as a predictor of public trust in physicians in China's ongoing efforts to control COVID-19. Methods: Data were gathered in February 2020 during the peak of the disease in China. Based on Nutbeam's conceptualization of HL, we measure HL vis-à-vis COVID-19 by using a six-item scale that includes two items each for functional, interactive, and critical HL. Trust in physicians was measured by assessing physicians' capability to diagnose COVID-19. A rank-sum test and ordinal logit regression modeling were used to analyze the data. Results: Two key findings: (a) trust in physician handling of treatment for COVID-19 is reported by about 74% of respondents; and (b) five of the six HL measures are positive predictors of public trust in physician treatment of the disease, with functional HL1 having the highest level of such association (coefficient 0.285, odds ratio 1.33%, p < 0.01). Conclusions: Improving public HL is important for better public-physician relationships, as well as for nations' efforts to contain the pandemic, serving as a possible behavioral, non-clinical antidote to COVID-19. Being confronted with the unprecedented virus, humans need trust. Health education and risk communication can improve public compliance with physicians' requirements and build a solid foundation for collective responses.


Subject(s)
COVID-19 , Health Literacy , Physicians , China/epidemiology , Cross-Sectional Studies , Humans , SARS-CoV-2 , Trust
12.
Front Immunol ; 12: 733418, 2021.
Article in English | MEDLINE | ID: covidwho-1450812

ABSTRACT

Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and abnormal fatigability due to the antibodies against postsynaptic receptors. Despite the individual discrepancy, patients with MG share common muscle weakness, autoimmune dysfunction, and immunosuppressive treatment, which predispose them to infections that can trigger or exacerbate MG. Vaccination, as a mainstay of prophylaxis, is a major management strategy. However, the past years have seen growth in vaccine hesitancy, owing to safety and efficacy concerns. Ironically, vaccines, serving as an essential and effective means of defense, may induce similar immune cross-reactivity to what they are meant to prevent. Herein, we outline the progress in vaccination, review the current status, and postulate the clinical association among MG, vaccination, and immunosuppression. We also address safety and efficacy concerns of vaccination in MG, in relation to COVID-19. Since only a handful of studies have reported vaccination in individuals with MG, we further review the current clinical studies and guidelines in rheumatic diseases. Overall, our reviews offer a reference to guide future vaccine clinical decision-making and improve the management of MG patients.


Subject(s)
COVID-19 Vaccines/adverse effects , COVID-19 Vaccines/immunology , COVID-19/prevention & control , Myasthenia Gravis/immunology , Myasthenia Gravis/pathology , SARS-CoV-2/immunology , Autoimmunity/immunology , Humans , Immune Tolerance/immunology , Influenza Vaccines/immunology , Risk , Vaccination/adverse effects
13.
Int J Environ Res Public Health ; 18(19)2021 09 28.
Article in English | MEDLINE | ID: covidwho-1444195

ABSTRACT

The outbreak of COVID-19 has prompted consideration of the importance of urban resilience. Based on a multidimensional perspective, the authors of this paper established a comprehensive evaluation indicator system for evaluating urban resilience in the Yellow River basin (YRB), and various methods such as the entropy value method, Theil index, exploratory spatial data analysis (ESDA) model, and geographical detector model were used to measure the spatiotemporal characteristics and influencing factors of urban resilience in the YRB from 2011 to 2018. The results are as follows. (1) From 2011 to 2018, the urban resilience index (URI) of the YRB showed a "V"-shaped dynamic evolution in the time series, and the URI increased by 13.4% overall. The resilience of each subsystem showed the following hierarchical structure: economic resilience > social resilience > ecological resilience > infrastructure resilience. (2) The URI of the three major regions-upstream, midstream, and downstream-increased, and the resilience of each subsystem in the region showed obvious regional characteristics. The comprehensive difference in URI values within the basin was found to be shrinking, and intraregional differences have contributed most to the comprehensive difference. (3) There were obvious zonal differences in the URI from 2011 to 2018. Shandong Peninsula and Hohhot-Baotou-Ordos showed a "High-High" agglomeration, while the southern and southwestern regions showed a "Low-Low" agglomeration. (4) Among the humanist and social factors, economic, fiscal, market, urbanization, openness, and innovation were found to be the factors that exert a high impact on the URI, while the impacts of natural factors were found to be low. The impact of the interaction of each factor is greater than that of a single factor.


Subject(s)
COVID-19 , China , Economic Development , Humans , Rivers , SARS-CoV-2 , Urbanization
15.
Front Immunol ; 12: 696370, 2021.
Article in English | MEDLINE | ID: covidwho-1357528

ABSTRACT

The COVID-19 pandemic is caused by SARS-CoV-2, a novel zoonotic coronavirus. Emerging evidence indicates that preexisting humoral immunity against other seasonal human coronaviruses (HCoVs) plays a critical role in the specific antibody response to SARS-CoV-2. However, current work to assess the effects of preexisting and cross-reactive anti-HCoVs antibodies has been limited. To address this issue, we have adapted our previously reported multiplex assay to simultaneously and quantitatively measure anti-HCoV antibodies. The full mPlex-CoV panel covers the spike (S) and nucleocapsid (N) proteins of three highly pathogenic HCoVs (SARS-CoV-1, SARS-CoV-2, MERS) and four human seasonal strains (OC43, HKU1, NL63, 229E). Combining this assay with volumetric absorptive microsampling (VAMS), we measured the anti-HCoV IgG, IgA, and IgM antibodies in fingerstick blood samples. The results demonstrate that the mPlex-CoV assay has high specificity and sensitivity. It can detect strain-specific anti-HCoV antibodies down to 0.1 ng/ml with 4 log assay range and with low intra- and inter-assay coefficients of variation (%CV). We also estimate multiple strain HCoVs IgG, IgA and IgM concentration in VAMS samples in three categories of subjects: pre-COVID-19 (n=21), post-COVID-19 convalescents (n=19), and COVID-19 vaccine recipients (n=14). Using metric multidimensional scaling (MDS) analysis, HCoVs IgG concentrations in fingerstick blood samples were well separated between the pre-COVID-19, post-COVID-19 convalescents, and COVID-19 vaccine recipients. In addition, we demonstrate how multi-dimensional scaling analysis can be used to visualize IgG mediated antibody immunity against multiple human coronaviruses. We conclude that the combination of VAMS and the mPlex-Cov assay is well suited to performing remote study sample collection under pandemic conditions to monitor HCoVs antibody responses in population studies.


Subject(s)
Antibodies, Viral/blood , Coronavirus/immunology , Cross Reactions/immunology , Immunoassay/methods , Antibodies, Viral/immunology , Betacoronavirus/immunology , COVID-19/immunology , Coronavirus 229E, Human/immunology , Coronavirus NL63, Human/immunology , Coronavirus Nucleocapsid Proteins/immunology , Coronavirus OC43, Human/immunology , Humans , Immunoglobulin A/blood , Immunoglobulin A/immunology , Immunoglobulin G/blood , Immunoglobulin G/immunology , Immunoglobulin M/blood , Immunoglobulin M/immunology , SARS Virus/immunology , SARS-CoV-2/immunology , Spike Glycoprotein, Coronavirus/immunology
16.
Magn Reson Lett ; 1(1): 2-10, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1347764

ABSTRACT

The ongoing pandemic of coronavirus disease 2019 (COVID-19) has been a great burden for the healthcare system in many countries because of its high transmissibility, severity, and fatality. Chest radiography and computed tomography (CT) play a vital role in the diagnosis, detection of complications, and prognostication of COVID-19. Additionally, magnetic resonance imaging (MRI), especially multi-nuclei MRI, is another important imaging technique for disease diagnosis because of its good soft tissue contrast and the ability to conduct structural and functional imaging, which has also been used to evaluate COVID-19-related organ injuries in previous studies. Herein, we briefly reviewed the recent research on multi-nuclei MRI for evaluating injuries caused by COVID-19 and the clinical 1H MRI techniques and their applications for assessing injuries in lungs, brain, and heart. Moreover, the emerging hyperpolarized 129Xe gas MRI and its applications in the evaluation of pulmonary structures and functional abnormalities caused by COVID-19 were also reviewed.

17.
Arch Public Health ; 79(1): 118, 2021 Jun 30.
Article in English | MEDLINE | ID: covidwho-1286838

ABSTRACT

BACKGROUND: Infection prevention and control (IPC) measures are crucial to combat the COVID-19 pandemic. This study aimed to explore the levels and determinants of HCWs' IPC behaviors based on the theoretical domains framework (TDF), which has been shown to be effective in guiding behavior change. METHODS: A cross-sectional survey was conducted in Wuhan, China in January 2020. Self-reported hand hygiene and droplet isolation behaviors (including the use of masks, gloves, goggles and gowns) were set as dependent variables. TDF domains and HCWs' characteristics were independent variables. Negative binomial regression analyses were performed to explore their relationships. RESULTS: HCWs reported good IPC behaviors, while the compliance with goggle and gown use was relatively low (below 85%). Environmental context and resources domain was significantly related to hand hygiene (ß = 0.018, p = 0.026), overall droplet isolation behaviors (ß = 0.056, p = 0.001), goggle (ß = 0.098, p = 0.001) and gown use (ß = 0.101. p < 0.001). Knowledge domain was significantly related to goggle (ß = 0.081, p = 0.005) and gown use (ß = 0.053, p = 0.013). Emotion domain was a predictor of overall droplet isolation behaviors (ß = 0.043, p = 0.016), goggle (ß = 0.074, p = 0.026) and gown use (ß = 0.106, p < 0.001). Social influences domain was a predictor of overall droplet isolation behaviors (ß = 0.031, p = 0.029) and gown use (ß = 0.039, p = 0.035). HCWs in high-risk departments had better behaviors of gown use (ß = 0.158, p = 0.032). HCWs who had encountered confirmed or suspected patients reported worse behaviors of goggle (ß = - 0.127, p = 0.050) and gown use (ß = - 0.153, p = 0.003). CONCLUSIONS: Adequate personal protective materials and human resources, education and training, as well as supervision and role model setting are necessary to improve IPC behaviors regarding the COVID-19 pandemic.

18.
Clin Infect Dis ; 71(16): 2109-2113, 2020 11 19.
Article in English | MEDLINE | ID: covidwho-1153167

ABSTRACT

BACKGROUND: Healthcare workers (HCWs) at the frontline are facing a substantial risk of infection during the coronavirus disease 2019 (COVID-19) outbreak. METHODS: We acquired information and data on general information on and infection and death status of HCWs in Wuhan during the COVID-19 outbreak and completed statistical analyses. RESULTS: We obtained the data on 2457 infected cases among HCWs in Wuhan, China. More than half of the infected individuals were nurses (52.06%), whereas 33.62% of infected cases were doctors and 14.33% of cases were medical staff. In particular, the case infection rate of nurses (2.22%) was remarkably higher than that of doctors (1.92%). Most infected cases among HCWs were female (72.28%). A majority of the infected HCWs (89.26%) came from general hospitals, followed by specialized hospitals (5.70%) and community hospitals (5.05%). The case infection rate of HCWs (2.10%) was dramatically higher than that of non-HCWs (0.43%). The case fatality rate of HCWs (0.69%) was significantly lower than that of non-HCWs (5.30%). CONCLUSIONS: The infection risk of HCWs is clearly higher than that of non-HCWs. HCWs play an essential role in fighting the pandemic. The analysis of the infection status of HCWs is essential to attract enough attention from the public, provide effective suggestions for government agencies, and improve protective measures for HCWs.


Subject(s)
COVID-19/epidemiology , China/epidemiology , Cross-Sectional Studies , Disease Outbreaks/statistics & numerical data , Female , Health Personnel/statistics & numerical data , Humans , Male , Pandemics
19.
Cells ; 10(3)2021 03 03.
Article in English | MEDLINE | ID: covidwho-1129685

ABSTRACT

(1) Background: Recently, influences of antihypertensive treatment on the renin-angiotensin-aldosterone system (RAAS) has gained attention, regarding a possible influence on inflammatory and anti-inflammatory pathways. We aimed to study the effects of newly initiated antihypertensive drugs on angiotensin (Ang) II and Ang (1-7) as representers of two counter-regulatory axes. (2) Methods: In this randomized, open-label trial investigating RAAS peptides after the initiation of perindopril, olmesartan, amlodipine, or hydrochlorothiazide, Ang II and Ang (1-7) equilibrium concentrations were measured at 8 a.m. and 12 a.m. at baseline and after four weeks of treatment. Eighty patients were randomized (1:1:1:1 fashion). (3) Results: Between the four substances, we found significant differences regarding the concentrations of Ang II (p < 0.0005 for 8 a.m., 12 a.m.) and Ang (1-7) (p = 0.019 for 8 a.m., <0.0005 for 12 a.m.) four weeks after treatment start. Ang II was decreased by perindopril (p = 0.002), and increased by olmesartan (p < 0.0005), amlodipine (p = 0.012), and hydrochlorothiazide (p = 0.001). Ang (1-7) was increased by perindopril and olmesartan (p = 0.008/0.002), but not measurably altered by amlodipine and hydrochlorothiazide (p = 0.317/ 0.109). (4) Conclusion: The initiation of all first line antihypertensive treatments causes early and distinct alterations of equilibrium angiotensin levels. Given the additional AT1R blocking action of olmesartan, RAAS peptides shift upon initiation of perindopril and olmesartan appear to work in favor of the anti-inflammatory axis compared to amlodipine and hydrochlorothiazide.


Subject(s)
Antihypertensive Agents/therapeutic use , Hypertension/drug therapy , Renin-Angiotensin System/drug effects , Antihypertensive Agents/pharmacology , Female , Humans , Hypertension/pathology , Male , Middle Aged
20.
Nurs Open ; 8(5): 2551-2557, 2021 09.
Article in English | MEDLINE | ID: covidwho-1092101

ABSTRACT

AIM: To assess the prevalence of burnout, secondary traumatic stress, and compassion satisfaction and explore their impacts on self-reported hand hygiene among medical aid teams in the COVID-19 period in Wuhan, China. DESIGN: Cross-sectional study. METHOD: A total of 1,734 healthcare workers from 17 medical aid teams were surveyed. The survey included burnout, secondary traumatic stress and compassion satisfaction measured by the professional quality of life scale and self-reported hand hygiene. Data were collected between 5-7 March 2020. Multiple regression analyses were performed. RESULTS: Burnout and secondary trauma stress were at low and average levels, and compassion satisfaction was at average and high levels. Burnout was negatively associated with hand hygiene, while compassion satisfaction was positively associated. Hospital administrators should pay attention to burnout and compassion satisfaction to improve infection control behaviours. Management of healthcare workers in our study may be constructive in emerging infectious diseases.


Subject(s)
Burnout, Professional , COVID-19 , Compassion Fatigue , Hand Hygiene , Burnout, Professional/epidemiology , Compassion Fatigue/epidemiology , Cross-Sectional Studies , Empathy , Health Personnel , Humans , Job Satisfaction , Pandemics/prevention & control , Personal Satisfaction , Quality of Life , SARS-CoV-2
SELECTION OF CITATIONS
SEARCH DETAIL