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1.
J Cell Mol Med ; 2021 Dec 24.
Article in English | MEDLINE | ID: covidwho-1583514

ABSTRACT

Growing evidence has shown that Transmembrane Serine Protease 2 (TMPRSS2) not only contributes to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but is also closely associated with the incidence and progression of tumours. However, the correlation of coronavirus disease (COVID-19) and cancers, and the prognostic value and molecular function of TMPRSS2 in various cancers have not been fully understood. In this study, the expression, genetic variations, correlated genes, immune infiltration and prognostic value of TMPRSS2 were analysed in many cancers using different bioinformatics platforms. The observed findings revealed that the expression of TMPRSS2 was considerably decreased in many tumour tissues. In the prognostic analysis, the expression of TMPRSS2 was considerably linked with the clinical consequences of the brain, blood, colorectal, breast, ovarian, lung and soft tissue cancer. In protein network analysis, we determined 27 proteins as protein partners of TMPRSS2, which can regulate the progression and prognosis of cancer mediated by TMPRSS2. Besides, a high level of TMPRSS2 was linked with immune cell infiltration in various cancers. Furthermore, according to the pathway analysis of differently expressed genes (DEGs) with TMPRSS2 in lung, breast, ovarian and colorectal cancer, 160 DEGs genes were found and were significantly enriched in respiratory system infection and tumour progression pathways. In conclusion, the findings of this study demonstrate that TMPRSS2 may be an effective biomarker and therapeutic target in various cancers in humans, and may also provide new directions for specific tumour patients to prevent SARS-CoV-2 infection during the COVID-19 outbreak.

2.
Canadian Literature ; - (245):106-125,193, 2021.
Article in English | ProQuest Central | ID: covidwho-1527310

ABSTRACT

The Better Mother tells the story of how Danny Lim, a gay Chinese Canadian man, negotiates the tensions between his sexual orientation and his patriarchal family, between his pursuit of art and beauty and the banality and monotony that permeate Vancouver's Chinatown, and between his desire for a glamorous mother and dissatisfaction with his homely and dowdy mother. Peter Merriman, in his call for an expansion of mobility studies in Micro-Mobilities in Lockdown" further draws scholarly attention to embodied micro-mobilities, which are defined as the myriad bodily movements and mobile embodied practices involved in all manner of actions, events, and systems, from the bodily movements involved in walking, driving, and flying, to the embodied movements involved in virus transmission and infection control (54). Bringing the frameworks of becoming and embodied micro-mobilities into dialogue as a critical lens through which to address the issue of AIDS in The Better Mother, this article argues that interracial and queer forms of care have the potential to mitigate the impact of AIDS upon queer mobilities, both physical and metaphysical, and trouble heteronormativity. [...]those infected, as Danny has noticed, show different symptoms and suffer from different diseases that result from HIV.

3.
Iran J Public Health ; 49(Suppl 1): 12-17, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-1502943

ABSTRACT

At present, new coronavirus pneumonia (COVID-19) is circulating worldwide. The pathogen of this coronavirus pneumonia is named SARS-CoV-2. The virus has a long incubation period and is highly contagious. There is currently no specific targeted drug treatment. The focus of anti-epidemic work should be more on prevention and control while cutting off the virus transmission route while treating infected patients, and protecting healthy people. In order to protect the safety and health of the Chinese citizens and to maintain the safety of world public health, the Chinese government and people have made unprecedented efforts to control the epidemic. Many people in the international community have joined in limiting the spread of COVID-19. This article combines the development of COVID-19 epidemic situation in Wuhan, the relevant prevention and control measures of the Wuhan government and local health authorities to share Wuhan's experience on control the cluster epidemic and provide new suggestions and ideas for epidemic prevention and control.

4.
Front Cardiovasc Med ; 8: 738044, 2021.
Article in English | MEDLINE | ID: covidwho-1497031

ABSTRACT

Background: Coronavirus disease 2019 (COVID-19) has outbroken in China and subsequently spread worldwide since the end of 2019. Chest computed tomography (CT) plays an important role in the diagnosis of lung diseases, but its value in the diagnosis of cardiac injury remains unknown. Methods: We enrolled 241 consecutive hospitalized patients (aged 61 ± 16 years, 115 males) with laboratory-confirmed COVID-19 at Renmin Hospital of Wuhan University from January 11 to March 2, 2020. They were divided into two groups according to whether major adverse cardiovascular events (MACEs) occurred during the follow-up. The anteroposterior diameter of the left atrium (LAD), the length of the left ventricle (LV), and cardiothoracic ratio (CTR) were measured. The values of myocardial CT were also recorded. Results: Of 241 patients, 115 patients (47.7%) had adverse cardiovascular events. Compared with no MACEs, patients with MACEs were more likely to have bilateral lesions (95.7% vs. 86.5%, p = 0.01). In multivariable analysis, bronchial wall thickening would increase the odds of MACEs by 13.42 (p = 0.01). LAD + LV and CTR was the best predictor for MACEs (area under the curve = 0.88, p < 0.001) with a sensitivity of 82.6% and a specificity of 80.2%. Plasma high-sensitivity troponin I levels in patients with cardiac injury showed a moderate negative correlation with minimum CT value (R 2 = -0.636, p < 0.001). Conclusions: Non-contrast chest CT can be a useful modality for detection cardiac injury and provide additional value to predict MACEs in COVID-19 patients.

5.
Dev Cogn Neurosci ; 52: 101020, 2021 Oct 11.
Article in English | MEDLINE | ID: covidwho-1469834

ABSTRACT

The ongoing Chinese Color Nest Project (CCNP) was established to create normative charts for brain structure and function across the human lifespan, and link age-related changes in brain imaging measures to psychological assessments of behavior, cognition, and emotion using an accelerated longitudinal design. In the initial stage, CCNP aims to recruit 1520 healthy individuals (6-90 years), which comprises three phases: developing (devCCNP: 6-18 years, N = 480), maturing (matCCNP: 20-60 years, N = 560) and aging (ageCCNP: 60-84 years, N = 480). In this paper, we present an overview of the devCCNP, including study design, participants, data collection and preliminary findings. The devCCNP has acquired data with three repeated measurements from 2013 to 2017 in Southwest University, Chongqing, China (CCNP-SWU, N = 201). It has been accumulating baseline data since July 2018 and the second wave data since September 2020 in Chinese Academy of Sciences, Beijing, China (CCNP-CAS, N = 168). Each participant in devCCNP was followed up for 2.5 years at 1.25-year intervals. The devCCNP obtained longitudinal neuroimaging, biophysical, social, behavioral and cognitive data via MRI, parent- and self-reported questionnaires, behavioral assessments, and computer tasks. Additionally, data were collected on children's learning, daily life and emotional states during the COVID-19 pandemic in 2020. We address data harmonization across the two sites and demonstrated its promise of characterizing the growth curves for the overall brain morphometry using multi-center longitudinal data. CCNP data will be shared via the National Science Data Bank and requests for further information on collaboration and data sharing are encouraged.

6.
World J Clin Cases ; 9(19): 4969-4979, 2021 Jul 06.
Article in English | MEDLINE | ID: covidwho-1449289

ABSTRACT

The coronavirus disease 2019 (COVID-19) raging around the world still has not been effectively controlled in most countries and regions. As a severe acute respiratory syndrome coronavirus, in addition to the most common infectious pneumonia, it can also cause digestive system disease such as diarrhea, nausea, vomiting, liver function damage, etc. In medical imaging, it manifests as thickening of the intestinal wall, intestinal perforation, pneumoperitoneum, ascites and decreased liver density. Angiotensin-converting enzyme 2 has great significance in COVID-19-related digestive tract diseases. In this review, we summarized the data on the clinical and imaging manifestations of gastrointestinal and liver injury caused by COVID-19 so far and explored its possible pathogenesis.

7.
Int J Environ Res Public Health ; 18(17)2021 09 06.
Article in English | MEDLINE | ID: covidwho-1390653

ABSTRACT

Previous COVID-19 tourism research has not considered the positive impact of a low-risk perception and a perception of the benefits of regional travel on taking alternative tourism. This study attempts to fill the research gap and examine the positive effect of these perceptions on tourists' attitudes to regional travel and intentions to undertake regional travel during the COVID-19 pandemic. A survey of 278 respondents confirmed that the perceived benefit positively influences tourists' attitudes and travel intentions, but that a low-risk perception only positively affects their attitudes. This study contributes to tourism risk management research by introducing the concept of a low-risk perception as a positive factor. For tourism recovery, it finds that relaxation, value, and convenience are benefits to drive people to travel.


Subject(s)
COVID-19 , Pandemics , Humans , Perception , SARS-CoV-2 , Tourism , Travel
8.
Environ Sci Pollut Res Int ; 28(47): 67310-67320, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1303358

ABSTRACT

Glucocorticoids (GCs) have drawn great concern due to widespread contamination in the environment and application in treating COVID-19. Most studies on GC removal mainly focused on aquatic environment, while GC behaviors in soil were less mentioned. In this study, degradation of three selected GCs in soil has been investigated using citric acid (CA)-modified Fenton-like processes (H2O2/Fe(III)/CA and CaO2/Fe(III)/CA treatments). The results showed that GCs in soil can be removed by modified Fenton-like processes (removal efficiency gt; 70% for 24 h). CaO2/Fe(III)/CA was more efficient than H2O2/Fe(III)/CA at low oxidant dosage (< 0.28-0.69 mmol/g) for long treatment time (> 4 h). Besides the chemical assessment with GC removal, effects of Fenton-like processes were also evaluated by biological assessments with bacteria and plants. CaO2/Fe(III)/CA was less harmful to the richness and diversity of microorganisms in soil compared to H2O2/Fe(III)/CA. Weaker phytotoxic effects were observed on GC-contaminated soil treated by CaO2/Fe(III)/CA than H2O2/Fe(III)/CA. This study, therefore, recommends CaO2-based treatments to remediate GC-contaminated soils.

9.
Immun Inflamm Dis ; 9(4): 1358-1369, 2021 12.
Article in English | MEDLINE | ID: covidwho-1303261

ABSTRACT

BACKGROUND: Since December 2019, coronavirus disease 2019 (COVID-19) has emerged as an international pandemic. COVID-19 patients with myocardial injury might need special attention. However, an understanding on this aspect remains unclear. This study aimed to illustrate clinical characteristics and the prognostic value of myocardial injury to COVID-19 patients. METHODS: This retrospective, single-center study finally included 304 hospitalized COVID-19 cases confirmed by real-time reverse-transcriptase polymerase chain reaction from January 11 to March 25, 2020. Myocardial injury was determined by serum high-sensitivity troponin I (Hs-TnI). The primary endpoint was COVID-19-associated mortality. RESULTS: Of 304 COVID-19 patients (median age, 65 years; 52.6% males), 88 patients (27.3%) died (61 patients with myocardial injury, 27 patients without myocardial injury on admission). COVID-19 patients with myocardial injury had more comorbidities (hypertension, chronic obstructive pulmonary disease, cardiovascular disease, and cerebrovascular disease); lower lymphocyte counts, higher C-reactive protein (CRP; median, 84.9 vs. 28.5 mg/L; p < .001), procalcitonin levels (median, 0.29 vs. 0.06 ng/ml; p < .001), inflammatory and immune response markers; more frequent need for noninvasive ventilation, invasive mechanical ventilation; and was associated with higher mortality incidence (hazard ratio [HR] = 7.02; 95% confidence interval [CI], 4.45-11.08; p < .001) than those without myocardial injury. Myocardial injury (HR = 4.55; 95% CI, 2.49-8.31; p < .001), senior age, CRP levels, and novel coronavirus pneumonia types on admission were independent predictors to mortality in COVID-19 patients. CONCLUSIONS: COVID-19 patients with myocardial injury on admission is associated with more severe clinical presentation and biomarkers. Myocardial injury and higher Hs-TnI are both strongest independent predictors to COVID-19-related mortality after adjusting confounding factors.


Subject(s)
COVID-19 , Aged , Female , Humans , Male , Pandemics , Prognosis , Retrospective Studies , SARS-CoV-2
10.
Front Robot AI ; 8: 580080, 2021.
Article in English | MEDLINE | ID: covidwho-1241221

ABSTRACT

In daily life, there are a variety of complex sound sources. It is important to effectively detect certain sounds in some situations. With the outbreak of COVID-19, it is necessary to distinguish the sound of coughing, to estimate suspected patients in the population. In this paper, we propose a method for cough recognition based on a Mel-spectrogram and a Convolutional Neural Network called the Cough Recognition Network (CRN), which can effectively distinguish cough sounds.

11.
Sensors (Basel) ; 21(3)2021 Jan 24.
Article in English | MEDLINE | ID: covidwho-1055108

ABSTRACT

In many medical image classification tasks, there is insufficient image data for deep convolutional neural networks (CNNs) to overcome the over-fitting problem. The light-weighted CNNs are easy to train but they usually have relatively poor classification performance. To improve the classification ability of light-weighted CNN models, we have proposed a novel batch similarity-based triplet loss to guide the CNNs to learn the weights. The proposed loss utilizes the similarity among multiple samples in the input batches to evaluate the distribution of training data. Reducing the proposed loss can increase the similarity among images of the same category and reduce the similarity among images of different categories. Besides this, it can be easily assembled into regular CNNs. To appreciate the performance of the proposed loss, some experiments have been done on chest X-ray images and skin rash images to compare it with several losses based on such popular light-weighted CNN models as EfficientNet, MobileNet, ShuffleNet and PeleeNet. The results demonstrate the applicability and effectiveness of our method in terms of classification accuracy, sensitivity and specificity.


Subject(s)
Diagnostic Imaging , Neural Networks, Computer , Sensitivity and Specificity
14.
Nan Fang Yi Ke Da Xue Xue Bao ; 40(4): 601-605, 2020 Apr 30.
Article in Chinese | MEDLINE | ID: covidwho-749257

ABSTRACT

Since the outbreak of COVID-19 pandemic, the detection capability has been improving and the detection techniques have been evolving with innovations. qRT- PCR and mNGS, which represent the current mainstay diagnostic technologies, play key roles in disease diagnosis and monitoring of virus variation. The detection technologies based on serum and plasma IgM and IgG antibodies are important for auxiliary diagnosis. RT-LAMP is highly specific for a diagnostic purpose. Digital PCR could quantitatively detect nucleic acid and SHERLOCK has a higher sensitivity. These techniques all have great potential for future development and application for pathogen detection. In this review the authors summarize the basic rationales, technical characteristics and the current application of the SARS-CoV-2 detection techniques.


Subject(s)
Betacoronavirus , Coronavirus Infections , Pandemics , Pneumonia, Viral , Antibodies, Viral , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques , Coronavirus Infections/diagnosis , Humans , Immunoglobulin G , Immunoglobulin M , Pneumonia, Viral/diagnosis , SARS-CoV-2
15.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 32(4): 430-434, 2020 Apr.
Article in Chinese | MEDLINE | ID: covidwho-594902

ABSTRACT

OBJECTIVE: To provide a reference for extracorporeal membrane oxygenation (ECMO) inter-hospital transport during coronavirus disease 2019 (COVID-19), based on the transport experience of 6 patients with severe H1N1 influenza virus pneumonia using ECMO. METHODS: Clinical data of patients with severe H1N1 influenza virus pneumonia implemented by ECMO in the First Affiliated Hospital of Wannan Medical College from October 2018 to December 2019 were retrospective analyzed, including general information, ECMO transport distance, time, clinical parameters before and after ECMO, including the patients' oxygenation index (PaO2/FiO2), respiratory rate (RR), pulse blood oxygen saturation (SpO2), arterial blood carbon dioxide partial pressure (PaCO2), and pH value, various complications during transport, mechanical ventilation time, patients' prognosis and other indicators. Experience from the aspects of personal protection, transport process and equipment, team cooperation, mid-transit monitoring, quality control, etc., was summarized to provide suggestions for patients with severe COVID-19 using ECMO during inter-hospital transport and protection. RESULTS: A total of 6 patients with severe H1N1 influenza virus pneumonia were transported on ECMO. All patients were transported to the intensive care unit (ICU) of the First Affiliated Hospital of Wannan Medical College by the ECMO transport team after the establishment of ECMO in the local hospital. The transfer distance was 11 to 197 km, with an average of (93.8±58.6) km; the transfer time was 30 to 150 minutes, with an average of (79.2±40.6) minutes. Two patients experienced a drop in ECMO flow and SpO2 during the process, and the main reason was insufficient volume, which was improved after fluid resuscitation and posture adjustment. All patients maintained SpO2 above 0.93. Six patients survived and were discharged. ECMO assisted time was 4-9 days, with an average of (6.5±1.5) days; mechanical ventilation time was 7-24 days, and median time was 10.0 (8.0, 14.5) days. No H1N1 transmission occurred in medical personnel. To achieve good therapeutic effect, the main experience was to choose the proper timing and mode of ECMO; intact transportation vehicles and equipment to reduce or avoid mechanical complications; the effective management of respiration and circulation during the transportation to avoid ventilation-associated lung injury (VALI) and serious hypoxemia; the appropriate space for the transfer team to quickly handle various critical situations; and personal protection to avoid infection. CONCLUSIONS: With an experienced ECMO transport team, good transport equipment, comprehensive protection measures, reasonable transport procedures, and a perfect emergency plan, it is safe to use ECMO transport for COVID-19 patients.


Subject(s)
Betacoronavirus , Coronavirus Infections/epidemiology , Extracorporeal Membrane Oxygenation , Influenza A Virus, H1N1 Subtype , Influenza, Human , Pneumonia, Viral/epidemiology , Pneumonia/therapy , Respiratory Distress Syndrome , COVID-19 , Humans , Pandemics , Retrospective Studies , SARS-CoV-2 , Treatment Outcome
16.
Academic Journal of Second Military Medical University ; 41(2):191-193, 2020.
Article | WHO COVID | ID: covidwho-11856

ABSTRACT

Since December 2019, many cases of pneumonia of unknown causes have been found in Wuhan and surrounding areas of Hubei Province, China. With the aggravation of the epidemic, on January 24, 2020, medical team of Naval Medical University (Second Military Medical University) in Wuhan started emergency medical rescue. This medical rescue was not only a treatment war, but also an antiepidemic war. It is very important to have strict personal protection, disinfection and isolation measures and epidemic prevention in the camp, which are the precondition and guarantee to ensure zero infection of medical staff. In this paper, we introduce our measures and experience on epidemic prevention and infection control, such as personnel management and decontamination.

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