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1.
SSRN; 2022.
Preprint in English | SSRN | ID: ppcovidwho-331803

ABSTRACT

This paper shows how the US, UK, Germany and China are financially connected through their stock market liquidity in the COVID-19 pandemic. Using high frequency data on transaction costs, we identify a decrease in stock market liquidity and an increase in liquidity commonality amongst these countries after the World Health Organisation (WHO) declared the global pandemic. There is an increased transmission of liquidity shocks from the country with higher COVID new cases and COVID-related death cases, indicating that markets are more connected with increased outbreak severity. Our results suggest that COVID-19 intensifies systematic liquidity risk and worsens the vulnerability of individual stock market's liquidity to aggregate liquidity shocks in the global market.

2.
10th International Conference on Design, User Experience, and Usability held as Part of the 23rd International Conference on Human-Computer Interaction (HCII) ; 12781:457-466, 2021.
Article in English | Web of Science | ID: covidwho-1767416

ABSTRACT

Under the background of COVID-19 epidemic, starting from the perspective of user satisfaction in the process of user's using news App, the research explores the relevant factors affecting user satisfaction based on the process of user's browsing news. Through user survey and literature research, combined with factor analysis method, the research sums up 13 factors affecting user satisfaction with the interface usability of news App. It uses decision-making experiment method to analyze and research 30 pcs of online and offline questionnaire data and draws cause and effect diagrams. Finally, it concludes that the three key factors affecting the user satisfaction with interface usability of news App are the factors: image, image-text layout, interface clarity;and the factor that affects other factors to a large extent is interface clarity. Finally, it clarifies the relationship among the relevant factors affecting user satisfaction with the interface usability of news App, further analyzes the problems existing in the current news App at the level of human cognition, and puts forward some relevant suggestions for the improvement of user satisfaction with the Interface Usability of news App.

3.
Drugs and Clinic ; 37(2):264-274, 2022.
Article in Chinese | Scopus | ID: covidwho-1766125

ABSTRACT

Objective To explore the mechanism of Lonicerae Japonicae Flos (LJF) intervening COVID-19 by network pharmacology and molecular docking. Methods The potential targets of ingredients in serum of LJF were searched by Swiss Target Prediction and Similarity Ensemble Approach platform, and to predict and screen the therapeutic targets of COVID-19 through GeneCards and CTD databases. Ingredients in serum-target pathway network model was established by Cytoscape 3.7.1 software. GO biological process enrichment analysis of anti-COVID-19 target genes in Lonicerae Japonicae Flos was performed by DAVID, and KEGG pathway enrichment analysis of anti-COVID-19 target genes in in serum of Lonicerae Japonicae Flos was performed by KOBAS 3.0. Results Ten ingredients in serum of Lonicerae Japonicae Flos such as hyperoside, 7-methoxycoumarin, 3-O-feruloylquinic acid, chlorogenic acid, neochlorogenic acid, cryptochlorogenic acid, dimethyl terephthalate, dibutyl sebacate, hexadecenoic acid, herboxidiene involved in PIK3R1, NFKB1, HRAS, IL6, TNF, TP53, CASP3, GRB2, GSK3B, JUN, MAPK10, MAPK14, MAPK8, PRKCA, and affected 27 mainly pathways involved in immune, inflammation, virus, nervous system, and so on. The molecular docking showed that the binding energy of hyperoside with the SARS-CoV-2 3CL hydrolase and ACE2 were most stable. Conclusion Ingredients in serum of Lonicerae Japonicae Flos may interfere proteins and pathways related to anti-inflammatory, antiviral immunity, antipyretic, analgesic and sedation to play a role against COVID-19. © Endocrinology Research Centre, 2022.

4.
21st IEEE International Conference on Data Mining Workshops, ICDMW 2021 ; 2021-December:517-526, 2021.
Article in English | Scopus | ID: covidwho-1730932

ABSTRACT

COVID-19 has been a public health emergency of international concern since early 2020. Reliable forecasting is critical to diminish the impact of this disease. To date, a large number of different forecasting models have been proposed, mainly including statistical models, compartmental models, and deep learning models. However, due to various uncertain factors across different regions such as economics and government policy, no forecasting model appears to be the best for all scenarios. In this paper, we perform quantitative analysis of COVID-19 forecasting of confirmed cases and deaths across different regions in the United States with different forecasting horizons, and evaluate the relative impacts of the following three dimensions on the predictive performance (improvement and variation) through different evaluation metrics: model selection, hyperparameter tuning, and the length of time series required for training. We find that if a dimension brings about higher performance gains, if not well-tuned, it may also lead to harsher performance penalties. Furthermore, model selection is the dominant factor in determining the predictive performance. It is responsible for both the largest improvement and the largest variation in performance in all prediction tasks across different regions. While practitioners may perform more complicated time series analysis in practice, they should be able to achieve reasonable results if they have adequate insight into key decisions like model selection. © 2021 IEEE.

6.
IEEE Internet of Things Journal ; 2022.
Article in English | Scopus | ID: covidwho-1705639

ABSTRACT

The concept of ‘human as sensors’defines a new sensing model, in which humans act as sensors by contributing their observations, perceptions, and sensations. This is crucial for the development of social Internet of Things, which is an integral part of Cyber-Physical-Social systems. Online social media platforms, as the most active places where users act as social sensors, are responsive to real-world events and are useful for gathering situational information in real-time. Unfortunately, posts rarely contain structured geographic information, thus hindering their usage for contributing to various challenges, such as emergency response. We address this limitation by introducing a general approach for extracting place names from tweets, named GazPNE2. It combines global gazetteers (i.e., OpenStreetMap and GeoNames), deep learning, and pretrained transformer models (i.e., BERT and BERTweet), which requires no manually annotated data. It can extract place names at both coarse (e.g., city) and fine-grained (e.g., street and POI) levels and place names with abbreviations. To fully evaluate GazPNE2 and compare it with 11 competing approaches, we use 19 public tweet datasets, containing 38,802 tweets and 22,197 places across the world. The results show GazPNE2 achieves much higher F1 (0.8) than the other approaches. Furthermore, we apply GazPNE2 to three large unannotated tweet datasets related to over 20 crisis events (e.g., COVID-19), containing 560,040 tweets. An F1 of 0.84 is achieved on 3,000 tweets, which are randomly selected from the three datasets and then manually annotated. Code and data are available on GitHub page: https://github.com/uhuohuy/GazPNE2. IEEE

7.
Journal of Real Estate Finance and Economics ; : 30, 2022.
Article in English | Web of Science | ID: covidwho-1681462

ABSTRACT

With unique datasets, this paper studies the effects of dockless bike sharing on house prices. We find that in neighborhoods relatively far from subway stations, house prices increase with the usage intensity of shared bikes. This indicates a positive value of bike sharing as a complement to the subway network. Meanwhile, shared bike usage intensity also has a negative impact on house prices. The negative effect is mitigated for luxury neighborhoods and neighborhoods near City Management Teams, suggesting that the negative effect is related to bike misplacement. Since the breakout of COVID-19, both the positive and negative price impacts have become more evident. This is consistent with the fact that the user base of shared bikes, which allow for social distancing in an open space, has increased during the pandemic. This may enhance people's confidence in the long survival of the bike sharing industry.

8.
Safety and Health at Work ; 13:S202, 2022.
Article in English | EMBASE | ID: covidwho-1677127

ABSTRACT

Introduction: The 19th National Congress of the Communist Party of China in October 2017 and 1st Session of the 13th National People’s Congress in March 2018 play key role in promoting development of Chinese society. This article present updated information on reform of occupational health (OH) management. Methods: The related information were collected and current practices were introduced. Results: National Health Commission (NHC) of State Council, established on basis of National Health and Family Planning Commission, is responsible all management work related OH, except for supervision of coal mine safety work, still by newly established Ministry of Emergency Management (former SAWS). The State Council strives to implement the advancing reform to delegate power, streamline administration and optimize government services and has an inter-ministerial joint annual conference system for occupational disease prevention and control. New agency entitled with Division of Occupational Health within NHC was established. NHC has revised several regulations, e.g, OH management in workplaces, classification of occupational hazards,diagnosis of occupational diseases, OH services management. Against pneumoconiosis, NHC, jointly with other 9 Ministries and approved by State Council, announced Action plan for pneumoconiosis prevention and treatment in 2019 and has promoted construction of pneumoconiosis rehabilitation stations in some provinces. To prevent Covid-19 epidemic, NHC released several guidelines to instruct the enterprises how to do. Conclusion: The improvement of systematicness of OH management system is still expected.

9.
Circulation ; 144(SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1632416

ABSTRACT

Cardiac microthrombi are postulated to underlie cardiac injury in critical COVID-19. To determine pathogenic mechanism(s) of cardiac injury in fatal COVID-19, we conducted a single-center prospective cohort study of 69 consecutive COVID-19 decedents. Microthrombi was the most commonly detected acute cardiac histopathologic feature (n=48, 70%). We tested associations of cardiac microthrombi with biomarkers of inflammation, cardiac injury, and fibrinolysis and with inhospital antiplatelet therapy, therapeutic anticoagulation, and corticosteroid treatment, while adjusting for multiple clinical factors, including COVID-19 therapies. Higher peak ESR and CRP during hospitalization were independently associated with higher odds of microthrombi (ESR, Pnonlinearity 0.015, Passociation=0.008;CRP per 20mg/L increase, OR 1.17, 95%CI 1.00-1.36). Using single nuclei RNA-sequence analysis, we discovered an enrichment of prothrombotic, anti-fibrinolytic, and extracellular matrix signaling amongst cardiac fibroblasts in microthrombi-positive COVID-19 hearts, compared with microthrombi-negative COVID-19 hearts and non-COVID-19 donor hearts. Our cumulative findings identify these specific transcriptomic changes in cardiac fibroblasts as salient features of COVID-19-associated cardiac microthrombi.

10.
21st COTA International Conference of Transportation Professionals: Advanced Transportation, Enhanced Connection, CICTP 2021 ; : 671-680, 2021.
Article in English | Scopus | ID: covidwho-1628308

ABSTRACT

The outbreak of COVID-19 in 2020 greatly impacted China's transportation industry. This paper aims to analyze this impact and the indispensable role of public transport control measures in preventing the spread of the epidemic. The impact of SARS and COVID-19 was compared. Taking Hebei Province as an example, the impact of the epidemic on the public transport industry was analyzed. The information of Jincheng public transport network and bus IC card data were selected for analysis. The parameters of bus network density and bus line repetition coefficient were calculated. The number of bus departures of each line before and after Jincheng epidemic was counted. Based on the data of bus IC card, the dynamic network of passenger contact was constructed, and the passenger contact network diagram was drawn. The analysis results can inform and enable urban public transport departments to take control measures when public health emergencies occur. © 2021 CICTP 2021: Advanced Transportation, Enhanced Connection - Proceedings of the 21st COTA International Conference of Transportation Professionals. All rights reserved.

11.
Journal of Electrostatics ; 115, 2022.
Article in English | Scopus | ID: covidwho-1626161

ABSTRACT

Respirators have become popular personal protective equipment since the COVID-19 pandemic. The key material in respirators is the melt-blown polypropylene electret fabric (MBPPEF). In this article, the filtering and inactivating effects of electrostatic fields in the respirator materials on Staphylococcus aureus (S. aureus) are studied. As a typical airborne microorganism, S. aureus is often employed to evaluate the antibacterial performance of air filtration equipment. The results prove that the electrostatic field in MBPPEF plays the key role in filtrating S. aureus. All MBPPEF from different charging method can have a filtering efficiency of more than 99% against S. aureus. The inactivation rate of positive corona charged sample is the highest. The charging method will affect the formation of electrostatic fields in the MBPPEF, thereby affecting their antibacterial performance. © 2022

12.
Biophys J ; 120(14): 2766-2770, 2021 07 20.
Article in English | MEDLINE | ID: covidwho-1603998

ABSTRACT

Understanding the structure of messenger RNA (mRNA) lipid nanoparticles, and specifically the microenvironment of the mRNA molecules within these entities, is fundamental to advancing their biomedical potential. Here, we show that a permeating cationic dye, thionine, can serve as a cryogenic electron microscopy contrasting agent by binding selectively to encapsulated mRNA without disturbing lipid nanoparticle morphology. Cryo-electron microscopy images identify the mRNA location, revealing that mRNA may exist within solvent-filled cavities or may be substantially lipid associated.


Subject(s)
Lipids , Nanoparticles , Cryoelectron Microscopy , RNA, Messenger/genetics
13.
European Heart Journal ; 42(SUPPL 1):3364, 2021.
Article in English | EMBASE | ID: covidwho-1554341

ABSTRACT

Background: Vascular injury has been implicated as a major cause of clinical complications in patients with coronavirus disease 2019 (COVID-19). Autopsy studies have revealed destruction of the endothelial cell lining, which might explain cardiovascular alterations arising from the infection. However, data demonstrating endothelial dysfunction during ongoing infection are sparse, and the underlying mechanisms are still largely unknown. Red blood cells (RBCs) are affected by COVID-19 with alterations in their structure and function, possibly contributing to vascular injury via increased oxidative stress. Purpose: To determine the presence of endothelial dysfunction in patients with COVID-19 and to explore the RBC as a possible mediator of such dysfunction. Methods: The study was performed on 17 patients hospitalized for moderate COVID-19 infection and age-and sex-matched healthy subjects. Inclusion criteria of the COVID-19 patients were PCR-verified SARS-CoV2 infection, pulmonary infiltrates on x-ray, oxygen demand during hospital stay and ≤ one cardiovascular co-morbidity. Microvascular endothelial function in vivo was assessed with a pulse amplitude tonometry device on each index finger at baseline and during reactive hyperemia and expressed as reactive hyperemia index (RHI). RBCs from COVID-19 patients (C19-RBCs) and healthy subjects (H-RBCs) were incubated with isolated rat aortic segments for evaluation of endothelium-dependent and -independent relaxation. Results: COVID-19 patients displayed profound impairment in endothelial function in vivo with RHI 1.56 (1.30-1.81, median and interquartile range) compared to healthy subjects 2.36 (1.97-2.79, p<0.001). C19-RBCs induced severe impairment in both endothelium-dependent (27% maximal relaxation) and -independent relaxations (54%) compared to H-RBCs (67% and 95% relaxation, respectively). Further, C19-RBCs induced upregulation of vascular arginase 1 (∼2 fold increase compared to H-RBCs) and markers of oxidative stress (∼6 fold). Consequently, inhibition of vascular arginase or superoxide attenuated the impairment in endothelial function induced by C19-RBCs. C19-RBCs were characterized by increased production of reactive oxygen species (∼1.4 fold) and reduced export of the nitric oxide metabolite nitrate. Following pre-incubation with interferon-γ, but not interleukin-6 or tumor necrosis factor-α, H-RBCs induced impairment in endothelial function. Conclusions: This study demonstrates the presence of marked endothelial dysfunction in an otherwise mainly healthy patient group hospitalized for COVID-19, and clearly implicates a central role of the RBC as a mediator of endothelial injury through enhancement of reactive oxygen species and arginase. These data shed light on a new pathological mechanism underlying vascular dysfunction in COVID-19 patients and may lay the foundation for future therapeutic developments.

14.
Multiple Sclerosis Journal ; 27(2 SUPPL):715-716, 2021.
Article in English | EMBASE | ID: covidwho-1495980

ABSTRACT

Introduction: Ofatumumab is a self-administered subcutaneous CD20 monoclonal antibody approved in the United States (US) in August 2020 (in the pandemic era) for the treatment of relapsing multiple sclerosis (MS) in adults. Since US approval, there is a lack of information available on the real-world utilisation of ofatumumab. Objectives: To understand the overall profile of MS patients initiating ofatumumab in the real-world clinical practice using data from a nationally representative claims database in the first 6 months post-approval. Aims: To evaluate patient demographics, treatment status, geographical distribution, premedication use, claims-based disability levels, disease-modifying therapy (DMT) use in the year prior, and corresponding median time to transition (treatment gap) for patients initiating ofatumumab. Methods: This retrospective cohort study used IQVIA opensource claims data. Adults with a diagnosis of MS who initiated ofatumumab from August 2020-February 2020 were included. The index date was defined based on the first prescription fill for ofatumumab, and the baseline period was 1-year prior to the index date. Results: Overall, 1015 patients initiating ofatumumab were included in the study. Mean (± standard deviation [range]) age was 48.2±12.3 (18-85) years, and 72.5% were females. Approximately, 33% of patients were ≥55 years of age. Most patients were from the Southern and Western regions of the US. Ofatumumab was mostly prescribed by neurologists (86.8%) vs PCP/NP/PAs. The proportion of patients with moderate to severe MS disability was 38.2%. Common comorbidities among patients were osteoarthritis (31.3%), hypertension (16.7%), and depression (12.2%). Overall, 54.8% were not on any DMT in the year prior to initiating ofatumumab. Patients commonly switched from ocrelizumab (24.2%), dimethyl fumarate (23.3%), platform injectables (19.3%) and teriflunomide (14.8%). The median transition period for dimethyl fumarate, teriflunomide, and ocrelizumab was 62, 51, and 174 days, respectively. Patients received ofatumumab pre-and post-COVID and influenza vaccine. Steroid and antihistamine use as premedication was minimal (≤2.5% of patients). Conclusions: In the real-world pandemic environment, ofatumumab was prescribed, also beyond the trial population. Most patients newly initiated ofatumumab had no treatment in the prior year. Understanding patient profile, prior DMT use in the realworld may help stakeholders guide treatment decisions.

15.
Journal of the American Society of Nephrology ; 32:539, 2021.
Article in English | EMBASE | ID: covidwho-1489411

ABSTRACT

Background: African Americans are disproportionately affected by hypertension (HTN) and CKD and evidence suggests dietary modifications towards a more Dietary Approaches to Stop Hypertension (DASH)-accordant diet could improve outcomes for this population. We aimed to explicate barriers and facilitators of healthy eating, and the perceived benefits of the intervention among completed participants of a dietary intervention trial for African Americans with HTN and CKD. Participants were randomized to one of two groups: 1) Self-Shopping DASH (S-DASH) diet group with $30/week grocery allowance for 4 mo. but no specific guidance on purchases, followed by no food allowance for 8 mo.;or 2) Coaching DASH (C-DASH) diet advice group with a $30/week food allowance and assistance in purchasing foods for 4 mo., followed by intermittent coaching without food allowance for 8 mo. Methods: We performed a content analysis of transcripts from semi-structured interviews with participants who completed the trial (13 C-DASH;12 S-DASH were randomly selected). Thematic analyses followed 5 stages: 1) reading and rereading all transcripts and utilizing audio recordings as needed for clarity;2) three coders reading two of the same transcripts, coding them, and comparing codes which were then used to create the initial coding framework;3) defining codes, coding additional transcripts, discussing/ revising the coding framework;4) formulating initial themes and 5) diagramming relationships among initial themes to merge overlapping themes. Results: Participants were a mean age of 62 ± 9.3 years, 36% were male. Key themes included healthy diet facilitators (food tracking, motivation, social support, and perception of healthy foods);barriers (transportation, past eating habits, stress and COVID mitigation);and impact of the trial on knowledge and health. Conclusions: Participants of a dietary intervention trial for African Americans with HTN and CKD identified several facilitators and barriers to healthy eating that could inform future efforts to address disease burden in this population.

16.
Front. Comput. Sci.-Switz ; 3:14, 2021.
Article in English | Web of Science | ID: covidwho-1477810

ABSTRACT

The recent outbreak of the novel coronavirus (COVID-19) has infected millions of citizens worldwide and claimed many lives. This paper examines the impact of COVID-19 on Chinese e-commerce by analyzing behavioral changes observed on a large online shopping platform. We first conduct a time series analysis to identify product categories that faced the most extensive disruptions. The time-lagged analysis shows that behavioral patterns of shopping actions are highly responsive to the epidemic's development. Based on these findings, we present a consumer demand prediction method by encompassing the epidemic statistics and behavioral features of COVID-19-related products. Experimental results demonstrate that our predictions outperform existing baselines and further extend to long-term and province-level forecasts. Finally, we discuss how our market analysis and prediction can help better prepare for future pandemics by gaining extra time to launch preventive measures.

17.
Chinese Journal of New Drugs ; 30(19):1775-1782, 2021.
Article in Chinese | EMBASE | ID: covidwho-1473137

ABSTRACT

Objective: To compare the correlation between the results of SARS-CoV-2 neutralizing antibody colloidal gold test cards prepared by two different principles and the SARS-CoV-2 pseudovirus neutralization experiment, and to evaluate the feasibility of the neutralizing antibody colloidal gold test card for the SARS-CoV-2 neutralizing antibody detection in different populations. Methods: Two kinds of SARS-CoV-2 neutralizing antibody colloidal gold test cards using double antigen sandwich method (manufacturer A) and competitive blocking method (manufacturers B) were used to detect the samples with SARS-CoV-2 neutralizing antibody titers. Detection sensitivity and the correlation between the two methods and the neutralization experiment were compared. The intravenous human immunoglobulin and specific immunoglobulin prepared before the outbreak of COVID-19 epidemic were detected to investigate the specificity of the eligible test card. In order to determine whether there is a hook effect, individual immunized plasma samples of high ELISA titers were tested with series of dilutions and original dilution. Single post-immunized plasma samples were detected with different ELISA titers, the positive rates were determined and the color changes were observed. Single post-immunized plasma samples were screened in the low-dilution area of ELISA according to chromaticity of 120NT50 and 300NT50 on the colorimetric card to prepare pooled plasma. The results were compared with the currently used indirect ELISA method. Results: The detection limits of manufacturers A and B for the first-generation NIBSC international standard 20/136 (anti-SARS-CoV-2 human immunoglobulin international standard) were 0.612 5 and 5 IU•mL-1, respectively. The results of different titers of pooled plasma (both of post-immunization with SARS-CoV-2 vaccine and COVID-19 convalescence plasma) have a good correlation with the neutralizing antibody titer. The post-immunization plasma with high ELISA dilutions (above 10 000) did not show hook effect. The positive rate of individual plasma of different ELISA dilution levels reached 100% when the dilution was above 160, and the uniformity of the chromaticity was higher when the dilution level was above 640. The overall chromaticity became darker as the ELISA dilution increased. The chromaticities of Ppool 120NT50 and Ppool 300NT50 screened according to the colorimetric chart were close to the neutralizing antibody titers. Conclusion: The correlation between the results of the manufacturer A neutralizing antibody test card using the dual antigen sandwich method to detect SARS-CoV-2 neutralizing antibody in convalescent plasma and post-immunization plasma and the titer of the pseudovirus neutralization experiment is better than that of the manufacturer B product using the competitive inhibition method and indirect ELISA. And the color brightness of the detection line is positively correlated with the level of neutralizing antibody, which can be used for preliminary screening of neutralizing antibody in different populations.

18.
7th International Conference on Information Science and Control Engineering, ICISCE 2020 ; : 1151-1156, 2020.
Article in English | Scopus | ID: covidwho-1470313

ABSTRACT

In order to enable middle-aged and elderly groups to have a more efficient access to epidemic information when facing diseases, this paper takes covid-19 information as an example, 12 related factors interrelated to the efficiency have been selected through literature and user studies, amog which the key points and their correlation have been found out through decision-making trial and evaluation laboratory(DEMATAL). Results shows that the key elements that ultimately affect the epidemic information acceptance of middle-aged and elderly groups are content presentation, page readability and shareability;and the three factors that largely affect others are vision problems, page readability and page layout. Besides, the problems in the process of the middle-aged and elderly groups using mobile products to obtain information are further analyzed, and related countermeasures and suggestions for improvement are proposed. © 2020 IEEE.

19.
Nat Commun ; 12(1): 5652, 2021 09 27.
Article in English | MEDLINE | ID: covidwho-1440473

ABSTRACT

The emergence of numerous variants of SARS-CoV-2, the causative agent of COVID-19, has presented new challenges to the global efforts to control the COVID-19 pandemic. Here, we obtain two cross-neutralizing antibodies (7D6 and 6D6) that target Sarbecoviruses' receptor-binding domain (RBD) with sub-picomolar affinities and potently neutralize authentic SARS-CoV-2. Crystal structures show that both antibodies bind a cryptic site different from that recognized by existing antibodies and highly conserved across Sarbecovirus isolates. Binding of these two antibodies to the RBD clashes with the adjacent N-terminal domain and disrupts the viral spike. Both antibodies confer good resistance to mutations in the currently circulating SARS-CoV-2 variants. Thus, our results have direct relevance to public health as options for passive antibody therapeutics and even active prophylactics. They can also inform the design of pan-sarbecovirus vaccines.


Subject(s)
Antibodies, Viral/immunology , Broadly Neutralizing Antibodies/immunology , COVID-19/therapy , Immunization, Passive/methods , SARS-CoV-2/immunology , Animals , Antibodies, Monoclonal/administration & dosage , Antibodies, Monoclonal/immunology , Antibodies, Monoclonal/isolation & purification , Antibodies, Monoclonal/metabolism , Antibodies, Viral/administration & dosage , Antibodies, Viral/isolation & purification , Antibodies, Viral/metabolism , Binding Sites/genetics , Binding Sites/immunology , Broadly Neutralizing Antibodies/administration & dosage , Broadly Neutralizing Antibodies/isolation & purification , Broadly Neutralizing Antibodies/metabolism , CHO Cells , COVID-19/epidemiology , COVID-19/immunology , COVID-19/virology , Chlorocebus aethiops , Cricetulus , Epitopes/immunology , HEK293 Cells , Humans , Mice , Middle East Respiratory Syndrome Coronavirus/genetics , Middle East Respiratory Syndrome Coronavirus/immunology , Neutralization Tests , Pandemics/prevention & control , Protein Multimerization , Receptors, Virus/metabolism , SARS-CoV-2/genetics , Sf9 Cells , Spike Glycoprotein, Coronavirus/genetics , Spike Glycoprotein, Coronavirus/immunology , Spike Glycoprotein, Coronavirus/metabolism , Vero Cells
20.
Chinese Journal of Practical Nursing ; 37(25):1995-2000, 2021.
Article in Chinese | Scopus | ID: covidwho-1438771

ABSTRACT

In recent years, "Internet + "medical treatment has gradually become an important form of medical care in China. Especially affected by the COVID-19, China′s maternal and child health care institutions have closely integrated "Internet + " technology with maternal health care to meet maternal health needs and reduce maternal risk. Based on a comprehensive analysis of Chinese literature on "Internet + " maternal health care in CNKI, Wanfang database, VIP, CBM in recent five years, this paper introduces the main forms, contents and effects of " Internet + " maternal health care in China, and points out the direction of clinical practice and scientific research in the future, which can be used for reference by the general colleagues. © 2021 Chinese Journal of Practical Nursing. All rights reserved.

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