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1.
European Review for Medical and Pharmacological Sciences ; JOUR(15):5574-5580, 26.
Article in English | Web of Science | ID: covidwho-2081706

ABSTRACT

- OBJECTIVE: The COVID-19 pan-demic has influenced regular medical proce-dures and health-seeking behaviors. In this study, we aimed to investigate the influence of the COVID-19 pandemic on the presentation and prognosis of acute ischemic stroke (AIS) pa-tients in county-level stroke centers.PATIENTS AND METHODS: We retrospec-tively collected AIS patients during the strict lockdown period (January 24, 2020, to March 27, 2020) and the corresponding "new normal" pe-riod (2021) of the COVID-19 pandemic. Patients seen during the same timeframe in 2019 were en-rolled as controls. Statistical analysis was con-ducted to compare the clinical characteristics of AIS patients who presented during the lockdown and new normal periods and those who present-ed during the pre-COVID-19 pandemic period.RESULTS: A total of 134 AIS patients present-ed during the lockdown period (the 2020 group), 207 patients in the pre-COVID-19 period (the 2019 group) and 201 patients in the "new normal" period (the 2021 group). Compared to the 2019 group, there was approximately 1/3 reduction in the number of patients who presented during the lockdown period, while the number of patients who received IVT or EVT was similar between the two groups. The number of patients, baseline characteristics, workflow intervals and clinical outcomes presented during the "new normal" period were similar between the 2019 and 2021 groups. Logistic regression showed that lock -down or new normal status were not risk factors associated with a poor outcome at 90 days.CONCLUSIONS: In county-level city stroke centers, the COVID-19 lockdown resulted in a reduction in the number of patients with AIS ad-mitted to the hospital but had no effect on pa-tients treated with IVT or EVT. Lockdown or new normal status did not influence the prognosis of AIS patients.

2.
IEEE Electron Device Letters ; : 1-1, 2022.
Article in English | Scopus | ID: covidwho-2078240

ABSTRACT

A stamp-based printing technique was applied to transfer the β-Ga<sub>2</sub>O<sub>3</sub> films grown by pulsed laser deposition (PLD) from Si substrates onto some flexible substrates, such as PET, PEN, and PI. It is demonstrated that the β-Ga<sub>2</sub>O<sub>3</sub>-based flexible solar-blind photodetectors (SBPDs) exhibit brilliant optoelectrical performances with a low dark current of 1.7 pA at 10 V, a I<sub>254nm</sub>/I<sub>dark</sub> ratio of 1.2×103, rise (τ<sub>r1</sub> = 0.079 s and τ<sub>r2</sub> = 0.413 s) and decay (τ<sub>d1</sub> = 0.029 s and τ<sub>d2</sub> = 0.316 s) times. In a further step, flexible imaging sensor arrays based on the β-Ga<sub>2</sub>O<sub>3</sub>/PET were fabricated, which exhibit good imaging capability and resolution. Moreover, wearable UVC-alarms based on the β-Ga<sub>2</sub>O<sub>3</sub>/PET were realized to monitor the UVC radiation in the environment in real time, which can be used in the COVID-19-related area. IEEE

3.
International Journal of Contemporary Hospitality Management ; 2022.
Article in English | Scopus | ID: covidwho-2078057

ABSTRACT

Purpose: With the rapid development of sharing economy, travelers are facing choices between conventional hotels and the peer-to-peer sharing accommodation in urban tourism. The purpose of this study is to examine how travelers form their preferences in such choice situations and whether/how their preference formation mode would change with the COVID-19 pandemic. Design/methodology/approach: A relative preference model was constructed and estimated for both domestic and outbound tourists, based on two waves of survey data collected before and after the COVID-19. The results of this study were compared to derive the evolution of preference formation patterns. Findings: A set of 15 key value attributes and personal traits was identified, together with their differential effects with the pandemic. Their divergent effects between domestic and outbound trips were also delineated. Based on these findings, the competitive edges and advantageous market profiles were depicted for both hotel and sharing accommodation sectors. Originality/value: This study contributes to the knowledge of tourists’ preference between accommodation types and adds empirical evidences to the impact of the pandemic on tourist behavior patterns. Both hotel and sharing accommodation practitioners can benefit from the findings to enhance their competitiveness. © 2022, Emerald Publishing Limited.

4.
Human Reproduction ; 37:232-233, 2022.
Article in English | Web of Science | ID: covidwho-2068448
5.
Materials Today Chemistry ; 26:101155, 2022.
Article in English | ScienceDirect | ID: covidwho-2061696

ABSTRACT

In this work, we coated perovskite quantum dots (CsPbBr3) with metal oxide (ZnO) by an in-situ oxidation strategy to obtain CsPbBr3@ZnO nanocrystals, which effectively improved the moisture stability of the perovskite material. In addition, the ZnO layer can also transfer the interaction with gas molecules to the inner CsPbBr3, giving the CsPbBr3@ZnO nanocrystals good gas-sensing properties at room temperature. This study considered CsPbBr3@ZnO films’ structural, morphological, and gas sensing properties;and simulated breath monitoring tests. Later a sensor based on CsPbBr3@ZnO nanocrystals was prepared and used to detect the presence of heptanal (a breath biomarker for lung cancer and COVID-19) in different gases, including air, artificial breath, and real breath. The sensor displayed a fairish sensitivity (S = 0.36) alongside a brief response/recovery time (36.5 s/5.3 s) towards 200 ppm heptanal prepared with air, and the limit of detection could reach up to 2 ppm in the air and 3 ppm in artificial breath (made up of air, ethanol, isopropanol, 7-tridecanone, and n-tetradecane). Furthermore, the intelligent classification algorithms were used to identified the real breath samples containing heptanal (1–5 ppm) with an 82.5% accuracy rate in simulated breath monitoring tests. Theory calculation results showed that the good response to heptanal was attributed to both the positive adsorption energy (+3 eV) and the increased lattice distortion induced by heptanal. These sensors show great potential to be an effective method for early detection and treatment of lung cancer and COVID-19 for a healthy and prolonged life. We believe that this research will open the door toward more stable and practical perovskite-based sensors.

6.
Polish Journal of Environmental Studies ; 31(5):4197-4204, 2022.
Article in English | Scopus | ID: covidwho-2056513

ABSTRACT

The pandemic of COVID-19 has led to a surge increase in the production of masks. Due to the rapid propagation of COVID-19 and the long survival time of plastic surfaces, a large number of masks are discharged into the environment without treatment. In this paper, the release of microplastics (MPs) in nature was simulated by using mask samples irradiated by ultraviolet (UV) light. After 28 days of ultraviolet radiation, part of the main chain of the mask was broken and a large number of transparent MPs fell off. The longer the UV irradiation time, the larger the proportion of small particle MPs. The middle layer of surgical mask is the most difficult to release MPs due to charge treatment, and N95 mask is the most difficult to degrade the inner material. © 2022, HARD Publishing Company. All rights reserved.

7.
IEEE Transactions on Dependable and Secure Computing ; : 1-17, 2022.
Article in English | Scopus | ID: covidwho-2052083

ABSTRACT

Many regions are in urgent need of facial masks for slowing down the spread of COVID-19. To fight the pandemic, people are contributing masks through donation systems. Most existing systems are built on a centralized architecture which is prone to the single point of failure and lack of transparency. Blockchain-based solutions neglect fundamental privacy concerns (donation privacy) and security attacks (collusion attack, stealing attack). Moreover, current auditing solutions are not designed to achieve donation privacy, thus not appropriate in our context. In this work, we design a decentralized, anonymous, and secure auditing framework Astraea based on private smart contracts for donation systems. Specifically, we integrate a Distribute Smart Contract (DiSC) with an SGX Enclave to distribute donations, prove the integrity of donation number (intention) and donation sum while preserving donation privacy. With DiSC, we design a Donation Smart Contract to refund deposits and defend against the stealing attack the collusion attack from malicious collector and transponder. We formally define and prove the privacy and security of Astraea by using security reduction. We build a prototype of Astraea to conduct extensive performance analysis. Experimental results demonstrate that Astraea is practically efficient in terms of both computation and communication. IEEE

8.
4th International Conference on Communications, Information System and Computer Engineering, CISCE 2022 ; : 156-159, 2022.
Article in English | Scopus | ID: covidwho-2018630

ABSTRACT

Agile development has been a common methodology in software development. In response to the covid-19, most software development teams choose to work remotely. As a result of the different network environments, the company cloud center network load cannot meet the requirements of remote development and fault tolerance requirements of the agile development process. We designed a mixed-method called the Edge Development approach for improving Agile software development during the decision-making process. The extensive literature review provided us with three categories of challenges as well as solutions to support Edge Development's decision-support process. In the light of the survey, Five main software development decision-making challenges were identified in this study. In addition, we made a series of recommendations to improve the decision-making process of Edge Development from a variety of perspectives. © 2022 IEEE.

9.
Human Reproduction ; 37:i232-i233, 2022.
Article in English | EMBASE | ID: covidwho-2008571

ABSTRACT

Study question: Does a history of SARS-CoV-2 vaccination (CoronaVac) in males influence male fertility, gamete and embryo development, and in vitro fertilization (IVF) outcomes? Summary answer: CoronaVac vaccination in males may not have an adverse effect on patient's performance or the gamete and embryonic development potential during ART treatments. What is known already: Vaccines against COVID-19 have been approved for emergency use in several countries and regions, while concerns about the potential negative effect of vaccines on fertility contributed to vaccine hesitancy. It is urgent to explore the effect of CoronaVac on human fertility to help to overcome vaccine hesitancy about possible fertility impairment. Study design, size, duration: A retrospective cohort study enrolled couples undergoing IVF cycles between June and August 2021 at Reproductive Medicine Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. According to the history of SARS-CoV-2 vaccination in males, the participants were divided into the vaccination group and the non-vaccination group. Participants/materials, setting, methods: A self-controlled study of semen analyses for males before and after CoronaVac vaccination was conducted. Baseline characteristics were matched using propensity score matching. Participants were categorized into the unexposed group (non-vaccination) and exposed group (vaccination), and the population was 271 for each. Semen parameters and IVF outcomes were the main outcomes. Main results and the role of chance: Generally, no statistically significant differences were exhibited between the matched cohorts regarding embryo developmental parameters, including fertilization rate, cleavage rate, high-quality embryo rate, blastocyst formation rate, and available blastocyst rate, as well as clinical outcomes, such as implantation rate, biochemical pregnancy rate, and clinical pregnancy rate. Moreover, males after vaccination seemed to have fluctuated semen parameters including increased semen volume, lower motility, and decreased normal forms of sperms, while the motile sperm counts were similar. In addition, all semen parameters were above the lower reference limits. Limitations, reasons for caution: It was a single-center retrospective cohort study with a small sample size, and the men enrolled were suffering from infertility, which limited the generalizability of the conclusions. In addition, the endpoint of the current is a confirmation of clinical pregnancy, a study with a longer period of follow-up was urgent. Wider implications of the findings: Our findings suggested that CoronaVac vaccinations in males may not have adverse effects on patient's performance or the gamete and embryonic development potential during ART treatments. Larger studies among a wider population with longer followup in the future are required to support and validate our observations.

10.
Eur Rev Med Pharmacol Sci ; 26(15): 5574-5580, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1988904

ABSTRACT

OBJECTIVE: The COVID-19 pandemic has influenced regular medical procedures and health-seeking behaviors. In this study, we aimed to investigate the influence of the COVID-19 pandemic on the presentation and prognosis of acute ischemic stroke (AIS) patients in county-level stroke centers. PATIENTS AND METHODS: We retrospectively collected AIS patients during the strict lockdown period (January 24, 2020, to March 27, 2020) and the corresponding "new normal" period (2021) of the COVID-19 pandemic. Patients seen during the same timeframe in 2019 were enrolled as controls. Statistical analysis was conducted to compare the clinical characteristics of AIS patients who presented during the lockdown and new normal periods and those who presented during the pre-COVID-19 pandemic period. RESULTS: A total of 134 AIS patients presented during the lockdown period (the 2020 group), 207 patients in the pre-COVID-19 period (the 2019 group) and 201 patients in the "new normal" period (the 2021 group). Compared to the 2019 group, there was approximately 1/3 reduction in the number of patients who presented during the lockdown period, while the number of patients who received IVT or EVT was similar between the two groups. The number of patients, baseline characteristics, workflow intervals and clinical outcomes presented during the "new normal" period were similar between the 2019 and 2021 groups. Logistic regression showed that lockdown or new normal status were not risk factors associated with a poor outcome at 90 days. CONCLUSIONS: In county-level city stroke centers, the COVID-19 lockdown resulted in a reduction in the number of patients with AIS admitted to the hospital but had no effect on patients treated with IVT or EVT. Lockdown or new normal status did not influence the prognosis of AIS patients.


Subject(s)
COVID-19 , Ischemic Stroke , Stroke , COVID-19/epidemiology , Communicable Disease Control , Humans , Ischemic Stroke/diagnosis , Ischemic Stroke/epidemiology , Pandemics , Prognosis , Retrospective Studies , Stroke/epidemiology , Stroke/therapy
11.
Journal of the Operational Research Society ; 2022.
Article in English | Scopus | ID: covidwho-1960657

ABSTRACT

Air cargo plays an important role in supporting global supply chains;this becomes more vital when facing uncertainties in a crisis such as the COVID-19 pandemic. This motivates our study on air cargo forwarding plans, considering demand uncertainties and economic conditions. Cargos are placed into air containers based on weights and volumes, and then flown from regional collection points into a hub, for consolidation before transporting to onward destinations. Decisions are made in advance by cargo forwarders as to the containers to book, both in regions and in the hub, since airlines offer discounts on containers booked in advance;however, cargo quantities are uncertain when advance bookings are made. We develop a two-stage stochastic programming model, where the first stage determines both the quantities and types of air containers to book;the second stage deals with ordering any extra containers, at higher cost, or returning unused containers, as well as making loading and consolidation plans. The objective is to minimise the total expected costs. We then extend it into a multistage case and design a genetic algorithm as the solution method. Experimental results demonstrate that the proposed approaches provide a cost-efficient plan and responsive to demand as it arises. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

12.
Chinese Journal of Microbiology and Immunology (China) ; 42(4):245-250, 2022.
Article in Chinese | EMBASE | ID: covidwho-1928717

ABSTRACT

Objective To analyze the genome characteristics and variations in nucleotides and amino acids of SARS-CoV-2 causing an outbreak in Henan Province in November 2021 and perform the traceability analysis.Methods In this study, throat swab specimens from cases in the acute phase were collected and tested for the nucleic acids of SARS-CoV-2 by real-time fluorescent RT-PCR.SARS-CoV-2 nucleic acid-positive samples were subjected to high-throughput genome sequencing and whole-genome alignment analysis.Results The median Ct values of ORF1ab gene and N gene in 70 positive specimens was 26.41 (15.58 to 39.27) and 24.43 (12.04 to 39.74), respectively.Compared with the sequence of Wuhan-Hu(NC_045512) reference strain, 47 to 49 nucleotide mutations sharing 47 nucleotide mutation and 41 amino acid mutations were found in 63 strains of successfully sequenced SARS-CoV-2.Nine nucleotide mutations and 12 amino acid mutations were found in the spike protein.The index case shared 47 mutations with the Russian imported cases in Henan Province on October 14 and the local cases in Jiangxi Province in October.Moreover, their genomes were highly homologous and they all belonged to the Delta variant (AY.122 evolutionary branch).Conclusions Continuous monitoring of imported COVID-19 cases and prolonging the period of quarantine were needed to reduce the risk of local outbreak and epidemic caused by imported COVID-19 cases.Analysis of the genomic characteristics of SARS-CoV-2 and the variations in nucleotides and amino acids was conducive to trace the origin of COVID-19 outbreak quickly and provide reference for precise control.

13.
Regional Studies ; : 12, 2022.
Article in English | Web of Science | ID: covidwho-1927135

ABSTRACT

Production fragmentation across multiple regions can result in a regional shock propagating along value chains to a wider array of regions. We propose a methodological framework to measure the economic exposure to regional value chain disruptions due to city lockdown during Covid-19. The exposure index is evaluated by applying a hypothetical extraction method to a regionally extended inter-country input-output framework incorporating China's interregional input-output table. Our methodology can be adapted to conduct disaster impact analyses at city, state and country levels. It provides a tool for the immediate assessment of the economic risks of value chain disruptions, enabling quick policy responses.

14.
35th AAAI Conference on Artificial Intelligence, AAAI 2021 ; 6A:4804-4811, 2021.
Article in English | Scopus | ID: covidwho-1857093

ABSTRACT

Coronavirus Disease 2019 (COVID-19) causes a sudden turnover to bad at some checkpoints and thus needs the intervention of intensive care unit (ICU). This resulted in urgent and large needs of ICUs posed great risks to the medical system. Estimating the mortality of critical in-patients who were not admitted into the ICU will be valuable to optimize the management and assignment of ICU. Retrospective, 733 in-patients diagnosed with COVID-19 at a local hospital (Wuhan, China), as of March 18, 2020. Demographic, clinical and laboratory results were collected and analyzed using machine learning to build a predictive model. Considering the shortage of ICU beds at the beginning of disease emergence, we defined the mortality for those patients who were predicted to be in needing ICU care yet they did not as Missing-ICU (MI)-mortality. To estimate MI-mortality, a prognostic classification model was built to identify the in-patients who may need ICU care. Its predictive accuracy was 0.8288, with an AUC of 0.9119. On our cohort of 733 patients, 25 in-patients who have been predicted by our model that they should need ICU, yet they did not enter ICU due to lack of shorting ICU wards. Our analysis had shown that the MI-mortality is 41%, yet the mortality of ICU is 32%, implying that enough bed of ICU in treating patients in critical conditions. Copyright © 2021, Association for the Advancement of Artificial Intelligence (www.aaai.org). All rights reserved.

15.
Discov Med ; 32(165):39-47, 2021.
Article in English | PubMed | ID: covidwho-1711114

ABSTRACT

BACKGROUND: The follow-up data of discharged patients with coronavirus disease 19 (COVID-19) have not yet been fully analyzed and reported. This study aimed to evaluate the clinical features, test results, and outcomes of COVID-19 patients after discharge. METHODS: 149 COVID-19 patients with follow-up data after discharge were included. Post-hospitalization data related to clinical features and outcomes were obtained by following the patients up to 6 weeks. RESULTS: The COVID-19 patients were followed for a median of 28.0 days (range of 22 days to 42 days) after discharge from hospital. At the end of follow-up, four patients (2.7%) still had cough. The proportions of leukopenia and lymphopenia were 7.4% and 4.7%, respectively. The proportions of ALT, AST, and Cr abnormalities were 26.2%, 6.0%, and 0%, respectively. Abnormal chest CT was detected in 94 (63.1%) patients, including 14 (9.4%) unilateral pneumonia and 80 (53.7%) bilateral pneumonia. However, the proportion of chest CT abnormality significantly decreased compared to that at the time of admission. CONCLUSIONS: One month after discharge, few patients with COVID-19 had clinical symptoms;however, a substantial proportion of COVID-19 patients harbored abnormal laboratory and radiological examinations. Moderately long-term medical follow-up would justifiably benefit COVID-19 patients after discharge.

16.
Cancer Epidemiology Biomarkers and Prevention ; 31(1 SUPPL), 2022.
Article in English | EMBASE | ID: covidwho-1677444

ABSTRACT

Background: There is an increasing body of literature that suggests a relationship between modifiable dietary behaviors and alcohol use and liver cancer. We designed and implemented a culturally tailored community-based education program to promote liver cancer prevention. Methods: Through NCI funded U54 TUFCCC/HC Cancer Partnership Community Outreach Core program, using CBPR approach, we engaged community-based organizations and community stakeholders serving underserved African, Asian, and Hispanic American communities in the Philadelphia metropolitan area and New York City. The community-based education incorporated in-person and virtual hybrid education workshops to address COVID-19 pandemic barriers. We conducted preeducation surveys and follow-up assessments at 6 months post-education. Participants' dietary behaviors, alcohol use, and sociodemographic characteristics were examined at both time points. Results: 526 participants were recruited including 92 African Americans, 247 Asian Americans, and 187 Hispanic Americans, with an average age of 59. We found that at 6-month follow-up assessment, participants had average decreased intake of red meat (3.148/6 vs. 2.685/6, p < 0.001), and average increased intake of vegetables (4.484/6 vs. 5.044/6, p < 0.001) and fruits (4.327/6 vs. 4.877/6, p < 0.001), compared to their intake at pre-education assessment. Additionally, average change in beer (-0.252) and spirit (-0.905) consumption substantively decreased from pre-intervention to 6-month follow-up assessment. Conclusion: This community-based education showed significant effects in improving healthy dietary behaviors and reducing alcohol intake among community members through CBPR community engagement from the two metropolitan areas. Future efforts are needed to sustain the positive changes in modifiable lifestyle behaviors and liver cancer prevention in these medically underserved communities.

17.
CCS Chemistry ; 4(1):112-121, 2022.
Article in English | Scopus | ID: covidwho-1644130

ABSTRACT

Currently, there is no effective antiviral medication for coronavirus disease 2019 (COVID-19) and the knowledge on the potential therapeutic target is in great need. Guided by a time-course transmission electron microscope (TEM) imaging, we analyzed early phosphorylation dynamics within the first 15 min during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral entry. Based on alterations in the phosphorylation events, we found that kinase activities such as protein kinase C (PKC), interleukin-1 receptor-associated kinase 4 (IRAK4), MAP/microtubule affinity-regulating kinase 3 (MARK3), and TANK-binding kinase 1 (TBK1) were affected within 15 min of infection. Application of the corresponding kinase inhibitors of PKC, IRAK4, and p38 showed significant inhibition of SARS-CoV-2 replication. Additionally, proinflammatory cytokine production was reduced by applying PKC and p38 inhibitors. By an acquisition of a combined image data using positiveand negative-sense RNA probes, as well as pseudovirus entry assay, we demonstrated that PKC contributed to viral entry into the host cell, and therefore, could be a potential COVID-19 therapeutic target. © 2022 Chinese Chemical Society. All right reserved.

18.
TMR Integrative Medicine ; 5, 2021.
Article in English | EMBASE | ID: covidwho-1573209

ABSTRACT

Patients with novel coronavirus disease-19 (COVID-19) pneumonia continue to have problems with respiratory function, physical and psychological function, the ability to perform activities of daily living, and social participation after discharge from the hospital. As such, strengthening rehabilitation treatments for discharged patients and relapse prevention after recovery are important aspects of the prevention and control of COVID-19. This paper combined the principles and practices of in Chinese and Western medicine and compiled the recommendations of both for home rehabilitation in the post-COVID-19 epidemic stage. The purpose of this paper is to facilitate the self-rehabilitation of patients with COVID-19 and to promote the prevention and control of COVID-19 at this current stage.

19.
Chinese Journal of Disease Control and Prevention ; 25(7):802-805, 2021.
Article in Chinese | Scopus | ID: covidwho-1566866

ABSTRACT

Objective To study the safety of inactivated SARS-CoV-2 vaccine (Vero cells) (SARS-CoV-2 vaccine) in Hefei during the emergency vaccination period, and to provide reference for the promotion and vaccination of this vaccine in the whole population in the later period. Methods A total of 19 vaccination clinics in Hefei were selected as active monitoring sites for immunization safety. Focus groups aged 18-59 years who were vaccinated with SARS-CoV-2 vaccine in Hefei from 15 December 2020 to 10 February 2021 were observed. The incidence, types and severity of adverse reactions after vaccination were descriptively analyzed. Results A total of 18 574 people were effectively observed, and 33 433 doses of SARS-CoV-2 vaccine were inoculated. 713 cases of general adverse reactions occurred, with an incidence of 2.13%. The incidence of adverse reactions in the first dose was 2.57%, which was higher than that in the second dose (1.58%, χ2=38.92, P < 0.001). There was no statistical significance in the incidence of general adverse reactions of inactivated vaccine produced by the two companies (χ2=3.08, P=0.082). Among the adverse events such as redness and swelling at the injection site, induration at the injection site, and fever, the incidence of grade 1, 2 and 3 adverse events were 0.65%, 1.42%, and 0.06%, but there were no ≥ grade 4, rare and extremely rare adverse events. Conclusion Domestic inactivated SARS-CoV-2 vaccine (Vero cells) is great safe. © 2021, Publication Centre of Anhui Medical University. All rights reserved.

20.
Chinese Pharmaceutical Journal ; 56(20):1690-1693, 2021.
Article in Chinese | Scopus | ID: covidwho-1566820

ABSTRACT

OBJECTIVE: To study the dose-based BCS (biopharmaceutical classification system) classification of dexamethasone for different indications. METHODS: Saturation shake-flask method was utilized with the conditions of shaking water bath at 37℃ and 120 r•min-1, somewhat excess solids added into saturate systems at pH 1.2, 4.5 and 6.8 buffers respectively. And high-performance liquid chromatography was used for saturation concentration measurement. In this study, the dosages of dexamethasone for both classic and new indications were collected, such as covid-19, which were divided into low-dose, intermediate-dose and high-dose. Then the dissolution volumes (DSVs) were calculated and the indication-based BCS classifications of dexamethasone was studied. RESULTS: At the low-dose, the BCS classification of dexamethasone was high solubility;at the high-dose, the BCS classification of dexamethasone was low;and at the intermediate-dose, the BCS classification of dexamethasone was on the edge of low solubility and high solubility. CONCLUSION: This study provides basic data for the BCS classification of dexamethasone;dose-related solubility classification has guiding significance for the BCS classification of dexamethasone for new indications, and provides refine reference for the rationality of the BE wavier for solid oral dosage forms in the consistency evaluation of generic drugs. Copyright 2021 by the Chinese Pharmaceutical Association.

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