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Gastroenterology ; 160(3): 925-928.e4, 2021 02.
Article in English | MEDLINE | ID: covidwho-1575253
Front Immunol ; 12: 639329, 2021.
Article in English | MEDLINE | ID: covidwho-1219713


Background: Infection with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a wide range of symptoms including gastrointestinal manifestations, and intestinal epithelial cells are a target of the virus. However, it is unknown how the intestinal immune system contributes to systemic immune responses in coronavirus disease 2019 (COVID-19). Methods: We characterized peripheral blood lymphocytes from patients with active COVID-19 and convalescent patients as well as healthy controls by flow cytometry. Results: The frequency and absolute number of circulating memory T and B cells expressing the gut homing integrin α4ß7 integrin was reduced during COVID-19, whether gastrointestinal symptoms were present or not. While total IgA-expressing B cells were increased, gut-imprinted B cells with IgA expression were stable. Conclusion: COVID-19 is associated with a decrease in circulating adaptive immune cells expressing the key gut homing marker α4ß7 suggesting that these cells are preferentially recruited to extra-intestinal tissues independently of α4ß7 or that the systemic immune response against SARS-CoV-2 is at least numerically dominated by extraintestinal, particularly pulmonary, immune cell priming.

B-Lymphocytes/metabolism , COVID-19/immunology , Integrin alpha4/metabolism , Integrins/metabolism , SARS-CoV-2/immunology , T-Lymphocytes/metabolism , Adult , B-Lymphocytes/immunology , Biomarkers/analysis , COVID-19/pathology , Female , Humans , Immunologic Memory/immunology , Intestinal Mucosa/cytology , Intestinal Mucosa/immunology , Lymphocyte Count , Male , Middle Aged , T-Lymphocytes/immunology
Gastroenterology ; 160(3): 925-928.e4, 2021 02.
Article in English | MEDLINE | ID: covidwho-977281