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1.
Sleep Science ; 15:76, 2022.
Article in English | EMBASE | ID: covidwho-1935162

ABSTRACT

Introduction: The inflammatory process and multisystemic manifestation caused by Covid-19 infection can involve multiple sequelae with damage on physical, cognitive, psychological, and biological aspects. This condition results on poor quality of life, fatigue, dyspnea and sleep difficulties. The focus on sleep difficulties, the most common symptoms are related to night drowsiness and insomnia, but little is known about the clinical characteristics of these patients who develop this complication. Objective: Evaluate the main complaints and clinical signs in patients after COVID-19. - Rate the quality of sleep in post-COVID-19 Syndrome patients who have had mild, moderate and/or severe symptoms of the disease. Methods: Observational study and descriptive, with a quantitative approach to data. A general and a specific sleep quality questionnaire were applied to patients undergoing rehabilitation after the diagnosis of COVID-19, who did or did not need to be hospitalized, with symptoms that had started at least 5 weeks before the questionnaire response date. Participants who were unable to answer the questionnaires due to a deficit in understanding the questions asked, or who gave up on completing the questionnaires without finishing, were excluded. Results: 177 participants participated in the research, 124 men (70%) and 53 women (30%). 62.7% of participants reported at least one comorbidity and only 23 people (12.9%) were not vaccinated with any dose until participation in this study. With regard to hospital admission, 109 participants (61.6%) required admission to the ICU and of these, 57.8% (63) required orotracheal intubation, with prolonged hospital stay for more than 12 days. The most common symptoms after covid-19 were muscle fatigue (78.3%), excessive daytime sleepiness (51.4%), persistent cough (47.4%) and headache (47.1%). 81.4% of participants reported that they felt their sleep quality had worsened after the diagnosis of COVID-19. And after applying a specific questionnaire (PSQI), 93.7% of participants were classified as poor sleepers. There was a very strong correlation (r>0.9) with participants who assessed hospitalized and in invasive mechanical ventilation, with bad sleep quality. Conclusion: The post-COVID-19 Syndrome, associated with age, comorbidities, length of stay and use of invasive mechanical ventilation, were factors that are associated with a higher prevalence of sleep disorders.

3.
Brazilian Journal of Infectious Diseases ; 26, 2022.
Article in Portuguese | EMBASE | ID: covidwho-1693855

ABSTRACT

Globalmente, cerca de 5 milhões de jovens com idades entre 15-25 anos vivem com o HIV, sendo uma parte deste grupo composta por aqueles que adquiriram a infecção por via vertical. Essa população constitui a única faixa etária em que a mortalidade relacionada ao HIV continua em curva ascendente. Estudos avaliando pacientes infectados pelo HIV-1 de forma vertical descrevem prioritariamente a população pediátrica, com poucos estudos acerca de jovens adultos e sua progressão de doença. Para melhor compreensão dessa população, cujo manejo da infecção pelo HIV se mantem desafiadora, analisamos 90 adultos que adquiriram HIV por via vertical, em acompanhamento em um Hospital terciário. Desta população, a média de idade é de 23 anos, sendo 47% do gênero feminino e 53% masculino. Todos receberam recomendação de uso de ARV, sendo que em 34% da população estudada, não havia controle virológico. Nestes, a mediana de HIV-RNA era 4096 cópias/mL. Por outro lado, do ponto de vista imunológico, 91% dos pacientes apresentavam contagem de células T CD4 > 200 cél/mm3, com mediana de CD4 de 644 cél/mm3, com relação CD4/CD8 mediana de 0,8. Contrário ao esperado, a combinação de ARV mais utilizada é TDF/3TC/DTG. Da população analisada, 52 participantes foram submetidos a genotropismo durante o seguimento, sendo que 71% apresentava vírus R5-trópico. Finalmente, retenção de tratamento foi analisada, nos anos 2019, 2020 e 2021, mostrando que 71% dos pacientes fechou critérios de retenção de tratamento. Por outro lado, a frequência em consultas, definida como “retenção do cuidado” foi menor, com 29% preenchendo as definições utilizadas. Demais dados demográficos e análises, incluindo de como a pandemia da COVID-19 influenciou a retenção de cuidado e o tratamento, serão apresentadas.

4.
Vigilancia Sanitaria Em Debate-Sociedade Ciencia & Tecnologia ; 9(3):92-101, 2021.
Article in Portuguese | Web of Science | ID: covidwho-1411591

ABSTRACT

Introduction: In December 2019, the first group of patients with symptoms of atypical pneumonia was discovered in Wuhan, China. On January 7, 2020, the etiologic agent was identified;it was a new betacoronavirus, genetically similar to SARS-CoV-1, consisting of a simple RNA strand, an enveloped virus of 50-200nm in diameter, which was called SARS-CoV-2. Soon after, the disease was named COVID-19. On January 30, WHO declared a Public Health Emergency of International Importance due to the spread of the coronavirus. Tests for serological detection of IgM and IgG antibodies are those that provide an estimate of the immune response to SARS-CoV-2, highlighting the Rapid Diagnostic Tests (RDT), simple and accessible with a result within 5-30 minutes, based on sensitization of antigens/antibodies conjugated to colloidal gold capturing specific proteins present in the infected serum, plasma or blood. Objective: This work aims to show the analysis carried out with RDT for COVID-19 diagnosis in compliance with the current legislation from 02.04 to 18.08.2020. Method: In March of 2020, 25 serum/plasma samples were donated, without any identification. These samples were the remaining samples of tests performed on individuals with a confirmed diagnosis of SARS-CoV-2 infection by the RT-PCR technique from health services (National Institute of Infectious Diseases Evandro Chagas - INI and State Institute of the Brain Paulo Niemeyer - IEC) located in the metropolitan region of the state of Rio de Janeiro. The samples obtained in order to become a serological panel were stored at -20 degrees C until the moment of use. Simultaneously, a panel of samples with confirmed reactivity for IgM and IgG antibodies from COVID-19 was being made, throughout the pandemic and the samples used were evaluated against three Rapid Tests, of different antigenic compositions or different brands;two ELISA tests for IgM and IgG;two chemiluminescence tests and when applicable, a molecular test. In order to assess the specificity of the products sent, surplus donation plasma samples were selected, known to be negative for HIV, HTLV, hepatitis b and c, chagas and syphilis, collected between 2013 and 2014, in the southern regions of the country, period in which SARS-CoV-2 was nonexistent in the world. In addition to True Positive (VP) and True Negative (VN) samples, interfering serum or plasma samples with reactivity for HIV, HCV, HTLV, HBsAg, chagas disease, syphilis and dengue were also included in the evaluation. Results: Out of 178 TR lots, 74.1%, 132 lots were from China and 25.9%, 46 TR lots were from Brazil;Germany;South Korea;Canada;USA;Singapore;Ireland and Switzerland. The analytical result showed that 57.0%, 101 TR lots obtained a Satisfactory result and 43%, 77 lots had Unsatisfactory results, when compared to the Sensitivity and Specificity values declared by the manufacturer, in the Instructions for Use. Conclusions: The results obtained show the need for constant monitoring of TRs for COVID-19 with the primary purpose of guaranteeing the quality of products sold in the country, one of the National Health Surveillance System pillars of action.

5.
Journal of Open Innovation: Technology, Market, and Complexity ; 7(1):1-24, 2021.
Article in English | Scopus | ID: covidwho-1134173

ABSTRACT

Facing one of the most challenging pandemics for organizational modus operandi (COVID-19), organizations are struggling for operational and strategic support. The adoption of remote work (RW) is increasing. For economic reasons, competitive advantage, or even as a pandemic response (business continuity plan), RW is a domain worth further investigation. However, the literature lacks insight regarding RW adoption. A design science research methodology was adopted, including a systematic literature review to elicit RW advantages, disadvantages, challenges and driving forces, as well as their relation. To evaluate and demonstrate findings, 129 qualitative interviews were performed with RW professionals. In the end, 57 decision factors were elicited, and 16 relations were validated. The authors concluded that cost-reduction and flexibility to promote work–life balance is the most positive outputs, while communication and technical problems, as well as management issues, are what most concerns professionals. Moreover, positive relations are more recognized among professionals over negative ones. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

6.
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