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1.
Current Traditional Medicine ; 9(1):44-83, 2023.
Article in English | EMBASE | ID: covidwho-2197854

ABSTRACT

Background: Over recent years, evidence-based modern medicine has overshadowed the use and efficacy of natural and traditional medicines. However, in the wake of the pandemic, the in-terest in the quest for therapeutic resources linked to traditional, complementary, and integrative medicine has substantially increased. This has further facilitated the research and development of potential therapeutic crude drugs or their formulations in the management of COVID-19 and the symptoms associated with the latter. This article attempts to provide a comprehensive review of the various traditional medicines used as integrative medicines in alleviating symptoms attributed to the COVID-19 infection. Method(s): The literature was thoroughly browsed for recent research articles, systematic reviews, case studies, and review articles on ScienceDirect, PubMed, and Google Scholar using keywords like complementary medicine, alternative medicine, and holistic approach to enlist a few. Subse-quently, they were thoroughly screened to include only recent studies and evidence. Additionally, the official guidelines published by the Government and other regulatory bodies were also sought to be included in the article. Study Design: The review article follows the narrative literature review method. However, the pri-mary data was skimm ed for relevance, and only recent shreds of evidence pertinent to the review were included. Result(s): The review elucidated the pharmacological activity of various treatment regimens in different systems of medicine, with available supportive clinical evidence. Additionally, it also under-scored the importance of holistic health interventions, and how these traditional and integrative systems of medicine cater to the same. Conclusion(s): The recent evidence presents a broad-spectrum effect of these therapeutic interven-tions, primarily in the fields of mental health, mild to moderate, and even severe forms of the infec-tion, employing various pharmacological pathways. These studies primarily include studies and sta-tistics pertaining to the SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2) but may include supporting evidence from other respiratory viruses. This information may prove imper-ative in guiding new research, and also in designing and supporting an integrative treatment regi-men. Conclusively, any suspicion pertaining to the COVID-19 infection should be sought by follow-ing the protocols recommended by the concerned health authorities of the respective region/country. Copyright © 2023 Bentham Science Publishers.

2.
Pharmacological Research ; 187 (no pagination), 2023.
Article in English | EMBASE | ID: covidwho-2170621

ABSTRACT

Cucurbitacin B (CuB, C32H46O8), the most abundant and active member of cucurbitacins, which are highly oxidized tetracyclic triterpenoids. Cucurbitacins are widely distributed in a variety of plants and mainly isolated from plants in the Cucurbitaceae family. CuB is mostly obtained from the pedicel of Cucumis melo L. Modern pharmacological studies have confirmed that CuB has a broad range of pharmacological activities, with significant therapeutic effects on a variety of diseases including inflammatory diseases, neurodegenerative diseases, diabetes mellitus, and cancers. In this study the PubMed, Web of Science, Science Direct, and China National Knowledge Infrastructure (CNKI) databases were searched from 1986 to 2022. After inclusion and exclusion criteria were applied, 98 out of 2484 articles were selected for a systematic review to comprehensively summarize the pharmacological activity, toxicity, and pharmacokinetic properties of CuB. The results showed that CuB exhibits potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective, and anti-cancer activities mainly via regulating various signaling pathways, such as the Janus kinase/signal transducer and activator of transcription-3 (JAK/STAT3), nuclear factor erythroid 2-related factor-2/antioxidant responsive element (Nrf2/ARE), nuclear factor (NF)-kappaB, AMP-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/Akt, cancerous inhibitor of protein phosphatase-2A/protein phosphatase-2A (CIP2A/PP2A), Wnt, focal adhesion kinase (FAK), Notch, and Hippo-Yes-associated protein (YAP) pathways. Studies of its toxicity and pharmacokinetic properties showed that CuB has non-specific toxicity and low bioavailability. In addition, derivatives and clinical applications of CuB are discussed in this paper. Copyright © 2022

3.
International Immunopharmacology ; 115:109635, 2023.
Article in English | ScienceDirect | ID: covidwho-2165422

ABSTRACT

The therapeutic benefits of curcuminoids in various diseases have been extensively reported. However, little is known regarding their preventive effects on extensive immunosuppression. We investigated the immunoregulatory effects of a curcuminoid complex (CS/M), solubilized with stevioside, using a microwave-assisted method in a cyclophosphamide (CTX)-induced immunosuppressive mouse model and identified its new pharmacological benefits. CTX-treated mice showed a decreased number of innate cells, such as dendritic cells (DCs), neutrophils, and natural killer (NK) cells, and adaptive immune cells (CD4 and CD8 T cells) in the spleen. In addition, CTX administration decreased T cell activation, especially that of Th1 and CD8 T cells, whereas it increased Th2 and regulatory T (Treg) cell activations. Pre-exposure of CS/M to CTX-induced immunosuppressed mice restored the number of innate cells (DCs, neutrophils, and NK cells) and increased their activity (including the activity of macrophages). Exposure to CS/M also led to the superior restoration of T cell numbers, including Th1, activated CD8 T cells, and multifunctional T cells, suppressed by CTX, along with a decrease in Th2 and Treg cells. Furthermore,CTX-injected mice pre-exposed to CS/M were accompanied by an increase in the levels of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase), which play an essential role against oxidative stress. Importantly, CS/M treatment significantly reduced viral loads in severe acute respiratory syndrome coronavirus2-infected hamsters and attenuated the gross pathology in the lungs. These results provide new insights into the immunological properties of CS/M in preventing extensive immunosuppression and offer new therapeutic opportunities against various cancers and infectious diseases caused by viruses and intracellular bacteria.

4.
Tanzania Journal of Health Research ; 23(Supplement 1):104, 2022.
Article in English | EMBASE | ID: covidwho-2115556

ABSTRACT

Background: Bersama abyssinica is a common tree in Africa, with diverse medical uses in different areas. The plant is well-known in Tanzania for treating respiratory disorders such as TB, tonsillitis, bronchitis and asthma, The plant has lately been utilized for treatment of COVID-19 symptoms. Water extract of leaf and stem bark has been registered as a herbal medication known as 'Coviba Dawa' for the treatment of viral and bacterial respiratory infections due to its broad medical benefits. The aim of this work was to test for the cytotoxicity and antiviral effects of bioactive ingredients from B. abyssinica extracts against the Delta variant of the SARS-CoV-2 coronavirus. Method(s): Bersama abyssinica leaves and stem barks were dried under shade in room temperature and then pulverized to obtain small pieces before soaking into different solvents. One hundred grams of each, leaves and stem barks were extracted in petroleum ether, dichloromethane, ethyl acetate and ethanol. Water extract was obtained by decoction of 100g of stem bark into water. Phenols, flavonoids, tannins with antioxidant activity were confirmed as components of the extracts. Analysis of aqueous extracts of bark stem bark and leaves was done by LC-MS/MS (Q-orbitrap-Ultra High Performance Thermofisher Company). Antiviral screening and cytotoxicity experiments were conducted in a Biosafety Level 3 (BSL-3) Laboratory facility according to previously established Standard operating procedures (SOPs). Result(s): The existence of four phenolic compounds in B. abyssinica water extract;2,4-di-tert-butylphenol, 4-formyl-2-methoxyphenyl propionate, 7,8-Dihydroxy-4-methylcoumarin, and 2,3, 6-trimethoxyflavone with antioxidant activity was confirmed by LC-MS/MS analysis. In-vitro testing of the extracts revealed antiviral activity against coronavirus the delta B1 variant of SARS-CoV2. Conclusion(s): We recommend further studies to characterize the medicinal value of B. abyssinica metabolites as potential antiviral and antibacterial agents.

5.
Journal of Pharmaceutical Negative Results ; 13:555-561, 2022.
Article in English | Web of Science | ID: covidwho-2111710

ABSTRACT

Background: Despite several scientific efforts against COVID 19, conundrum of biomolecular deterioration in Post COVID syndrome patients are still in dark at an unprecedented scale globally and affected the patient's health multidimensionally. It is conceivable that patients recovered from COVID-19 after second wave are at enhanced risk of secondary complications.Aim: The present study was carried out to estimate the serum vitamin D and total antioxidant activity (TAC) along with markers of oxi-inflammatory stress in post COVID patients diagnosed RT-PCR negative after second wave of COVID-19 and to determine their role in predicting secondary complications.Methodology: 50 subjects (30-55 years) of Delhi-NCR region were recruited and categorized into two groups (n=25 in each group;on the basis of their history of COVID infection). By using standard methods, study group parameters were estimated in Post COVID patients and statistically compared it with that of 25 non affected healthy controls by using student's t-test.Result: Serum CRP, TNF-alpha, MDA and uric acid levels were significantly high (p<0.05) in Post COVID patients as compared to healthy controls. Conversely, serum vitamin D and TAC levels along with SOD activities were found to be significantly low (P<0.001) in Post COVID patients as compared healthy controls. However, ceruloplasmin level was altered insignificantly (p<0.1) with respect to Group I subjects. Vitamin D levels were positively correlated with TAC and SOD activity (P<0.001) and negatively correlated with MDA, CRP, TNF-alpha and uric acid levels in post COVID patients.Conclusion: Therefore, the present study emphasizes the dire need of special attention to Post COVID population by providing vitamin D supplementation, antioxidant and mineral rich diet along with adoption of regular aerobic exercise not only to rejuvenate the biomolecular homeostasis but also to reduce oxi-inflammatory stress mediated future complications.

6.
Química Nova ; 2022.
Article in English | Web of Science | ID: covidwho-2100670

ABSTRACT

The pandemic caused by the new coronavirus has resulted in a global health emergency and has prompted an urgent need for new treatment strategies. No target-specific drugs are currently available for SARS-CoV-2, but new drug candidates targeting the viral replication cycle are being explored. A prime target of drug-discovery efforts is the SARS-CoV-2 main protease (Mpro). In this work, we identified a potential inhibitor for SARS-CoV-2 main protease using in silico methodologies. Molecular docking and molecular dynamics studies were carried out to ascertain the inhibitory action of a and 13 anomers of Punicalagin from fruit peel of Punica granatum against the Mpro protease. The molecular dynamics results revealed that the 13-anomeric configuration of punicalagin allowed access to more hydrogen bonds and hydrophobic interaction leading to higher selectivity and specificity of 13-anomer than a-anomer. Therefore, the 13-anomer of Punicalagin could act as potential inhibitor against the main protease of SARS-CoV-2 and may act as a potential drug candidate.

7.
Ethnobotany Research and Applications ; 24, 2022.
Article in English | Scopus | ID: covidwho-2081514

ABSTRACT

Background: Plant natural products have a long history of usage as a source of therapeutic agents. Oroxylum indicum (L.) Kurz is a prominent therapeutic plant in South Asia, comprising several phytochemicals with substantial medical significance, including the treatment of COVID-19. Methods: Herein, we documented the medicinal importance of O. indicum throughout Nepal using a questionnaire-based survey and and validated the findings through biochemical analyses. Results: All fractions (water, hexane and dichloromethane) obtained from different extraction solvents revealed a high abundance of alkaloids, flavonoids, phenolic compounds, saponins, and carbohydrates that is consistent with its vast ethnomedicinal uses generated through the questionnaire survey. Conclusions: In a nutshell, O. indicum is a promising medicinal plant based on our current experiment, and more research on ethnomedicinal and plant biochemical capabilities might lead to new scientific avenues and novel drug discoveries. It further paves the scope of documentation of traditional knowledge for the benefit of local and national communities. © 2022, Ilia State University, Institute of Botany, Department of Ethnobotany. All rights reserved.

8.
World Journal of Traditional Chinese Medicine ; 8(4):463-490, 2022.
Article in English | EMBASE | ID: covidwho-2066828

ABSTRACT

Curcumae Longae Rhizoma (CLR) is the rhizome of Curcuma longa L. Pharmacological studies show that CLR can be used to treat cervical cancer, lung cancer, lupus nephritis, and other conditions. In this paper, we review botany, traditional application, phytochemistry, pharmacological activity, and pharmacokinetics of CLR. The literature from 1981 to date was entirely collected from online databases, such as Web of Science, Google Scholar, China Academic Journals full-text database (CNKI), Wiley, Springer, PubMed, and ScienceDirect. The data were also obtained from ancient books, theses and dissertations, and Flora Reipublicae Popularis Sinicae. There are a total of 275 compounds that have been isolated from CLR, including phenolic compounds, volatile oils, and others. The therapeutic effect of turmeric has been expanded from breaking blood and activating qi in the traditional sense to antitumor, anti-inflammatory, antioxidation, neuroprotection, antibacterial, hypolipidemic effects, and other benefits. However, the active ingredients and mechanisms of action related to relieving disease remain ill defined, which requires more in-depth research and verification at a clinical level.

9.
Rasayan Journal of Chemistry ; 15(3):1642-1645, 2022.
Article in English | Scopus | ID: covidwho-2026547

ABSTRACT

The effect of milk on physicochemical and functional properties of kencur jelly drink has been investigated. The results of the analysis showed a decrease in water, ash, total sugar, phenol and flavonoid content, antioxidant activity, and syneresis in the kencur-milk jelly drinks. However, the addition of milk was detected to increase protein, fat, pH, and antibacterial activity against Salmonella typhimurium and Escherichia coli bacteria. © 2022, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.

10.
Applied Sciences ; 12(16):8063, 2022.
Article in English | ProQuest Central | ID: covidwho-2023096

ABSTRACT

This study was conducted to investigate the influence of pumpkin cultivar as a fermented semi-product on the selected quality parameters of functional non-dairy frozen desserts, which were prepared using the potentially probiotic strain cultures L. rhamnosus Lock 0900 and L. casei O14. Microbiological status, pH, sugar and carotenoids content, antioxidant activity, color and sensory quality have been checked. Regardless of the pumpkin cultivar used, the lactic acid fermentation of pulps with selected bacterial strains decreased reducing sugar and total sugars content. Improvement in the antioxidant activity was also observed. The impact of the individual sensory attributes on the overall quality was determined. The overall quality of the investigated pumpkin sorbets was positively driven by the sweet taste, pumpkin flavor, smoothness of texture, and negatively driven by acidic flavor, pungent taste, and bitter taste, verified by PCA method. All of the final products achieved high survival of probiotics (higher than 8.4 log CFU/g) and revealed a good sensory quality (overall quality higher than 8 c.u). The treatments with the cultivar “Melon Yellow” of the Cucurbita maxima species, were characterized by significantly higher (p < 0.05) carotenoids content, total sugars and reducing sugars content and antioxidant activity, measured by two methods. It can be concluded that the pumpkin cultivar and strain culture used for the fermentation affect the count of potentially probiotic bacteria in the final products, the composition of bioactive compounds, antioxidant activity and sensory quality of the functional pumpkin frozen desserts.

11.
Antioxidants (Basel) ; 11(8)2022 Aug 17.
Article in English | MEDLINE | ID: covidwho-2023091

ABSTRACT

Electron transfer plays a crucial role in ROS generation in living systems. Molecular oxygen acts as the terminal electron acceptor in the respiratory chains of aerobic organisms. Two main mechanisms of antioxidant defense by exogenous antioxidants are usually considered. The first is the inhibition of ROS generation, and the second is the trapping of free radicals. In the present study, we have elucidated both these mechanisms of antioxidant activity of glycyrrhizin (GL), the main active component of licorice root, using the chemically induced dynamic nuclear polarization (CIDNP) technique. First, it was shown that GL is capable of capturing a solvated electron, thereby preventing its capture by molecular oxygen. Second, we studied the effect of glycyrrhizin on the behavior of free radicals generated by UV irradiation of xenobiotic, NSAID-naproxen in solution. The structure of the glycyrrhizin paramagnetic intermediates formed after the capture of a solvated electron was established from a photo-CIDNP study of the model system-the dianion of 5-sulfosalicylic acid and DFT calculations.

12.
Biocatalysis and Agricultural Biotechnology ; : 102470, 2022.
Article in English | ScienceDirect | ID: covidwho-2007464

ABSTRACT

Essential oil extracted from plants has many applications in the field of medicine, cosmetic and pharmaceuticals due to cost effectiveness and therapeutic effects associated. In this article, we have compiled discussion on the essential oil extracted from ginger, cinnamon, and lemon leaves. Essential oils are rich source of antioxidant compounds like cinnamaldehyde, zingiberene and limonene. This review article covers the literature related to antioxidant and biological activities of essential oils extracted from ginger, cinnamon and lemon. In addition, applications of the essential oils in the field of medical, pharmacology, cosmetic etc, have been discussed. Role of essential oils, for anti-cancer, anti-hypertension, reduction of heart diseases and maintaining of blood circulation and digestion due to presence of antioxidant components, has been discussed. Literature has also supported Covid-19 preventive effects of essential oils. Keeping in view the positive effects on health, essential oils can be used as supplements. Furthermore, essential oils must be further investigated for their biological activities followed by development of essential oil based drugs and pharmaceutics.

13.
Biocell ; 46, 2022.
Article in English | EMBASE | ID: covidwho-2002968

ABSTRACT

The proceedings contain 62 papers. The topics discussed include: antifungal activity of plant extracts on pathogenic fungi of cereals;activity of extracts from Justicia xylosteoides and Astronium balansae on pathogens responsible of maize ear rot;characterization of starch extracted from rhizomes of Sechium edule (JACQ.) SWARTZ;evaluation of physical, chemical and microbiological parameters in yogurts with added coconut and its derivatives;purification of anti-RBD antibodies obtained from llama (Lama glama) for potential COVID-19 therapy;water quality assessment of the Miraflores River, using the benthic entomofauna as bioindicators;altitudinal distribution of scorpiones, pseudoscorpiones, solifugae and opiliones (arthropoda: arachnida) in the Ambato Department, Catamarca;and phytochemical analysis, antioxidant activity and cytotoxicity of phenolic fraction from Geoffroea decorticans stem bark.

14.
Molecules ; 27(15)2022 Aug 05.
Article in English | MEDLINE | ID: covidwho-1994118

ABSTRACT

The aim of this study was to determine the variability of several chemical compounds and the antioxidant and antimicrobial activities of eight types of berries harvested from two different geographical regions in the same year. The analyses were performed on bilberry, black currant, gooseberry, red currant, raspberry, sea buckthorn, strawberry and sour cherry, which were handpicked during the summer of 2019, in the same periods when they are typically harvested for consumer purposes. Total anthocyanins content (TAC), total flavonoids content (TFC), total polyphenolic compounds (TPC), determination of the Ferric-Reducing Antioxidant Power (FRAP), determination of the DPPH free radical scavenging assay (RSA), determination of nine phenolic compounds by HPLC-UV assay and antimicrobial activity were determined for undiluted hydroalcoholic extracts of all the studied berries. The results showed that the berries from Romania were richer in antioxidant compounds than the berries from Russia. The TPC content varied between 4.13-22.2 mg GAE/g d.w., TFC between 3.33-8.87 mg QE/g d.w. and TAC between 0.13-3.94 mg/g d.w. The highest variability was determined for TPC. Regarding the antioxidant activity assessed by FRAP assay, values were between 6.02-57.23 µmols TE/g d.w. and values for the RSA method between 18.44-83.81%. From the eight types of berries analyzed, bilberries and raspberries had the highest antioxidant activity considering both regions and both determination methods. Not only the type, but also the environmental and cultivation conditions in which the berries grow, can lead to variations in their chemical composition. The extracted polyphenolic compounds from the studied berries showed antibacterial properties on pathogens, such as Escherichia coli, Bacillus subtilis and Staphyloccocus aureus. The inhibitory action on Salmonella typhi and fungi Candida albicans and Aspegillus niger was absent to very low. The antimicrobial activity of the hydroalcoholic extracts was dependent on the provenance of the berries, too.


Subject(s)
Anti-Infective Agents , Ribes , Vaccinium myrtillus , Anthocyanins/analysis , Anthocyanins/pharmacology , Anti-Bacterial Agents/pharmacology , Anti-Infective Agents/analysis , Anti-Infective Agents/pharmacology , Antioxidants/chemistry , Flavonoids/analysis , Flavonoids/pharmacology , Fruit/chemistry , Phytochemicals/analysis , Phytochemicals/pharmacology , Plant Extracts/chemistry , Ribes/chemistry
15.
Tropical Journal of Natural Product Research ; 6(7):1124-1130, 2022.
Article in English | EMBASE | ID: covidwho-1988910

ABSTRACT

Diabetes is the tenth most common comorbidity in coronavirus disease, hence COVID-19 patients with this disease showed higher mortality rates and worse outcomes. Therefore, Management of diabetes during the pandemic became more critical, especially in ensuring patients consume functional foods containing diets, such as sweet potato, cassava, and taro, among the top ten abundant-traditional tubers in Indonesia. These foods are rich in protein, vitamin C, thiamine, riboflavin, niacin, and dietary fibre. Carbohydrate-rich foods, which constitute around 60% of the average diet should be considered. This study evaluated the potential of the three most consumed Indonesian tubers;sweet potato, cassava, and taro, as functional foods for managing diabetes during the pandemic. These foods were selected based on their chemical composition, antioxidant activity, and in silico molecular docking against COVID-19 and diabetes-related target proteins. The target proteins are ACE2 (angiotensin-converting enzyme 2), TMPRSS-2 (transmembrane serine protease 2), DPP IV (dipeptidyl peptidase IV), and α-glucosidase. The results showed that sweet potato has the highest phenolic compounds content and antioxidant activity, valued at 7.40 ± 0.20 mg/g GAE and 9.39 ± 0.3%, respectively. Moreover, molecular docking results indicated that sweet potato phenolic compounds, namely isorhamnetin, peonidin, and catechin against DPP IV, isorhamnetin, peonidin, and quercetin against ACE2, isorhamnetin and quercetin against α-glucosidase, and epicatechin against TMPRSS2 strongly interacted with the target proteins. In conclusion, cassava, taro, and sweet potato were the most potential functional foods for diabetes management during the pandemic.

16.
International Journal of Early Childhood Special Education ; 14(5):4169-4174, 2022.
Article in English | Web of Science | ID: covidwho-1979683

ABSTRACT

Plant secondary metabolites are an important source of new drugs, especially flavonoids, were shown to have antioxidant, antiviral, antibacterial, anticancer.. Antioxidant compounds have the potential to improve the prognosis of COVID-19 infections. The antiviral effect of flavonoids, which are secondary plant phenolics, as well as other antioxidants has been explored for their effect on SARS-CoV-2. There are various methods for measuring biological compounds. Qualitative and quantitative techniques of polyphenols measurement include chromatography such as HPLC and GC-MS. These techniques are expensive and time-consuming.In this study, for the first time, the amount of vitamins of vitamin B12, vitamin C and Hawthorn extract flavonoids by plant biosensor that is a new approach was become to a visible rotation, and its amount can be detected through this rotation. For the detection of vitamin B12, vitamin C and Hawthorn extract flavonoids the rotations of them were analyzed by plant bionanosensor in a completely randomized design with three replications by sas9.1 software. It was determined that plant bionanosensor capability of detecting vitamin B12, vitamin C and flavonoids through the rotation is likely to be 99%

17.
Antioxidants (Basel) ; 11(7)2022 Jun 22.
Article in English | MEDLINE | ID: covidwho-1963676

ABSTRACT

Nowadays, food fortification with bioactive compounds deriving from agri-food waste is of great interest all over the world. In this work, apple pomace (AP), the most abundant by-product of apple juice manufacturing, was characterised by chemical, chromatographic and spectrophotometric analyses. AP showed valuable antioxidant activity, due to the presence of phenolic compounds (8.56 mg gallic acid equivalents/g), including quercetin-3-O-galactoside, quercetin-3-O-arabinofuranoside, and phloridzin. Dried AP, at 7% and 14%, was added to pork meat to produce Italian salami, then subjected to 25 days of ripening. Physicochemical, colorimetric and microbiological analyses were carried out at days 0, 5, 11, 19 and 25, while nutritional and sensory evaluations were performed at the end of the ripening. The overall acceptability was slightly higher for 7% AP compared to 14% AP sample, and generally the replacement of a percentage of meat with apple pomace allowed the production of salami with sensory properties comparable to those obtained with classic recipes. The improved fibre and phenol content, together with the lower fat and calories, represent the most interesting characteristics of fortified salami. The results confirm that the addition of AP represents a valid approach to adding healthy compounds to salami.

18.
J Food Sci Technol ; 59(9): 3511-3521, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1943356

ABSTRACT

The present pandemic situation has increased demand for functional foods that enhance all aged groups' people immunity against COVID-19. This factor has led to innovation in snack market because healthy and good quality snack products are lacking. In this study, attempt has been made to develop functional snack bar that is beneficial for malnourished population from various combinations of amaranth grain, oat, and banana peel powder. Among various combinations amaranth grain (60%), oats (25%) and banana peel powder (15%) was found better than other combinations in respect to organoleptic and nutritional quality. Oat and banana peel powder addition increased the contents of protein, mineral, ß-glucan, dietary fibre, essential amino acid, phenolic, and antioxidant activity of functional snack bar. TGA analysis shows that active components present in it were stable even at high temperature which adds benefit to its functional property. Microbial studies of FSB revealed it could be stored up to 60 days without microbial contamination and acceptable by consumer. The cost of a functional snack bar was 9.57 per bar, which was less than market snack bar. This study showed that developed functional snack bar snack increases market's revenue and enables snack market to develop new type snack bar.

19.
Drying Technology ; : 1-13, 2022.
Article in English | Web of Science | ID: covidwho-1937552

ABSTRACT

Currently, an estimated 20% of the population in Sub-Saharan Africa is food insecure with the incidence of hunger and malnutrition still rising. This trend is amplified by the socio-economic consequences of the COVID-19 pandemic. In contrast, more than a third of the harvestable perishable produce is lost due to a lack of preservation or failure to utilize preservation as is the case for underutilized crops (UCs). Moreover, some of the preservation techniques utilized are poor, leading to the deterioration of food quality, especially the micronutrients. In this study, we thus exemplarily investigated the impact of different drying settings on the quality of two highly nutritious UCs, namely cocoyam and orange-flesh sweet potato (OFSP) (40, 60, and 80 degrees C for cocoyam and 40, 50, 60, and 70 degrees C for OFSP) to deduce the optimum quality retention and further develop a theoretical design of processing units and processing guidelines for decentralized food processing. Drying cocoyam at 80 degrees C and OFSP at 60 degrees C, respectively resulted in a relatively shorter drying time (135 and 210 min), a lower total color difference (2.29 and 11.49-13.92), greater retentions for total phenolics (0.43 mg GAE/100 g(DM) and 155.0-186.5 mg GAE/100 g(DM)), total flavonoid (128 mg catechin/100 g(DM) and 79.5-81.7 mg catechin/100 g(DM)) and total antioxidant activity (80.85% RSA and 322.58-334.67 mg AAE/100 g(DM)), respectively for cocoyam and OFSP. The beta-carotene, ascorbic acid and vitamin A activity per 100 g(DM) of the OFSP flours ranged between 6.91- 9.53 mg, 25.90 - 35.72 mg, and 0.53 - 0.73 mg RAE, respectively.

20.
Thai Journal of Pharmaceutical Sciences ; 46(2):137-148, 2022.
Article in English | EMBASE | ID: covidwho-1913271

ABSTRACT

Introduction: Berberis tinctoria an evergreen shrub, endemic and predominantly found at a higher altitude of the Nilgiri Biosphere Reserve, India. This leaf and fruit are edible, which are also used in homeopathic remedies for countless illnesses. Objectives: B. tinctoria with diverse ethnomedicinal uses was focused in the prevailing study to detailed the phytochemical and pharmacological properties for further imminent research in this species. Materials and methods: Published data in this review were all gathered from the online bibliographical databases: PubMed, Elsevier, Scopus, Google Scholar, Web of Science, and local ethnic community peoples of Kurumba and Toda. Results: B. tinctoria was used as a Ayurvedic and homeopathy medicine by the tribal communities. The previous findings of B. tinctoria were used for skin diseases, wound healing, inflammatory, menorrhagia, diarrhea, jaundice, and a snakebites. The phytochemical studies revealed that secondary metabolites, antioxidants, and antimicrobial activity as a result of major alkaloid isoforms of berberine, berbamine, jatrorrhizine, etc. Conclusion: B. tinctoria is an important plant due to the presence of bioactive phytochemicals, especially berberine protoberberine group of benzylisoquinoline. As a result of its diverse ethnopharmacological importance, as well as numerous commercial products and novel bioactive compounds yet to be discovered for future drug discovery and development.

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