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1.
Rev Panam Salud Publica ; 46: e104, 2022.
Article in Spanish | MEDLINE | ID: covidwho-2205515

ABSTRACT

This analysis compares and systematizes some of the milestones (between December 2020 and October 2021) in the approval by Brazil and Chile of the CoronaVac vaccine made by the Chinese laboratory Sinovac, with regard to how the efficacy and immunogenicity of the vaccine was determined. To this end, a comprehensive analysis was conducted of official public documentation of the vaccine's approval in both countries; likewise, relevant technical articles on the subject, as well as dissemination and discussion in the media were considered. In both cases, a wide range of private and public actors expressed clearly competing interests in the measurement and dissemination of figures on the vaccine's efficacy. This reveals the challenges that middle-income countries face-and will continue to face-when certifying the quality of products in a pandemic period, and the need to institutionally strengthen regulatory authorities to ensure a sound and accurate evaluation of vaccine quality, in terms of safety and efficiency.


Esta análise compara e sistematiza alguns marcos da aprovação, no Brasil e no Chile, da vacina CoronaVac, do laboratório chinês Sinovac, de dezembro de 2020 a outubro de 2021, especificamente sobre como sua eficácia e imunogenicidade foram fundamentadas. Para tanto, foi realizada uma análise exaustiva da documentação pública oficial sobre a aprovação da vacina em ambos os países. Da mesma forma, foram considerados artigos técnicos pertinentes sobre o assunto, e divulgações e discussões realizadas na mídia. Em ambos os casos, uma disputa de interesses de uma ampla gama de atores privados e públicos em torno da medição e divulgação dos números referentes à eficácia foi claramente expressa. Isso permite visualizar os enormes desafios que os países de renda média enfrentam e enfrentarão para certificar a qualidade dos produtos em um contexto epidemiológico de pandemia e a necessidade de fortalecer institucionalmente as autoridades reguladoras para viabilizar uma avaliação íntegra e acertada da qualidade das vacinas em relação a sua segurança e eficiência.

2.
Policy and Society ; 2022.
Article in English | Web of Science | ID: covidwho-2190199

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic posed several challenges to the Brazilian health system, among them the general context of ambiguity and uncertainty and the conflicting positioning of the government in power concerning scientific advice resources. Different aspects can be analyzed to explore the dynamics of strengthening and resilience of the system. This paper focuses on its analytical capacity, examining how it was developed and recently challenged. The investigation employed survey data, analysis of official documents and newspaper articles, and in-depth interviews with specialists and federal bureaucrats. The research shows the magnitude and relevance of that dimension of policy capacity in the federal health system and how it was crucial to the resilience of the system in defining the directions of the fight against COVID-19 in Brazil, although scientific-based recommendations were rejected by political leaders.

3.
9th International Conference on Information Technology and Quantitative Management, ITQM 2022 ; 214:478-486, 2022.
Article in English | Scopus | ID: covidwho-2182436

ABSTRACT

Antarctica is the southernmost continent of our planet, and it has been verified as the coldest region on earth. The Brazilian Antarctic Program (PROANTAR) has as its main objective the promotion of high-quality scientific research in the Antarctic region, seeking to understand the events that occur there. PROANTAR, coordinated by the Navy Commander, has some sectors that are based in Brazil and others that are located in the Antarctic continent. The military that volunteers to occupy any vacancy that is allocated to that continent needs, besides passing through several pre-established criteria, to pass the selection process. The purpose of this article is to help the Naval Administration in the selection of volunteer officers to occupy a vacancy in the Antarctic continent. To obtain the alternatives, the officers that best fit the established vacancy, and the criteria to be evaluated, Value-Focused Thinking (VFT) was applied. Next, with all the necessary data, the CRITIC-GRA-3N method was used as a Multicriteria Decision Support (MDS) technique, the CRITIC-GRA-3N method, the CRITIC Importance Through Intercriteria Correlation (CRITIC) method to obtain the criteria weights and the Grey Relational Analysis (GRA) method, with three normalizations, to order the alternatives. At the end of the application of the methods, the article can generate five ordinations of the volunteer officers to occupy the vacancy offered in PROANTAR. © 2022 The Authors. Published by Elsevier B.V.

4.
9th International Conference on Information Technology and Quantitative Management, ITQM 2022 ; 214:63-70, 2022.
Article in English | Scopus | ID: covidwho-2182428

ABSTRACT

The recent increase in the number of cases of COVID-19 in Brazil and worldwide, caused by the Omicron Variant, has brought to light concern to the population and the government, especially in the states most affected by the pandemic. To find a way to help combat the pandemic, a case study was conducted to acquire new speedboats by the Brazilian Navy (BN), through the application of the ELECTRE-MOr multicriteria method. The boats would be employed as mobile hospitals, aiming to perform first aid and evacuation of patients from riverside regions to qualified hospitals. Another important use would be the transport of vaccines, medicines and basic supplies for riverside populations, such as water, food and hygiene materials. For the proposed analysis, we consulted three specialists from the BN, who evaluated eight boat models in seven tactical, operational and medical criteria. After the application of the method, the Guardian 25 and RAC boats were chosen to be employed in humanitarian assistance. This study brings a valuable contribution to academia and society since it represents the application of a multi-criteria decision-aid method in the state of the art to contribute to the solution of a real problem that affects millions of people in Brazil and worldwide. © 2022 The Authors. Published by Elsevier B.V.

5.
Law of Justice Journal ; 36(3):82-113, 2022.
Article in Portuguese | Scopus | ID: covidwho-2168302

ABSTRACT

This article aims to demonstrate the connection between the crisis of Brazilian federalism and the phenomenon of the Covid-19 pandemic and its consequences in the national legal system. Initially, the process of transformation of Brazilian federalism and its respective institutional crisis is observed. As a result of the inaction of the Brazilian State in the fight against the pandemic, two demands are analyzed in this study, the Direct Action of Unconstitutionality No. 672, which gave rise to a major political dispute at the heart of the Covid-19 crisis and which, in turn, came to set up a Parliamentary Commission of Inquiry, to investigate the acts carried out by the Executive Branch. © 2022, University of Passo Fundo. All rights reserved.

6.
Minerva Psychiatry ; 63(4):319-328, 2022.
Article in English | EMBASE | ID: covidwho-2205199

ABSTRACT

BACKGROUND: The emergence of the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) pandemic has created unprecedented challenges for contemporary society, generating fear. We aimed to validate a fear scale to identify and assess the severity of fear related to SARS-CoV-2. METHOD(S): This was a cross-sectional study conducted through an online survey and applied to the general Brazilian population. Participants were randomly recruited via social networking platforms during the pandemic (N.=1332). A self-reported fear scale (SARS-CoV-2 Fear Scale [SCoV-2-FS]) comprising 11 questions addressing the fear of contracting SARS-CoV-2 infection during essential daily activities was validated. RESULT(S): The reliability and validity of the SCoV-2-FS were psychometrically evaluated using reliability measures and confirmatory factor analysis (CFA). Cronbach's alpha was 0.9, indicating excellent internal reliability. CONCLUSION(S): The results of the CFA showed that the unidimensional factor structure of the SCoV-2-FS fitted well with the data. The SCoV-2-FS is a valid and reliable tool with robust psychometric properties and is thus useful for assessing fear associated with SARS-CoV-2 infection. Copyright © 2022 Authors. All rights reserved.

7.
Revista de Gestão e Secretariado ; 13(4):2314-2336, 2022.
Article in English | ProQuest Central | ID: covidwho-2203459

ABSTRACT

The development of studies on technological innovations in the public sector, specifically in justice system, is still little explored in the literature. This article aimed to develop and validate a scale of technological innovation in the justice system during the period of the COVID-19 pandemic. Data collection procedures were carried out by means of questionnaires sent to 20.727 e-mails of civil servants and judges of the state courts of justice in Brazil. The relationships among the innovation variables that make up the technological innovation construct in the Brazilian judiciary were studied. The factor analyses resulted in the main factors listed by the respondents, as the innovative trend factor (IT);technological resources factor (TR);governance factor and its evidence (G);and innovation and technology factor (IT). For responses to the studies, descriptive statistical analysis was performed, and the innovative sensitivity and technological integration variables presented greater commonalities, and the two factors extracted explain 74% and 67% of the variance. After the descriptive statistical treatment, the confidence level was 99% and the error margin was 4.87%, resulting in a sample of 679 respondents.

8.
Revista De Gestao E Secretariado-Gesec ; 13(3):1890-1908, 2022.
Article in English | Web of Science | ID: covidwho-2203457

ABSTRACT

This study aimed to analyze the economic and financial performance of the four largest companies in the Meat Agribusiness Sector listed on B3 S.A., before and after the onset of the Coronavirus Pandemic (period from 2018 to 2020). The analysis was carried out by means of financial indicators of capital structure and profitability, focusing in particular on the DuPont Identity, calculated based on values of accounting accounts in the companies' financial statements. The collection was performed through the structured financial statements presented on the B3 S.A. website and with the use of the Economatica database. The research is characterized as descriptive, documentary, and quantitative. Comparing the percentages corresponding to the indicators for each year and the economic scenario of the period, the research used Pearson's Correlation to analyze the relationship between the variations of the indicators with respect to the variation of the Gross Domestic Product (GDP) of the Livestock Branch, in the period studied. Among the main findings, a significant improvement of the Return on Assets and Return on Equity, in medium and strong positive correlations with the sector's GDP growth, is evident. Furthermore, an extremely strong positive correlation was found between the companies' Revenue from Goods and Services and the Livestock Industry GDP. It is concluded that, overall, in addition to the sector's GDP growth, despite the economic crisis resulting from the pandemic, companies raised their revenues and improved profitability and profitability.

9.
Appl Energy ; 313: 118848, 2022 May 01.
Article in English | MEDLINE | ID: covidwho-2158437

ABSTRACT

This paper proposes a time-series stochastic socioeconomic model for analyzing the impact of the pandemic on the regulated distribution electricity market. The proposed methodology combines the optimized tariff model (socioeconomic market model) and the random walk concept (risk assessment technique) to ensure robustness/accuracy. The model enables both a past and future analysis of the impact of the pandemic, which is essential to prepare regulatory agencies beforehand and allow enough time for the development of efficient public policies. By applying it to six Brazilian concession areas, results demonstrate that consumers have been/will be heavily affected in general, mainly due to the high electricity tariffs that took place with the pandemic, overcoming the natural trend of the market. In contrast, the model demonstrates that the pandemic did not/will not significantly harm power distribution companies in general, mainly due to the loan granted by the regulator agency, named COVID-account. Socioeconomic welfare losses averaging 500 (MR$/month) are estimated for the equivalent concession area, i.e., the sum of the six analyzed concession areas. Furthermore, this paper proposes a stochastic optimization problem to mitigate the impact of the pandemic on the electricity market over time, considering the interests of consumers, power distribution companies, and the government. Results demonstrate that it is successful as the tariffs provided by the algorithm compensate for the reduction in demand while increasing the socioeconomic welfare of the market.

10.
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration ; 23(Supplement 1):36-37, 2022.
Article in English | EMBASE | ID: covidwho-2160819

ABSTRACT

Introduction: Poliomyelitis is an inflammatory viral disease that causes destruction of motoneurons. Despite being eradicated in Brazil, it left sequelae on survivors, making them need continuous treatments. Considering the sequelae and new symptoms related to Post-Polyomyelitis Syndrome (PPS), these patients may be vulnerable in the Covid-19 Pandemic. Objective(s): To characterize and analyze the prevalence of risk factors for contracting COVID-19 as well as developing its severe form in patients with Sequelae of Poliomyelitis and Post-polio Syndrome. Method(s): An epidemiological study was carried out through an online questionnaire, where epidemiological, physical and psycho-emotional health issues were addressed in the pandemic. Approved by CEP UNIFESP under Ndegree4,087,073. Result(s): 383 responses were obtained in the following groups: Sequelae of Poliomyelitis (GP-49%;n=190) and PPS (GPPS-50.4%;n=193). Female and age 50-59 years were more prevalent. The most common disorders were monoparesis (38.9% GP;21.7% GSPP), followed by paraparesis in GP (18.9%) and tetraparesis in GSPP (16.6%). As for comorbidities, 37.4% of the GP and 37.3% of the GSPP reported Hypercholesterolemia;42.6% (GP) and 47.1% (GSPP) Hypertension and 19.5% (GP) and 14.5% (GSPP) Diabetes. About 29% of the GP were obese against 35.2% (GSPP). In the physical aspects, 57.9% (GP) and 65.8% (GSPP) reported worsening in the quarantine and 19.7% (GSPP). Discussion(s): Patients affected with Poliomyelitis had a proportion of Hypercholesterolemia, Hypertension and Diabetes about twice that of the Brazilian population over 18 years (14.6%;23.9 and 7.7%, respectively) (1). In this sense, research shows an increased risk for severity and death from COVID- 19 in patients with Hypertension (2,3), Diabetes (2,3) and Hypercholesterolemia (2). People with disabilities can be disproportionately impacted by emergencies and the disruption of services can be a contributing factor (4). This impact could be perceived by the reports of worsening in the physical aspect during the quarantine, especially in GPPS who have a higher frequency of tetraparesis, which can difficult to carry out the necessary hygiene measures. Conclusion(s): Poliomyelitis survivors have comorbidities, in addition to limitations and dependence in their activities of daily living that can make them more vulnerable to contagion by COVID-19 as well as making them more susceptible to the severe form of the disease.

11.
Saude e Sociedade ; 31(3) (no pagination), 2022.
Article in English, Portuguese | EMBASE | ID: covidwho-2154442

ABSTRACT

This literature critical analysis reflects on the social, political and historical background responsible for racial discrepancies in hospital mortality by COVID-19 among the Brazilian population. During the pandemic, the COVID-19 mortality among the Black population gained notoriety. Rather than an isolated fact, this finding has historical roots dating back to Brazil's foundation and draws on structural racism, which reveals degrading living and health conditions experienced by the Black population before the pandemic. This situation of vulnerability affecting the Black population is a recurring scenario that is treated with the neglect inherent to structural racism. COVID-19 mortality portrays one way in which racism impacts and reproduces itself in the life and death of Black people. Copyright © 2022, Universidade de Sao Paulo. Museu de Zoologia. All rights reserved.

12.
Revista Juridica ; 4(71):237-267, 2022.
Article in Portuguese | Scopus | ID: covidwho-2164594

ABSTRACT

Objective: this article aims to highlight the way in which the Law System acts in the inclusion / exclusion processes of individuals from social benefits from different spheres of world society. Methodology: the methodology to be used is the Niklas Luhmann's Social Systems Theory (2016), the basic theory for all the proposed observation. The indirect documentation search technique will be used, with a review of foreign national bibliography, and the qualitative analysis of judicial decisions. Results: as one of the results obtained, the means of the proposed analysis demonstrated how the System of Law plays a fundamental role in the dynamics of social inclusion and exclusion, both in the processes of guarantee of inclusion (access to justice and guarantee of the right to health), and in the legitimation of exclusion processes determined by the State, with a view to compel the citizen to vaccinate (compulsory vaccination), in order to reduce the risks that the contraryness to this act may generate in the Health System. Contributions: the study brings as a contribution, after a comparison between hypotheses of determination or legitimation of inclusion and exclusion by the System of Law, a balance between these decisions with the scope, above all, of highlighting the imprescindibility of a broader social observation for the understanding and resolution of the current problems of constitutional law. In the specific case of the research, the determining role of the Health System in the decisions of the Judiciary in the case of Covid-19 is evidenced. © 2022, Centro Universitario Curitiba - UNICURITIBA. All rights reserved.

13.
Meta: Avaliacao ; 14(42):218-236, 2022.
Article in Portuguese | Scopus | ID: covidwho-2146059

ABSTRACT

The article aims to analyze the transparency and data on the Covid-19 pandemic in Brazilian capitals. The study was based on the application of the Covid-19 Transparency Index through descriptive documentary research with a qualitative approach. Data collection was performed using observational protocols. Four surveys were carried out to verify if there would be an evolution of the picture referring to the Covid-19 pandemic and if the managers were taking steps to make the portals more transparent in relation to information about the virus. It was found that the most disseminated information refers to the age and sex of infected individuals, in addition to the type of hospitalization. The least publicized information refers to the occupation of beds and available tests, and no portal provided information in an open format, that is, data structured in a spreadsheet with editable format. There are capitals that are treading a path in the search for transparency, especially those classified in the study as medium and good, since there were no classified in the high level. Capitals classified at the opaque level, which means the near absence of transparency and data on the Covid-19 pandemic, seem further away from this path. © 2022 Fundacao Cesgranrio. All rights reserved.

14.
Revista Opiniao Juridica ; 20(35):139-161, 2022.
Article in Portuguese | Scopus | ID: covidwho-2145268

ABSTRACT

Objective: This paper aims to test the hypothesis of the constitutionality of the public policies implementation by the Federal Supreme Court to tackle Covid-19 in the Brazilian prison system supported by the unconstitutional state of affairs theory developed by the Constitutional Court of Colombia. Background: To this end, it addresses the serious political and legal issues of the prison system, which have been aggravated by the current pandemic moment. Method: The indicative paradigm was prioritized as the methodology of the present work, with the study of two paradigmatic cases analyzed under the theoretical frameworks necessary to apprehend concepts inherent to the theme. Results: As obtained, the research shows that the declaration by the Federal Supreme Court of the unconstitutional state of affairs in the Brazilian prison system innovates by opening possibilities for the Court to take on the role in the formulation, implementation and control of public policies. In cooperation with the other Powers (and eventually with private actors). With the aim of promoting material democracy. Despite the caution that must be taken in order to guarantee the soundness of the separation of Powers (an essential element of a democratic State). An analysis based on the principle of the unity of the Constitution (which must be interpreted as a system of interrelated norms) endorses the legitimacy of applying the theory of the unconstitutional state of affairs in cases where it is not possible to achieve the realization of fundamental rights. As is the case of the prison system. Conclusion: In this way, the intersections between constitutionalism and democracy are worked, as well as the role of the Powers in facing the health crisis from the theoretical analysis of these elements (bibliographic review);an analysis of the paradigmatic decisions (albeit in a preliminary order) of the Federal Supreme Court (ADPF 347 and ADPF 684), which embraces, for the first time in Brazil, the theory of the unconstitutional state of affairs;paradigm decisions are compared with the Covid-19 numbers provided by public entities. In the end, this work proves the constitutionality and the need to implement public policies to protect the rights of the vulnerable in the penal system. It is especially true in the context of the Covid-19 pandemic, and that the Constitutional Court's role in this mission does not corrupt the Separation of Powers, if the requirements of the unconstitutional state of affairs theory are met. © 2022 R. Opin. Jur. All rights reserved.

15.
Journal of Health Management ; 2022.
Article in English | Web of Science | ID: covidwho-2123288

ABSTRACT

The article seeks to identify the government initiatives to mobilise the Brazilian industry during the pandemic crisis. The motivation for the work stems from evidence showing the omissions at the federal level, with relevant implications for the death figures in Brazil. Public policies agenda and a conceptual review was carried out on industrial reconversion in severe emergency conditions, including international experiences in the current scenario. A documental survey was conducted with the federal government and selected state governments. The survey was carried out on the official portals of governments, related agencies and business entities representing the industrial sector. Lack of industry-coordinated mobilisation is given by the combination of intrinsic and extrinsic factors concerning the pandemic crisis, industrial reconversion is another relevant absence at the public agenda. Weak answers of Brazilian government regarding the industrial mobilisation for fighting the pandemic crisis, leading to further hypotheses on the structured agenda of possible effects. The study shows weakness of federal measures coming from the Brazilian government also in the economic front, adding the industrial reconversion absence in the policies agenda as another remarkable feature on the health impacts of COVID-19 pandemics.

16.
International Conference on Production and Operations Management, POMS 2021 ; 391:153-169, 2022.
Article in English | Scopus | ID: covidwho-2094328

ABSTRACT

The COVID-19 pandemic impacted several sectors of the economy, including the Brazilian electricity sector. Motivated by the considerable changes in energy consumption behavior in Brazil during the pandemic, the present study conducts an application of several statistical models to quantify the impact of restrictive measures imposed by the government on energy consumption throughout the country. In this way, monthly forecasts of electricity consumption over the year 2020 were generated by considering two scenarios: the actual pandemic scenario and a hypothetical, counterfactual scenario in which the pandemic did not take place. The study used electricity consumption data in Brazil extracted from the Brazilian energy research company (EPE). Forecasts in the counterfactual scenario were generated using exponential smoothing methods and hierarchical reconciliation. The differences in consumption between the two designs were then computed and compared against two indexes published by the Oxford COVID-19 Government Response Tracker: the stringency index and the risk of opening the economy. The correlation results suggest that restrictive measures affected consumption in some regions and classes more than others. In particular, the Northern and Northeastern regions were more likely to be more affected by the adoption of restriction measures, along with commercial consumption. Implications are further discussed. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

17.
International Journal of Electronic Governance ; 13(4):442-461, 2021.
Article in English | Scopus | ID: covidwho-2089474

ABSTRACT

This paper aims to map and analyse the digital actions of Brazilian legislative houses at the federal and state levels in response to the pandemic caused by the new coronavirus (Sars-CoV-2). A prospecting of initiatives was carried out, which resulted in the collection of 102 cases, 78 at the federal level and 24 from state parliaments. The occurrences were categorised according to their function: information about the pandemic;transparency about implemented actions;and engagement and participation. The results point to the discrepancy in initiatives at the national and subnational levels;the prevalence of public hearings;and little diversity in the use of digital tools by parliaments, except for the Federal Senate. An in-depth analysis of each type of initiative also allowed us to conclude that some initiatives, even with few cases, made important contributions. Copyright © 2021 Inderscience Enterprises Ltd.

18.
Interface: Communication, Health, Education ; 26 (no pagination), 2022.
Article in English, Portuguese | EMBASE | ID: covidwho-2065231

ABSTRACT

With the objective of investigate the therapeutic itineraries followed for search the health care by the brazilian population in a situation of social vulnerability during the covid-19 pandemic, a scope review was carried out from July to September 2021, as proposed by the Joanna Briggs Institute, in the BVS, PubMed, EMBASE, Scielo, PsycInfo, Scopus and Web of Science databases within the 2020 and 2021 clippings. 11 articles were analyzed and divided into three categories: strategies care of population;health offerings;difficulties in accessing healthcare. Results explained gaps and potentialities existing on therapeutic itineraries in the search for health care for populations in a situation of social vulnerability and how these aspects became more evident in this pandemic period. There was a movement of this vulnerable populations to overcome the daily difficulties that determine the unfavorable conditions for health care. Copyright © 2022, Fundacao UNI Botucatu/UNESP.

19.
American Journal of Transplantation ; 22(Supplement 3):639, 2022.
Article in English | EMBASE | ID: covidwho-2063504

ABSTRACT

Purpose: Compared to azathioprine (AZA), mycophenolate (MPA) is implicated in an increased risk of several viral infections. Contrariwise, mTOR inhibitors (mTORi) are protective. Therefore, the study proposal is to evaluate the Covid-19 outcomes among kidney transplants (KT) patients under different maintenance immunosuppressive regimens. Method(s): We analyzed 90-day outcomes after Covid-19 infection using nationalwide Brazilian cohort data. RT-PCR positive patients tested between Mar/20 and Apr/21 (before immunization) were included. Patients using calcineurin-inhibitors (CNI)-free regimens were excluded. Result(s): 1,833 patients from 44 centers were analyzed, divided into three groups: CNI-AZA (n=389), CNI-MPA (n=1,258), and CNI-mTORi (n=186). Except for donor source, time after KT, and diabetes, demographics were similar among groups (Table1). The main outcomes are shown in Table 1. Considering CNI-AZA as the reference group, center-adjusted multivariable Cox regression showed that the CNIMPA group was associated with higher 30-day fatality (HR 1.65, 95% CI 1.17-2.33, p=0.004), effected also demonstrated in 90-day fatality (HR 1.43, 95%CI 1.06-1.93, p=0.020). CNI-mTORi was neutral for the 30-day fatality (HR 0.75, 95%CI 0.43- 1.29, p=0.296), but protective for the 90-day (HR 0.56, 95%CI 0.34-0.94, p=0.027). Conclusion(s): This data suggests that maintenance immunosuppressive drugs impact Covid-19 outcomes in kidney transplant patients. While MPA is associated with poor prognosis, mTORi seems to be protective. (Figure Presented).

20.
Environmental and Molecular Mutagenesis ; 63:7, 2022.
Article in English | EMBASE | ID: covidwho-2059392

ABSTRACT

The world population is getting older, but a great challenge is how to increase health span and not only lifespan. What is the role of genetics versus environment? Several recent breakthroughs such as the human genome project, the IPS stem-cells and the CRISPR technology for gene editing will allow a revolution in gene therapy, precision and regenerative medicine and xenotransplantation. Aiming to contribute to a healthier longevity, our group is developing several projects including the characterization of the genome of our elderly highly admixed population. We have performed whole genome sequencing of about 1500 healthy Brazilians older than 60, which represents the largest genome databank in Latin America. Our aims were a) to have a database from our population in order to improve the interpretation of pathogenicity of rare unknown variants in patients with undiagnosed genetic disorders and precision medicine b) identify “protective” variants underlying healthy longevity. We found 2 million genetic variants which were not present in the international databanks (Naslavsky et al., 2022). Since the advent of COVID-19 pandemic, we are investigating genetic variants in individuals, who were exposed to SARS-Cov-2 and remained asymptomatic. To address this question, we investigated discordant couples where one was infected and develop COVID-19 while the partner remained asymptomatic and serum negative. We collected samples from nonagenarians and centenarians who survived COVID-19 or remained asymptomatic. We will infect different IPS derived cell lines from “resistant” centenarians with SARS-Cov2 in an attempt to increase our understanding on “resistant genetic variants and mechanisms”.

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