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Russian Journal of Infection and Immunity ; 12(5):859-868, 2022.
Article in English | EMBASE | ID: covidwho-2227673


In our study, we aimed to evaluate the significance of specific cytokines in blood plasma as predictive markers of COVID-associated mortality. Materials and methods. In plasma samples of 29 patients with PCR-confirmed COVID-19 we measured the concentrations of 47 molecules. These molecules included: interleukins and selected pro-inflammatory cytokines (IL-1alpha, IL-1beta, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17A/CTLA8, IL-17-E/IL-25, IL-17F, IL-18, IL-22, IL-27, IFNalpha2, IFNgamma, TNFalpha, TNFbeta/Lymphotoxin-alpha(LTA));chemokines (CCL2/MCP-1, CCL3/MIP-1alpha, CCL4/MIP-1beta, CCL7/MCP-3, CCL11/Eotaxin, CCL22/MDC, CXCL1/GROalpha, CXCL8/IL-8, CXCL9/MIG, CXCL10/IP-10, CX3CL1/Fractalkine);anti-inflammatory cytokines (IL-1Ra, IL-10);growth factors (EGF, FGF-2/FGF-basic, Flt-3 Ligand, G-CSF, M-CSF, GM-CSF, PDGF-AA, PDGFAB/BB, TGFalpha, VEGF-A);and sCD40L. We used multiplex analysis based on xMAP technology (Luminex, USA) using Luminex MagPix. As controls, we used plasma samples of 20 healthy individuals. Based on the results, we applied Receiver Operating Characteristic (ROC) analysis and Area Under Curve (AUC) values to compare two different predictive tests and to choose the optimal division point for disease outcome (survivors/non-survivors). To find optimal biomarker combinations, we as used cytokines concentrations as dependent variables to grow a regression tree using JMP 16 Software.Results. Out of 47 studied cytokines/chemokines/growth factors, we picked four pro-inflammatory cytokines as having high significance in evaluation of COVID-19 outcome: IL-6, IL-8, IL-15, and IL-18. Based on the results received, we assume that the highest significance in terms of predicting the outcome of acute COVID-19 belongs to IL-6 and IL-18. Conclusion. Analyzing concentrations of IL-6 and IL-18 before administering treatment may prove valuable in terms of outcome prognosis. Copyright © Arsentieva N.A. et al., 2022.

Chest ; 162(4):A712-A713, 2022.
Article in English | EMBASE | ID: covidwho-2060673
Pediatrics ; 149, 2022.
Article in English | EMBASE | ID: covidwho-2003414
Journal of General Internal Medicine ; 37:S397-S398, 2022.
Article in English | EMBASE | ID: covidwho-1995666
Frontiers in Immunology ; 13, 2022.
Article in English | EMBASE | ID: covidwho-1987492
American Journal of Respiratory and Critical Care Medicine ; 205(1), 2022.
Article in English | EMBASE | ID: covidwho-1927920
Hematology, Transfusion and Cell Therapy ; 43:S527, 2021.
Article in Portuguese | EMBASE | ID: covidwho-1859736
Hematology, Transfusion and Cell Therapy ; 43:S508, 2021.
Article in Portuguese | EMBASE | ID: covidwho-1859701
Reviews in Medical Microbiology ; 33(1):E180-E188, 2022.
Article in English | EMBASE | ID: covidwho-1853286
Open Forum Infectious Diseases ; 8(SUPPL 1):S51-S52, 2021.
Article in English | EMBASE | ID: covidwho-1746790
Journal of Investigative Medicine ; 70(2):557-558, 2022.
Article in French | EMBASE | ID: covidwho-1698858
Pediatric Rheumatology ; 20(SUPPL 1), 2022.
Article in English | EMBASE | ID: covidwho-1677521