ABSTRACT
The unpredictable impacts of sudden shocks such as the current COVID-19 pandemic or the current energy crisis accelerated by the Russia-Ukraine war have led to a renewed interest in regional economic resilience. Much of the literature focuses attention on how regional economies and industries could bounce back, that is, how they could return to their pre-shock conditions. Other scholars have proposed to construe resilience as bouncing forward to capture the mechanisms and processes that underpin positive adaptation and structural change in response to an acute crisis. In this article, we argue that both conceptualisations do not consider shocks and crises as a window of opportunity for regional economies to transform into a radically different and more desirable trajectory. We bring a new perspective into play, that is, transformative resilience which places shifts towards more sustainable pathways centre stage. This understanding of regional economic resilience acknowledges that a crisis may bring about permanent structural change and considers to what extent these transformations are to the benefit of society and the environment. This article seeks to identify in a conceptual way what factors and dynamics are vital for enhancing the transformative resilience of regions. To this end, we draw on recent insights from the debate on challenge-oriented regional innovation systems and elaborate on the role of pre-shock conditions and various core processes in building up regional transformative resilience.
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This research aims to identify online challenge-based learning (CBL) that builds on the problem-based learning practice to support professors working in two Mexican institutions with solutions to six social challenges defined by the institutions. Thirty-five professors from Tecnologico de Monterrey participated in developing the solutions related to given challenges by taking a social approach. For this activity, an online training session of one week was organized by the Faculty Development and Educational Innovation Center (CEDDIE) of Tecnologico de Monterrey in Mexico City, Mexico. The data was collected through an online survey based on quantitative and qualitative questionnaires. We received fifteen complete responses out of thirty-five. Analyzing the results of this study affirmed that online CBL activities served professors to promote social interactions, develop pedagogical competencies, and share knowledge based on their learning experience through active collaboration with peers in the same institutions but from different disciplines and campuses to identify and solve existing societal issues. © 2023 IEEE.
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Background Recently, several cases of mucormycosis in people with coronavirus disease 2019 (COVID-19) have been increasingly reported worldwide, in particular from India. As an increasing number of post-COVID patients with mucormycosis are presenting for surgical management, the onus is on the anaesthesiologists to adequately evaluate and optimise such patients.Case presentationWe present three cases to highlight the anaesthetic challenges in patients undergoing functional endoscopic sinus surgery (FESS) with debridement surgery for mucormycosis through a series of three cases. In our manuscript, two cases had comorbidities as a challenge uncontrolled diabetes and hypertension. The third case had difficult intubation due to a small mouth opening which was probably due to swelling and tenderness as a result of rhino orbital mucormycosis.ConclusionsProper anticipation, optimization and timed promptness to deal with the anaesthetic challenges pertaining to the multisystemic involvement and sequelae of mucormycosis should be done.
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This research paper aimed to identify the level of psychological hardiness, the level of death anxiety, and the level of existential vacuum among the elderly, also the role of the predictive ability of death anxiety and existential vacuum in the psychological hardiness of the elderly at the governorates of Tafilyah and Ma'an in light of the Corona pandemic in Jordan. The descriptive-analytical approach was utilized. sample consists (500) elderly, that were selected by a simple random approach. Then the needed statistical measure was operated to achieve the required results. The results indicated a low level of psychological hardiness, a high level of death anxiety, and an existential vacuum in the elderly. The results show a suitable predictive ability for each of death anxiety and the existential vacuum in reducing psychological hardiness. The research paper recommended the necessity of rehabilitating the elderly in Jordan regarding the mental and psychological aspects.
ABSTRACT
Infectious bronchitis, an acute and highly contagious disease that affects chickens, is caused by the infectious bronchitis virus (IBV). The antigenic variant QX-like IBV was first reported in China in 1996 and is now endemic in many countries. Our previous study reported the first detection and isolation of QX-like IBVs in Japan and that they were genetically related to the recently detected strains in China and South Korea. The pathogenicity of 2 Japanese QX-like IBV strains (JP/ZK-B7/2020 and JP/ZK-B22/2020) was evaluated by inoculating specific pathogen-free (SPF) chickens with 102 to 106 median embryo infectious dose. Both strains caused clinical signs of respiratory symptoms, gross tracheal lesions, and moderate-to-severe suppression of tracheal ciliostasis. To evaluate the efficacy of commercial IBV live vaccines against the JP/ZK-B7/2020 strain, vaccinated SPF chickens were challenged with the JP/ZK-B7/2020 strain at 104 EID50 (median embryo infectious dose). Only the JP-â ¢ vaccine provided high levels of protection (reduced suppression of tracheal ciliostasis and reduced viral loads in organs), whereas the Mass vaccine showed little protective effect. Virus neutralization test results and comparisons between IBV genotypes based on the S1 gene suggested that QX-like and JP-III genotypes were closely related. These results suggest that the JP-III IBV vaccine, which has relatively high S1 gene homology with QX-like IBVs, is effective against Japanese QX-like IBV strain.
Subject(s)
Coronavirus Infections , Infectious bronchitis virus , Poultry Diseases , Viral Vaccines , Animals , Chickens , Japan , Coronavirus Infections/prevention & control , Coronavirus Infections/veterinary , Vaccines, AttenuatedABSTRACT
Available COVID-19 vaccine only provide protection for a limited time due in part to the rapid emergence of viral variants with spike protein mutations, necessitating the generation of new vaccines to combat SARS-CoV-2. Two serologically distinct replication-defective chimpanzee-origin adenovirus (Ad) vectors (AdC) called AdC6 and AdC7 expressing early SARS-CoV-2 isolate spike (S) or nucleocapsid (N) proteins, the latter expressed as a fusion protein within herpes simplex virus glycoprotein D (gD), were tested individually or as a mixture in a hamster COVID-19 SARS-CoV-2 challenge model. The S protein expressing AdC (AdC-S) vectors induced antibodies including those with neutralizing activity that in part cross-reacted with viral variants. Hamsters vaccinated with the AdC-S vectors were protected against serious disease and showed accelerated recovery upon SARS-CoV-2 challenge. Protection was enhanced if AdC-S vectors were given together with the AdC vaccines that expressed the gD N fusion protein (AdC-gDN). In contrast hamsters that just received the AdC-gDN vaccines showed only marginal lessening of symptoms compared to control animals. These results indicate that immune response to the N protein that is less variable than the S protein may potentiate and prolong protection achieved by the currently used S protein based genetic COVID-19 vaccines.
Subject(s)
COVID-19 , Animals , Cricetinae , Humans , COVID-19/prevention & control , SARS-CoV-2/genetics , COVID-19 Vaccines/genetics , Pan troglodytes , Adenoviridae/genetics , Nucleocapsid , Immunization , Antibodies, Viral , Antibodies, NeutralizingABSTRACT
Background: Workplaces play a highly important role in controlling or spreading the prevalence of coronavirus disease 2019 (COVID-19). Therefore, the lack of proper implementation of hygienic protocols in these environments might increase the risk of getting infected with the COVID-19 among the employees, following the increase of the COVID-19 at the family and community levels. This qualitative study aims to explain the challenges of coping with the coronavirus crisis in the workplaces. Methods: The present qualitative study was conducted with a conventional content analysis approach. We used purposeful sampling with maximum diversity in terms of working processes. Data were collected through semi-structured interviews. Interviews were performed to the point of information saturation. MAXQDA software version 10 was used for data management. Results: Through the content analysis of the interviews with the participants, we identified two main classes and nine sub-classes. The main classes included intra-organizational challenges (job nature, budget allocation problems, individual factors, disorganization, manpower and equipment, lack of commitment, and insufficient support of managers) and extra-organizational challenges (lack of accessibility to valid information, black market, and inter-sectorial coordination problems). Conclusion: The study findings indicated that organizations and industries face numerous internal and external challenges in coping with the COVID-19 pandemic. Paying attention to the mentioned limitations and attempting to eliminate them, especially by the governmental organizations, employers, and managers, could help in effectively confronting the COVID-19 pandemic.
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The global SARS-CoV-2 pandemic caused significant social and economic disruption worldwide, despite highly effective vaccines being developed at an unprecedented speed. Because the first licensed vaccines target only single B-cell antigens, antigenic drift could lead to loss of efficacy against emerging SARS-CoV-2 variants. Improving B-cell vaccines by including multiple T-cell epitopes could solve this problem. Here, we show that in silico predicted MHC class I/II ligands induce robust T-cell responses and protect against severe disease in genetically modified K18-hACE2/BL6 mice susceptible to SARS-CoV-2 infection.