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1.
Research Journal of Pharmaceutical, Biological and Chemical Sciences ; 14(1):27-31, 2023.
Article in English | EMBASE | ID: covidwho-2218114

ABSTRACT

Coronavirus disease 2019 is predominantly a respiratory illness that can cause hypercoagulable states with multisystem involvement. A single centre retrospective study was carried out in 37 patients who were diagnosed as COVID 19 with AKI from January 2022 to march 2022. Baseline D dimer was evaluated on hospital admission. Patients who were diagnosed with AKI on admission or during the stay in hospital were included in the study, In this study 37 COVID patients with AKI were analysed. Mean age of subjects was 62.51+/-15.18 years. Majority were in the age group 61-70 years (24.3%). 78.4% were males and 21.6% were females. Mean blood urea among subjects was 131.86+/-56.55(mmol/L), mean serum creatinine was 4.71+/-2.52(mg/dl). mean d dimer at admission was 3.701+/-4.48570(mg/L).70.3% of subjects had AKI at hospital admission and 29.7% developed AKI during hospital stay. Cause of AKI was prerenal in 89.2%, renal 18.9%,and post renal in 8.1%. D dimer levels >3.05 had highest validity in predicting the need for RRT with sensitivity 39.29%, specificity 100%, positive predictive value of 100% and negative predictive value of 34.6%. from this study it was concluded that d dimer has specificity of 100%in predicting the need of RRT Copyright © 2023, Research Journal of Pharmaceutical, Biological and Chemical Sciences.All Rights Reserved.

2.
Gazi Medical Journal ; 34(1):43-48, 2023.
Article in English | Web of Science | ID: covidwho-2217640

ABSTRACT

Objective: COVID-19 is a disease caused by SARS-COV-2 and early diagnosis and classification of the COVID-19 are critical for the better prognosis. This study aimed to combine laboratory data of COVID-19 patients with Computed Tomography Segmentation-Volume Analysis (CT-SVA). Thus, we hope to contribute to the early diagnosis and classification of the disease. Methods: Patients were divided into two groups according to disease severity as mild/moderate (n=41) and severe/critical (n=42). Some laboratory parameters were recorded and evaluated together with CT-SVA. Results: The results of the study have shown that sodium, C-reactive protein, D-dimer, ferritin, fibrinogen, interleukin 6, procalcitonin, white blood cells, neutrophil, neutrophil-lymphocyte ratio values were significantly higher at first admission in the severe/critical diseased group (p<0.05), while albumin, lymphocyte, and venous blood pH values were significantly lower (p<0.05). CT-SVA results have shown negative correlation with albumin, while having a positive correlation with C-reactive protein, D-dimer, ferritin, fibrinogen, interleukin 6 and procalcitonin. The results of the performed Receiver Operating Characteristics analysis revealed that CT-SVA has a cut-off value of 15.92 with a sensitivity of 87.1% and a specificity of 80.0% in predicting disease severity. Binary logistic regression model has included CT-SVA, D-dimer, ferritin, interleukin 6, and neutrophil-lymphocyte ratio. The model correctly classified 88.1% of cases. CT-SVA, D-dimer, ferritin, interleukin 6, and neutrophil-lymphocyte ratio were detected to be the independent predictors of disease severity. Conclusion: Evaluation of laboratory parameters together with CT-SVA results will help identification of cases with a poor prognosis and accelerate intervention.

3.
Cureus Journal of Medical Science ; 14(11), 2022.
Article in English | Web of Science | ID: covidwho-2217538

ABSTRACT

Background Coronavirus disease 2019 (COVID-19) infection can vary from asymptomatic infection to multi-organ dysfunction. The most serious complication of infection with COVID-19 is death. Various comorbid conditions and inflammatory markers have been associated with an increased risk of mortality, specifically within the immediate post-infection period;however, less is known about long-term mortality outcomes. Objectives Our objective is to determine risk factors associated with six-month mortality in hospitalized COVID-19 patients. Methods This is a single-institution, retrospective study. We included patients hospitalized with COVID-19 from the University of Toledo Medical Center in Toledo, Ohio, who were admitted from March 20, 2020, to June 30, 2021. This study was approved by a biomedical institutional review board at the University of Toledo. Patients with available pre-stored blood samples for laboratory testing were included, and hospital charts were assessed up to six months from the date of a positive COVID-19 test result. Two groups were created based on the mortality outcome at six months from COVID-19 positive test results: survivors and non-survivors. The clinical variables or outcomes and laboratory values were compared between the two groups using non-parametric methods due to the small sample size and non-normality of the data. Either the Mann-Whitney U-test for continuous variables or Fisher's exact test for categorical variables was used for statistical analysis. Results Lactate dehydrogenase (LDH) and D-dimer levels on admission were found to be significantly higher in non-survivors than in survivors. The median high D-dimer level in non-survivors was 5.96 micrograms/milliliter (mu g/mL) (interquartile range (IQR): 3.95-11.29 mu g/mL) vs 1.82 mu g/mL (IQR 1.13-5.55 mu g/mL) in survivors (p = 0.019). Median LDH levels were also higher in non-survivors vs survivors, i.e., 621.00 international units per liter (IU/L) (IQR 440.00-849.00 IU/L) vs 328.00 IU/L (IQR 274.00-529.00 IU/L), respectively (p = 0.032). The demographic profile, comorbidity profile, and laboratory data (typically associated with short-term mortality, inflammation, and organ dysfunction) were similar between survivors and non-survivors, except for LDH and D-dimer. Conclusion Higher LDH and D-dimer levels on admission were found to be associated with an increased six-month mortality rate in hospitalized COVID-19 patients. These hematologic data can serve as risk stratification tools to prevent long-term mortality outcomes and provide proactive clinical care in hospitalized COVID-19 patients.

4.
European Journal of Molecular and Clinical Medicine ; 9(8):3155-3161, 2022.
Article in English | EMBASE | ID: covidwho-2167918

ABSTRACT

Background: COVID-19 pandemic hit the world in 2019 and its successive waves have created high alerts periodically across many nations including India. At the time of successive waves of the COVID-19 pandemic, one of the key concerns among developing nations was to manage the patient burden in hospitals with limited available infrastructure. Objective(s): In the present study we have analysed the role of common laboratory markers as a predictor of hospital stay in COVID-19-positive patients so that hospital resources can be managed efficiently. Method(s): We studied the data of 200 COVID-19-positive patients for TLC, LDH, D-dimer, and serum ferritin and analysed their correlation with hospital stay Results: TLC and LDH exhibit a positive correlation with hospital stay whereas D-dimer and serum ferritin showed a negative correlation with hospital stay among COVID-19 patients. Patients with a negative CRP showed a longer duration of hospital stay with a median stay of 9 days. Conclusion(s): Being a developing nation, healthcare centres in India have limited resources. In such a scenario, common laboratory markers can prove to be a promising tool in managing hospital resources by estimating the hospital stay of patients. Copyright © 2022 Ubiquity Press. All rights reserved.

5.
Gaceta Medica Boliviana ; 45(2):117-127, 2022.
Article in Spanish | Scopus | ID: covidwho-2206863

ABSTRACT

Introduction: The lack of a clear definition of cytokine release syndrome (CRS) allowed this study to analyze the utility of interleukin-6 (IL-6), ferritin, and D-dimer (DD) with other variables and their clinical evolution. Methods: A prospective, observational, and analytical study was conducted from October 2020 to July 2021 in 125 patients in the intensive care unit (ICU) of Hospital Obrero Nro. 2 of the Caja Nacional de Salud in Cochabamba, Bolivia. The three markers and other exams were requested to determine correlations, survival, and relationship with CRS. Results: The mean ferritin was 1193.7±814.8 ng/ml, D-dimer 1427±1005 ng/ml, and IL-6 58.5±34.1 pg/mL. No statistical association was found between these markers, but a Spearman's Rho of 0.5 between ferritin and DD (p<0.05) was found in patients who died. In addition, there were associations between male gender and ferritin, DD and dyspnea, and IL-6 and tracheostomy. Survival was 9 days 95% CI (8.02-9.98) with similar values of DD and ferritin for both normal and elevated levels. The values of the area under the curve (AUC) did not show prediction of mortality, but a rate of 70%. Survival was better in those who did not suffer from acute respiratory distress syndrome (ARDS), with eight days (p=0.011). Conclusions: It is not possible to relate CRS to IL-6, DD, and ferritin, or to define it with fever, leukocytosis, renal failure, tracheostomy, due to the heterogeneous values of IL-6 in relation to COVID-19 and other inflammatory pathologies. The position of a hypoinflammatory disease rather than a hypercytokinemia remains in doubt. © 2022 The authors.

6.
Malaysian Journal of Medicine and Health Sciences ; 18:67-71, 2022.
Article in English | Scopus | ID: covidwho-2206842

ABSTRACT

Introduction: Coagulopathy is commonly seen with coronavirus disease (COVID-19). Abnormal coagulation parameters are important to determine the prognosis and severity of the disease. There is scant evidence of coagulation in the Omicron variant of COVID-19. This study aimed to analyse the correlation between D-dimer level and clinical severity among 284 hospitalised patients with COVID in Jakarta, Indonesia. Methods: A retrospective cross-sectional study was conducted among 284 patients with COVID-19 admitted to Wisma Atlet Kemayoran COVID-19 Emergency Hospital between August 2021 and January 2022. D-dimer levels were determined on I-Chroma cs2100 and x-rays were taken with a Rotanode E7239X. p<0.05 was defined as statistically significant. The analytics were calculated using SPSS ver. 21. Results: Elevated D-dimer was discovered in 175 patients with the Omicron variant of COVID-19 (61.61%). Radiological signs of pneumonia were found in 38 patients (13.3%). Only one patient (0.35% severity rate) was diagnosed with a severe clinical case. A correlation was identified between an elevated D-dimer level and radiological signs of pneumonia in the Omicron variant of COVID-19 (p=0.045). Conclusion: The Omicron variant of COVID-19 tends to generate milder symptoms and less severe cases. Elevated D-dimer can be one of the signs of severity in the Omicron variant of COVID-19 due to its correlation with radiological signs of pneumonia. © 2022 UPM Press. All rights reserved.

7.
Journal of Pharmaceutical Negative Results ; 13:2905-2911, 2022.
Article in English | EMBASE | ID: covidwho-2206761

ABSTRACT

Coronavirus disease 2019 (COVID-19) is the present global public health problem that has already caused pandemic since 2020. This respiratory corona viral infection can cause severe respiratory illness and death might be the outcome in severe cases. COVID-19 can manifest several atypical clinical presentations including neurological presentation. An important neurological problem is neurovascular thrombotic disorder A thrombotic event might be due to arterial or venous system affection. The study was conducted in the public laboratories on the outskirts of Baghdad after collecting 100 samples, (60) of people infected with Covid - 19 and (40) of healthy people and the ages of the people ranged from 18-80 years and the ages of the healthy ones from 18-70 years old. The study was conducted to investigate some biochemical indicators which includes Chemokine CXCL10, Fibrinogen, D-dimer, ferritin, C-reactive protein, iron and fibrinogen. The results showed a significant increase in the level of the chemokine CXCL10 in patients infected with Covid-19 virus compared to the control group, and a significant increase in the levels of D-dimer, ferritin, C-reactive protein, iron and fibrinogen which are important biochemical indicators in Covid - 19 patients. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

8.
Journal of Pharmaceutical Negative Results ; 13:1665-1671, 2022.
Article in English | EMBASE | ID: covidwho-2206724

ABSTRACT

The significance of D-dimer coagulation (DD), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (Fg) and PCT in predicting the severity and prognosis of COVID-19 was studied. Violation of the function of blood coagulation occurred in almost all, more often in severe patients. Indicators of hemostatic homeostasis, such as D-dimer, prothrombin time, fibrinogen and procalcitonin, can be used as predictors of disease severity in patients. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

9.
Indian Journal of Public Health Research and Development ; 14(1):294-301, 2023.
Article in English | EMBASE | ID: covidwho-2206453

ABSTRACT

Introduction: Worldwide there was recent outbreak of a novel Corona Virus infection i.e. SARS COV19. Although it involves primarily the pulmonary system other systems like Cardiovascular, renal, neurological, hematological systems are also significantly involved by SARS COV19 infection. Aim(s): In this study our aim was to analyze the pathophysiologic mechanism of hematological abnormalities in COVID-19 patients and its role in risk stratification, severity & prognosis of the disease. Material(s) and Method(s): In this study we have analyzed the clinical presentation and pathological laboratory results of hematological abnormalities retrospectively from previous records of COVID-19 patients admitted to our hospital. All the hematological parameters i.e. changes in Hb%, WBC Count, Platelet Count and Coagulation Profile parameters i.e. PT-INR, aPPT& D-dimer were analyzed and correlated with the disease severity and its prognosis. Statistical analysis was done be x2 test. Result(s): In our study the most common hematological abnormality was Lymphopenia followed by Leukocytosis and majority of the patient were >60 Yrs. age with male predominance. Conclusion(s): Among all the hematological abnormalities coagulation parameter D-dimer (elevated levels) are most significantly associated with disease severity. Among the other hematological abnormalities the most common abnormality was Lymphopenia which along with combined features of Anemia, Leukocytosis andNeutrophilia were also significantly associated with disease severity. So, monitoring & evaluation of hematological parameters could be a crucial step towards risk stratification & management of COVID-19 patients. Copyright © 2023, Institute of Medico-legal Publication. All rights reserved.

10.
Research Journal of Pharmaceutical, Biological and Chemical Sciences ; 13(6):70-79, 2022.
Article in English | EMBASE | ID: covidwho-2206094

ABSTRACT

COVID-19 disease is caused by Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). In most of the cases the patients present with typical symptoms of fever, cough, dyspnea, sore throat etc. The involvement of central nervous system by SARS-CoV-2 resulting in encephalopathy, encephalitis and neuropsychiatric symptoms such as anxiety, depression, panic attack and post traumatic symptoms have been described in the literature. But the clinical presentation of Psychosis as a neuropsychiatric manifestation in COVID-19 patients has been described in very few literatures. Our aim of the study was to find out the incidence of Psychosis in COVID-19 patients and its association with elevated levels of inflammatory markers such as IL-6, CRP etc, and with that of elevated coagulation parameter such as D-dimer values. Severity of Pneumonia (by HRCT thorax), neuropsychiatric presentation of Psychosis and the various interventions received by the COVID-19 patients with Psychosis were also studied. Out of 2752 COVID-19 cases new onset COVID Psychosis was seen only in 36 cases with an incidence of 1.308%. Out of these, 30 cases were aged > 60 years (83.3%) with male predominance (n=25)(69.44%) Psychotic manifestations such as delusion, hallucinations and mania were seen in 34 (94%), 32(88.8%) and 28 (77.7%) cases respectively. Copyright © 2022, Research Journal of Pharmaceutical, Biological and Chemical Sciences. All Rights Reserved.

11.
Biointerface Research in Applied Chemistry ; 13(5), 2023.
Article in English | Scopus | ID: covidwho-2206048

ABSTRACT

Since December 2019, the COVID-19 pandemic has continued to spread across the world. Elevated D-dimer has known to have occurred in COVID-19 patients, which was associated with hypercoagulable conditions and could lead to various complications. This literature study aims to identify the effect of increasing D-dimer on the severity, mortality, and other outcomes and the benefits of anticoagulants used in COVID-19 patients. The research was conducted from February 17, 2021, to July 28, 2021, through PubMed, Scopus, and Clinical Trials.gov databases. It was then updated on November 1, 2022, and 116 articles were obtained for this study. The results showed that increased D-dimer was associated as a risk factor for severity, disease progression, and mortality and could predict several outcomes, such as the need for intensive care, cardiac injury, respiratory failure, and thromboembolic events. Several studies suggested the benefit of using prophylactic anticoagulants in COVID-19 patients, but there was insufficient evidence showing that higher doses of anticoagulants were beneficial. © 2023 by the authors.

12.
Asian Journal of Pharmaceutical and Clinical Research ; 15(12):92-94, 2022.
Article in English | EMBASE | ID: covidwho-2205064

ABSTRACT

Objective: Coronavirus disease 2019 (COVID-19) is primarily a respiratory illness causing thrombotic disorders. Pro-inflammatory cytokines are one of the responsible causes of cytokine storm syndrome in patients with COVID-19. Coagulopathy and inflammation are associated with COVID-19 severity. The coronavirus spike protein facilitates the entry of the virus into the target cells causing coagulopathy and inflammation.Other infections include direct viral toxicity, endothelial cell damage, inflammation, and deregulation of the immune response and renin-angiotensinaldosterone system. The study aims to estimate levels of D-Dimer and Serum Ferritin in symptomatic and asymptomatic COVID-19 patients and its comparison with healthy controls. Method(s): The study includes 30 healthy control and 30 symptomatic and 30 asymptomatic COVID-19 patients of both sexes. Analysis of serum ferritin was done on a fully automated immunology analyzer-SIEMENS based on the principle of chemiluminescence. D-dimer was estimated on mLab which is cartridge-based. Result(s): We observed that the levels of D-Dimer and Serum Ferritin significantly increased in symptomatic COVID-19 patients as compared to asymptomatic COVID-19 positive patients and healthy non-COVID-19 controls. Conclusion(s): The elevated serum ferritin and D-dimer were associated with a poor outcome and poor prognosis and could predict the worsening of COVID-19 patients. The significant increase showed that D-Dimer and serum ferritin accurately predicts patients developing severe COVID- infection. Copyright © 2022 The Authors. Published by Innovare Academic Sciences Pvt Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

13.
Asian Journal of Pharmaceutical and Clinical Research ; 15(12):61-66, 2022.
Article in English | EMBASE | ID: covidwho-2205059

ABSTRACT

Objectives: Along the course human history of scientific research, the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is the most concerning global health problem. Second wave of COVID-19 has adversely affected India. However, India embarked on its immunization program on January 16, 2021, operating 3006 vaccination centers onset Covaxin and CoviShield. This study aimed to ascertain if there is an association amidst ABO blood type and probability of COVID-19 infection in wave. Method(s): This is analytical and observational study conducted on 713 SARS-COVID-19-positive patients of a known ABO blood type, who attended outpatient department and inpatient department during March 26-May 20, 2021, in tertiary care hospital Udaipur (Raj.) Serum inflammatory markers were evaluated by Cobas 6000. Result(s): Out of the 713 patients who were tested positive, 15.56% was blood group Type A, 19.91% was blood group Type B, 13.65% was blood group Type AB, and 46.28% was blood group Type O. On statistical analysis, there were positive association between O+ blood type and peak inflammatory marker (interleukin-6 and D-Dimer). Patients with blood Type O who received a test were more likely to test positive and blood Type B+, A+, A+, AB+, O-, A-, B-, and AB- were less likely to test positive. Conclusion(s): The present study shows an evidence for interrelation between ABO blood groups and SARS-COVID-19. Reported infection prevalence is moderately increased among O+ blood type individuals. Determination of level of inflammatory markers might prove to be helpful to clinicians so as to keep track of severity of infection and evaluate the prognosis of SARS-COVID-19 with specific ABO blood groups. Copyright © 2022 The Authors. Published by Innovare Academic Sciences Pvt Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

14.
Journal of Clinical and Diagnostic Research ; 17(1):OC13-OC17, 2023.
Article in English | EMBASE | ID: covidwho-2203495

ABSTRACT

Introduction: Known independent predictors of extended Length Of Stay (LOS) in Coronavirus Disease 2019 (COVID-19) included older age, chronic kidney disease, elevated maximum temperature, and low minimum oxygen saturation. Additional known predictors of prolonged hospitalisation included male sex, chronic obstructive pulmonary disease, hypertension, and diabetes. Elevated levels of C-Reactive Protein (CRP), creatinine, and ferritin are proven determinants of hospitalisation and LOS. Determining predictors of LOS will aid in triaging and management of COVID-19 patients. Aim(s): To assess the clinical, biochemical and radiological profile of admitted COVID-19 patients and determine the predictors of prolonged length of stay at hospital. Material(s) and Method(s): It was a retrospective, cross-sectional observational, record-based study included hospital records of 544 confirmed COVID-19 patients, above age of 18 years admitted at Bharati Vidyapeeth Medical College and Hospital, Pune, Maharashtra, India, during February 2021 to June 2021. Possible determinants of LOS were studied including their demographic, epidemiological, clinical and radiological characteristics. The patients were divided into two groups as per median LOS i.e, group I with LOS <10 days (n=277) and group II with LOS >=10 days (n=267). Statistical analysis was done using Chi-square test, proportion test, Z test, Mann-Whitney U test, regression analysis by Statistical Package for the Social Sciences (SPSS) software version 23.0. Result(s): Mean age in group I and II was 47.83+/-16.34 years and 53.21+/-15.63 years (p-value <0.0001), respectively. The fatigue was significantly more in group II than group I (p-value=0.018). Diabetes mellitus was more (p-value=0.026) and severity of illness (p-value<0.0001) was significantly higher in group II than group I. In univariate analysis, mean Neutrophil/Lymphocyte ratio (p-value<0.0001), serum LDH (p-value<0.018), blood urea level (p-value<0.0001), random blood sugar (p-value=0.003), glycated haemoglobin (HbA1c) (p-value=0.072) and serum creatinine (p-value=0.41) were significantly more in group II. Median CRP (p-value<0.0001), D-dimer (p-value<0.0001), serum ferritin (p-value<0.0001), procalcitonin (p-value<0.0001), Serum Glutamic Oxaloacetic Transaminase (SGOT) (p-value=0.002) was significantly higher in group II. Lung involvement {chest radiograph or High-Resolution Computed Tomography (HRCT) chest} was significantly (p-value<0.0001) more in group II. Conclusion(s): Fatigue, older age, diabetes mellitus, severity of illness, mean neutrophil/lymphocyte ratio, CRP, D-dimer, serum ferritin, serum Lactate Dehydrogenase (LDH), procalcitonin, blood urea, SGOT were associated with prolonged LOS among hospitalised COVID-19 patients. Copyright © 2023 Journal of Clinical and Diagnostic Research. All rights reserved.

15.
Journal of Clinical and Diagnostic Research ; 17(1):SC01-SC06, 2023.
Article in English | EMBASE | ID: covidwho-2203491

ABSTRACT

Introduction: Inflammatory markers have been used as predictors of adverse outcomes in adults with Coronavirus Disease-2019 (COVID-19) infection. Children mostly have mild infections and raised inflammatory markers have been reported only with severe COVID-19 or Multisystem Inflammatory Disorder (MIS-C). Studies in children showing the role of inflammatory markers in disease prognosis are few, and findings are not conclusive. Aim(s): To find out correlation, if any, between the inflammatory markers {Interleukin-6 (IL-6), C-reactive Protein (CRP), procalcitonin, Pro-B-type natriuretic Peptide (Pro-BNP), ferritin, D-dimer} with clinical presentation, prognosis, and outcome in children with acute COVID-19. Material(s) and Method(s): The prospective, observational study was conducted at a tertiary care COVID-19 Paediatric Intensive Care Unit {PICU (Vardhaman Medical College and Hospital, New Delhi)}, Northern India, between September 2020 and December 2020. All children aged less than 12 years, with a positive COVID-19 report were enrolled and investigated. Data was collected for clinical presentation, severity, treatment and outcome. The following variables were recorded: Complete Blood Count (CBC), Kidney Function Test (KFT) and Liver function Test (LFT), Absolute Lymphocyte Count (ALC), Absolute Neutrophil Count (ANC), Neutrophil-lymphocyte Ratio (NLR), Platelet Count (PLT), C-reactive Protein (CRP), Procalcitonin (PCT), serum ferritin, Lactate Dehydrogenase (LDH), fibrinogen, and Erythrocyte Sedimentation Rate (ESR) and ProBNP. Coagulation parameters like Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), International Normalised Ration (INR), D-dimer were taken. Data was analysed using Statistical Package for the Social Sciences (SPSS) software version 21.0. Result(s): A total of 35 children were admitted during the study period. Seventeen children met the criteria for severe disease. Seven children met the criteria for MIS-C. Children presenting with conjunctivitis (n=3) were more likely to have signs of peripheral inflammation hypotension (n=4), tachycardia (n=6), and raised IL-6 levels (pg/mL) as well as the need for inotropic support. IL-6 values were higher in children (Mean+/-SD= 182.47+/-149.83). Median IL-6 value 199.8 (96.17-275.24) was highest in children with CRP <10 mg/dL (p-value<0.01). Children with raised D-dimer (Mean+/-SD=1881.94+/-1265.66 mg/dL) had a longer duration of stay (p-value=0.031). conclusion: The study didn't find any correlation between inflammatory markers with clinical presentation and the outcome of COVID-19 infection in children. Copyright © 2023 Journal of Clinical and Diagnostic Research. All rights reserved.

16.
Archives of Medical Science ; 18(6):1488-1497, 2022.
Article in English | Web of Science | ID: covidwho-2202534

ABSTRACT

Introduction: Clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in old adults from Southern Italy is little known. This study aims to investigate the mortality risk related to risk factors, therapy and clinical course and to suggest prognostic indicators based on day-to-day follow-up of clinical and laboratory findings.Material and methods: It was designed as a retrospective longitudinal co-hort study of adult SARS-CoV-2 patients admitted at Partinico COVID Hos-pital in Palermo, Southern Italy. Patients were recruited between 4 March and 25 April and followed up until 31 May 2020, day-to-day until death or hospital discharge. Clinical data, laboratory tests and treatment data were extracted from medical records and epidemiologic information was obtained by clinical history and the medical interview.Results: Forty-seven patients (median age = 75 IQR: 59.50-86.00) were fol-lowed up during a 87 days observation period, accounting for a total of 1,035 person days. At the end of follow-up, 28 (60%) patients were discharged and 19 (40%) died, so that the estimated incidence density rate was 0.018 deaths per day (18 SARS-CoV-2-related deaths per 1,000 patient days). Di-abetes (HR = 8.13, 95% CI: 1.91-34.67), chronic kidney failure (HR = 5.86, 95% CI: 1.36-25.21), dementia (HR = 7.84, 95% CI: 1.80-34.20), and neu-trophil/lymphocyte ratio > 7 (HR = 10.37, 95% CI: 2.24-48.14) were found as significant prognostic factors.Conclusions: The joint evaluation of dementia, diabetes, chronic kidney fail-ure and neutrophil/lymphocyte ratio showed an optimal prognostic value already in the first week of follow-up. The day-to-day follow-up provides essential information for clinical monitoring and treatment of the disease in a hospital setting and improves the disease's home management, especially for older patients with frailty.

17.
Annals of Clinical and Analytical Medicine ; 13(12):1409-1413, 2022.
Article in English | Web of Science | ID: covidwho-2202451

ABSTRACT

Aim: This study aimed to compare clinical data and laboratory results in patients examined for suspected pulmonary embolism (PE) in the emergency department based on three groups: patients with coronavirus disease-2019 (COVID-19), patients with PE and patients with both COVID-19 and PE.Material and Methods: This retrospective study was approved by the local ethics committee of the university. Patients included in the study were divided into three groups: Group 1, consisting of COVID-19-polymerase chain reaction (PCR) (negative) and PE (positive) patients;Group 2, consisting of COVID-19-PCR (positive) and PE (negative) patients, and Group 3, consisting of COVID-19-PCR (positive) and PE (positive) patients.Results: The three patient groups included in the study had no difference in terms of age (p = 0.916) or sex. The laboratory results of the groups were compared using the Kruskal-Wallis test, which showed significant differences in the levels of white blood cells (p = 0.005), lymphocytes (p < 0.001), neutrophils (p = 0.016), D-Dimer (p < 0.001) and lactate (p = 0.001). Receiver operating characteristic curve analysis with a cut-off value of >2590 for D-Dimer showed 71.43% specificity and 78% sensitivity in differentiating Group 1 from Group 2, and with a cut-off value of >3640, it had 80% specificity and 81.82% sensitivity in differentiating Group 3 from Group 2.Discussion: COVID-19 leads to increased incidence of PE. In addition to clinical data, D-Dimer and lactate levels can be used in the differentiation of these patients.

18.
Egyptian Journal of Chest Diseases and Tuberculosis ; 71(4):481-484, 2022.
Article in English | EMBASE | ID: covidwho-2201699

ABSTRACT

Background Several studies are ongoing to obtain more information about post-COVID-19 (corona virus disease-19) pulmonary fibrosis. Old-aged patients are more likely to evolve lung fibrosis in COVID-19. Another risk factor is the degree of disease severity, including comorbidities, such as hypertension, diabetes, as well as lab findings, for example, lymphopenia and leukocytosis. Aims of work To assess the prevalence of post-COVID-19 pulmonary fibrosis and reveal some of its predictors. Results The study included 50 patients in the outpatient clinics of Chest and EL-Helal Hospitals with a mean age of 49.6 +/- 17.7 years. It included 32 (64%) males and 18 (36%) females. Pulmonary fibrosis was detected in 34 (68%) patients. Pulmonary fibrosis was bilateral in 24 patients and unilateral in 10 patients. Leucopenia, elevated serum ferritin, elevated D-dimer, and elevated C-reactive protein (CRP) were associated with pulmonary fibrosis (P value 0.001). Conclusion Pulmonary fibrosis is recognized as a complication between survivors. Immune response due to lung injury by viral infection, and trials to repair are keys to the procedure of fibro genesis. Predictors of lung fibrosis involve increased lab parameters such as serum ferritin, C-reactive protein, and D-dimer. Copyright © 2022 The Egyptian Journal of Chest Diseases and Tuberculosis.

19.
Open Access Macedonian Journal of Medical Sciences ; Part B. 10:2417-2422, 2022.
Article in English | EMBASE | ID: covidwho-2201131

ABSTRACT

BACKGROUND: COVID-19 is a condition that is characterized by an abnormal coagulation state, which is a reason for severe thrombotic problems. AIM: We aim to determine the correlation of coagulation parameters levels with clinical outcomes of critically ill patients with COVID-19 admitted to intensive care at a national referral hospital in Indonesia. METHOD(S): This retrospective cohort study analyzed 227 patients with a primary diagnosis of COVID-19 on mechanical ventilation who were admitted to the COVID-19 intensive care unit, Dr. M. Djamil from 2020 to 2021 taken in the medical record. Numerical data were analyzed using an independent t-test, while the categorical data were analyzed using the Chi-square test. RESULT(S): One hundred and one patients were >65 years old. The mean +/- SD of INR levels, D-dimer levels, and platelet count on the first and the 5th days were 1.22 +/- 0.77 and 1.36 +/- 1.16;4.624 +/- 3.533 microg/L and 4.334 +/- 3.365 microg/L;and 160.162 +/- 117.203/microl and 234.070 +/- 126.816/microl. There was a significant correlation between age (p = 0.002), INR levels on the 5th day (p = 0.041), platelet count on the 5th day (0.012) with clinical outcomes of patients. CONCLUSION(S): There is a significant increase in the average platelets and INR levels on day 5. There is a significant correlation between INR levels and platelet count on 5th days with clinical outcomes of patients. Copyright © 2022 Dedy Kurnia, Eti Yerizel, Andani Ekaputra, Dwitya Elvira.

20.
World Journal of Gastroenterology ; 28(45):6328-6344, 2022.
Article in English | Web of Science | ID: covidwho-2201053

ABSTRACT

Coronavirus disease 2019 (COVID-19), caused by a severe acute respiratory syndrome coronavirus 2 infection, has raised serious concerns worldwide over the past 3 years. The severity and clinical course of COVID-19 depends on many factors (e.g., associated comorbidities, age, etc) and may have various clinical and imaging findings, which raises management concerns. Gut microbiota composition is known to influence respiratory disease, and respiratory viral infection can also influence gut microbiota. Gut and lung microbiota and their relationship (gut-lung axis) can act as modulators of inflammation. Modulating the intestinal microbiota, by improving its composition and diversity through nutraceutical agents, can have a positive impact in the prophylaxis/treatment of COVID-19.

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