Quantum Inspired Differential Evolution with Explainable Artificial Intelligence-Based COVID-19 Detection

Recent advancements in the Internet of Things (Io), 5G networks, and cloud computing (CC) have led to the development of Human-centric IoT (HIoT) applications that transform human physical monitoring based on machine monitoring. The HIoT systems find use in several applications such as smart cities, healthcare, transportation, etc. Besides, the HIoT system and explainable artificial intelligence (XAI) tools can be deployed in the healthcare sector for effective decision-making. The COVID-19 pandemic has become a global health issue that necessitates automated and effective diagnostic tools to detect the disease at the initial stage. This article presents a new quantum-inspired differential evolution with explainable artificial intelligence based COVID-19 Detection and Classification (QIDEXAI-CDC) model for HIoT systems. The QIDEXAI-CDC model aims to identify the occurrence of COVID-19 using the XAI tools on HIoT systems. The QIDEXAI-CDC model primarily uses bilateral filtering (BF) as a preprocessing tool to eradicate the noise. In addition, RetinaNet is applied for the generation of useful feature vectors from radiological images. For COVID-19 detection and classification, quantum-inspired differential evolution (QIDE) with kernel extreme learning machine (KELM) model is utilized. The utilization of the QIDE algorithm helps to appropriately choose the weight and bias values of the KELM model. In order to report the enhanced COVID-19 detection outcomes of the QIDEXAI-CDC model, a wide range of simulations was carried out. Extensive comparative studies reported the supremacy of the QIDEXAI-CDC model over the recent approaches. © 2023 Authors. All rights reserved.

Foreign exchange forecasting and portfolio optimization strategy based on hybrid-molecular differential evolution algorithms.

At present, the COVID-19 epidemic is still spreading at home and abroad, and the foreign exchange market is highly volatile. From financial institutions to individual investors, foreign exchange asset allocation has become important contents worthy of attention. However, most intelligent optimization algorithms (hereinafter IOAS) adopt the existing data and ignore the forecasted one in the foreign exchange portfolio allocation, which will result in a huge difference between portfolio allocation and actual demand; at the same time, many IOAS are less adaptable and have lower optimization ability in portfolio problems. To solve the aforementioned problems, this paper first proposed a DETS based on hybrid tabu search and differential evolution algorithms (DEAs), which has excellent optimization ability. Subsequently, the DETS algorithm was applied to support vector machine (SVM) model. Experiments show that, compared with other algorithms, the MAE and RMSE obtained by using DETS optimization parameters are reduced by at least 3.79 and 1.47%, while the CTR is improved by at least 2.19%. Then combined with the DETS algorithm and Pareto sorting theory, an algorithm suitable for multi-objective optimization was further proposed, named NSDE-TS. Finally, by applying NSDE-TS algorithm, the optimal foreign exchange portfolio is acquired. The empirical analysis shows that the Pareto front obtained by this algorithm is better than that of NSGA-II. Since the lower the uniformity index and convergence index, the stronger the optimization performance of the corresponding algorithm, compared with NSGA-II, its uniformity and convergence index decreased by 15.7 and 39.6%.

Optimization of empty container allocation for inland freight stations considering stochastic demand.

In the post-COVID-19 epidemic era (PCEE), the supply of empty containers will face stronger uncertainty. Estimating the amount of self-owned and leased empty containers that need to be allocated to each inland freight station in a specific area becomes a critical issue for liner companies in PCEE. However, owing to the high degree of unpredictability of the demand and the limited flexibility of empty container relocation, the abovementioned issue has not been fully addressed. This paper provides a model for empty container allocation without knowing the probability distribution function of empty container demand in advance. The abovementioned model can jointly optimize the quantities of self-owned empty containers and leased containers allocated to each inland freight station. To solve the model, a largest-debt-first policy is adopted to simplify the complicated model, and a differential evolutionary (DE) algorithm is developed to solve the simplified model. Compared with some commonly used algorithms, DE has advantages considering the ability to explore the optimal solution. In addition, the utility of the largest-debt-first policy proposed in this paper is compared with that of the traditional method. Experimental results show that in the case of high demand fluctuations, the proposed policy is better in controlling the operational and management costs. Overall, the theory and method proposed in this paper can effectively help the carrier set a reasonable regional empty container stock level and determine the number of self-owned and leased empty containers.

An improved Fuzzy based GWO algorithm for predicting the potential host receptor of COVID-19 infection.

Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has infected millions worldwide. SARS-CoV-2 spike protein uses Angiotensin-converting enzyme 2 (ACE2) and Transmembrane serine protease 2 (TMPRSS2) for entering and fusing the host cell membrane. However, interaction with spike protein receptors and protease processing are not the only factors determining coronaviruses' entry. Several proteases mediate the entry of SARS-CoV-2 virus into the host cell. Identifying receptor factors helps understand tropism, transmission, and pathogenesis of COVID-19 infection in humans. The paper aims to identify novel viral receptor or membrane proteins that are transcriptionally and biologically similar to ACE2 and TMPRSS2 through a fuzzy clustering technique that employs the Grey wolf optimizer (GWO) algorithm for finding the optimal cluster center. The exploratory and exploitation capability of GWO algorithm is improved by hybridizing mutation and crossover operators of the evolutionary algorithm. Also, the genetic diversity of the grey wolf population is enhanced by eliminating weak individuals from the population. The proposed clustering algorithm's effectiveness is shown by detecting novel viral receptors and membrane proteins associated with the pathogenesis of SARS-CoV-2 infection. The expression profiles of ACE2 protein and its co-receptor factor are analyzed and compared with single-cell transcriptomics profiling using the Seurat R toolkit, mass spectrometry (MS), and immunohistochemistry (IHC). Our advanced clustering method infers that cell that expresses high ACE2 level are more affected by SARS-CoV-infection. So, SARS-CoV-2 virus affects lung, intestine, testis, heart, kidney, and liver more severely than brain, bone marrow, skin, spleen, etc. We have identified 58 novel viral receptors and 816 membrane proteins, and their role in the pathogenicity mechanism of SARS-CoV-2 infection has been studied. Besides, our study confirmed that Neuropilins (NRP1), G protein-coupled receptor 78 (GPR78), C-type lectin domain family 4 member M (CLEC4M), Kringle containing transmembrane protein 1 (KREMEN1), Asialoglycoprotein receptor 1 (ASGR1), A Disintegrin and metalloprotease 17 (ADAM17), Furin, Neuregulin-1,(NRG1), Basigin or CD147 and Poliovirus receptor (PVR) are the potential co-receptors of SARS-CoV-2 virus. A significant finding is that heparin derivative glycosaminoglycans could block the replication of SARS-CoV-2 virus inside the host cytoplasm. The membrane protein N-Deacetylase/N-Sulfotransferase-2 (NDST2), Extostosin protein (EXT1, EXT2, and EXT3), Glucuronic acid epimerase (GLCE), and Xylosyltransferase I, II (XYLT1, XYLT2) could act as the therapeutic target for inhibiting the spread of SARS-CoV-2 infection. Drugs such as carboplatin and gemcitabine are effective in such situations.

Designing optimal convolutional neural network architecture using differential evolution algorithm.

Convolutional neural networks (CNNs) are deep learning models used widely for solving various tasks like computer vision and speech recognition. CNNs are developed manually based on problem-specific domain knowledge and tricky settings, which are laborious, time consuming, and challenging. To solve these, our study develops an improved differential evolution of convolutional neural network (IDECNN) algorithm to design CNN layer architectures for image classification. Variable-length encoding is utilized to represent the flexible layer architecture of a CNN model in IDECNN. An efficient heuristic mechanism is proposed in IDECNN to evolve CNN architecture through mutation and crossover to prevent premature convergence during the evolutionary process. Eight well-known imaging datasets were utilized. The results showed that IDECNN could design suitable architecture compared with 20 existing CNN models. Finally, CNN architectures are applied to pneumonia and coronavirus disease 2019 (COVID-19) X-ray biomedical image data. The results demonstrated the usefulness of the proposed approach to generate a suitable CNN model.

Differential evolution and particle swarm optimization against COVID-19.

COVID-19 disease, which highly affected global life in 2020, led to a rapid scientific response. Versatile optimization methods found their application in scientific studies related to COVID-19 pandemic. Differential Evolution (DE) and Particle Swarm Optimization (PSO) are two metaheuristics that for over two decades have been widely researched and used in various fields of science. In this paper a survey of DE and PSO applications for problems related with COVID-19 pandemic that were rapidly published in 2020 is presented from two different points of view: 1. practitioners seeking the appropriate method to solve particular problem, 2. experts in metaheuristics that are interested in methodological details, inter comparisons between different methods, and the ways for improvement. The effectiveness and popularity of DE and PSO is analyzed in the context of other metaheuristics used against COVID-19. It is found that in COVID-19 related studies: 1. DE and PSO are most frequently used for calibration of epidemiological models and image-based classification of patients or symptoms, but applications are versatile, even interconnecting the pandemic and humanities; 2. reporting on DE or PSO methodological details is often scarce, and the choices made are not necessarily appropriate for the particular algorithm or problem; 3. mainly the basic variants of DE and PSO that were proposed in the late XX century are applied, and research performed in recent two decades is rather ignored; 4. the number of citations and the availability of codes in various programming languages seems to be the main factors for choosing metaheuristics that are finally used.

COVID-19 forecasting and intervention planning using gated recurrent unit and evolutionary algorithm.

The rapid spread of COVID-19, caused by the SARS-CoV-2 virus, has had and continues to pose a significant threat to global health. We propose a predictive model based on the gated recurrent unit (GRU) that investigates the influence of non-pharmaceutical interventions (NPIs) on the progression of COVID-19. The proposed model is validated by case studies for multiple states in the United States. It should be noted that the proposed model can be generalized to other regions of interest. The results show that the predictive model can achieve accurate forecasts across the US. The forecast is then utilized to identify the optimal mitigation policies. The goal is to identify the best stringency level for each policy that can minimize the total number of new COVID-19 cases while minimizing the mitigation costs. A meta-heuristics method, named multi-population evolutionary algorithm with differential evolution (MPEA-DE), has been developed to identify optimal mitigation strategies that minimize COVID-19 infection cases while reducing economic and other negative implications. We compared the optimal mitigation strategies identified by the MPEA-DE model with three baseline search strategies. The results show that MPEA-DE performs better than other baseline models based on prescription dominance.

Learning deep neural networks' architectures using differential evolution. Case study: Medical imaging processing.

The COVID-19 pandemic has changed the way we practice medicine. Cancer patient and obstetric care landscapes have been distorted. Delaying cancer diagnosis or maternal-fetal monitoring increased the number of preventable deaths or pregnancy complications. One solution is using Artificial Intelligence to help the medical personnel establish the diagnosis in a faster and more accurate manner. Deep learning is the state-of-the-art solution for image classification. Researchers manually design the structure of fix deep learning neural networks structures and afterwards verify their performance. The goal of this paper is to propose a potential method for learning deep network architectures automatically. As the number of networks architectures increases exponentially with the number of convolutional layers in the network, we propose a differential evolution algorithm to traverse the search space. At first, we propose a way to encode the network structure as a candidate solution of fixed-length integer array, followed by the initialization of differential evolution method. A set of random individuals is generated, followed by mutation, recombination, and selection. At each generation the individuals with the poorest loss values are eliminated and replaced with more competitive individuals. The model has been tested on three cancer datasets containing MRI scans and histopathological images and two maternal-fetal screening ultrasound images. The novel proposed method has been compared and statistically benchmarked to four state-of-the-art deep learning networks: VGG16, ResNet50, Inception V3, and DenseNet169. The experimental results showed that the model is competitive to other state-of-the-art models, obtaining accuracies between 78.73% and 99.50% depending on the dataset it had been applied on.