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1.
Journal of Cardiovascular Disease Research ; 12(6):1304-1306, 2021.
Article in English | EMBASE | ID: covidwho-1884960

ABSTRACT

Background: COVID-19 is due to severe acute respiratory syndrome coronavirus 2 (SARSCoV2) and was declared a global pandemic by World Health Organization. Various biochemical parameters and serial High Resolution Computed Tomography (HRCT) chest were used to evaluate the severity of the disease. Aim & Objectives: The study was done to assess the association between biochemical parameters and serial HRCT chest. Material and Methods: It was a retrospective observational study at a tertiary hospital in Central India. Patients >/= 18 years old admitted from 01 July 2020 to 31 December 2020 with laboratory-confirmed COVID-19 cases were included in the study. The laboratory parameters included lymphopenia, neutrophil-lymphocyte ratio (NLR), C- Reactive protein (CRP), Lactate Dehydrogenase (LDH), Ferritin, D- Dimer. Only Serial HRCT chest patients were included in the study. Results: In the study total of 44 patients (29 Males/15 Females) were taken. Serial HRCT chest severity and biochemical markers severity were assessed, and the results were obtained. It was found that there is a definite correlation between biochemical markers severity and HRCT chest severity. Conclusion: Since there was a definitive relationship between the severity of biochemical markers and the severity of HRCT chest, biochemical profile can be utilized to determine severity in the absence of HRCT chest.

2.
Revista Medica de Chile ; 149(7):1090-1092, 2021.
Article in Spanish | EMBASE | ID: covidwho-1884527

ABSTRACT

In patients with severe COVID-19, it has been proposed as mechanism of respiratory failure, intra and extrapulmonary shunt. However, there are no reported or documented cases of this mechanism. Also, there are studies showing this mechanism is not relevant. In this report, we present the case of a patient with severe COVID-19 pneumonia, who after two months, during his rehabilitation period, presented persistent hypoxemia with orthodeoxia. Persistent oval foramen with shunt from right to left was diagnosed. The patient underwent a percutaneous closure of the defect and at 48 hours oxygen therapy could be discontinued and the patient discharged.

3.
Revista Medica de Chile ; 149(7):1081-1084, 2021.
Article in Spanish | EMBASE | ID: covidwho-1884526

ABSTRACT

We report a 47-year-old male with a severe disease caused by COVID-19, who required mechanical ventilation for 18 ays. During the hospital stay he received dexamethasone and anticoagulation with heparin. After discharge a new chest CT scan showed homogeneous hypo vascular enlargement of both adrenal glands, not present in the initial imaging studies. It was interpreted as a subacute bilateral adrenal hemorrhage. The patient remained stable and without any complaint.

4.
Tohoku J Exp Med ; 257(2): 147-151, 2022 Jun 08.
Article in English | MEDLINE | ID: covidwho-1883774

ABSTRACT

The number of cases of coronavirus disease-2019 (COVID-19) globally is over 225 million, and disease-related deaths are over 4 million. The type, prevalence, and antibody susceptibility of the virus variants of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and the vaccination rate and coverage are considered critical factors in the progress of COVID-19. We aimed to compare the clinical and laboratory parameters of the patients hospitalized due to COVID-19 in pre-vaccination and post-vaccination periods. We conducted this retrospective cross-sectional study in a tertiary clinic in Turkey. The files of the patients over the age of 18, whose real-time polymerase chain reaction (RT-PCR) tests were positive and who were hospitalized before (November-December 2020, Group 1) and after (March-April 2021, Group 2) COVID-19 vaccination were scanned. Patients' demographical data, clinical severity, laboratory parameters, thorax computed tomography involvement, and mortalities were recorded. The obtained data were compared among the groups. 601 patients (344 male, 57% and 257 female, 43%) were included in the study. It was observed that the patients in the Group 2 were younger (60.71 ± 14.06 vs. 66.95 ± 14.57, p < 0.001), and a significant decrease in mortality [83 (28.6%) vs.139 (44.6%), p = 0.001] were observed in Group 2. The number of patients who needed ventilatory support and the rate of pulmonary involvement was lesser in Group 2, but the difference was non-significant. C-reactive protein, D-dimer, procalcitonin levels were significantly lower in Group 2 patients. Our study shows that the age and mortality of hospitalized COVID-19 patients decreased significantly after vaccination. An increase in the number of booster doses in individuals with advanced age (age > 75) and comorbidity (especially malignancy) may contribute to the control of the disease and immunity in this population.


Subject(s)
COVID-19 , Adult , COVID-19/prevention & control , COVID-19 Vaccines , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Retrospective Studies , SARS-CoV-2 , Vaccination
5.
Topics in Antiviral Medicine ; 30(1 SUPPL):178-179, 2022.
Article in English | EMBASE | ID: covidwho-1880267

ABSTRACT

Background: Trials on convalescent plasma (CP) for hospitalized patients with COVID-19 have not demonstrated clear benefits. However, data on outpatients with early symptoms are limited. We studied if treatment with CP reduces disease burden of outpatients treated in the first 7 days of symptoms. Methods: Two double blind randomized trials (NCT04621123, NCT04589949) were merged. Pooling of data started when <20% of their predefined sample size had been recruited. A Bayesian adaptive individual patient data meta-analysis was implemented. Analyses were done with Bayesian proportional odds and logistic models, where odds ratios(OR)<1.0 indicate a favorable outcome for CP. A DSMB monitored the accumulating data for efficacy. Patients aged ≥50, diagnosed with COVID-19 and symptomatic for ≤7days were eligible for participation. The intervention was one unit (200-300mL) of CP with a predefined minimum level of antibodies. The two primary endpoints were (a) a 5-point disease severity scale (fully recovered by day 7 or not, hospital or ICU admission and death) and (b) a composite of hospitalization or death. Secondary endpoints were efficacy in patients with ≤5days of symptoms and time to full symptom resolution. Results: Of 797 patients included, 390 received CP and 392 placebo. They had a median age of 58, 1 comorbidity, symptoms for 5 days and 93% tested negative for SARS-CoV-2 S-protein IgG antibodies. 74 patients were hospitalized, 6 required mechanical ventilation and 3 died. The OR of CP for an improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311). The OR for hospitalization or death was 0.919 (CI 0.592-1.416). The effect of CP on hospital admission or death was largest in patients with ≤5days of symptoms (OR 0.658, 95% CI 0.394-1.085). CP did not decrease the time to full symptom resolution (p=0.62). Conclusion: Treatment with CP of outpatients in the first 7 days of symptoms did not improve outcome of COVID-19. The possible beneficial effect in patients with ≤5days of symptoms requires further study.

6.
Kazan Medical Journal ; 102(6):843-854, 2021.
Article in English | Scopus | ID: covidwho-1879705

ABSTRACT

Aim. To analyze COVID-19 comorbidities and their impact on disease course and the risk for unfavorable outcomes. Methods. This study examined a group of 110 patients aged 32 to 97 who were admitted to the intensive care unit of the Pskov Regional Infectious Diseases Hospital in the period from October 7, 2020 to March 23, 2021. The mean age of patients was 65 years, 51% (56 people) were male. The study recorded age, comorbidities on a binary scale (yes - no), course of the disease, the degree of lung injury, hospital length of stay, treatment outcome. The impact of comorbidities on the disease severity and outcomes was assessed by using logistic regression analysis. Results. It was shown that a regional sample of patients showed an increased hospital mortality rate compared with the data of the ACTIV registry (33.5 versus 7.6%). Chronic respiratory diseases in patients with COVID-19 regional cohorts affected the fatal outcome 2.7 times less than those registered in the Russian register. The presence of endocrine and thrombotic circulatory system diseases was generally close to the register. Concomitant cardiovascular diseases in patients of the regional cohort affected the mortality of COVID-19 outcomes two times less (in patients of the region, the risk of mortality increased by 2.066 times) than in the registry. The reliability of the conclusions is confirmed by testing statistical hypotheses and reliability coefficients below 5%. Conclusion. The study shows the statistically significant effect of comorbidities on the COVID-19 outcomes;the specificity of the results related to the sampling characteristics and the regional component. © Kazan Medical Journal. All rights reserved.

7.
Front Cell Infect Microbiol ; 12: 862656, 2022.
Article in English | MEDLINE | ID: covidwho-1875399

ABSTRACT

Objectives: To assess humoral and cellular immune responses against SARS-CoV-2 variants in COVID-19 convalescent and confirmed patients, to explore the correlation between disease severity, humoral immunity, and cytokines/chemokines in confirmed patients, and to evaluate the ADE risk of SARS-CoV-2. Methods: Anti-RBD IgG were quantified using an ELISA. Neutralization potency was measured using pseudovirus and real virus. Cellular immunity was measured using ELISpot. Cytokine/chemokine levels were detected using multiplex immunoassays. In vitro ADE assays were performed using Raji cells. Results: One-month alpha convalescents exhibited spike-specific antibodies and T cells for alpha and delta variants. Notably, the RBD-specific IgG towards the delta variant decreased by 2.5-fold compared to the alpha variant. Besides, serum from individuals recently experienced COVID-19 showed suboptimal neutralizing activity against the delta and omicron variants. Humoral immune response, IL-6, IP-10 and MCP-1 levels were greater in patients with severe disease. Moreover, neither SARS-CoV-1 nor SARS-CoV-2 convalescent sera significantly enhanced SARS-CoV-2 pseudovirus infection. Conclusions: Significant resistance of the delta and omicron variants to the humoral immune response generated by individuals who recently experienced COVID-19. Furthermore, there was a significant correlation among disease severity, humoral immune response, and specific cytokines/chemokine levels. No evident ADE was observed for SARS-CoV-2.


Subject(s)
COVID-19 , Cytokines , Immunity, Cellular , Immunity, Humoral , SARS-CoV-2 , COVID-19/immunology , Cytokines/immunology , Humans , Immunoglobulin G , Severity of Illness Index
8.
Cells ; 11(11)2022 May 30.
Article in English | MEDLINE | ID: covidwho-1869482

ABSTRACT

HLA allelic distribution was analysed in a cohort of 96 Northern Italian subjects (53M/43F) (mean age 59.9 ± 13.3 years) from Lombardy who developed COVID-19 during the first two pandemic waves to investigate possible correlations between HLA molecules and disease severity. An important role of HLA- B and HLA-C loci in modulating the clinical severity of COVID-19 disease was identified. In particular, the HLA-B07 supertype was observed to be associated with a significant risk for severe disease; conversely, the HLA-B27 supertype and C*12:02 allele played a protective role as they were associated with milder disease. These associations were confirmed after applying a multinomial regression analysis to adjust the correlation for age, gender and comorbidities with COVID-19 severity. Though the power of results is limited by the small sample size, data herein contribute to shedding light on the role played by genetic background in COVID-19 infection.


Subject(s)
COVID-19 , HLA-B Antigens , HLA-C Antigens , Aged , Alleles , COVID-19/genetics , Gene Frequency , HLA-B Antigens/genetics , HLA-C Antigens/genetics , Humans , Italy , Middle Aged , Pandemics , SARS-CoV-2
9.
Saudi J Biol Sci ; 29(7): 103329, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1867771

ABSTRACT

To understand the effectual role of COVID-19 vaccination, we must analyze its effectiveness in dampening the disease severity and death outcome in patients who acquire infection and require hospitalization. The goal of this study was to see if there was an association between disease progression in admitted COVID-19 patients and their prior vaccination exposure. A prospective cohort study based on 1640 admitted COVID-19 patients were carried between June 2021 and October 2021. Depending on vaccination exposure they were divided into vaccinated (exposed) and unvaccinated (unexposed) groups, excluding partially vaccinated patients. Disease severity was assessed at admission on severity index scale. Disease progression to mortality or need of mechanical ventilation and survival were taken as outcome. Absolute difference with 95%CI and Risk Ratio were calculated using cross tabulation, Chi square test and multivariable logistic regression analysis. Among 1514 total analyzed cohort (median age, 53 years [IQR, 17,106]; 43.7% from 46 to 65 years of age group, 56.2% males,33.4% with no comorbid factor for disease progression) 369(24.4%) were vaccinated breakthrough cases and 1145(75.6%) were unvaccinated controls. 556(36.7%) progressed to death or mechanical ventilation, 958(63.3%) patients survived and were discharged home. Disease progression to death or mechanical ventilation was significantly associated with decreased likelihood of vaccination (24.9% among vaccinated breakthrough vs 40.5% unvaccinated controls, [Absolute difference -15.6% 95%CI (-10.2% to -20.6%); RR 0.615 95%CI (0.509, 0.744); p <.001]). This association was stronger for old age population and for increase time span between second dose of vaccine and onset of symptoms. There was no statistically significant difference among different types of vaccination and occurrence of outcome when compared to unvaccinated controls (RR 0.607(0.482, 0.763); 0.673(0.339, 1.33) and 0.623(0.441, 0.881) for Inactivated virus vaccine, mRNA and Adenovirus vector-based vaccine respectively. The patients who were fully vaccinated against SARS-COV-2 die or shift to mechanical ventilation less frequently than unvaccinated COVID-19 admitted patients.

10.
U.S. Pharm. ; 46:31-35, 2021.
Article in English | EMBASE | ID: covidwho-1866164

ABSTRACT

Very little data are available on how the coronavirus disease 2019 (COVID-19) pandemic will affect influenza, and although new information is emerging daily, much remains to be learned. Infection-control measures undertaken as a result of the COVID-19 pandemic have significantly impacted the annual influenza season, with a substantial drop in positive influenza cases compared with previous years. Despite the lack of influenza circulation, data suggest that coinfection with influaenza and severe acute respiratory syndrome coronavirus 2 worsens disease severity and worsens prognosis. Although the spread of influenza decreased, misinformation has widely increased. Pharmacists have proven to be essential in the community, offering support not only in vaccine administration and point-of-care testing but also in combating misinformation through education.

11.
Index de Enfermeria ; 30(3):184-188, 2021.
Article in English | EMBASE | ID: covidwho-1865876

ABSTRACT

Objective: To measure the effects of the prone position on ventilatory parame-ters in the treatment of patients with acute respiratory syndrome secondary to COVID-19. Methods: Through a descrip-tive, cross-sectional, prospective study, a sample of 103 patients with acute respira-tory syndrome (ARDS) secondary to COVID-19 was studied. The patients were placed in the prone position indefinitely and clinical ventilatory pa-rameters were monitored such as blood pressure oxygen (PaO2), oxygen saturation (SatO2) and relationship between partial pressure of oxy-gen and inspired fraction of oxygen (PaO2/FiO2). Results: The concentration of FiO2 decreased from 100% in the su-pine position to 69% in the prone position, the PaO2/FiO2 increased from 74 to 122 millimeters of mercury (mmHg), the basal PaO2 was recorded at 51 mmHg and after the change in position it was of 89 mmHg, also the SatO2 improved from 84% to 93%. Conclusions: The prone position can significantly improve the PaO2, SatO2 values, as well as the PaO2/FiO2 ratio, and in general, the clinical status of the patient with ARDS.

12.
Drug Topics ; 165(12):12-13, 2021.
Article in English | EMBASE | ID: covidwho-1865861
13.
Egyptian Journal of Radiology and Nuclear Medicine ; 53(1), 2022.
Article in English | EMBASE | ID: covidwho-1862182

ABSTRACT

Background: Worldwide, millions of people got COVID-19 infection since the start of the pandemic with a large number of deaths. Re-infection with SARS-CoV-2 is possible, because it can mutate into new strains as it is an RNA virus. The main objective of our study is to correlate between CT severity score of the patients re-infected with COVID-19 during the first and second attack and its clinical impact. Results: We performed a retrospective cohort study. It was carried out on fifty symptomatic patients (11 females and 39 males). Their ages ranged from 38 to 71 years. We included only patients who were re-infected after more than 6 months of the first infection and showed clinical symptoms with SARS-CoV-2 PCR-positive test. We found that CT severity score was decreased in the second infection in 47 (94%) of our patients associated with decreased respiratory distress as well as oxygen requirements, while the CT severity score was increased in two patients and only one patient showed no change in CT score severity between two infections. Conclusion: The reduction in CT severity score in the majority of re-infected patients suggested the role of the immunity developed from first infection in protection against severe lung affection in case of repeated infection even after 6 months despite poor immunity against re-infection.

14.
Clinical Case Studies ; 21(3):175-191, 2022.
Article in English | EMBASE | ID: covidwho-1862045

ABSTRACT

Although misophonia is not yet included in the primary diagnostic manuals used by psychologists or psychiatrists, proposed criteria suggest that this condition is characterized by a strong negative reaction to and avoidance of certain trigger sounds. Misophonic trigger sounds are largely human-made (e.g., chewing and slurping) and evoke responses such as disgust, irritation, and/or anger that are out of proportion to the situation and cause distress and/or impairment. Currently, there is no gold standard evidence-based treatment for misophonia. As the misophonia treatment literature grows, several important questions are arising: (1) should exposure to aversive sound triggers be included in treatment for misophonia and (2) how can clinicians best assess misophonia symptoms. This case offers one example of misophonia being successfully treated with a cognitive-behavioral approach to treatment (including exposures) in an adolescent girl. This case also offers an example of how clinicians may conduct a comprehensive assessment of misophonia symptoms. Theoretically and empirically derived recommendations for including exposure in misophonia treatment are presented. Information from this case may be helpful in informing future research, as there is a paucity of evidence-based assessment and treatment protocols for misophonia.

15.
J Clin Med ; 11(10)2022 May 21.
Article in English | MEDLINE | ID: covidwho-1862829

ABSTRACT

There are few data on the dynamics of SARS-CoV-2 viral manifestations in obese and overweight persons during each of the five waves that occurred in Romania during the last two years. As such, the purpose of this research was to characterize the variance in case severity, symptomatology, ICU hospitalizations, and mortality among overweight and obese individuals infected with the SARS-CoV-2 virus. We included 250 overweight and obese patients admitted to hospital with COVID-19, where 50 patients were selected from each of the five pandemic waves that existed in Romania until March 2022. A total of 113 patients with normal body mass index were included in the study. They were matched with overweight and obese patients by age, gender, and cardiovascular comorbidities to avoid the effect of confounding factors. Between the five waves of the COVID-19 pandemic in Romania, the present investigation found substantial changes in overweight and obese patient features. Obesity increases the risk of hospitalization, severe complications, and mortality from COVID-19. However, this unique demographic is disproportionately affected by obesity-related comorbidities, which contribute to these adverse outcomes. We advocate for the development of new guiding principles for the formulation of healthcare strategies aimed at high-prevalence special populations such as overweight and obese individuals, while also promoting pandemic containment and avoiding the recurrence of pandemic waves with the same guidelines that proved detrimental in terms of economic and human life loss.

16.
Embase; 2022.
Preprint in English | EMBASE | ID: ppcovidwho-337770

ABSTRACT

We present here research from 2020 relevant to Tourette syndrome (TS). The authors briefly summarize a few reports they consider most important or interesting.

17.
Health Sci Rep ; 5(3): e569, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1858809

ABSTRACT

Background and Aims: Vitamin D deficiency is associated with increased vulnerability to respiratory infections. This study aimed to determine the potential relationships between coronavirus disease 2019 (COVID-19) severity, serum vitamin D concentrations, and some inflammatory markers among pediatric COVID-19 patients in Iran. Methods: A retrospective study was conducted among hospitalized pediatric COVID-19 cases in Abuzar Hospital (Ahvaz, Iran) for 6 months. The COVID-19 diagnosis was based on the real-time reverse transcription-polymerase chain reaction technique. Demographic and clinical data of patients were recorded. Patients with serum vitamin D levels lower than 20 ng/ml were assigned as Group 1 and those with serum vitamin D concentrations equal to or more than 20 ng/ml were considered as Group 2. Results: A total of 144 patients were enrolled. Their mean age was 80 ± 49 months (range: 1-16 years). Patients in Group 1 had significantly lower levels of serum vitamin D, calcium, and lymphocytes, as well as higher fibrinogen, d-dimer, and C-reactive protein (CRP) levels compared with those in Group 2 (p < 0.001). In addition, they had a significantly higher dry cough, fever, chest radiographic findings, respiratory rate, and longer hospital length of stay than patients in Group 2. Serum concentrations of vitamin D were positively correlated with levels of serum calcium, lymphocytes, and neutrophils but negatively correlated with CRP, fibrinogen, and d-dimer values. Furthermore, patients with moderate or severe courses of COVID-19 had significantly higher inflammatory markers (CRP, d-dimer, and fibrinogen), as well as lower levels of serum calcium, vitamin D, lymphocytes, and neutrophils than those with mild COVID-19 (p < 0.001). In the multivariate analysis, fibrinogen level on admission was detected as the independent predictor of severe COVD-19 (odds ratio = 1.06, 95% confidence interval: 1.03-1.09; p < 0.001). Conclusion: This study indicated associations between the severity of COVID-19, serum vitamin D concentrations, and some inflammatory markers in pediatric COVID-19 patients.

18.
European Journal of Molecular and Clinical Medicine ; 8(4):1948-1954, 2021.
Article in English | EMBASE | ID: covidwho-1856969

ABSTRACT

Background: Hearing difficulties in COVID may range from mild to severe and vary based on COVID-19 severity. They range from the self-manageable at home to the ones needing hospitalization. They include dizziness, vertigo, tinnitus, and/or hearing loss. Aims: To assess the long-term impact of COVID-19 on the existence of audiovestibular disorders in subjects hospitalized previously for COVID-19. Materials and Methods: 30 test and 30 control subjects hospitalized in the institution after COVID-19 were assessed for audiovestibular screening Tonal Audiometry was then done to measure bone and air conduction thresholds. Gain threshold was assessed for vestibular loss set at a value less than 0, 6 at 60ms, and vHIT was performed. The collected data were subjected to statistical evaluation and the results were formulated. Results:Dizziness was seen in 10% (n=3) subjects, tinnitus in 3.33% (n=1) subject, spinning vertigo in 3.33% (n=1) subject, Dynamic disequilibrium/ imbalance in 3.33% (n=1) subject, static disequilibrium/ imbalance in 6.66% (n=2) subjects, and hearing loss in 10% (n=3) subjects. PTA values were statistically non-significant at all frequencies except at 0.25, 0.5, 2, and 4 kHz with respective p-values of 0.003, 0.083, 0.04, and 0.03. In gain values only vHIT significant gain was seen in right anterior canal with values of 0.798±0.257 in cases and 0.949±0.121 in controls and the p-value of 0.004 Conclusion:Within its limitations, the present study concludes that audiovestibular symptoms and components are involved in subjects with COVID-19. No definitive conclusion can be drawn on auditory involvement in subjects with a history of COVID-19 with the previous hospitalization.

19.
Pakistan Journal of Medical and Health Sciences ; 16(4):102-104, 2022.
Article in English | EMBASE | ID: covidwho-1856784

ABSTRACT

Aim: To determine the long term impact of covid-19 infection on sleep and mental health. Study design: Cross-sectional study Place and duration of study: Department of Psychiatry, Ghulam Mohammad Mahar Medical College Sukkur from 1st April 2021 to 30th September 2021. Methodology: Fifty patients were enrolled after their positivity confirmation of coronavirus-19 through nasal swab test polymerase chain reaction. Categorization was done on the basis of disease severity. HRCT was performed for complete chest examination and grading of covid-19. Other laboratory tests were also done for day to day assessment of patient. Patients after their recovery were asked to follow up after six months of their disease. The demographic, gender, clinical history and clinical record were documented on a well-structured questionnaire. Co-morbidities associated were also recorded. Sleep and mental health were assessed by Pittsburgh sleep quality index. This assessment tool is used to identify sleep disturbances. The scoring techniques use seven sub scores ranging between 0-3. Results: The mean age was 49.56±12.2 years with almost equal males and females. In 66% of the participants of severe group and critical group were suffering from poor sleep quality followed by non severe group. Phobic anxieties were more common in non-severe and severe cases while paranoid ideation was normal in severe cases but at borderline in critical cases. Paranoid ideation was more common in married as well as single patients. Conclusion: Corona virus badly influences normal sleep cycle and also leads towards various mental and psychological disorders.

20.
Pakistan Journal of Medical and Health Sciences ; 16(4):12-14, 2022.
Article in English | EMBASE | ID: covidwho-1856768

ABSTRACT

Aim: To assess the respiratory outcomes twelve weeks after the management with non-invasive positive pressure ventilation (NIPPV) in patients recovered from severe corona virus disease 2019 (COVID-19). Methodology: The cross-sectional analytical study was conducted in the Department of Pulmonology, Sir Ganga Ram Hospital Lahore between October 2020 and March 2021. Total 124 patients visiting the hospital twelve weeks after recovery from COVID-19 were enrolled using convenience sampling. After excluding patients with a history of previous respiratory symptoms before the development of COVID-19, data from 87 patients who required oxygen >15 L/minute and NIPPV support were subjected to final analysis. Results: The proportion of middle-aged adults was 52.9%, males 64.4% and smokers 49.4%. Twelve weeks after treatment with NIPPV, O2 saturation <97.0% at rest was found in 97.7% patients, PR >100 at rest in 16.1% patients, severe dyspnea in 65.5% patients, O2 dependency >5 L/min in 2.3% patients, severe CXR abnormalities in 20.7% patients and lung fibrosis in 27.6% patients. The distribution of SpO2, PR, and dyspnea status twelve weeks after recovery from severe COVID-19 were not significantly different between NIPPV duration groups (p-value >0.05). However, the number of patients with O2 dependency, severe CXR abnormality, and lung fibrosis were significantly different between NIPPV duration groups (all p-values <0.05). Conclusion: Oxygen desaturation, severe dyspnea and severe CXR abnormalities twelve weeks after the treatment with NIPPV were common among patients recovered from COVID-19. Severe CXR abnormality, lung fibrosis, and O2 dependency were significantly associated with prolonged duration of NIPPV.

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