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1.
Journal of Retailing and Consumer Services ; 69:103100, 2022.
Article in English | ScienceDirect | ID: covidwho-1983547

ABSTRACT

The COVID-19 pandemic brought about an increase in online shopping because of government-imposed restrictions and consumer anxiety over the potential health risk associated with in-store shopping. By end of 2021, many health concerns had been alleviated through efforts such as vaccinations and reductions in hospitalizations in certain countries. Some governments started to relax their restrictions and consumers started to return to in-store shopping, creating the possibility that the volume of online shopping would decrease once stores reopened. However, consumers may continue to shop online more than they did prior to the pandemic because of their experience during the lockdown. This study seeks to understand the factors that explain the potential of online shopping continuance. A novel model is constructed by extending ES-QUAL, and adding hedonic motivation, social shopping and health susceptibility as mediators. Empirical data is collected from Canada, Germany and the US. We find that convenience and efficiency, as well as security for some females, are important factors contributing to online shopping's perceived usefulness and, ultimately, intentions to continue shopping online. In addition, creating an enjoyable online shopping experience adds to these continuance intentions.

2.
Táplálkozásmarketing ; 9(1):39-53, 2022.
Article in Hungarian | ProQuest Central | ID: covidwho-1964901

ABSTRACT

The COVID-19 pandemic has had a significant impact on the daily lives of the population, primarily due to the disease control measures. The focus has shifted to health protective factors, with a healthy diet playing a key role in increasing the human body's resistance to pathogens. In addition, being overweight has a negative impact on the course of the disease, making the virus an even greater threat to our society. Our aim was to examine how the pandemic has changed our daily diet, with a particular focus on fruit and vegetable consumption. Data collection included both secondary and primary research. With 242 responses, our primary analysis was conducted using an online questionnaire. The results showed, that half of the respondents had changed their eating habits and one third had gained extra weight during the pandemic. A higher percentage regard their fruit and vegetable consumption as sufficient enough, while only 29.6% think they are eating the daily recommended amount. The results showed that there is a lack of awareness among respondents of the recommended daily intake of fruit and vegetables, which is a fundamental problem in terms of dietary health. JEL Code: I12Alternate : A COVID-19 fertőzés jelentős mértékben hatott a lakosság mindennapi életvitelére, melynek oka elsődlegesen a járványellenes megszorító intézkedések voltak. Előtérbe kerültek az egészséget védő tényezők, melyek közül az egészséges táplálkozásnak kiemelt szerepe van az emberi szervezet kórokozókkal szembeni ellenállás fokozásában. Ezen kívül a túlsúly kedvezőtlenül befolyásolja a betegség lefolyását, így társadalmunkra még nagyobb veszélyt jelent a vírus. Célunk volt vizsgálni, hogy milyen változásokat hozott a pandémia a mindennapi étkezésünkben, kiemelten a zöldség és gyümölcs fogyasztást. Az adatgyűjtés során szekunder és primer kutatást is végeztünk. Primer vizsgálatunkat online kérdőív segítségével végeztük, melyre 242 válasz érkezett. Megállapítottuk, hogy a megkérdezettek felénél változtak a táplálkozási szokások és egy harmada plusz kilókkal küzd a pandémia alatt. Nagyobb százalékban gondolják azt, hogy elegendő zöldség/gyümölcs fogyasztásuk, míg a napi ajánlott mennyiség bevitele már csak 29,6%-ra jellemző. Az eredmények rámutatnak arra, hogy a napi ajánlott zöldség/gyümölcs mennyiségével nincsenek tisztába a megkérdezettek, amely az egészséges táplálkozás szempontjából is alapvető problémaként tekinthető. JEL kód: I12

3.
Journal of Environmental Chemical Engineering ; 10(4), 2022.
Article in English | Scopus | ID: covidwho-1945561

ABSTRACT

Advancements in polymer science and engineering have helped the scientific community to shift its attention towards the use of environmentally benign materials for reducing the environmental impact of conventional synthetic plastics. Biopolymers are environmentally benign, chemically versatile, sustainable, biocompatible, biodegradable, inherently functional, and ecofriendly materials that exhibit tremendous potential for a wide range of applications including food, electronics, agriculture, textile, biomedical, and cosmetics. This review also inspires the researchers toward more consumption of biopolymer-based composite materials as an alternative to synthetic composite materials. Herein, an overview of the latest knowledge of different natural- and synthetic-based biodegradable polymers and their fiber-reinforced composites is presented. The review discusses different degradation mechanisms of biopolymer-based composites as well as their sustainability aspects. This review also elucidates current challenges, future opportunities, and emerging applications of biopolymeric sustainable composites in numerous engineering fields. Finally, this review proposes biopolymeric sustainable materials as a propitious solution to the contemporary environmental crisis. © 2022 Elsevier Ltd.

4.
Orv Hetil ; 163(20): 774-787, 2022 May 15.
Article in English | MEDLINE | ID: covidwho-1896505

ABSTRACT

Coronavirus disease 2019 (COVID-19) displays tremendous inter-individual variability, ranging from asymptomatic infections to life-threatening illness. Although more studies are needed, a picture has begun to emerge that variability in the immune system components is a main contributor to the heterogeneous disease courses. Here, we provide a concept for the interaction of the innate and adaptive immune systems with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to link the observations that have been made during the first two years of the pandemic. Inborn errors of, and autoantibodies directed against, type I interferons, dysregulated myeloid response, hyperinflammation, lymphopenia, lymphocyte impairment, and heterogeneous adaptive immunity to SARS-CoV-2 are discussed, as well as their impact in the course of COVID-19. In addition, we will also review part of the key findings that have helped define and delineate some of the essential attributes of SARS-CoV-2-specific humoral and cell-mediated immune memory. Orv Hetil. 2022; 163(20): 774-787.


Subject(s)
COVID-19 , SARS-CoV-2 , Humans , Pandemics
5.
International Journal of Organizational Analysis ; 2022.
Article in English | Scopus | ID: covidwho-1891325

ABSTRACT

Purpose: This study aims to examine the impact of environmental scanning on organizational resilience through organizational learning based on organizational information processing theory (OIPT) in Egyptian small and medium-sized enterprises (SMEs) during the COVID-19 pandemic. Furthermore, this study aims to examine the moderating role of environmental uncertainty in this relationship. Design/methodology/approach: The data for the mediation analysis was obtained using a cross-sectional design. Using a self-administered questionnaire, the authors collected data from a sample of 249 Egyptian SMEs. The authors tested the hypotheses using the smart partial least square structural equation modeling approach. Findings: Organizational learning affects organizational resilience. Environmental scanning does not have a direct effect on organizational resilience. However, organizational learning fully mediates the relationship between environmental scanning and organizational resilience. Furthermore, environmental uncertainty does not moderate the indirect relationship between environmental scanning and resilience. Research limitations/implications: The sample included only Egyptian manufacturing SMEs. The results in the service sector and in other countries may differ. This study was cross-sectional, which was limited in its ability to trace the long-term effects of environmental scanning and organizational learning on organizational resilience. Practical implications: Egyptian SMEs’ managers should experience organizational learning as a pathway for environmental scanning to build organizational resilience. Originality/value: To the best of the authors’ knowledge, this study is the first to investigate the role of environmental scanning in building organizational resilience through organizational learning and the moderating role of environmental uncertainty in this relationship. © 2022, Emerald Publishing Limited.

6.
Pénzügyi Szemle ; 66(1):32-48, 2021.
Article in Hungarian | ProQuest Central | ID: covidwho-1879832

ABSTRACT

A vizsgált téma aktualitását indokolja, hogy az űripar ma az egyik leginnovatívabb, gyorsan fejlődő, válságokra kevésbé érzékeny, világméretekben rendkívül dinamikusan növekvő iparág. Rezilienciáját1 mutatja a 2020 tavaszától indult világméretű pandémiás járvány időszakában elért fejlődése. Világszerte munkahelyeket őrzött meg és újakat hozott létre, valamint technológiai-innovációs teljesítménye is töretlennek bizonyult. A cikk megalapozását szolgáló, módszerében felmérésekre, statisztikai és más adatbázisokra támaszkodó kutatás azt a célt szolgálta, hogy felvázolja a hazai űrszektor és űripar kontúrjait, és a magyarországi űrszektor számára fejlődési utat nyitó állami szerepvállalás lehetséges irányát, összetevőit. A tanulmány megállapította, hogy a magyar űripar - jóllehet, ma még szerény a hozzájárulása a társadalmi teljesítményhez - kis létszámú, de arányában máris jelentős, magasan képzett munkaerőt foglalkoztat, élenjáró technológiákat honosít meg. Magas innovációs teljesítményével, technikai-tudományos transzfereivel, jelenlegi kapacitásaival is hatással van a versenyképesség erősítésére. Megfelelő támogatással, átgondolt befektetésekkel az űripar hozzáadott értéke, növekedési és nemzetközi potenciálja, valamint a nemzetközi űripari értékláncokban való részvétele a jelenleginél jóval nagyobb arányban használható ki.Alternate :This study was motivated by the fact that space industry has become one of the most innovative, rapidly developing, least crisis-sensitive industries, which grows dynamically worldwide. Its resilience to shocks is quite apparent. Since the outbreak of the pandemic in spring 2020, the sector preserved many jobs and created new ones, while its innovative and technological advances remained uninterrupted. This study – based on surveys, statistical and other databases – aims to take stock of the current state of the Hungarian space sector and industry, and to set out possible directions for state involvement to enhance further progress. Our research confirmed that the Hungarian space industry, although its direct contribution to social performance is moderate today, employs a significant number of highly skilled workers and introduces cuttingedge technologies. Furthermore, through its innovations and technological and scientific transfers, its contribution to the competitiveness of the Hungarian economy is significant, even at the current level of its capacities. With adequate support and wise investments, the added value, the growth and international potential and the global space industry value chain involvement the space industry can be exploited to a much greater extent than at present.

7.
Belügyi Szemle ; 70(5):1039-1055, 2022.
Article in Hungarian | ProQuest Central | ID: covidwho-1871845

ABSTRACT

Cél: Jelen cikk célja, hogy bemutassa az Európai Unió humanitárius segítségnyújtási és polgári védelmi szakpolitikáját, megvizsgálja a COVID–19 helyzetet és értékelje a vírus által okozott világjárvánnyal kapcsolatos segítségnyújtási intézkedéseket, a hatékonyságot. Módszertan: Elemzi a jövőbeli fejlesztési igényeket és a lehetőségeket a megelőzés, felkészülés, reagálás vonatkozásában. Ennek érdekében az Európai Unió honlapján található infografikai ábrák és a feltüntetett adatok elemzése mellett, az Európai Polgári Védelem és Humanitárius Segítségnyújtási Műveletek Főigazgatóságának napi jelentéseit, az Európai Bizottság adatait vizsgálták meg a szerzők. Megállapítások: Az adatok alapján megállapítható, hogy az Európai Unió a polgári védelmi mechanizmusán keresztül globálisan nyújt segítséget, még a COVID–19 járványügyi helyzetben is, mikor a koronavírus mindegyik uniós tagállamot időben és térben egyszerre sújtotta. Érték: A kollektív együttműködés hiányosságai a válság első évében igazolták azt, hogy a fenyegetések kezelésére irányuló erőfeszítések hatékonyságát növelni kell, a tagállamok közötti segítségnyújtási hajlandóságot, képességeket, kapacitásokat erősíteni, fejleszteni szükséges.Alternate : Aim: The article aims to present the humanitarian aid and civil protection policy of the European Union;examines the COVID–19 situation and evaluates the effectiveness of the measures taken in response to the pandemic caused by the virus. Methodology: It analyses future development needs and opportunities in terms of prevention, preparedness and response. In order to accomplish this, in addition to analysing the infographic figures and data on the original website of the European Union, the authors studied the daily reports of the European Directorate-General for Civil Protection and Humanitarian Aid, as well as reports of the European Commission. Findings: The data show that the European Union is providing global assistance through its civil protection mechanism, even in the epidemiological situation of COVID–19 – all during a time when the coronavirus has affected all EU Member States simultaneously, regardless of time and place. Value: The shortcomings of its collective co-operation in the first year of the crisis confirmed the need to increase the effectiveness of efforts to address the threats, to strengthen and develop the willingness, capabilities and capacities of the Member States to provide assistance.

8.
International Journal of Emerging Technologies in Learning (Online) ; 16(8):47-60, 2021.
Article in English | ProQuest Central | ID: covidwho-1871096

ABSTRACT

Examination malpractice is a deliberate wrong doing contrary to official examina-tion rules designed to place a candidate at unfair advantage or disadvantage. The proposed system depicts a new use of technology to identify malpractice in E-Exams which is essential due to growth of online education. The current solu-tions for such a problem either require complete manual labor or have various vulnerabilities that can be exploited by an examinee. The proposed application en-compasses an end-to-end system that assists an examiner/evaluator in deciding whether a student passes an online exam without any probable attempts of mal-practice or cheating in e-exams with the help of visual aids. The system works by categorizing the student's VFOA (visual focus of attention) data by capturing the head pose estimates and eye gaze estimates using state-of-the-art machine learn-ing techniques. The system only requires the student (test-taker) to have a func-tioning internet connection along with a webcam to transmit the feed. The exam-iner is alerted when the student wavers in his VFOA, from the screen greater than X, a predefined threshold of times. If this threshold X is crossed, the appli-cation will save the data of the person when his VFOA is off the screen and send it to the examiner to be manually checked and marked whether the action per-formed by the student was an attempt at malpractice or just momentary lapse in concentration. The system use a hybrid classifier approach where two different classifiers are used, one when gaze values are being read successfully (which may fail due to various reasons like transmission quality or glare from his specta-cles), the model falls back to the default classifier which only reads the head pose values to classify the attention metric, which is used to map the student's VFOA to check the likelihood of malpractice. The model has achieved an accuracy of 96.04 percent in classifying the attention metric.

9.
Pan Afr Med J ; 41: 174, 2022.
Article in English | MEDLINE | ID: covidwho-1847712

ABSTRACT

Introduction: on 16th March 2020, Tanzania announced its first COVID-19 case. The country had already developed a 72-hour response plan and had enacted three compulsory infection prevention and control interventions. Here, we describe public compliance to Infection Prevention and Control (IPC) public health measures in Dar es Salaam during the early COVID-19 response and testing of the feasibility of an observational method. Methods: a cross sectional study was conducted between April and May 2020 in Dar es Salaam City. At that time, Dar es Salaam was the epi centre of the epidemic. Respondents were randomly selected from defined population strata (high, medium and low). Data were collected using a structured questionnaire and through observations. Results: a total of 390 subjects were interviewed, response rate was 388 (99.5%). Mean age of the respondents was 34.8 years and 168 (43.1%) had primary level education. Out of the 388 respondents, 384 (98.9%) reported to have heard about COVID-19 public health and social measures, 90.0% had heard from the television and 84.6% from the radio. Covering coughs and sneezes using a handkerchief was the most common behaviour observed among 320 (82.5%) respondents; followed by hand washing hygiene practice, 312 (80.4%) and wearing face masks, 240 (61.9%). Approximately 215 (55.4%) adhered to physical distancing guidance. Age and gender were associated with compliance to IPC measures (both, p<0.05). Conclusion: compliance to public health measures during the early phase of COVID-19 pandemic in this urban setting was encouraging. As the pandemic continues, it is critical to ensure compliance is sustained and capitalize on risk communication via television and radio.


Subject(s)
COVID-19 , Adult , COVID-19/prevention & control , Cross-Sectional Studies , Humans , Masks , Pandemics , Tanzania/epidemiology
10.
Genet Med ; 24(8): 1653-1663, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1819495

ABSTRACT

PURPOSE: Emerging evidence suggest that infection-dependent hyperactivation of complement system (CS) may worsen COVID-19 outcome. We investigated the role of predicted high impact rare variants - referred as qualifying variants (QVs) - of CS genes in predisposing asymptomatic COVID-19 in elderly individuals, known to be more susceptible to severe disease. METHODS: Exploiting exome sequencing data and 56 CS genes, we performed a gene-based collapsing test between 164 asymptomatic subjects (aged ≥60 years) and 56,885 European individuals from the Genome Aggregation Database. We replicated this test comparing the same asymptomatic individuals with 147 hospitalized patients with COVID-19. RESULTS: We found an enrichment of QVs in 3 genes (MASP1, COLEC11, and COLEC10), which belong to the lectin pathway, in the asymptomatic cohort. Analyses of complement activity in serum showed decreased activity of lectin pathway in asymptomatic individuals with QVs. Finally, we found allelic variants associated with asymptomatic COVID-19 phenotype and with a decreased expression of MASP1, COLEC11, and COLEC10 in lung tissue. CONCLUSION: This study suggests that genetic rare variants can protect from severe COVID-19 by mitigating the activity of lectin pathway and prothrombin. The genetic data obtained through ES of 786 asymptomatic and 147 hospitalized individuals are publicly available at http://espocovid.ceinge.unina.it/.


Subject(s)
COVID-19 , Aged , COVID-19/genetics , Collectins/genetics , Collectins/metabolism , Germ Cells , Humans , Lectins/genetics , SARS-CoV-2 , Whole Exome Sequencing
11.
24th RoboCup International Symposium, RoboCup 2021 ; 13132 LNAI:352-359, 2022.
Article in English | Scopus | ID: covidwho-1797709

ABSTRACT

Due to the Covid-19 pandemic, the RoboCup WorldCup 2021 was held completely remotely. For this competition the Webots simulator (https://cyberbotics.com/ ) was used, so all teams needed to transfer their robot to the simulation. This paper describes our experiences during this process as well as a genetic learning approach to improve our walk engine to allow a more stable and faster movement in the simulation. Therefore we used a docker setup to scale easily. The resulting movement was one of the outstanding features that finally led to the championship title. © 2022, Springer Nature Switzerland AG.

12.
J Int Assoc Provid AIDS Care ; 21: 23259582221084543, 2022.
Article in English | MEDLINE | ID: covidwho-1794048

ABSTRACT

Background: Adherence to antiretroviral therapy (ART) is the key determinant of virological suppression in people living with HIV (PLHIV). This study reports factors associated with non-adherence among PLHIV one year after introducing dolutegravir (DTG) based regimens in Tanzania. Methods: A hospital-based cross-sectional study was conducted in two health facilities in Dar es Salaam, Tanzania, in 2020. Results: A total of 406 PLHIV were recruited, where the majority (73.4%) were females, with 94.6% of patients being on DTG based regimens. Factors such as refill interval and sharing of antiretrovirals had significant effects on adherence. Multivariate analysis found that patients attending care and treatment center (CTC) at Temeke Regional Referral Hospital (RRH) were 4.3 times more likely to have non-adherence compared to those attending Amana RRH (aOR [adjusted odds ratio] 4.3, 95% CI [confidence interval]: 2.38 - 7.91, p-value < 0.0001). Conclusions: Sustainable adherence counseling is warranted to overcome non-adherence to ART.


Subject(s)
HIV Infections , Anti-Retroviral Agents/therapeutic use , Cross-Sectional Studies , Female , HIV Infections/psychology , Heterocyclic Compounds, 3-Ring , Humans , Male , Oxazines , Piperazines , Pyridones , Tanzania/epidemiology
13.
Párbeszéd ; 8(2), 2021.
Article in Hungarian | ProQuest Central | ID: covidwho-1599865

ABSTRACT

A Covid-19 világjárvány miatt kialakult egészségügyi válság új, váratlan helyzetbe hozta a szociális munkásokat képző egyetemeket is. A pandémia időszaka alatt szervezett „on-line” szemeszterek során egyre többször hangzott el a kérdés: hogyan lehet a szociális munkások számára gyakorlatalapú képzési programot szervezni „karanténban”? Hogyan fejleszthetők a szakmához elengedhetetlenül szükséges gyakorlati készségek, ha a tereptanárokkal, a szociális szolgáltatókkal és a célcsoporttal korlátozott a kapcsolattartás? A megváltozott körülményeket figyelembe véve és azt feltételezve, hogy a világ nem lesz ugyanaz a világjárvány után, mint annak előtte, úgy véltük, itt az ideje a szociális munkások gyakorlati képzésének és munkaformáinak újra gondolására és olyan technikák, gyakorlati képzési módszerek megismerésére, amelyek jobban megfelelnek egyfelől a környezeti kihívásoknak, másfelől az egyetemekre belépő, 21. századi digitális generációhoz tartozó hallgatók kompetenciáinak, tanulási formáinak. Az „on-line szemeszterek” időszakában kialakult képzési innovációk és a gyakorlati képzés során is hatékonyan alkalmazható jó gyakorlatok megismerése érdekében a Debreceni Egyetem Bölcsészettudományi Karának szociális munkás képzésében résztvevő tereptanárok és hallgatók körében fókuszcsoportos interjúkat szerveztünk, hogy a következő kérdésekre választ kapjunk: Milyen új gyakorlati képzési formák alakultak ki a „karantén” időszakban? Milyen előnyei vannak az online oktatásnak? Mit tartanának meg a tereptanárok a jelenleg kikísérletezett munkaformákból a válság utáni időszakban? Kutatásunk első eredményei azt bizonyítják, hogy a szociális munkás képzést is erősen érintő korlátozások a várakozásokkal ellentétben nem szükségszerűen jártak kizárólag veszteségekkel az oktatási formákat illetően. Sok vonatkozásban a képzési lehetőségek a személyes találkozások korlátozásának idején még bővültek is. A digitális eszközök és munkaformák intenzív használatával ugyanis elérhetővé váltak pl. távoli helyszínek, célcsoportok, speciális tudáselemek kerültek be a képzésbe, új lehetőségek nyíltak a személyes készségek fejlesztésére és a digitális szociális munka jelenleginél jóval szélesebb körű alkalmazására. Kutatásunk eredményeit összefoglaló tanulmányunkban a szociális munkás hallgatók gyakorlati képzését érintő, a pandémia okozta válsághelyzettel kapcsolatban megjelenő kételyeket, a kihívásokra adott válaszokat és képzési innovációkat mutatjuk be.

14.
TQM Journal ; 2021.
Article in English | Scopus | ID: covidwho-1595814

ABSTRACT

Purpose: This paper aims to find out if it is possible to consider live virtual tours, in the connotation assumed during the COVID-19 outbreak, as experiential tourism products. The paper focuses on Holbrook's “four Es” (“experience”, “entertainment”, “exhibitionism” and “evangelising”) to study the experience of live virtual tours. Design/methodology/approach: This article develops an exploratory analysis and presents a content analysis of 1052 reviews of 108 live virtual tours posted on TripAdvisor and Viator. Findings: The findings show that live virtual tours are perceived as experiences, all “four Es” are covered and two more sub-categories emerge. Research limitations/implications: The analysis is limited to the perception of tourists that are confident with the technology, to a small sample and a period of travel restrictions due to the COVID-19 outbreak. Practical implications: Live virtual tours create a new segment, which “travels from home”. This does not preclude tourists from deciding to physically visit the places seen virtually. Originality/value: Research on the analysis of the reviews of live virtual tours has not yet been carried out. © 2021, Emerald Publishing Limited.

15.
Latin American Economic Review ; 30(1):1-27, 2021.
Article in English | Web of Science | ID: covidwho-1576691

ABSTRACT

The COVID-19 pandemic not only generated real shocks affect- ing economic activity severely, but also a broad uncertainty that un-leashed an extreme shock to financial markets. In this paper, we focus on the financial dimension of the pandemic from the view- point of an emerging market economy. Accordingly, we estimate a financial conditions index for Mexico since 1993 and find that the acute turmoil generated by the pandemic stands among the four largest episodes of financial distress experienced by the country. In addition, we find evidence suggesting that real variables have re- sponded differently to shocks that worsen financial conditions than to shocks that improve them.

16.
Results Phys ; 27: 104495, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1525938

ABSTRACT

The first known case of Coronavirus disease 2019 (COVID-19) was identified in December 2019. It has spread worldwide, leading to an ongoing pandemic, imposed restrictions and costs to many countries. Predicting the number of new cases and deaths during this period can be a useful step in predicting the costs and facilities required in the future. The purpose of this study is to predict new cases and deaths rate one, three and seven-day ahead during the next 100 days. The motivation for predicting every n days (instead of just every day) is the investigation of the possibility of computational cost reduction and still achieving reasonable performance. Such a scenario may be encountered in real-time forecasting of time series. Six different deep learning methods are examined on the data adopted from the WHO website. Three methods are LSTM, Convolutional LSTM, and GRU. The bidirectional extension is then considered for each method to forecast the rate of new cases and new deaths in Australia and Iran countries. This study is novel as it carries out a comprehensive evaluation of the aforementioned three deep learning methods and their bidirectional extensions to perform prediction on COVID-19 new cases and new death rate time series. To the best of our knowledge, this is the first time that Bi-GRU and Bi-Conv-LSTM models are used for prediction on COVID-19 new cases and new deaths time series. The evaluation of the methods is presented in the form of graphs and Friedman statistical test. The results show that the bidirectional models have lower errors than other models. A several error evaluation metrics are presented to compare all models, and finally, the superiority of bidirectional methods is determined. This research could be useful for organisations working against COVID-19 and determining their long-term plans.

17.
Orv Hetil ; 162(44): 1761-1768, 2021 10 31.
Article in Hungarian | MEDLINE | ID: covidwho-1496600

ABSTRACT

Összefoglaló. Bevezetés: 2020 elso negyedévében a koronavírus gyors terjedése, az általa okozott betegségek súlyos következményei miatt világszerte, így hazánkban is megváltozott az egészségügyi ellátás. Közleményünkben bemutatjuk, hogyan befolyásolták egy fovárosi kórház hasi sebészeti osztályának betegellátását, az ellátott esetek számát és összetételét a járvány elso, 2020-as tavaszi hulláma idején bevezetett járványügyi korlátozó intézkedések. Célkituzés: Célunk az volt, hogy adatokkal összehasonlítsuk 2021., 2020. és 2019. április sebészeti fekvobeteg-ellátásának jellemzoit osztályunkon. Módszer: A 2019. április 1. és 30., 2020. április 1. és 30. és 2021. április 1. és 30. közötti idoszakokban a fovárosi Bajcsy-Zsilinszky Kórház Sebészeti, Érsebészeti és Mellkassebészeti Osztályán az általános sebészeti fekvobeteg-ellátás keretében végzett hasi sebészeti mutéti beavatkozások adatait hasonlítottuk össze. Az adatokat MS Excel és SPSS (25. verzió) programokkal vizsgáltuk, és statisztikai elemzéseket végeztünk. Eredmények: A bevonási kritériumoknak 197 eset felelt meg 2019 áprilisában, 77 eset 2020 áprilisában és 95 eset 2021 áprilisában. Az osztályos ápolási ido 2019-ben átlagosan 4,51 nap, míg 2020-ban 6,31 nap és 2021-ben 6,29 nap volt. 2019-ben napi átlagban 2,54 akut és 6,2 tervezett mutét, 2020-ban napi 2 akut és 1 tervezett mutét, míg 2021-ben napi 2,8 akut és 0,9 tervezett mutét történt. Az 1 fore jutó kíséro betegségek száma a tervezett mutétek esetében 2019-ben 1,69 volt, míg 2020-ban 2,97, 2021-ben pedig 2,74. Az akut mutétre került betegek kíséro betegségeinek eloszlása szignifikánsan eltért, 1 betegre 2019-ben átlagosan 2,5, 2020-ban 3,75, míg 2021-ben 3,25 kíséro betegség jutott. Az akut sebészeti ellátáson átesett betegek halálozása 2019-ben 11,8%, 2020-ban 13,33%, 2021-ben 15,66% volt. Következtetés: A COVID-19-járvány miatt bevezetett járványügyi intézkedések velejárója volt, hogy hasi sebészeti osztályunkon lényegesen kevesebb elektív mutétet végeztünk. A sürgosséggel ellátott páciensek kíséro betegségeinek száma szignifikánsan emelkedett, valószínuleg ezzel magyarázható a halálesetek számának párhuzamos emelkedése. Orv Hetil. 2021; 162(44): 1761-1768. INTRODUCTION: Due to the rapid spread of the coronavirus and the serious consequences of the diseases, the organization of healthcare worldwide changed in the first quarter of 2020. We show effects of restriction due to protection against the first (April 2020) wave of coronavirus in our surgery care. OBJECTIVE: The aim of this study was to compare characteristics of general surgical inpatient care in April 2020 and April 2021 with April 2019 by the hospital database. METHOD: We compared general surgical data of April 2021, 2020, and 2019 from the medical informatic system at the General, Vascular and Thoracal Surgery Department of the Bajcsy-Zsilinszky Hospital in Budapest. The data were analyzed with MS Excel and SPSS (version 25) programs. RESULTS: Study inclusion criteria met with 197 cases from April 2019, 77 cases from April 2020, and 95 cases from April 2021. Length of stay at surgical department was average 4.51 days in 2019, 6.31 days in 2020, and 6.29 days in 2021. In 2019, average 2.54 urgent and 6.2 planned operations were done, in 2020 these numbers were average 2 and 1 per day and in 2021, 2.8 urgent and 0.9 planned surgical procedures were performed. The number of co-morbidities per capita in elective cases was 1.69 in 2019, 2.97 in 2020, and 2.74 in 2021. Distribution of coded co-morbidities in the case of patients with urgent surgery was significantly different between the groups, in 2019 it was 2.5, in 2020 3.75, and in 2021 3.25 per capita. Postoperative mortality at the same care of patients after urgent surgery was 11.8% in 2019, 13.33% in 2020, and 15.66% in 2021. CONCLUSION: Due to the government instructions because of COVID-19 pandemic, less elective general surgery procedures were performed in our department. Co-morbidities of patients with urgent surgery significantly increased, probably this is responsible for the increase of postoperative mortality. Orv Hetil. 2021; 162(44): 1761-1768.


Subject(s)
COVID-19 , Pandemics , Elective Surgical Procedures , Hospitals , Humans , Hungary , SARS-CoV-2
18.
Orv Hetil ; 162(43): 1710-1716, 2021 10 24.
Article in Hungarian | MEDLINE | ID: covidwho-1484906

ABSTRACT

Összefoglaló. Bevezetés: A koronavírus-2 által okozott fertozések igen gyakran súlyos, akut légzoszervi károsodás kialakulásához vezetnek, melynek következtében légzési elégtelenség manifesztálódik. A pneumoniák kialakulásának kezdete (2019. december) óta igen sok beteg szorult kórházi kezelésre. A súlyos tüdogyulladások ellátása során igazolódott, hogy a légzoszervi gyulladásos folyamatok során a betegek jelentos részében vénás, ritkábban artériás thrombosisok alakulnak ki, tovább súlyosbítva a klinikai állapotot. Célkituzés: A 2020. szeptember és 2021. március közötti idoszakban 1590, koronavírus-2 által megfertozött, tüdogyulladással szövodött beteget láttunk el osztályunkon. Betegeinkben azt vizsgáltuk, hogy milyen jellegu és arányú a thromboemboliás szövodmények elofordulása. Módszer: Az 1590, koronavírus-2 által fertozött beteg mindegyikében meghatároztuk a pneumonia súlyosságát; klinikai gyanú eseteiben alsó végtagi Doppler-ultrahangvizsgálatot, valamint komputertomográfiával végzett tüdoangiográfiát végeztünk. Eredmények: A képalkotó vizsgálatok eredményei azt igazolták, hogy a koronavírus-2 által okozott tüdogyulladással kezeltekben 13%-os gyakorisággal fordult elo mélyvénás thrombosis; akut tüdoemboliát a betegek 17%-ában kórisméztünk. Következtetés: A koronavírus-2 által okozott fertozésekben elsosorban a tüdoben, de egyéb szervekben is (szív, vese, máj) súlyos gyulladással járó kórfolyamatok alakulhatnak ki, amelyek hatására fokozott thrombosiskészség jelentkezik a gyulladásos és koagulációs rendszer interakciója következtében. A fokozott thrombosishajlam végeredményeként vénás és ritkábban artériás thrombosisok kialakulása súlyosbítja a betegek klinikai állapotát, s kedvezotlen hatást gyakorol az életkilátásra. Orv Hetil. 2021; 162(43): 1710-1716. INTRODUCTION: The infections caused by coronavirus-2 very often lead to severe, acute respiratory damages, because of which respiratory insufficiency is manifested. As a result, since the development of pneumonias (December, 2019), many patients have required hospitalization. When treating the severe pneumonia cases, it was proved that in a significant number of patients with respiratory inflammatory processes, venous, less often arterial thrombosis occured, making the clinical state even more severe. OBJECTIVE: We treated 1590 coronavirus-2 infected, pneumonia-connected patients between September, 2020 and March, 2021 at our department. We examined the nature and the proportion of the thromboembolic complications. METHOD: We determined the severity of pneumonia in the 1950 coronavirus-2 infected patients; when clinically suspected, they had lower limb Doppler ultrasound examination and angiography carried out with computer tomograph. RESULTS: The result of imaging examinations proved that in 13% of cases deep vein thrombosis occured; in 17% of cases acute pulmonary embolia occured with pneumonia caused by coronavirus-2. CONCLUSION: In coronavirus-2 infected cases, mainly in the lung, but also in other organs (heart, kidney, liver), severe inflammatory disease-processes may occur, as a result of which increased thrombosis tendency shows because of the ineraction of the inflammatory and coagulatory system. As a result of the increased thrombosis tendency, venous and less often arterial thrombosis worsen the clinical state of patients, and have unfavourable effect on life expectancy. Orv Hetil. 2021; 162(43): 1710-1716.


Subject(s)
COVID-19 , Acute Disease , Humans , SARS-CoV-2
19.
Mayo Clin Proc Innov Qual Outcomes ; 5(5): 820-826, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1364353

ABSTRACT

Limited access to mental health and behavioral interventions is a public health issue that predated and is further worsened by coronavirus disease 2019 (COVID-19) social distancing restrictions. The Healthy Action to Benefit Independence and Thinking (HABIT) program is a cognitive rehabilitation and wellness program for patients with a diagnosis of mild cognitive impairment and their partners that involves groups of up to 32 people (16 dyads) at a time. Thus, the public health recommendation to avoid groups at the start of the COVID-19 pandemic immediately impacted our ability to offer this treatment protocol. This brief report provides patient and partner satisfaction data as well as clinical outcomes with a virtual adaptation of the HABIT program developed because of the COVID-19 pandemic. At the time of their participation, patients who attended in-person sessions had an average age of 74.4 years and those who attended virtual sessions had an average age of 75.4 years (P=.60). Both groups had an average of 16.3 years of education (P=.95). Approximately half of the patients in both groups were male (30 of 57 [53%]), most were White (54 of 57 [95%]) and were accompanied to the program by a spouse (50 of 57 [88%]). Overall, patient and partner satisfaction with the HABIT program remained high, ranging from a mean score of 5.8 to 6.6 on a rating scale of 1 to 7 for patients and partners, and clinical outcomes remained consistent with our face-to-face formatting when compared with pre-COVID pandemic sessions. The most notable changes across both formats were improvements in patient anxiety (Cohen's d=0.25 face-to-face; d=0.39 virtual), partner anxiety (d=0.37 face-to-face; d=0.34 virtual), and partner depression (d=0.37 face-to-face; d=0.35 virtual). This preliminary program evaluation suggests that transitioning the HABIT program to virtual formatting provides high-quality care similar to our in-person care models. Ongoing program evaluation is planned as we continue using virtual treatment for safety. Even after COVID-19 pandemic public health restrictions are lifted, these findings will have continued relevance to ongoing demand for telehealth.

20.
Stem Cells Transl Med ; 10(11): 1491-1499, 2021 11.
Article in English | MEDLINE | ID: covidwho-1321718

ABSTRACT

Experimental cell models are indispensable for clarifying the pathophysiology of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and for developing therapeutic agents. To recapitulate the symptoms and drug response of COVID-19 patients in vitro, SARS-CoV-2 studies using physiologically relevant human embryonic stem (ES)/induced pluripotent stem (iPS) cell-derived somatic cells and organoids are ongoing. These cells and organoids have been used to show that SARS-CoV-2 can infect and damage various organs including the lung, heart, brain, intestinal tract, kidney, and pancreas. They are also being used to develop COVID-19 therapeutic agents, including evaluation of their antiviral efficacy and safety. The relationship between COVID-19 aggravation and human genetic backgrounds has been investigated using genetically modified ES/iPS cells and patient-derived iPS cells. This review summarizes the latest results and issues of SARS-CoV-2 research using human ES/iPS cell-derived somatic cells and organoids.


Subject(s)
COVID-19 , Human Embryonic Stem Cells/physiology , Organoids/physiology , SARS-CoV-2/physiology , Biomedical Research/methods , Biomedical Research/trends , COVID-19/etiology , COVID-19/pathology , COVID-19/therapy , Genetic Therapy/methods , Genetic Therapy/trends , Human Embryonic Stem Cells/transplantation , Humans , Induced Pluripotent Stem Cells/physiology , Induced Pluripotent Stem Cells/transplantation , Organoids/cytology , Organoids/transplantation
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