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1.
Heart ; 108(Suppl 1):A85, 2022.
Article in English | ProQuest Central | ID: covidwho-1888411

ABSTRACT

114 Figure 1Flow diagram of patient recruitment to HFVW[Figure omitted. See PDF]ConclusionHFVW provides and exciting opportunity to monitor and optimise heart failure patients in the community with specialist support using digital technology. The patients recruited were predominantly patients with reduced ejection fraction and are highly co-morbid. There remain significant challenges to tackle digital exclusion to increase the proportion of heart failure patients recruited as currently only 1 in 6 patients are successfully recruited.Conflict of InterestNone

2.
Asian American Policy Review ; 31:76-79,93, 2021.
Article in English | ProQuest Central | ID: covidwho-1887845

ABSTRACT

Higuchi asserts that Iyekichi Higuchi prepared to leave the Heart Mountain camp for Japanese Americans in May 1945 to return to San Jose, California, look for a home for his wife and two at-home children, and to find a job. He had been forced to sell his 14.25-acre home in San Jose three years earlier when the federal government had forced 120,000 Japanese Americans from the West Coast because of hysteria about the alleged security threat they posed in the days following the 7 December 1941, Japanese attack on the naval base at Pearl Harbor, Hawaii. What faced those returning Japanese Americans mirrors the hate crimes now facing Americans of Asian descent who are blamed for spreading the COVID-19 virus that originally started in China to the United States. Since the pandemic took over in March, thousands of Asian Americans have been accosted in public spaces, spit on or assaulted and told to go back where they came from, even if that was not Asia at all.

3.
American Family Physician ; 105(6):678-679, 2022.
Article in English | ProQuest Central | ID: covidwho-1887752

ABSTRACT

Fidaxomicin is expensive, with a cost of about $4,300 for a 10-day course compared with $75 for a 10-day course of vancomycin. Because fidaxomicin has not been studied in fulminant infections, vancomycin with intravenous metronidazole (Flagyl) continues to be recommended in the rare cases of fulminant CDI. Bezlotoxumab Reduces Further Recurrence Bezlotoxumab (Zinplava) is a monoclonal antibody against C. difficile toxin B approved by the U.S. Food and Drug Administration (FDA) for prevention of recurrent CDI in high-risk adults. Recommended Treatment Options for CDI Presentation Treatment options Additional information Initial case Preferred:  Fidaxomicin (Dificid), 200 mg twice daily for 10 days Alternative:  Vancomycin, 125 mg four times daily for 10 days Alternative for nonsevere CDI if above agents not available:  Metronidazole (Flagyl), 500 mg three times daily for 10 to 14 days Fidaxomicin: Caution for use in patients with congestive heart failure Diagnosis of nonsevere cases supported by:  White blood cell count < 15,000 cells per μL (15 × 109 per L)  Serum creatinine < 1.5 mg per dL (132.6 μmol per L) First recurrence Preferred:  Fidaxomicin, 200 mg twice daily for 10 days or twice daily for five days followed by once every other day for 20 days Alternatives:  Vancomycin in a tapered and pulsed regimen  Vancomycin, 125 mg four times daily for 10 days Adjunct:  Bezlotoxumab (Zinplava), 10 mg per kg given intravenously once Tapered and pulsed vancomycin regimen example:  125 mg four times daily for 10 to 14 days, two times daily for seven days, once daily for seven days, and then every two to three days for two to eight weeks Subsequent recurrences Preferred:  Fidaxomicin, 200 mg twice daily for 10 days or twice daily for five days followed by once every other day for 20 days Alternatives:  Vancomycin in a tapered and pulsed regimen  Vancomycin, 125 mg four times daily for 10 days, followed by rifaximin (Xifaxan), 400 mg three times daily for 20 days  Fecal microbiota transplantation Adjunct:  Bezlotoxumab, 10 mg per kg given intravenously once Infectious Diseases Society of America guideline panel recommends appropriate antibiotic treatments should be tried for at least two recurrences (i.e., three CDI episodes) before offering fecal microbiota transplantation Fulminant CDI Vancomycin, 500 mg four times daily;if ileus is present, consider adding rectal dosing of vancomycin Metronidazole, 500 mg intravenously every eight hours, administered with oral or rectal vancomycin, particularly if ileus is present Definition of fulminant CDI is supported by:  Hypotension or shock, ileus, megacolon CDI = Clostridioides difficile infection.

4.
Curr Heart Fail Rep ; 19(3): 75-108, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1889027

ABSTRACT

PURPOSE OF REVIEW: In this article, we review a range of digital technologies for possible application in heart failure patients, with a focus on lessons learned. We also discuss a future model of heart failure management, as digital technologies continue to become part of standard care. RECENT FINDINGS: Digital technologies are increasingly used by healthcare professionals and those living with heart failure to support more personalised and timely shared decision-making, earlier identification of problems, and an improved experience of care. The COVID-19 pandemic has accelerated the acceptability and implementation of a range of digital technologies, including remote monitoring and health tracking, mobile health (wearable technology and smartphone-based applications), and the use of machine learning to augment data interpretation and decision-making. Much has been learned over recent decades on the challenges and opportunities of technology development, including how best to evaluate the impact of digital health interventions on health and healthcare, the human factors involved in implementation and how best to integrate dataflows into the clinical pathway. Supporting patients with heart failure as well as healthcare professionals (both with a broad range of health and digital literacy skills) is crucial to success. Access to digital technologies and the internet remains a challenge for some patients. The aim should be to identify the right technology for the right patient at the right time, in a process of co-design and co-implementation with patients.


Subject(s)
COVID-19 , Heart Failure , Telemedicine , COVID-19/epidemiology , Digital Technology , Heart Failure/therapy , Humans , Pandemics
5.
Cardiol Young ; 32(3): 465-471, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1886195

ABSTRACT

BACKGROUND: Caring for infants after the first-stage palliative surgery for single-ventricle heart disease bring challenges beyond the usual parenting responsibilities. Current studies fail to capture the nuances of caregivers' experiences during the most critical "interstage" period between the first and second surgery. OBJECTIVES: To explore the perceptions of caregivers about their experiences while transitioning to caregiver roles, including the successes and challenges associated with caregiving during the interstage period. METHODS: Constructivist Grounded Theory methodology guided the collection and analysis of data from in person or telephonic interviews with caregivers after their infants underwent the first-stage palliative surgery for single-ventricle heart disease, and were sent to home for 2-4 months before returning for their second surgery. Symbolic interactionism informed data analyses and interpretation. RESULTS: Our sample included 14 parents, who were interviewed 1-2 times between November, 2019 and July, 2020. Most patients were mothers (71%), Latinx (64%), with household incomes <$30K (42%). Data analysis led to the development of a Grounded Theory called Developing a Sense of Self-Reliance with three categories: (1) Owning caregiving responsibilities despite grave fears, (2) Figuring out how "to make it work" in the interstage period, and (3) Gaining a sense of self-reliance. CONCLUSIONS: Parents transitioned to caregiver roles by developing a sense of self-reliance and, in the process, gained self-confidence and decision-making skills. Our study responded to the key research priority from the AHA Scientific Statement to address the knowledge gap in home monitoring for interstage infants through qualitative research design.


Subject(s)
Heart Defects, Congenital , Hypoplastic Left Heart Syndrome , Univentricular Heart , Caregivers , Female , Heart Defects, Congenital/surgery , Humans , Infant , Palliative Care , Parents
6.
Intervencni a Akutni Kardiologie ; 21(2):108-111, 2022.
Article in Slovak | EMBASE | ID: covidwho-1887458

ABSTRACT

At the time of the ongoing coronavirus pandemic, we are encountering patients who are Covid-19 positive and have severe coronary artery disease. Patients requiring cardiac surgery are particularly challenging. A multidisciplinary discussion aimed at assessing surgery tolerability and considering the most appropriate approach is important given the higher risk of surgical mortality. We report a case of a high-risk Covid-19 positive symptomatic female patient with an acute coronary syndrome and a critical calcified stenosis of the main stem of the left coronary artery. This patient was not suitable for cardiac surgery and she underwent a percutaneous coronary intervention using a left ventricular mechanical support system and intravascular lithotripsy.

7.
Journal of Cardiovascular Disease Research ; 13(1):884-893, 2022.
Article in English | EMBASE | ID: covidwho-1887445

ABSTRACT

The prevalence of Pheochromocytoma in pat ient with hypertension is 0.1 -0.6%. These types of tumours are known for unpredictable perioperative course and hemodynamic instability. Various different drugs and anaesthesia techniques can be used to tackle these situations. Dexmedetomidine is emerged as newer agent with better hemodynamic stability, reducing requirement of other anaesthesia drugs, blunting of sympathoadrenal response in resection of Pheochromocytoma. We report four cases operated between January 2021 to June 2021.Preoperative preparation was done with α and β blockade. Dexmedetomidine was used during induction as 1 mcg/kg over 10 mins followed by 0.7mcg/kg/hr intraoperatively. Combination of Dexmedetomidine, Fentanyl, NTG, Isoflurane and Epidural analgesia was used. IF needed boluses of Esmolol and Labetalol were used during tumor manipulation. All the patients had an uneventful perioperative course. Dexmedetomidine with pre-operative α and β blockade reduce the need of other drugs intraoperatively and can be used as anaesthetic adjunct to maintain steady hemodynamic.

8.
Revue Medicale de Bruxelles ; 43(2):110-116, 2022.
Article in French | EMBASE | ID: covidwho-1887427

ABSTRACT

Introduction : The pandemic caused by the SARS-CoV-2 virus has affected nearly 240 million people around the world. This pandemic has had a great impact on individual and collective clinical practice. Objective : Impact of SARS-CoV-2 on out-of-hospital cardiac arrest (OCAH), through gender, context, initial rhythm, survival and neurological recovery. Design, settings, and participants : A retrospective analysis of a cohort of OCAH patients who were treated by the mobile emergency and intensive care unit (MICU) of the Erasme hospital - University clinics of Brussels was conducted. All interventions concerning an OCAH, from 01/01/2019 to 12/31/2019, reflecting a non-pandemic period and from 01/01/2020 to 12/31/2020, reflecting a period of SARSCoV-2 pandemic were analyzed. Main results : This study shows an increase in the male/ female ratio, as well as an increase in the number of OCAH. During the second wave, more than half of OCAHs had a suspected respiratory etiology. This period indicate an increase in ventricular fibrillation, as well as better autonomy and neurological sequelae, despite the statistical tests between a non-pandemic and a pandemic SARS-CoV-2 period were not significant. Conclusion : This retrospective cohort of patients who used MICU of HE-CUB during a non-pandemic and a pandemic period, highlights the impact of SARS-CoV-2 in absolute numbers on OCAH.

9.
Acta Medica Mediterranea ; 38(3):1935-1939, 2022.
Article in English | EMBASE | ID: covidwho-1887391

ABSTRACT

Introduction: After the outbreak of the Corona Virus Disease 2019 (COVID-19), there have been reports of impaired cardiac function in patients infected with this coronavirus. The tests are mostly based on myocardial injury markers and routine cardiac ultrasound examinations, which are mostly seen in critically ill patients. In this study, two-dimensional speckle tracking imaging (2DSTI) combined with Tei index and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) were used to more sensitively diagnose cardiac function impairment in COVID-19 patients. Materials and methods: For some COVID-19 patients in our hospital, there were 68 cases of mild disease (including mild and common types) and 11 cases of severe disease (4 cases of severe death), and 10 healthy volunteers were included as the control group. On the basis of conventional echocardiography in all subjects, the left ventricular end-diastolic volume (LV-EDV), left ventricular end-systolic volume (LV-ESV), and left ventricular ejection fraction (LV-EF) were obtained by Simpson method, the left ventricular Tei index by tissue Doppler, and the left ventricular global peak longitudinal strain (GLPS), left ventricular global peak radial strain (GRPS), and left ventricular global peak circumferential strain (GCPS) by 2DSTI offline analysis. The COVID-19 patients were subjected to quantitative detection of serum NT-proBNP for statistical analysis. Results: Left ventricular GLPS, left ventricular GRPS, and left ventricular GCPS in COVID-19 patients were significantly lower than those in the control group (P<0.05): The left ventricular GLPS was more significant (P<0.01), and the severe group (including the death group) < the mild group < the control group. The left ventricular Tei index: The severe group (including the death group) of COVID-19 was significantly higher than the mild group and the control group (P<0.05), and there was no statistical significance between the mild group and the control group. NT-proBNP: The severe group of COVID-19 was significantly higher than the mild group (P<0.05). Although the LV-EF in the COVID-19 patients was significantly lower than that in the control group (P<0.05), except for 2 sever cases less than 50%, the rest were all ≥50%;although there was a significant difference in LV-ESV among multiple groups (P<0.05), but there was no significant difference for the pairwise comparison, and there was no significant difference in LV-EDV. Conclusion: 2DSTI can more sensitively detect latent cardiac function impairment in COVID-19 patients, and the left ventricular GLPS is the most sensitive. Tei index is an effective indicator to reflect the degree of cardiac function impairment. NT-proBNP has significant significance in predicting the severity of cardiac dysfunction. The combined application of the three can significantly increase the predictive performance of cardiac function impairment, provide a diagnostic basis for cardiac function impairment with preserved ejection fraction, and predict the degree of impairment. Our study demonstrated that the cardiac function of COVID-19 patients is impaired to varying degrees.

10.
Cardiometry ; - (21):102-106, 2022.
Article in English | EMBASE | ID: covidwho-1887370

ABSTRACT

Based on the analysis of 308 electronic medical records of patients with a confirmed diagnosis of a new coronavirus infection COVID-19, the features of the course of cardiovascular diseases at the regional level were studied. It was found that in patients with cardiovascular diseases, the severity of the course and mortality are higher than in patients without cardiac pathology.

11.
Cardiovascular Journal of Africa ; 33(2):88-94, 2022.
Article in English | Web of Science | ID: covidwho-1887305

ABSTRACT

The 15th biennial Pan-African Society of Cardiology (PASCAR) congress held in Mombasa, Kenya, in November 2021, convened in its legacy of being the largest Pan-African conference on cardiovascular diseases (CVDs). The congress brough together members of cardiovascular societies from across the continent in the shared mission of advancing cardiovascular health in Africa. In partnership with the Kenyan Cardiac Society (KCS), the specific aims of the PASCAR conference were to (1) advance knowledge on CVDs in the region;(2) share local data, clinical cases, challenges and solutions and reinforce collaborative capacity initiatives in research and workforce training;(3) engage with policy makers to address health-system issues affecting access to CVD care in Africa;and (4) bring together local and international thought leaders in cardiovascular medicine to strengthen the partnerships between PASCAR, KCS, other African cardiac societies and key global stakeholders. Due to the COVID-19 pandemic, this congress demonstrated great success in providing both an in-person and a virtual platform of attendance, therefore making this an inaugural hybrid PASCAR congress, with inclusive and widespread participation from across the globe. We highlight the key areas of focus, various educational programmes and innovative initiatives that shaped the 15th PASCAR congress, including expert consensus on the future directions for advancing CVD care in Africa.

12.
9th IEEE International Conference on e-Health and Bioengineering (EHB) ; 2021.
Article in English | Web of Science | ID: covidwho-1886585

ABSTRACT

Due to the current medical crisis, visits to doctor and medical centers have not been in reach for most people who suffered from minor illnesses;this situation is the same regarding routine medical checks. The idea of this work came after a difficult and uncertain year, 2020, Covid-19 year. The possibility of being connected with the patient's doctor is paramount in these times. A first sign of Covid-19 disease would be indicated by the following parameters: blood oxygen level and body temperature. These are acquired by the prototype through pulse oximeter and temperature sensors, also the heart rate of the patient will be monitored. The system will be tightly packed, portable and will have a stand-alone functionality. It can store on microSD the measurement results and even plotting the evolution graphs in time, through the windows application that comes along.

13.
Journal of Urology ; 207(SUPPL 5):e482, 2022.
Article in English | EMBASE | ID: covidwho-1886508

ABSTRACT

INTRODUCTION AND OBJECTIVE: COVID-19 has caused significant disruption to the management of urological cancer, this study aims to assess 30-day postoperative outcomes for patients undergoing urological cancer surgery during the COVID-19 pandemic. METHODS: COVIDSurg study is the largest international, multicentre study of COVID-19 in surgical patients performed to date. COVIDSurg-Cancer explored the safety of performing elective cancer surgery during the pandemic. All bladder, kidney, UTUC and prostate cancer patients who underwent elective cancer surgery between March 2020 and July 2020 were included. Univariable and multivariable regression was performed to assess association of patient factors with mortality, respiratory complications and operative complications. RESULTS: A total of 1,902 patients from 36 countries were included. 658 (34.6%) patients had bladder cancer, 590 (31.0%) kidney cancer or UTUC, and 654 (34.4%) prostate cancer. These patients underwent elective curative surgery for their cancers (prostatectomies, nephrectomies, cystectomies, nephroureterectomy, TURBTs). 62% of sites were not designated “hot” COVID-19 sites (i.e. did not actively admit patients with COVID-19).A total of 42/1902 (0.2%) patients were diagnosed with COVID-19 during their inpatient stay. 21 (0.1%) mortalities were observed;of those, 8 (38.1%) were diagnosed with COVID-19. Mortalities were found to be more likely in patients with concurrent COVID-19 infection (OR 31.7, 95% CI 12.4- 81.42, p<0.001), aged over 80, ASA grade 3+ and ECOG grade 1+. 40 (0.2%) respiratory complications (acute respiratory distress syndrome or pneumonia) were observed within 30 days of surgery. Respiratory complications were more likely in patients aged with concurrent COVID-19 infection (OR 40.6, 95%CI 11.41-144.45, p<0.001), over 70, from an area with high community risk or with a revised cardiac risk index of 1+. There were 84 major complications (Clavien-Dindo score ≥3). Patients with a concurrent COVID-19 infection (OR 7.45, 95% CI 2.73-20.3, p<0.001) or aged 80 or above were more likely to experience major complications. CONCLUSIONS: Elective urological cancer surgeries are safe to perform during the COVID-19 pandemic. This study highlights important risk-factors associated with worse outcomes. Our data can inform health services to safely select patients for surgery during the pandemic. Patients with concurrent COVID-19 infection have a higher risk of mortality and respiratory complications and should not undergo surgery if possible.

14.
Journal of Urology ; 207(SUPPL 5):e207, 2022.
Article in English | EMBASE | ID: covidwho-1886485

ABSTRACT

INTRODUCTION AND OBJECTIVE: In 2015, English statistician and academic David Spiegelhalter wrote a book backed by the History of Medicine of the Wellcome Foundation entitled Sex by Numbers: What Statistics Can Tell Us About Sexual Behaviour. This represents an investigation into the statistics of human sexual activity to update the statistics of Kinsey and show the startling influence by the COVID-19 pandemic. METHODS: The investigation of the statistics of sexual activity is as enlightening as it is entertaining and there is a plethora of literature on modern sexual practices. This represents a concerted effort to track down these numbers and this data. The largest pornographic site, Pornhub®, also tracks its own statistics since its founding in 2007. RESULTS: An intriguing statistic is that the average number of sexual partners is about 9.9 (6.6 at Kinsey Center) for males and about 3.4 (4.3 at Kinsey) for females in their lifetimes. The exception to this is with homosexual persons, where the averages are much higher. Nature versus nurture is the classic tale of which is more important, genetics or environment, but most often there is a bit of both behind the scenes. Sexual activity is one of the most difficult topics of historical significance, because it is interleaved with so many socio-religious overtones. The average male loses his virginity at age 16.9, compared to age 17.4 for females. About 1 in 10 married adults sleep alone and not with their married spouse - shades of Dick Van Dyke and Mary Tyler Moore in The Dick Van Dyke Show. Only 29% of females achieve orgasm during sexual encounters, compared to 75% in their male counterparts. Currently, 66% of male college students report having “friends with benefits.” Also, currently 50% of sexually active men and women are infected with HPV at some point in their sexual lives. Sexual activity burns about 100-200 calories in males and about 69 calories in females but the heart rate at orgasm is about 140 and equal in both sexes. CONCLUSIONS: Spiegelhalter dedicated his statistical analysis “to everyone in history who has struggled with sex. And eventually called it a draw.” There is something like 900,000,000 acts of just heterosexual intercourse per year in Great Britain alone or roughly 100,000 per hour. This can all be extrapolated to the 7 billion humans around the world making close to 166,667 copulations per minute (or almost 4,000 per second).

15.
Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine ; 77(sup1):1-33, 2022.
Article in English | EMBASE | ID: covidwho-1886341
16.
Australasian Medical Journal ; 15(1):321-323, 2022.
Article in English | EMBASE | ID: covidwho-1885223
17.
European Journal of Molecular and Clinical Medicine ; 9(3):5861-5865, 2022.
Article in English | EMBASE | ID: covidwho-1885214

ABSTRACT

Aim: To determine the relationship between biochemical indicators and the severity of COVID-19. Methods: Blood samples were obtained by competent doctors and nurses in accordance with ICMR guidelines. The samples were then forwarded to the central biochemistry laboratory for additional analysis. The Access-2 completely automated chemical analyzer was used to test ferritin, quantitative CRP, and IL-6, while the AU 480 analyzer was used to assess LDH. Results: We included 200 confirmed covid-19 patients in our trial. All of the patients were above the age of 18. The prevalence of HTN, diabetes, CKD, COPD, and Cardiac Disease in the study patients was 40%, 32%, and 15%, respectively. 20 and 30 percent, respectively. In the current research, the mean values of IL-6, ferritin, CRP, and LDH were shown to be higher in covid patients, with the rise being greater in patients on intubation. The mean and standard deviation of biochemical parameters in non-ICU, ICU, and intubation patients. Conclusion: Serum CRP, LDH, IL-6, and ferritin levels that are increased may be employed as laboratory indicators for a bad prognosis in COVID-19.

18.
Diagnostics (Basel) ; 12(4)2022 Mar 27.
Article in English | MEDLINE | ID: covidwho-1887178

ABSTRACT

COVID-19 has been associated with cardiovascular consequences, including myocardial infarction, thromboembolic events, arrhythmia, and heart failure. Numerous overlapping mechanisms, such as the IL-6 dependent cytokine storm and unopposed angiotensin II stimulation, could be responsible for these consequences. Cardiac damage is hypothesized to be a consequence of the direct viral infection of cardiomyocytes, resulting in increased metabolic demand, immunological activation, and microvascular dysfunction. Patients with pre-existing chronic heart failure are therefore at increased risk of decompensation, further heart damage, and significant health deterioration. Based on the aforementioned assumptions, we developed a study aiming to provide a detailed description of changes in biological parameters and cardiac injury markers of patients with heart failure and SARS-CoV-2 infection by correlating them with the clinical presentation and COVID-19 vaccination status, to predict the probability of ICU admission based on their initial hospital presentation. A two-year retrospective study was performed on heart failure patients with a history of SARS-CoV-2 infection and detailed records of biological biomarkers; a total of 124 eligible patients with COVID-19 and 236 without COVID-19 were recruited. Patients with heart failure and SARS-CoV-2 infection had significantly elevated baseline biological parameters and cardiac markers compared to those without COVID-19. Several cardiac injury markers were identified as significant independent risk factors for ICU admission: CK-MB (HR = 4.1, CI [2.2-6.9]), myoglobin (HR = 5.0, CI [2.3-7.8]), troponin-I (HR = 7.1 [4.4-9.6]), troponin-T (HR = 4.9, CI [1.7-7.4]). The elevation of a basic panel of acute inflammation markers (CRP, IL-6, fibrinogen), D-dimers, and BNP was also a significant risk factor. The follow-up of survivors at four weeks after viral clearance determined a worsened clinical picture by NYHA classification, worsened cardiac ultrasound findings, and a mild improvement in cardiac and inflammatory markers. Increased levels of myocardial damage parameters in association with cardiac ultrasound findings and basic inflammatory markers may enable early risk assessment and triage in hospitalized heart failure patients infected with SARS-CoV-2.

19.
Cells ; 11(6)2022 03 14.
Article in English | MEDLINE | ID: covidwho-1887165

ABSTRACT

The epicardial adipose tissue (EAT) is the visceral fat depot of the heart which is highly plastic and in direct contact with myocardium and coronary arteries. Because of its singular proximity with the myocardium, the adipokines and pro-inflammatory molecules secreted by this tissue may directly affect the metabolism of the heart and coronary arteries. Its accumulation, measured by recent new non-invasive imaging modalities, has been prospectively associated with the onset and progression of coronary artery disease (CAD) and atrial fibrillation in humans. Recent studies have shown that EAT exhibits beige fat-like features, and express uncoupling protein 1 (UCP-1) at both mRNA and protein levels. However, this thermogenic potential could be lost with age, obesity and CAD. Here we provide an overview of the physiological and pathophysiological relevance of EAT and further discuss whether its thermogenic properties may serve as a target for obesity therapeutic management with a specific focus on the role of immune cells in this beiging phenomenon.


Subject(s)
Adipose Tissue , Coronary Artery Disease , Adipokines/metabolism , Adipose Tissue/metabolism , Coronary Artery Disease/metabolism , Humans , Obesity/metabolism , Pericardium/metabolism
20.
BMC Cardiovasc Disord ; 22(1): 262, 2022 Jun 11.
Article in English | MEDLINE | ID: covidwho-1886916

ABSTRACT

BACKGROUND: Previous studies have observed inconsistent associations between coronavirus disease 2019 (COVID-19) and heart failure (HF), but these studies were prone to bias based on reverse causality and residual confounding factors. We aimed to investigate genetic liability between COVID-19 and heart failure using a bidirectional Mendelian randomization study. METHODS: The causal relationship between COVID-19 (including COVID-19, hospitalized COVID-19 compared with the general population, and severe COVID-19) and HF are determined by using a bidirectional Mendelian randomization analysis. We drew on summary statistics from the largest HF genome-wide association study (GWAS) meta-analysis on individuals of European ancestry, which included 47,309 HF patients and 930,014 controls. The inverse variance weighted (IVW), an adaption of the Egger regression (MR-Egger), the weighted median, and weighted model were conducted for the Mendelian randomization analysis to estimate a causal effect. To confirm the stability, we performed a "leave-one-out" approach for the sensitivity analysis. RESULTS: Genetically predicted severe COVID-19 was not significantly associated with the risk of HF [odds ratio (OR), 1.003; 95% confidence interval (CI), 0.969-1.037; p = 0.867]. The IVW demonstrated that there was no association between genetically hospitalized COVID-19 infection and HF risk [OR, 1.009; 95% CI, 0.939-1.085; p = 0.797]. There was no evidence to support the association between genetically determined COVID-19 and the risk of HF [OR, 1.066; 95% CI, 0.955-1.190; p = 0.253]. In addition, genetically predicted HF was also not causally associated with COVID-19 [OR, 1.162; 95% CI, 0.824-1.639; p = 0.393]. MR-Egger analysis indicated no evidence of directional pleiotropy. CONCLUSION: The current bidirectional Mendelian randomization analysis overcomes the limitations of observational studies. Our findings indicated that there is no causal association between COVID-19 and HF.


Subject(s)
COVID-19 , Heart Failure , COVID-19/genetics , Genome-Wide Association Study , Heart Failure/diagnosis , Heart Failure/genetics , Humans , Mendelian Randomization Analysis , Polymorphism, Single Nucleotide
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