Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 1.026
Filter
Add filters

Year range
1.
Egypt J Neurol Psychiatr Neurosurg ; 58(1): 127, 2022.
Article in English | MEDLINE | ID: covidwho-2109128

ABSTRACT

Pandemic represents challenging medical emergency as it is usually associated with high rates of mortalities and morbidities. Along the last 2 and half years the world has faced the emergence of severe acute respiratory syndrome corona virus 2 pandemic that caught medical agencies and health authorities by surprise and costed more than half billion morbidities and 6 million mortalities. Unfortunately, the way developed countries contained the novel corona virus was unsatisfactory in means of early quarantines as well as obtaining and distributing an effective vaccine. This failure in management might have been responsible for the emergence of a new potential pandemic caused by monkeypox virus. Along the current review article, a detailed comparison is presented between corona virus and monkeypox virus based on virological characteristics, role of corona virus in monkeypox spread, pathogenesis, neuropsychiatric manifestations, and treatment and management. It is obvious that both viruses have a major role in causing various neuropsychiatric manifestations. Neurological manifestations are either bound directly to the virus spread to central and peripheral nervous system or secondary to triggering an immune reaction. Psychiatric ones are mostly related to stigmatization, isolation as well as changes that takes place in neurotransmitters and their metabolites within the nervous system. Dealing properly with monkeypox virus spread through previously learned lessons from corona virus might protect the world from a new pandemic.

2.
Musculoskeletal Care ; 2022 Nov 04.
Article in English | MEDLINE | ID: covidwho-2103668

ABSTRACT

INTRODUCTION: Socioeconomic deprivation is associated with multi-morbidity and frailty, but influence on hip fracture outcomes is poorly understood. The primary aim was to investigate the association between deprivation and mortality, and secondary aims were to assess the effects on: (i) age at presentation; (ii) inpatient outcomes, and (iii) post-discharge outcomes. METHOD: This cohort study included all patients aged >50 years admitted with a hip fracture to a high-volume centre between 01 March 2020 and 20 November 2021. Data were collected contemporaneously by specialist auditors and underwent validation using live health records after 180 days follow-up. Variables were demographics including Scottish Index of Multiple Deprivation, injury and management factors, and outcome measures including length of stay, discharge destination, readmission, and mortality status at 180 days. RESULTS: There were 1822 patients of which 1306/1822 (72%) were female. Deprivation was independently associated with younger age at hip fracture, demonstrating a linear correlation with each deprivation level. The overall mean age was 80.7 years (range 50-102), with the mean age in the most deprived group being 77.2 years (95% CI; 75.7-78.7) versus 82.8 years (95% CI; 82.0-83.5) in the least deprived. Multivariate logistic regression showed no association between deprivation and 30- or 180-day mortality risk. Kaplan-Meier survival analysis demonstrated no difference between the most deprived versus least deprived (log-rank, p = 0.854). Deprivation had no influence on length of stay, discharge destination, or COVID-19 status, but deprived patients had an increased risk of readmission (OR 1.63, 95% CI [1.18-2.24]; p = 0.003). CONCLUSION: Deprivation showed no linear correlation with early mortality risk (within 180 days of injury), but it was associated with an earlier age at presentation (the most deprived sustained a hip fracture 5.6 years earlier than the least deprived) which may impact overall life expectancy. More deprived patients were more likely to require further acute hospital admissions.

3.
AJPM Focus ; : 100046, 2022.
Article in English | ScienceDirect | ID: covidwho-2095355

ABSTRACT

Introduction This study presents data from two population-based surveys of youth (reservation-area American Indian (AI) adolescents and U.S. adolescents) on self, family, and friend morbidity, and changes in substance use and negative affect during COVID-19. Material and Methods Data were obtained in Spring 2021 from surveys of AI students on or near reservations (8th grade, n=398;10th grade, n=367, 12th grade, n=290) and national students from Monitoring the Future (MTF) (8th grade, n=11,446, 10th grade, n=11,792, 12th grade, n=9,022). Main outcomes were COVID-19 testing, perceived morbidity/mortality, substance-use changes, and emotional changes during COVID-19. Results The AI sample had a greater proportion of testing (e.g., AI 8th grade: 58.1% [95% CI;48.6-68.8];MTF 8th grade: 43.6% [95% CI;39.8-47.5]) and friend/family hospitalization (e.g., AI 8th grade: 36.2% [95% CI;26.2-47.5];MTF 8th grade: 11.9% [95% CI;10.6-13.3]). Across grades, greater proportions of the national sample reported increased anxiety, anger, boredom, loneliness, depression, worry, and trouble concentrating, while greater proportions of reservation-area AIs reported decreased anxiety, loneliness, depression. Conclusions Findings indicate that reservation-area AI youth experienced unique health consequences one year into the COVID-19 pandemic compared to national students, illustrating the need for AI-specific COVID-19 public health monitoring and response.

4.
Vaccine ; 2022 Oct 26.
Article in English | MEDLINE | ID: covidwho-2086815

ABSTRACT

AIM: We assessed the impact of COVID-19 vaccination status and time elapsed since the last vaccine dose on morbidity and absenteeism among healthcare personnel (HCP) in the context of a mandatory vaccination policy. METHODS: We followed 7592 HCP from November 15, 2021 through April 17, 2022. Full COVID-19 vaccination was defined as a primary vaccination series plus a booster dose at least six months later. RESULTS: There were 6496 (85.6 %) fully vaccinated, 953 (12.5 %) not fully vaccinated, and 143 (1.9 %) unvaccinated HCP. A total of 2182 absenteeism episodes occurred. Of 2088 absenteeism episodes among vaccinated HCP with known vaccination status, 1971 (94.4 %) concerned fully vaccinated and 117 (5.6 %) not fully vaccinated. Fully vaccinated HCP had 1.6 fewer days of absence compared to those not fully vaccinated (8.1 versus 9.7; p-value < 0.001). Multivariable regression analyses showed that full vaccination was associated with shorter absenteeism compared to not full vaccination (OR: 0.56; 95 % CI: 0.36-0.87; p-value = 0.01). Compared to a history of ≤ 17.1 weeks since the last dose, a history of > 17.1 weeks since the last dose was associated with longer absenteeism (OR: 1.22, 95 % CI:1.02-1.46; p-value = 0.026) and increased risk for febrile episode (OR: 1.33; 95 % CI: 1.09-1.63; p-value = 0.004), influenza-like illness (OR: 1.53, 95 % CI: 1.02-2.30; p-value = 0.038), and COVID-19 (OR: 1.72; 95 % CI: 1.24-2.39; p-value = 0.001). CONCLUSIONS: The COVID-19 pandemic continues to impose a considerable impact on HCP. The administration of a vaccine dose in less than four months before significantly protected against COVID-19 and absenteeism duration, irrespective of COVID-19 vaccination status. Defining the optimal timing of boosters is imperative.

5.
Eur J Epidemiol ; 2022 Oct 27.
Article in English | MEDLINE | ID: covidwho-2085442

ABSTRACT

There is a male sex disadvantage in morbidity and mortality due to COVID-19. Proposed explanations to this disparity include gender-related health behaviors, differential distribution of comorbidities and biological sex differences. In this study, we investigated the association between sex and risk of severe COVID-19 while adjusting for comorbidities, socioeconomic factors, as well as unmeasured factors shared by cohabitants which are often left unadjusted. We conducted a total-population-based cohort study (n = 1,854,661) based on individual-level register data. Cox models was used to estimate the associations between sex and risk for severe COVID-19. We additionally used a within-household design and conditional Cox models aiming to account for unmeasured factors shared by cohabitants. A secondary aim was to compare the risk of COVID-19 related secondary outcomes between men and women hospitalized due to COVID-19 using logistic regression. Men were at higher risk for hospitalization (HR = 1.63;95%CI = 1.57-1.68), ICU admission (HR = 2.63;95%CI = 2.38-2.91) and death (HR = 1.81;95%CI = 1.68-1.95) due to COVID-19, based on fully adjusted models. However, the effect of sex varied significantly across age groups: Among people in their 50s, men had > four times higher risk of COVID-19 death. The within-household design did not provide any further explanation to the sex disparity. Among patients hospitalized due to COVID-19, men had an increased risk for viral pneumonia, acute respiratory distress syndrome, acute respiratory insufficiency, acute kidney injury, and sepsis which persisted in fully adjusted models. Recognition of the combined effect of sex and age on COVID-19 outcomes has implications for policy strategies to reduce the adverse effects of the disease.

6.
Journal of Primary Health Care ; 2022.
Article in English | Web of Science | ID: covidwho-2082472

ABSTRACT

Introduction. New Zealand general practice and primary care is currently facing significant challenges and opportunities following the impact of the coronavirus disease 2019 (COVID-19) pandemic and the introduction of health sector reform. For future sustainability, it is important to understand the workload associated with differing levels of patient case mix seen in general practice. Aim. To assess levels of morbidity and concomitant levels of socio-economic deprivation among primary care practices within a large primary health organisation (PHO) and associated Maori provider network. Methods. Routinely collected practice data from a PHO of 57 practices and a Maori provider (PHO) of five medical practices in the same geographical area were used to compare a number of population health indicators between practices that had a high proportion of high needs patients (HPHN) and practices with a low proportion of high needs patients (Non-HPHN). Results. When practices in these PHOs are grouped in terms of ethnicity distribution and deprivation scores between the HPHN and Non-HPHN groups, there is significantly increased clustering of both long-term conditions and health outcome risk factors in the HPHN practices. Discussion. In this study, population adverse health determinants and established co-morbidities are concentrated into the defined health provider grouping of HPHN practices. This 'concentration of complexity' raises questions about models of care and adequate resourcing for quality primary care in these settings. The findings also highlight the need to develop equitable and appropriate resourcing for all patients in primary care.

7.
Revista De Pesquisa-Cuidado E Fundamental Online ; 14, 2022.
Article in English | Web of Science | ID: covidwho-2082375

ABSTRACT

Objective: to identify the scientific evidence on the factors that are associated with morbidity and mortality from covid-19 in the elderly Methods: this is a scope review, carried out from a search in five databases/libraries. To guide the preparation of this study, the recommendations of the Joanna Briggs Institute were followed. The PCC strategy was used to elaborate the following guiding question: what factors are associated with morbidity and mortality from covid-19 in the elderly? 38 articles were included in the final sample. Results: the presence of comorbidities, especially cardiovascular and endocrine diseases;advanced age;male;laboratory alterations, among other factors, may be predictive of worse clinical outcomes. Conclusion: the elderly population was one of the most affected by the pandemic and some factors corroborate a worse prognosis.

8.
Embase; 25.
Preprint in English | EMBASE | ID: ppcovidwho-346621

ABSTRACT

Background: Since the first year of the COVID-19 global pandemic, a hypothesis concerning the possible protection/immunity of beta-thalassemia carriers remains in abeyance. Method(s): Three databases (Pubmed Central, Scopus and Google Scholar) were screened and checked in order to extract all studies about incidence of confirmed COVID-19 cases OR mortality rate OR severity assessment OR ICU admission among patients with beta-thalassemia minor, were included in this analysis. The language was limited to English. Studies such as case reports, review studies, and studies that did not have complete data for calculating incidences were excluded. Results and discussion: Three studies upon 2265 were selected. According to our systematic-review meta-analysis, beta-thalassemia carriers could be less COVID-19 affected than general population [IRR= 0.9250(0.5752;1.4877)], affected by COVID-19 with a worst severity [OR=1.5933(0.4884;5.1981)], less admissible into ICU [IRR=0.3620(0.0025;51.6821)] and more susceptible to die from COVID-19 or one of its consequences [IRR=1.8542(0.7819;4.3970)]. However, all of those results stay insignificant with a bad p-value (respectively 0.7479, 0.4400, 0.6881, 0.1610). Other large case-control or registry studies are needed to confirm these trends. Copyright The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

9.
J Postgrad Med ; 68(4): 199-206, 2022.
Article in English | MEDLINE | ID: covidwho-2080671

ABSTRACT

Background: : Risk assessment with prognostic scoring, though important, is scarcely studied in emergency surgical patients with COVID-19 infection. Methods and Material: We conducted a retrospective cohort study on adult emergency surgical patients with COVID-19 infection in our institute from 1 May 2020 to 31 October 2021 to find the 30-day postoperative mortality and predictive accuracy of prognostic scores. We assessed the demographic data, prognostic risk scores (American Society of Anesthesiologists-Physical Classification (ASA-PS), Sequential Organ Failure Assessment (SOFA), Quick SOFA (qSOFA), Physiologic and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM) and Portsmouth-POSSUM (P-POSSUM) scores), surgical and anesthetic factors. We assessed the postoperative morbidity using the Clavien-Dindo scale and recorded the 30-day mortality. Correlation of prognostic scores and mortality was evaluated using Univariate Cox proportional hazards regression, receiver operating characteristic curve (ROC), Youden's index and Hosmer- Lemeshow goodness of fit model. Results: Emergency surgery was performed in 67 COVID-19 patients with postoperative complication and 30-day mortality rate of 33% and 19%, respectively. A positive qSOFA and ASAPS IIIE/IVE had a 9.03- and 12.7-times higher risk of mortality compared to a negative qSOFA and ASA-PS IE/IIE (P < 0.001), respectively. Every unit increase of SOFA, POSSUM and P-POSSUM scores was associated with a 50%, 18% and 17% higher risk of mortality, respectively. SOFA, POSSUM and P-POSSUM AUCROC curves showed good discrimination between survivors and non-survivors (AUC 0.8829, 0.85 and 0.86, respectively). Conclusions: SOFA score has a higher sensitivity to predict 30-day postoperative mortality as compared to POSSUM and P-POSSUM. However, in absence of a control group of non-COVID-19 patients, actual risk attributable to COVID-19 infection could not be determined.


Subject(s)
COVID-19 , Adult , Humans , Retrospective Studies , Prognosis , Postoperative Period , Risk Assessment/methods , ROC Curve , Postoperative Complications/etiology , Severity of Illness Index
10.
Rev. Univ. Ind. Santander, Salud ; 53: e301, dic. 2021. graf
Article in Spanish | WHO COVID, LILACS (Americas) | ID: covidwho-2081182

ABSTRACT

Resumen Introducción: Diversas investigaciones han intentado establecer el impacto de algunos parámetros meteorológicos y de calidad del medio ambiente en la transmisión del SARS-CoV-2, tomando en consideración las características geográficas de cada país y con el fin de mitigar el avance de la enfermedad mediante el control de esos factores. Objetivo: Analizar la evidencia existente sobre la posible relación entre factores ambientales y la morbilidad y mortalidad por SARS-CoV-2/COVID-19 en el panorama mundial y colombiano. Metodología: Se realizó una revisión exhaustiva de la literatura científica en las bases de datos electrónicas. Además, se analizó el impacto de algunas variables ambientales y la gravedad de los casos de COVID-19 durante el período del 8 de abril al 29 de julio de 2020 en la ciudad Bogotá. Resultados: El análisis correlacional entre la ocupación de camas UCIs en Bogotá con los factores ambientales como temperatura, las concentraciones de PM2 5, O3, NO, NO2 y CO mostraron una relación inversamente significativa. Entre tanto, se presentó una correlación positiva entre los niveles de óxidos de nitrógeno (NO/NO2) y el monóxido de carbono (CO). Algunos de estos resultados posiblemente están relacionados con los efectos de la cuarentena impuesta por el gobierno local. Conclusión: Nivel mundial existe suficiente evidencia para relacionar algunas condiciones y parámetros ambientales con un aumento en la morbilidad y mortalidad por COVID-19. Las evidencias a nivel nacional aún son escasas.


Abstract Introduction: Several investigations have attempted to establish the impact of some meteorological and environmental parameters on the transmission of SARS-CoV-2, considering each country's geographical characteristics and seeking to mitigate the disease's advancement by controlling these factors. Objective: Analyze the evidence on the possible relationship between environmental factors, morbidity, and mortality due to SARS-CoV-2/COVID-19, both globally and within Colombia. Methodology: A comprehensive review of the scientific literature was carried out in the electronic databases. Additionally, the impact of some environmental variables and the severity of COVID-19 cases were analyzed during the period from April 8 to July 29, 2020, for the city of Bogotá. Results: The correlational analysis between the ICU admission rates in Bogotá and the environmental factors like temperature, PM2 5, O3, NO, NO2 y CO levels, and ozone concentration showed an inversely significant relationship. Meanwhile, there was a positive correlation between the levels of nitrogen oxides (NO/NO2) and carbon monoxide (CO). Some of these results could be related to the effects of the quarantine imposed by local governments. Conclusion: Globally, there is enough evidence to link environmental conditions and parameters with increased morbidity and mortality for COVID-19. Evidence at the national level is still scarce.

11.
Journal of Pharmaceutical Negative Results ; 13:235-242, 2022.
Article in English | Web of Science | ID: covidwho-2072532

ABSTRACT

In the last two years, coronavirus infections increased the mortality rate among the elderly and especially patients who suffer from chronic diseases. Despite vaccination, many people are still dying from COVID-19. Among these, the role of minerals in increasing the function of the immune system and combating coronavirus infection has been proven. Selenium (Se) is a crucial valuable element for human health with a determinative in decreasing the amount of ROS produced in response to different viral infections within the body. The role of selenoprotein enzymes in struggling oxidative caused by ROS overproduction is very important. The overall function of cytotoxic cells increases by the presence of selenium. Recent clinical trials carried out on patients with COVID-19 have demonstrated that the deficiency of selenium is obvious in patients who suffer from acute respiratory infections. Due to the role of selenium in viral inflammation, it is expected that this substance will prevent the cytokine storm and ultimately mortality of infected people by reducing the production of inflammatory cytokines. The present study investigates the role of selenium and selenoproteins and their possible mechanisms in the pathogenesis of viral infections. Further comprehension on the the role of the pathogenesis of viral infections and their mortality could be achieved through identifying potential selenoproteins in the COVID 19 genome by means of computational tools. The following core competencies are addressed in this article: The effect of selenium on pathogenicity and mortality of COVID-19.

12.
Journal of Pure and Applied Microbiology ; 16(3):1441-1446, 2022.
Article in English | Web of Science | ID: covidwho-2072398

ABSTRACT

Mucormycosis is a rare type of fungal infection commonly known as zygomycosis, the infection tends to crop up more commonly in individuals with low and weakened immunity level, if left untreated, the mucormycosis can be life-threatening and fatal. Mucormycosis previously known as zygomycosis is a consequential type of infection caused by several mildews known as micromycetes. The revised taxonomical studies revealed that the micromycetes causing the infections are classified as the species of phylum Glomeromycota, class Glomeromycetes, subphylum Mucoromycotina, order Mucorales. The genera of Rhizopus, Mucor, Lichtheimia, Cunninghamella, Rhizomucor, and Apophysomyces, constitute the causative agents of the majority of cases of mucormycosis. The angioinvasive type of disorder caused by mucormycosis is further classified as Mucorales. The patients with Diabetes ketoacidosis and diabetes mellitus are at high-risk factors, followed by the patients with organ transplant, immunocompromised disease, and malignancy. The route of exposure to Mucormycosis may be through the wounded infection that can be pneumonic, or dermal in origin. In the ectodermal form, the fungal organism can invade the skin through open or puncture wounds, or the laceration on the skin. However, the infection has a high mortality rate, the key to successful treatment is early diagnosis, and administration of antifungal drugs, with extensive therapy, followed by surgical debridement of the infection. The morbidity and mortality rate are still at a high number, due to the negligence of the patient to seek medical treatment. Hence the early diagnosis and treatment with antifungal drugs with surgical debridement is a must. The efficacy of oral and venous formulations in the treatment of mucorales is still under debate. Despite the aggressive therapy, the mortality rate is increasing worldwide. The studies have to be conducted to invent the fastest treatment protocol for the treatment of Mucormycosis.

13.
Cureus ; 14(7): e27006, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-2072150

ABSTRACT

Introduction Children were affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus during the first and second waves of the coronavirus disease 2019 (COVID-19 pandemic. Although the severity was less in children, the fear of contracting SARS-CoV-2 at the hospital might have led to a delayed health-seeking attitude. The objective of the study was tailored around emergency health care utilization affecting outcomes. The study was done to compare the trend concerning the utilization of pediatric healthcare and immunization services, changes in the profile of diseases, and the outcomes between the pre-COVID-19 period and the COVID-19 period in a tertiary care hospital. Methods This retrospective observational study was conducted in a tertiary care hospital in western Odisha. Data were collected retrospectively from different hospital registers (outpatient register, inpatient register, and immunization records) and analyzed between the pre-COVID-19 period (April 2019 to March 2020) and the COVID-19 period (April 2020 to March 2021) with appropriate statistical procedures. Results There was a 60%, 49.8%, 51.1%, and 25.5% reduction in outpatient attendance, indoor pediatric admissions, nutritional rehabilitation centre admissions, and newborn admissions, respectively in COVID-19 period as compared to the pre-COVID-19 period. The pediatric bed occupancy rate was reduced by 54.5%. Unfavourable outcomes (death, left against medical advice, and referral) were significantly high in hospitalized children (24% vs. 18.1%, p < 0.001). The reduction in hospitalization due to common conditions like acute respiratory tract infections, bronchiolitis and asthma, and acute gastroenteritis during COVID-19 was 76.5%, 86.2%, and 39.5%, respectively. A higher percentage of low birth weight and preterm (<34 weeks) babies were admitted to special neonatal care unit (SNCU) during the pandemic (61.8% vs. 58%, p < 0.05; 18.9% vs. 15.8%; p < 0.05 respectively). Conclusion The COVID-19 pandemic and the associated lockdown led to a significant decrease in pediatric and neonatal healthcare utilization. The impact of lower care-seeking and attendance resulting in poor patient-related outcomes (malnutrition, upsurge of vaccine-preventable diseases, disease-specific hospitalization, and mortality) post-pandemic is a real threat.

14.
J Pers Med ; 12(10)2022 Oct 17.
Article in English | MEDLINE | ID: covidwho-2071576

ABSTRACT

BACKGROUND: Immune dysregulation has been linked to morbidity and mortality in COVID-19 patients. Understanding the immunology of COVID-19 is critical for developing effective therapies, diagnostics, and prophylactic strategies to control the disease. AIM: The aim of this study was to correlate cytokine and chemokine serum levels with COVID-19 disease severity and mortality. SUBJECTS AND METHODS: A total of 60 hospitalized patients from the Tabuk region of Saudi Arabia with confirmed COVID-19 were included in the study. At hospital admission, the IL-1 ß, IL-2, IL-8, IL-10, LT-B4, and CCL-2 serum levels were measured. The cytokine levels in COVID-19 patients were compared to the levels in 30 healthy matched control subjects. RESULTS: The IL-1 ß, IL-2, LTB-4, CCL-2, and IL-8 levels (but not IL-10) were significantly higher in all COVID-19 patients (47 survivors and 13 non-survivors) compared with the levels in the healthy control group. In the non-survivor COVID-19 patients, patients' age, D-dimer, and creatinine kinase were significantly higher, and IL-1 ß, IL-2, and IL-8 were significantly lower compared with the levels in the survivors. CONCLUSION: Mortality rates in COVID-19 patients are associated with increased age and a failure to mount an effective immune response rather than developing a cytokine storm. These results warrant the personalized treatment of COVID-19 patients based on cytokine profiling.

15.
Osteopathic Family Physician ; 14(4):10-15, 2022.
Article in English | EMBASE | ID: covidwho-2067635

ABSTRACT

Each year, the U.S. Centers for Disease Control and Prevention (CDC) releases the adult vaccine schedule. The 2022 adult vaccine schedule has several changes which will be discussed in the following manuscript. The Advisory Committee on Immunization Practices reviews the preliminary schedules usually at their October or November meetings. The following professional societies also approve the adult schedules prior to the 2022 publications: American College of Physicians (ACP), American Academy of Family Physicians (AAFP), American College of Obstetricians and Gynecologists (ACOG), American College of Nurse-Midwives (ACNM), American Academy of Physician Assistants (AAPA) and the Society for Healthcare Epidemiology of America (SHEA). Once the final draft is approved by the CDC, it is published in the Morbidity and Mortality Weekly Report (MMWR) and released to healthcare providers and the general public with a cover page, tables, notes and—new for the 2022 schedule—an appendix with contraindications and precautions for the different approved vaccines.

16.
Pediatricheskaya Farmakologiya ; 19(2):196-200, 2022.
Article in Russian | EMBASE | ID: covidwho-2067387

ABSTRACT

Background. Students, as the most active and mobile part of population, often unite into educational and informal groups, move to other regions or countries, and present a specific risk group for the spread of new coronavirus infection. Thus, they require preventive vaccination. objective. the aim of the study is to study the immunological potency, tolerance, and efficacy of GamCOVID-Vac vaccine among students of Krasnodar. methods. 119 seronegative students (18–30 years old) were examined. SARSCoV-2 IgG (ELISA method) was determined 1, 3, and 6 months after two completed rounds of vaccination. Post-vaccination adverse events and COVID-19 cases were evaluated in the study. results. SARS-CoV-2 IgG level 1 month after vaccination ranged from 6.15 to 19.38 and was to 16.39 (AU/mL) ± 1,12. Immunological potency values ranged from 4.407 to 21.5 (AU/mL) (14.74 ± 2.93) 3 months after. IgG titers were in the range of 4.14 to 17.71 (AU/mL) (10.97 ± 4.69) 6 months after. Adverse events after vaccination were revealed in 34 respondents (28.6%). Among them, local (hyperemia, pain, edema) — 21 (17.6%): slight — 90.4%, major — 9.6%;general (fever, weakness, algor, headache, arthralgia, myalgia) — 13 (10.9%): slight — 69.2%, major — 30.8%. The increase in vaccination coverage in students from 30.3 to 79.1% reduced the COVID-19 morbidity from 3.81 to 1.57%. conclusion. Gam-COVID-Vac vaccine induced stable humoral response, demonstrated sufficient safety, and reduced morbidity 2.4-fold.

17.
Pediatricheskaya Farmakologiya ; 19(1):78-81, 2022.
Article in Russian | EMBASE | ID: covidwho-2067385

ABSTRACT

Background. The morbidity of new coronavirus infection remains high (in children as well). Children with bronchial asthma are not at risk this disease development and severe course of COVID-19 according to the previous studies results. Objective. The aim of the study is to compare the morbidity rate of COVID-19 among children with and without bronchial asthma between May 2020 and October 2021 with the results from the beginning of pandemics. Methods. Online questionnaires in Google form have been developed and sent to parents of 83 patients aged from 7 to 17 years who have been interviewed at the beginning of the pandemics. The main group includes 49 patients diagnosed with bronchial asthma, and the control group includes 25 children without bronchial asthma. Results. 45% (22) of patients had COVID-19 in the main group and 32% (8) — in the control group (p = 0.636). 80% of patients had mild course of disease and 20% — moderate in the main group, and 62% and 37% in the control group respectively. Febrile fever was observed in 40% of respondents in the main group and in 33% — in the control group;anosmia — in 35% in the main and in 14% — in the control group;pulse oximetry was used by 44% of patients in the main group (SpO2 94–98%) and 42% in the control group (SpO2 98–99%);66% of patients had baseline therapy and 6% had rescue medications in the main group. No one from both groups has been hospitalized. Conclusion. Pediatric patients both with and without bronchial asthma have COVID-19 more often compared to the pandemics beginning. The disease in most cases had mild course and did not require hospitalization, aggravations of bronchial asthma were rare and saturation values did not decrease below 94%.

18.
NeuroQuantology ; 20(9):4342-4350, 2022.
Article in English | EMBASE | ID: covidwho-2067291

ABSTRACT

People suffering from severe mental illness (SMI) have a significant negative impact on their communities as compared to the normal population. There are a variety of factors that contribute to the majority of this excess mortality. It is reported in this paper on a study that was conducted to explore the impact on mental health among psychiatric patients all over the world. We were able to determine the prevalence rates as well as the factors that contributed to the elevated morbidity and mortality rates. There is evidence that increased risk for the majority of physical diseases is caused by a combination of lifestyle variables as well as treatment-specific risk factors. There is also adequate data to imply that people with SMI are less likely than the general population to obtain normal levels of care for the majority of illnesses than the general population. The current period of Covid 19 demonstrates the enormous amount of mental stress experienced by health practitioners all across the world. A range of mental health disorders are caused by the pandemic, which is particularly widespread among psychiatric patients due to the unusual nature of the outbreak. Psychiatric patients are frequently affected by anxiety, depression, burnout, insomnia, and other stress-related diseases, according to the American Academy of Family Physicians (Freudenberger, H). It is the purpose of this study, as well as other low-resource countries, to draw attention to the mental health aspects of the pandemic among psychiatric patients.

19.
Journal of Clinical and Diagnostic Research ; 16(9):OC05-OC09, 2022.
Article in English | EMBASE | ID: covidwho-2067202

ABSTRACT

Introduction: Coronavirus Disease-2019 (COVID-19) had devastating effects on the healthcare and economic sector worldwide. India stands second in the list of most number of COVID-19 cases. Most of the deaths due to COVID-19 were seen in patients with associated co-morbidities like hypertension, diabetes, chronic kidney disease and obesity. This study would like to examine specific co-morbidities in relation to the COVID-19 disease progression and outcomes. Aim(s): To compare the clinicoradiological profile and outcome of COVID-19 in patients with and without co-morbidities (diabetes and hypertension). Material(s) and Method(s): The present observational, cross-sectional study was conducted at Jawaharlal Nehru Medical College, Aligarh, Uttar Pradesh between June 2020 to September 2020, after obtaining Institutional Ethics Committee (IEC) approval. A total of 148 patients with COVID-19 were included in the study. The COVID-19 patients admitted in the hospital were divided into four groups as those having only diabetes, only hypertension, both diabetes and hypertension, and those without any co-morbidities. Those with any other co-morbidity were excluded from the study. The general clinical characteristics, laboratory parameters, disease severity, morbidity and mortality were compared among various groups and the data was analysed. Categorical data were analysed using the Chi-square test. Result(s): A total of 148 patients with COVID-19 were included in the study, of which 26 patients were diabetic, 36 were hypertensive, 24 were both hypertensive and diabetic and 62 patients didn't had any significant co-morbidity. Severe COVID-19 disease was most commonly observed in those with diabetes (n=14) (53.8%). The highest proportion of patients requiring oxygen (84.6%) and Non Invasive Ventilator (NIV) support (46.1%) was also seen among diabetics. The presence of diabetes, severe disease and leukocytosis at presentation increased the risk of mortality. The association of hypertension with COVID-19 does not seem to affect the in-hospital mortality. Conclusion(s): COVID-19 in diabetics is associated with both increased risk of severe disease and increased odds of death. In diabetics, those with uncontrolled diabetes were more prone to severe disease and death than those with good glycaemic control. Hypertension, on the other hand, showed no association. Copyright © 2022 Journal of Clinical and Diagnostic Research. All rights reserved.

20.
Archives of Clinical Infectious Diseases ; 17(4), 2022.
Article in English | EMBASE | ID: covidwho-2067097

ABSTRACT

Context: The current pandemic of COVID-19 affected all people of the world. Evidence Acquisition: Most complications of SARS-CoV-2 are causally related to severe pneumonia due to host immune response in the form of a cytokine storm. The other causes of an increased mortality rate among COVID-19 patients are secondary infections. Results: Mucormycosis is a life-threatening infection that gained much attention in the ongoing COVID-19 pandemic. A rise in the frequency of COVID-19-associated mucormycosis (CAM) occurred in 2020 and 2021. Overall, mortality of CAM has been reported as 54%-75%. Conclusions: Although awareness of the disease has increased among treating physicians, disease-associated morbidity and mortality are still high. The guideline is intended to serve as a reference to prevent mucormycosis in COVID-19 patients and help health-care providers choose diagnostic and treatment methods for the best management of CAM cases.

SELECTION OF CITATIONS
SEARCH DETAIL