Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 260
Filter
1.
Journal of Pharmaceutical Negative Results ; 13:184-192, 2022.
Article in English | Web of Science | ID: covidwho-2072530

ABSTRACT

Background: The pathogenesis of SARS-CoV-2 is not fully understood, and currently there is currently no definitive drug or treatment against it. So, the drugs used to treat SARS-CoV-2 are mainly based on their effectiveness on previous species of coronaviruses. This review aimed to evaluate the studies performed on the use of the available drugs in the treatment of Covid-19 since the onset of this disease. Method: Comprehensive search strategy was conducted in the following databases: PubMed, Web of Science (IR) and Scopus, Psycinfo, Google Scholar, and national databases, including Scientific Information Database (SID) and Maglran from inception of Covid-19 to June 2022. Studies that reported the effect of different drugs in treatment of Covid-19 patients were included. Results: 38 studies (114,552 participants) were included in this systematic review study on used drug treatment of patients with Covid-19 including Remdesivir, HCQ & Chloroquine, Favipiravir, Molnupiravir, Arbidol, Kaletra, Oseltamivir, IVIG & Interferon. Conclusions: Remdesivir, HCQ & Chloroquine, Favipiravir, Molnupiravir, Arbidol, Kaletra, Oseltamivir, IVIG & Interferon are the most commonly used drugs in treatment of Covid-19. Although these drugs may be effective in improving the condition of Covid-19 patients in the inflammatory phase, the confirmation of their use requires more extensive clinical research.

2.
World Journal of Traditional Chinese Medicine ; 8(4):463-490, 2022.
Article in English | EMBASE | ID: covidwho-2066828

ABSTRACT

Curcumae Longae Rhizoma (CLR) is the rhizome of Curcuma longa L. Pharmacological studies show that CLR can be used to treat cervical cancer, lung cancer, lupus nephritis, and other conditions. In this paper, we review botany, traditional application, phytochemistry, pharmacological activity, and pharmacokinetics of CLR. The literature from 1981 to date was entirely collected from online databases, such as Web of Science, Google Scholar, China Academic Journals full-text database (CNKI), Wiley, Springer, PubMed, and ScienceDirect. The data were also obtained from ancient books, theses and dissertations, and Flora Reipublicae Popularis Sinicae. There are a total of 275 compounds that have been isolated from CLR, including phenolic compounds, volatile oils, and others. The therapeutic effect of turmeric has been expanded from breaking blood and activating qi in the traditional sense to antitumor, anti-inflammatory, antioxidation, neuroprotection, antibacterial, hypolipidemic effects, and other benefits. However, the active ingredients and mechanisms of action related to relieving disease remain ill defined, which requires more in-depth research and verification at a clinical level.

3.
Wound Repair and Regeneration ; 30(5):A3, 2022.
Article in English | EMBASE | ID: covidwho-2063960

ABSTRACT

Background: It has long been known that the fetal response to skin injury is regenerative, with a lack of abnormal collagen deposition or scar, and restoration of normal dermal architecture. This response is associated with minimal inflammation.We have shown that the decreased inflammation is due to decreased production of pro-inflammatory cytokine production compared to the adult response. In addition, we have shown fetal tendon and the fetal heart can heal by regeneration, with restoration of structure and function, and is also associated with decreased proinflammatory cytokine production and decreased inflammation. We hypothesized that strategies targeting inflammation and associated oxidative stress could be used in adult diseases. We have identified diabetic wounds, acute lung injury, and colitis where inflammation and oxidative stress plays a central role in the pathogenesis the disease. Material(s) and Method(s): We have developed a novel strategy using nanotechnology to target inflammation and oxidative stress. We have conjugated novel cerium oxide nanoparticles, which act as potent scavengers of reactive oxygen species, to the anti-inflammatory microRNA miR146a, which suppresses the NFkB pathway and the production of the pro-inflammatory cytokines IL-6 and IL-8. Result(s): In diabetic wounds, impaired healing is associated with chronic inflammation and oxidative stress. We have demonstrated, in both small and large diabetic animals models, that CNP-miR146a can decrease inflammation and oxidative stress and correct the diabetic wound healing impairment and promote regeneration, similar to rates of healing in non-diabetic animals. We have also examined other disease states where inflammation and oxidative stress is pathogenic. Following acute lung injury, inflammation and oxidative stress leads to the development of adult respiratory distress syndrome or ARDS, the number one cause of mortality with COVID-19, and is associated with a 30-50% mortality. Inflammation and oxidative stress play a central role in the pathogenesis of ARDS. We have shown in models of acute lung injury, including bleomycin, LPS, MRSA, ventilator induced lung injury (VILI) and mustard gas, that CNP-miR146a decreases inflammation and oxidative stress, promotes regeneration and restoration of function, and decreased mortality. Finally, pathogenic inflammation plays a central role in the development of colitis or inflammatory bowel disease. We have shown that CNP-miR146a enemas can prevent progression of disease, restore weight gain, and lacks the adverse effects of systemic immunosuppression. Conclusion(s): We have used our understanding of the mechanisms of fetal regeneration following injury, which progresses with minimal inflammation and oxidative stress, to develop strategies targeting these processes to promote regeneration in adult disease.

4.
Materials Today ; 2022.
Article in English | ScienceDirect | ID: covidwho-2061637

ABSTRACT

Face masks have been used as the most effective and economically viable preventive tool, which also creates a sense of social solidarity in collectively combatting the airborne health hazards. In spite of enormous research literature, massive production, and a competitive market, the use of modern age face masks-respirators (FMR) is restricted for specific purposes or during public health emergencies. It is attributed to lack of awareness, prominent myths, architect and manufacturing limitations, health concerns, and probable solid waste management. However, enormous efforts have been dedicated to address these issues through using modern age materials and textiles such as nanomaterials during mask fabrication. Conventional FMRs possess bottlenecks of breathing issues, skin problems, single use, fungal infections, communication barrier for differently abled, inefficiency to filter minute contaminants, sourcing secondary contamination and issue of solid-waste management upon usage. Contrary, FMR engineered with functional nanomaterials owing to the high specific surface area, unique physicochemical properties, and enriched surface chemistries address these challenges due to smart features like self-cleaning ability, biocompatibility, transparency, multiple usages, anti-contaminant, good breathability, excellent filtration capacity, and pathogen detecting and scavenging capabilities. This review highlights the state-of-the-art smart FMR engineered with different dimensional nanomaterials and nanocomposites to combat airborne health hazards, especially due to infectious outbreaks and air contamination. Besides, the myths and facts about smart FMR, associated challenges, potential sustainable solutions, and prospects for “point-of-action” intelligent operation of smart FMRs with the integration of internet-of-nano-things, 5G wireless communications, and artificial intelligence are discussed.

5.
Advances in Materials Science and Engineering ; 2022, 2022.
Article in English | ProQuest Central | ID: covidwho-2053395

ABSTRACT

The coronavirus disease 2019 pandemic has shown that a disposable surgical face mask is a good protective wall against infection due to its ability to prevent virus transmission from sick to healthy people. Nevertheless, these surgical masks are disposable, not ecofriendly, and are single-use items. The use and disposal of traditional masks lead to high secondary risks such as environmental pollution, pathogen transmission, overload demands, and user discomfort. Nanotechnology is one of the most investigated strategies to safely and economically reuse masks in the 21st century. These strategies are based on four key elements as follows: (1) super mechanical properties that give masks flexibility, durability, and good lifetime storage;(2) high thermal properties that give masks heat self-sterilization;(3) an electric charge controller that gives masks triboelectric (TE) filtration;and (4) response to the antimicrobial effect that stays in the mask before, during, and after safe use. These properties give new-generation masks the ability to remove the drawbacks of traditional surgical masks, such as microbial growth and low filtration efficiency. The graphene family has introduced the self-sterilization and TE effects of surgical masks. Silver nanoparticles have supported antimicrobial effects. Nanofiber membranes are fabricated to have a high surface area that improves the fiber diameter and porosity ratio. A traditional mask could only block a maximum of 50% of the exhaled viruses, but a nanofiber-based mask has been tested to intercept 90% to 99% of particle viruses while breathing during use. Complex nanocomposite materials have succeeded in collecting all these advantages.

6.
Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance ; : 305-364, 2022.
Article in English | Scopus | ID: covidwho-2048813

ABSTRACT

Coronavirus disease 2019 (COVID-19) infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global burden to public health that manifests various symptoms, including self-limiting upper respiratory disorder, severe pneumonia, multi-organ failure, and even death. Thus, efficient approaches to tackle the rapid biological diversity and mutations of coronaviruses (CoVs) are required. Recently, nanotechnology approaches have enabled control of virus transmission by offering efficient personal protective equipment, antiviral surface coatings, and disinfectants. Besides, nanotechnology could be used in viral infection sampling, sample processing, amplification, and sensing to create rapid, sensitive, and accurate diagnostic tests. Nanomaterials have been increasingly used to deliver potential therapeutic agents, vaccines, and artificial viruses because of their certain properties such as high surface-to-volume ratio, specific optical, antiviral action, drug encapsulation, nanoscale biorecognition, and controlled release properties. This chapter covers nanotechnology-based approaches for preventing, diagnosing, and treating CoV infections with an emphasis on SARS-CoV-2. © 2022 Elsevier Inc. All rights reserved.

7.
Nanoparticle Therapeutics: Production Technologies, Types of Nanoparticles, and Regulatory Aspects ; : 563-579, 2022.
Article in English | Scopus | ID: covidwho-2048736

ABSTRACT

A narrative intended for science interns and scientists to overview regulatory pathways and federal perspectives pertinent to the complexity of nanoparticle systems and chaos precipitated by the COVID-19 pandemic. It elaborates on fundamental aspects of US FDA guidance on nanotechnology. It juxtaposes guidance on nanotechnology with the COVID-19 guidance documents to get a deeper understanding of “good practices” in the context of professional response in chaotic, complex, complicated, and simple systems. The narrative spirals in on practical consideration for experiential learning to be self-assured. © 2022 Elsevier Inc. All rights reserved.

8.
Nano-enabled Agrochemicals in Agriculture ; : 1-6, 2022.
Article in English | Scopus | ID: covidwho-2035538

ABSTRACT

There are two major challenging problems facing humanity today which are the ongoing Coronavirus disease (COVID-19) pandemic started in late 2019 and the environmental crisis due to fossil fuels combustion causing over increase of greenhouse gases in the atmosphere. While the first problem seems to be a temporary remedy for the second one due to less travels by individuals, actual solution of both problems may require comprehensive scientific, technological, and socioeconomic decisions. In this chapter we look at the role of nanotechnology and nano-scale materials towards the solution of these two major challenges. © 2022 Elsevier Inc. All rights reserved.

9.
Bioprocess Biosyst Eng ; 45(11): 1753-1769, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2035057

ABSTRACT

The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Symptoms of COVID-19 can range from asymptomatic to severe, which could lead to fatality. Like other pathogenic viruses, the infection of SARS-CoV-2 relies on binding its spike glycoprotein to the host receptor angiotensin-converting enzyme 2 (ACE 2). Molecular studies suggested that there is a high affinity between the spike glycoprotein and ACE 2 that might arise due to their hydrophobic interaction. This property is mainly responsible for making this virus highly infectious. Apart from this, the transmissibility of the virus, prolonged viability in certain circumstances, and rapid mutations also contributed to the current pandemic situation. Nanotechnology provides potential alternative solutions to combat COVID-19 with the development of i. nanomaterial-based COVID-19 detection technology, ii. nanomaterial-based disinfectants, iii. nanoparticle-based vaccines, and iv. nanoparticle-based drug delivery. Hence, this review provides diverse insight into understanding COVID-19.


Subject(s)
COVID-19 , SARS-CoV-2 , Humans , Spike Glycoprotein, Coronavirus/genetics , Spike Glycoprotein, Coronavirus/metabolism , Peptidyl-Dipeptidase A/genetics , Peptidyl-Dipeptidase A/metabolism , Biology
10.
Nanotechnological Applications in Virology ; : 41-55, 2022.
Article in English | Scopus | ID: covidwho-2035633

ABSTRACT

Viruses have caused some of most deadly epidemics and pandemics of humanity. They can cause major health problems, the collapse of the health and economic systems, as well as have negative social and psychological implications. Although science has aided in the management of some viruses, it still requires additional research on new and emerging viruses. The virus SARS-CoV-2 has caused the COVID-19 pandemic leading to the death of many people globally. Several vaccinations have been developed to try to eradicate the virus;however, due to the high mutation rate of the virus, vaccines are still rigorously tested in research and trials. Nanotechnology is a pretty modern technology that offers the potential to treat viruses. For the introduction of advanced antiviral medicines and vaccines, research in this field is becoming increasingly crucial. Furthermore, in a pandemic situation, employing nanomaterials to regulate drug distribution can be a fantastic method to make them successful across a broad range of activity. This book chapter is aimed to highlight recent studies and new technologies on the use of nanomaterials as antiviral therapy, focusing on the drug delivery system, its principles, potential, and economic viability. Because we are in the midst of a COVID-19 epidemic, this research is critical in determining the potential of nanotechnology in medicine, as well as future prospects for drug delivery and nanotherapies generated from NPs of promising nanomaterials. © 2022 Elsevier Inc. All rights reserved.

11.
Nanotechnological Applications in Virology ; : 195-218, 2022.
Article in English | Scopus | ID: covidwho-2035630

ABSTRACT

Since 2019, the entire world has been immobilized by the SARS-CoV-2 virus, which caused Covid-19. Different viruses spread infections and can cause frequent pandemics on the planet, so we need to understand and explore this invisible world. Despite the worldwide uproar over the pandemic, it is necessary to argue that other, less contagious but no less dangerous viruses are plaguing humanity. Viruses impact socioeconomic development and cause serious public health problems in the region where the virus has spread, which generally expands and may reach pandemic levels. These characteristics associated with virus spreads cause irreparable disorders for all humanity. Globalization promotes a more intense circulation of people worldwide, and therefore the spread of viruses tends to increase. Traditional treatments through vaccines or drugs may not efficiently control the spread of infectious diseases. So, these treatments have become less and less efficient. Nanoscience can be considered one of the most significant discoveries of humanity in recent times. The nanotechnologies makes it possible to solve humanity’s problems because of the lack of efficient traditional technologies. From prevention, diagnosis, treatment to vaccine production, this chapter presents an overview based on nanotechnological concepts and applications, focusing on viral infections causing hepatitis and influenza. With advances in studies associated with nanotechnological protocols, it will be possible to use nanotechnologies to combat the spread of these viruses. This chapter discusses the role of nanotechnology in the diagnosis, treatment, and development of vaccines of these viral diseases. Nanotechnology could be a great ally for a new way to fight these viruses and treat these diseases. © 2022 Elsevier Inc. All rights reserved.

12.
Nanotechnological Applications in Virology ; : 79-111, 2022.
Article in English | Scopus | ID: covidwho-2035629

ABSTRACT

The concept of masks and sanitizers has become an essential requirement that has been comprehensively used as a first line of defense toward numerous disease-causing viruses, bacterial agents, or environmental pollutants. However, conventional masks lack adequate capacity to provide full protection against certain bacterial and viral particles. Sanitizers have been an additional line of support that prevents the spread of bacteria or viruses. Thus, masks and sanitizers have been used together to protect oneself and others from disease-causing agents. Various types of masks and hand sanitizers have been developed by various research groups across the world for commercial application as an important personal protective covering. Masks and sanitizers developed in the last 2years have been exclusively used for protection against COVID-19 virus. There have been several types of masks fabricated with various levels of protection. Nanomaterial-based masks have been exclusively researched for their superior protection and to combat any viral particles. The efficacy of sanitizers and other disinfectants is based on their ability to reduce contamination levels. This chapter gives an overview on nanomasks and sanitizers that have been developed lately for self-hygiene and self-protection purposes and the advanced nanomaterials used in the fabrication and manufacturing of nanomasks and sanitizers. © 2022 Elsevier Inc. All rights reserved.

13.
Nanotechnological Applications in Virology ; : 57-77, 2022.
Article in English | Scopus | ID: covidwho-2035628

ABSTRACT

The outbreak of COVID-19 has raised a worldwide need for effective measures to break the transmission chain of the virus and limit its R number to prevent the spread. Various preventive measures include vaccination, face masks, sanitizers and disinfectants, social distancing, and lockdown. However, face masks are the most critical public health preventive measure to combat various viruses and pathogens due to their airborne nature. Touted as a game-changing technology, nanotechnology has shown immense potential in research and development related to face masks. The inclusion of nanomaterials in the mask has addressed various problems related to bulk materials based on conventional masks, including the efficiency of filtering virus and pathogens, retaining of viruses over the mask surface, breathing and other respiratory issues, facial skin problems, and disposal-related issues. This chapter illustrates the use of various nanotechnology-based materials, including graphene, nanoparticles, nanofibers, nano-membranes, and nanocomposites, to fabricate nano-masks. It also focuses on the advantages of nano-masks over conventional masks based on bulk materials. Further, prospects and suggestions for limiting nano-waste due to nanomaterials in textiles have also been proposed. © 2022 Elsevier Inc. All rights reserved.

14.
Nanotechnological Applications in Virology ; : 1-12, 2022.
Article in English | Scopus | ID: covidwho-2035626

ABSTRACT

Nanotechnology is the recent emerging technology in the field of therapeutics and diagnostics. Nanomaterials play a crucial role in diagnosis, drug delivery, drug formulations, and therapy to overcome several life-threatening diseases like diabetes, cancer, bacterial and fungal infections, neurodegenerative diseases, and AIDS. Viruses and viral infections are problematic due to their wide-spreading nature and also the ability to sustain the development through genetic mutation. In the last few decades, the cases of viral infections have severely increased including SARS severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS), Nipah virus, Zika virus, dengue fever, and the recent global pandemic COVID-19. These episodes of viral epidemics have emerged unexpectedly and caused substantial damage to the social and economic structure of society. Due to the high mortality rate and global transmission capacity viral infections need immediate attention for the development of detection, treatment, and vaccination techniques. Nanoparticles due to their unique properties and smaller size offer a plethora of opportunities in the field of medical innovations. Nanotechnology-based therapeutic approaches and their drug delivery potential can essentially help in the diagnosis and therapy of virus-related infections. In the present chapter, we provide an overview of virus-related infections and nanotechnology-based solutions for the detection, drug delivery, and treatment of virus infections have been discussed. © 2022 Elsevier Inc. All rights reserved.

15.
Biosens Bioelectron X ; 12: 100222, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2031164

ABSTRACT

We report two novel genosensors for the quantification of SARS-CoV-2 nucleic acid using glassy carbon electrodes modified with a biocapture nanoplatform made of multi-walled carbon nanotubes (MWCNTs) non-covalently functionalized with avidin (Av) as a support of the biotinylated-DNA probes. One of the genosensors was based on impedimetric transduction offering a non-labelled and non-amplified detection of SARS-CoV-2 nucleic acid through the increment of [Fe(CN)6]3-/4- charge transfer resistance. This biosensor presented an excellent analytical performance, with a linear range of 1.0 × 10-18 M - 1.0 × 10-11 M, a sensitivity of (5.8 ± 0.6) x 102 Ω M-1 (r2 = 0.994), detection and quantification limits of 0.33 aM and 1.0 aM, respectively; and reproducibilities of 5.4% for 1.0 × 10-15 M target using the same MWCNTs-Av-bDNAp nanoplatform, and 6.9% for 1.0 × 10-15 M target using 3 different nanoplatforms. The other genosensor was based on a sandwich hybridization scheme and amperometric transduction using the streptavidin(Strep)-biotinylated horseradish peroxidase (bHRP)/hydrogen peroxide/hydroquinone (HQ) system. This genosensor allowed an extremely sensitive quantification of the SARS-CoV-2 nucleic acid, with a linear range of 1.0 × 10-20 M - 1.0 × 10-17 M, detection limit at zM level, and a reproducibility of 11% for genosensors prepared with the same MWCNTs-Av-bDNAp1 nanoplatform. As a proof-of-concept, and considering the extremely high sensitivity, the genosensor was challenged with highly diluted samples obtained from SARS-CoV-2 RNA PCR amplification.

16.
2nd International Conference on Medical Imaging and Additive Manufacturing, ICMIAM 2022 ; 12179, 2022.
Article in English | Scopus | ID: covidwho-2029448

ABSTRACT

Plasmonic nanobiosensors have an enormous application range. It has the capacity to detect a wide variety of substances including metal, protein and even nucleic acids due to the superiority of SPR and LSPR. Plasmonic biosensors have been widely applied in the field of disease diagnosis, environmental conservation and food safety, eliminating barriers of traditional diagnosis methods and providing sensitive, quick and label-free devices. The applications of plasmonic biosensors in detection of many concerned diseases like cancer and SARS-CoV-2 are making an improvement on our medical condition. In the field of environmental protection, plasmonic-based biosensors also show great potential. They can efficiently detect two main types of contaminants, inorganic heavy metals involving Pb, Cd, As and Hg, and organic pollutants like polycyclic aromatic hydrocarbons (PAHs). Plasmonic biosensors could also overcome challenges on food allergen detection. This paper mainly focusses on SPR and LSPR-based nanobiosensors' application in environmental protection, food safety and health-care. © 2022 SPIE. Downloading of the is permitted for personal use only.

17.
Sustainability ; 14(16):10391, 2022.
Article in English | ProQuest Central | ID: covidwho-2024162

ABSTRACT

The increasingly fierce competition in food trends requires producers to innovate and develop new foods to be accepted and to avoid neophobia by consumers at the same time. Food neophobia’s motivational adoption barriers include the consumption of novel foods, social norms and conflicting eating goals. Therefore, appropriate strategies are needed to avoid neophobia amid the presence of new food trends in the market. Efforts to avoid food neophobia can also be accepted as part of the sustainability concept, in which the consumer has new foods to choose from in order to reduce scarcity in one particular type of food. The food industry is also challenged to produce healthy food by producing food from natural ingredients. In this article, new food trends and advances in food processing are described, and through them, strategies to avoid neophobia and increase consumer acceptance of new food trends are referenced. Neophobia meets marketing food products delivered to consumers facing motivational adoption barriers, such as the consumption of novel foods, social norms and conflicting eating goals, which are indicated to be challenges to purchase drivers in new food trends. Tasting foods is indicated as one of the most efficient means to ensure neophobia reduction in new foods and new food trends. Other factors identified to reduce food neophobia are education, income, taste and exposure to novel foods. Some preconditions for novel foods to be accepted by consumers are related to the very nature of food innovation, the manufacturer’s features and market circumstances. Food processed with advanced technologies may differ depending on the brand of the food production company and the knowledge of consumers about the novel foods. Moreover, food technology is seen as more acceptable for plant food products based or natural ingredients for consumers. In addition to the focus on health benefits, it is supports the sustainability of food systems. Another accidental element is the transparent traceability system providing accurate and adequate information about such novel foods.

18.
Chemosensors ; 10(8):299, 2022.
Article in English | ProQuest Central | ID: covidwho-2023203

ABSTRACT

The rapid and selective detection of bacterial contaminations and bacterial infections in a non-laboratory setting using advanced sensing materials holds the promise to enable robust point-of-care tests and rapid diagnostics for applications in the medical field as well as food safety. Among the various possible analytes, bacterial enzymes have been targeted successfully in various sensing formats. In this current work, we focus on the systematic investigation of the role of surface area on the sensitivity in micro- and nanostructured autonomously reporting sensing hydrogel materials for the detection of bacterial enzymes. The colorimetric sensing materials for the detection of β-glucuronidase (ß-GUS) from Escherichia coli (E. coli) were fabricated by template replication of crosslinked pullulan acetoacetate (PUAA) and by electrospinning chitosan/polyethylene oxide nanofibers (CS/PEO NFs), both equipped with the chromogenic substrate 5-bromo-4-chloro-3-indolyl-β-D-glucuronide. The investigation of the dependence of the initial reaction rates on surface area unveiled a linear relationship of rate and thereby time to observe a signal for a given concentration of bacterial enzyme. This knowledge was exploited in nanoscale sensing materials made of CS/PEO NFs with diameters of 295 ± 100 nm. Compared to bulk hydrogel slabs, the rate of hydrolysis was significantly enhanced in NFs when exposed to bacteria suspension cultures and thus ensuring a rapid detection of living E. coli that produces the enzyme β-GUS. The findings afford generalized design principles for the improvement of known and novel sensing materials towards rapid detection of bacteria by nanostructuring in medical and food related settings.

19.
Polymers (Basel) ; 14(16)2022 Aug 16.
Article in English | MEDLINE | ID: covidwho-2024010

ABSTRACT

The tendon, as a compact connective tissue, is difficult to treat after an acute laceration or chronic degeneration. Gene-based therapy is a highly efficient strategy for diverse diseases which has been increasingly applied in tendons in recent years. As technology improves by leaps and bounds, a wide variety of non-viral vectors have been manufactured that attempt to have high biosecurity and transfection efficiency, considered to be a promising treatment modality. In this review, we examine the unwanted biological barriers, the categories of applicable genes, and the introduction and comparison of non-viral vectors. We focus on lipid-based nanoparticles and polymer-based nanoparticles, differentiating between them based on their combination with diverse chemical modifications and scaffolds.

20.
IOP Conference Series. Earth and Environmental Science ; 1056(1):012015, 2022.
Article in English | ProQuest Central | ID: covidwho-2017611

ABSTRACT

Resilient buildings have become a widely researched topic in the engineering discipline. A building has enabled connectivity between building systems, including air conditioning, ventilation, safety and security system. They are even more important with growing pandemic risks and the spread of airborne viruses such as Covid-19. The literature indicates that nanotechnology applications can have a great role in the designing resilient office buildings. Nanotechnologies play a major role in architectural design;building materials combined with nanotechnology became smaller, lighter, and more efficient than conventional materials. Thus, this research aims to develop design guidelines for resilient office buildings in Egypt using nanotechnology applications. The methodology applied includes a review on nanotechnology and resilient office buildings key design features, following a simulation using design builder program where conducted to modify the nanomaterials in resilient office buildings recorded through quantified data. After applying the nanotechnology concept on walls, the roof and glazing types by inserting nanomaterials. The research concluded that the use of vacuum insulation panel, Nano-gel glass and Nano-painting had the highest impact on decreasing the total energy consumption by 14.5% and carbon dioxide emissions by 42%.

SELECTION OF CITATIONS
SEARCH DETAIL