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1.
Journal of Drug Delivery and Therapeutics ; 12(4-s):101-111, 2022.
Article in English | CAB Abstracts | ID: covidwho-2056786

ABSTRACT

In-silico Computer-Aided Drug Design (CADD) often comprehends virtual screening (VS) of datasets of natural pharmaco-active compounds for drug discovery protocols. Plant Based Natural Products (PBNPs) still, remains to be a prime source of pharmaco-active compounds due to their unique chemical structural scaffolds and functionalities with distinct chemical characteristic feature from natural source that are much acquiescent to drug metabolism and kinetics. In the Post-COVID-Era number of publications pertaining to PBNPs and publicly accessible plant based natural product databases (PBNPDBs) has significantly increased. Moreover, PBNPs are important sources of inspiration or starting points to develop novel therapeutic agents. However, a well-structured, indepth ADME/Tox profile of PBNPs has been limited or lacking for many of such compounds, this hampers the successful exploitation of PBNPs by pharma industries. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties play key roles in the discovery/ development of drugs, pesticides, food additives, consumer products, and industrial chemicals. In the present study, ADMET-informatics of Tetradecanoic Acid (Myristic Acid) from ethyl acetate fraction of Moringa oleifera leaves to predict drug metabolism and pharmacokinetics (DMPK) outcomes has been taken up. This work contributes to the deeper understanding of Myristic acid as major source of drug from commonly available medicinal plant - Moringa oleifera with immense therapeutic potential. The data generated herein could be useful for NP based lead generation programs.

2.
African Journal of Infectious Diseases ; 16(2):80-96, 2022.
Article in English | CAB Abstracts | ID: covidwho-2056737

ABSTRACT

Background: The 2'-O-methyltransferase is responsible for the capping of SARS-CoV-2 mRNA and consequently the evasion of the host's immune system. This study aims at identifying prospective natural inhibitors of the active site of SARS-CoV-2 2'O-methyltransferase (2'-OMT) through an in silico approach. Materials and Method: The target was docked against a library of natural compounds obtained from edible African plants using PyRx - virtual screening software. The antiviral agent, Dolutegravir which has a binding affinity score of -8.5 kcal mol-1 with the SARS-CoV-2 2'-OMT was used as a standard. Compounds were screened for bioavailability through the SWISSADME web server using their molecular descriptors. Screenings for pharmacokinetic properties and bioactivity were performed with PKCSM and Molinspiration web servers respectively. The PLIP and Fpocket webservers were used for the binding site analyses. The Galaxy webserver was used for simulating the time-resolved motions of the apo and holo forms of the target while the MDWeb web server was used for the analyses of the trajectory data.

3.
Journal of Xinyang Normal University Natural Science Edition ; 33(2):210-219, 2020.
Article in Chinese | CAB Abstracts | ID: covidwho-2055548

ABSTRACT

ADMEN prediction was used to perform the first round screening from Traditional Chinese Medicine Database and Analysis Platform(TCMSP). then VASARA and molecular docking were used to screen again based on targets spike glyoprotein and angiotensin converting enzyme 2. and finally the interaction between target and drug was analyzed. 425 candidate ingredients of traditional Chinese medicine were screened from TCMSP database. when targeted by Spike glycoprotein. 12 ingredients were screened. They were contained artemisia apiacea salvia miltiorrhiza bge. scutellaria baicalensis. pinellia ternate. liquorice. radixImplettri and other traditional Chinese medicine. With ACE2 as the target. 77 components of traditional Chinese medicine were screened out. including salvia miltiorrhiza bge scutellaria baicalensis. pinellia ternatc. Liquorice. radix bupleuri. ephedra and other traditional Chinese medicine. At last. salviolone and dihydrotanshinlactone were found to be the potential inhibitor.

4.
Journal of Drug and Alcohol Research ; 10(236120(2), 2021.
Article in English | CAB Abstracts | ID: covidwho-2045354

ABSTRACT

COVID-19 is an infectious disease caused by a newly discovered CORONAVIRUS. It's a type of Severe Acute Respiratory Syndrome. The symptoms of SARS-nCOV-2 cause dry cough, fever, Tiredness, and difficulty of breathing (severe cases). We can cure the symptoms and defects of the whole body (vata, pitta, kapha) caused by the system and its qualitative therapists.

5.
Indian Coconut Journal ; 64(7):23-26, 2022.
Article in English | CAB Abstracts | ID: covidwho-2045305

ABSTRACT

Monolaurin and lauric acid (C12) have demonstrated considerable viral activity. Lauric acid is a medium-chain fatty acid that accounts for around 50% of coconut oil;monolaurin is a metabolite produced by the body's enzymes after ingestion of coconut oil and is available as a supplement. Sodium lauryl sulfate, a lauric acid-based surfactant, exhibits antiviral properties. Several antiviral products contain lauric acid, monolaurin, and sodium lauryl sulfate (also known as sodium dodecyl sulfate). This article summarizes the 3 mechanisms proposed to explain the antiviral activity of lauric acid and monolaurin: first, they cause virus envelope disintegration;second, they can inhibit late maturation in the virus replication cycle;and third, they can prevent viral proteins from binding to the host cell membrane. This article also discusses several in vitro, animal, and human research that support the potential of coconut oil, lauric acid, and its derivatives.

6.
Journal of Henan Normal University Natural Science Edition ; 49(4):206-211, 2022.
Article in Chinese | CAB Abstracts | ID: covidwho-2040773

ABSTRACT

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease-19 (COVID-19), has become a global health issue. Spike proteins from the virus have a vital role in infection. Herbal medicines such as Lagerstroemia, Euphorbia hirta, and Kleinhovia hospita have several pharmacological functions such as anticancer, antiviral, and antioxidant because of their bioactive compound content. Based on an in silico study, this research was conducted on the possibility of phytochemicals from herbal Lagerstroemia, E. hirta, and K. hospita to inhibit spike protein SARS-CoV-2. A three-dimensional (3D) compound structure of each herbal medicine was docked with HR protein using AutoDock Vina software. The docking result, which has the best binding energy value, is continued with the analysis of molecular dynamics simulation. Lagerine, rutin, and nicotiflorin compounds might bind to proteins with lower binding energy. Protein was unstable when complexed with compounds compared with control, as seen from the root-mean-square deviation (RMSD) value. Therefore, this research is pre-experimental to inhibit SARS-CoV-2 spike proteins by herbal medicines.

7.
Postepy Fitoterapii ; 1:23-32, 2022.
Article in Polish | CAB Abstracts | ID: covidwho-2040622

ABSTRACT

COVID-19 is a disease caused by the SARS-CoV-2 virus, multi-organ, with a wide spectrum of symptoms, the most common being pneumonia with fever, dry cough and shortness of breath. There are more and more reports of persistent long-term effects, especially after acute disease. Regardless of the way the virus enters the brain, it attacks neurons, contributing to neurological complications. The main symptoms of the central and peripheral nervous system are dizziness and headaches, impaired consciousness, sometimes acute ischemic stroke and intracranial hemorrhages, loss of taste and smell, visual disturbances, neuralgia and skeletal muscle damage. After recovery, patients experience symptoms such as persistent fatigue, diffuse muscle aches, symptoms of depression, non-renewable sleep, tinnitus, and erectile dysfunction. Early intervention and supportive care at the end of the acute phase of COVID-19 could alleviate the symptoms of the disease as well as prevent their long-term consequences. Taking into account plant raw materials, the standardized extract of Ginkgo leaves (Ginkgo biloba) may be useful at various stages of the disease: it prevents the penetration of the virus into the host cells, has anti-inflammatory, antioxidant and antithrombotic properties, and above all, it is the only plant material with proven neuroprotective and neuroregulatory properties, widely used in the treatment of Alzheimer's, Parkinson's and other diseases and disorders related to the nervous system.

8.
Pakistan Journal of Science ; 73(5):539-545, 2021.
Article in English | CAB Abstracts | ID: covidwho-2034337

ABSTRACT

In this study eco-friendly antimicrobial finish was developed by Azadirachata indica, Butea monosperma and Litchi chinensis and then applied on 100% silk fabric. The effectiveness of antimicrobial finish was checked up to 25 washes. The antimicrobial finish was extracted from leaves of these plants and applied on silk fabric by using pad dry cure method. It is true experimental study with pre-test and post-test control group design. FTIR and SEM tests were used to observe the presence of antimicrobial finish on silk fabric. The antimicrobial finish was fixed on silk fabric by the use of poly urethane binder. The antimicrobial activity of treated and untreated fabric and durability to successive washes were assessed by using ASTEM E2149 shake flask method. The treated fabric with A. indica and B.monosperme showed 100% reduction in microorganism presence while L. chinensis revealed 60% reduction against microorganisms. The antimicrobial finish showed 100% reduction after successive laundring up to 25 washes. This fabric is beneficial for home furnishing, sportswear and footwear industry as well as in apparel sector such as in formal wear and making matching face mask against COVID-19 pandemic.

9.
Aroma Research ; 21(4):316-325, 2020.
Article in Japanese | CAB Abstracts | ID: covidwho-2034173

ABSTRACT

Stress such as uncertainty about the future, including the problem of new coronavirus infection, is a very serious problem not only for physical health but also for mental health. It is certain that stress is one of the risk factors for developing mental disorders. We have found stress-responsive biomarker (stress marker) candidates through studies on the process from stress to disease onset. Recently, we have been trying to prove the stress-suppressing effect of aroma with brain factors. We analyzed how aroma affects behavioral changes due to stress and the expression of stress marker candidates in the brain. In this article, the data on aroma that we have accumulated so far will be introduced. Specifically, we will describe changes happened in experimental animals when they smelled coffee beans, lavender, cypress, a-pinene, and thyme linalool. When considering the biological effects of aroma, it is inevitable that not only the olfactory pathway but also odor molecules act through the bloodstream by nasal and transdermal absorption. The brain transferability of odor molecules may be a bottleneck in analyzing the biological effects of volatile components. Thus, we would like to discuss on this issue.

10.
MENA RP Working Paper 2021. (37):v + 36 pp. many ref. ; 2021.
Article in English | CAB Abstracts | ID: covidwho-2022487

ABSTRACT

The Egyptian government has prioritized the idea of cluster-based development-that is, the geographic concentration of specialized firms, such as in this case, those producing similar or related products. The establishment of such clusters, however, presents significant challenges, bottlenecks, and obstacles. Based on primary field work, this paper focuses on two case studies of the impacts of shocks on business clusters. The first study involved the relocation of an established leather cluster from Cairo to a newly created industrial park, Robbiki Leather City, which was promoted by Egypt's Ministry of Trade and Industry. Although the relocation partly solved the existing issues of water contamination, new challenges emerged relating to increased production and transportation costs, and unforeseen impacts on the community. The second study assessed the short-term impact of the COVID-19 pandemic on a business cluster producing medicinal and aromatic plants. Overall the MAPs sector was resilient to the outbreak and there are opportunities to offset any negative impacts of the pandemic by taking advantage of new markets for Egyptian MAPs stemming from supply disruptions in other countries;increased global demand for MAPs due to their pharmacological and health properties;and increased international demand for organically grown MAPs. Findings indicate that it is essential for governments to develop policy responses to the challenges - and especially barriers - to the development of business clusters, while simultaneously supporting and creating incentives for the cooperation, entrepreneurship, and collective action needed for business clusters to thrive and grow. As anticipated, challenges and obstacles - whether overarching or in response to shocks - are unique to specific sectors, contexts, and times, and hence need to be dealt with as an ongoing facilitation process.

11.
Genetics & Applications ; 5(2):1-9, 2021.
Article in English | CAB Abstracts | ID: covidwho-1994923

ABSTRACT

The genus Artemisia (fam. Asteraceae) is one of the largest and widely distributed with around 500 species, majority used as aromatic and medicinal plants. Artemisia annua L. is widely used as a dietary spice, herbal tea, as a supplement, and in a non-pharmaceutical form for treatment of malaria and fever. It is orally consumed as capsules, extracts and tinctures and topically applied as an essential oil diluted in lotions and ointments. Artemisinin is the main constituent of Artemisia annua L. extracts. Since the discovery that the artemisinin is efficient in malaria treatment, there is also a growth in consumption of A. annua extracts for antitumour and even recently for antiviral treatments against SARS-CoV-2 infections. This study aimed to investigate genotoxic effect in peripheral blood culture and cytotoxic effects in cancer and normal cell lines, of commercially available A. annua L. tincture in series of dilutions. Both comet and neutral red uptake assays revealed dose-dependent genotoxicity and cytotoxicity of A. annua tincture dilutions. Comet assay revealed significantly increased DNA damage in peripheral blood cells while neutral-red assays showed increase in cytotoxicity (p<0.001) in both normal and cancer cell cultures treated with the lowest extract dilution compared to the highest one applied. Obtained results indicate caution needed in A. annua L. tincture use, especially when poorly diluted.

12.
Plant Archives ; 22(1):288-296, 2022.
Article in English | CAB Abstracts | ID: covidwho-1935065

ABSTRACT

For the past two years, the globe has been in deep despair as a result of the fast spread of the new Coronavirus, SARS CoV-2, and several of its variations such as Delta, Omicron, and others. This pandemic has caused widespread rumours and misconceptions, wreaking havoc on the worldwide health-care system. Due to the periodic outbreaks of this infectious disease, along with the administration of effective antiviral vaccines and adherence to mandatory government protocols, every human being's recourse has been to strengthen their immunity to resist this infectious disease using kitchen ingredients like herbs and spices with medicinal properties and other home remedies. The results showed that there was a significant rise in the usage of kitchen pharmacy and the application of traditional knowledge, compared to the pre-pandemic times, owing to its immunity boosting properties. Along with increase in usage of kitchen pharmacy, there was also a surge observed in usage of ayurveda, other home remedies and yoga, in comparison with allopathy. The statistical analysis showed that 40.9% of the respondents showed marked recovery after the continual usage of home remedies.

13.
Menara Perkebunan ; 90(1):11-22, 2022.
Article in Indonesian | CAB Abstracts | ID: covidwho-1934873

ABSTRACT

The SARS-CoV-2 virus is a virus that emerged in late 2019 and has yet to find a cure. On the other hand, the incidence of cervical cancer in women continues to increase along with the emergence of cases of COVID-19 caused by SARS-CoV-2. Based on WHO data in 2020 stated that there were 107 per 72,314 cancer patients infected with SARS-CoV-2. Meniran (Phyllanthus niruri L.) is a herbaceous plant in Indonesia that has secondary metabolites derived from the tannin group, such as corilagin. This compound has the potential to be developed as an antiviral and anticancer agent. Thus, the purpose of this study was to determine the potential of corilagin in meniran herbs to act as an antiviral SARS-CoV-2 and cervical anticancer compared to the drug compounds molnupiravir and paclitaxel through the STITCH & STRING bioinformatics in silico test and molecular docking method. The results of the bioinformatics test of corilagin against the SARS-CoV-2 virus showed predictions of high protein binding to AGTR2 and ENPEP with a docking score of -10.9 and -9.9 kcal/mol, respectively. Meanwhile, cervical cancer cells showed the highest predicted protein binding to IL-10 and MAPK3 with a docking score of -10.5 and -10.8 kcal/mol. The docking score of molnupiravir against the COVID-19 virus protein, AGTR2, and ENPEP were -7.4 and -7.2 kcal/mol, respectively. The docking scores of paclitaxel for IL10 and MAPK3 were -8.2 and -8.9 kcal/mol, respectively. These values indicate that the activity of corilagin with proteins AGTR2, ENPEP, IL10, and MAPK3 has stronger affinity energy than the comparison drugs molnupiravir and paclitaxel. Thus, the corilagin compound from the tannin group in meniran (Phyllanthus niruri L.) has the potential to be developed and formulated as a treatment and prevention of SARS-CoV-2 antiviral and cervical anticancer.

14.
Veterinary Integrative Sciences ; 20(2):419-430, 2022.
Article in English | CAB Abstracts | ID: covidwho-1934647

ABSTRACT

During COVID-19 outbreak, alcohol-based hand sanitizer (ABHS) has been widely used for hand cleaning and removing pathogens including human pathogens and zoonosis pathogens. High concentration of alcohol induces dehydrated skin in the users. Therefore, the objective of this study was to investigate moisturizing property and antimicrobial activity of alcohol-based hand sanitizer formulations using coconut oil as a moisturizing agent against pathogens including Escherichia coli and Staphylococcus aureus. The properties including antimicrobial activity, stability of the ABHS, and satisfaction levels of the coconut oil with two existing formulations by WHO and the Ministry of Public Health of Thailand (MOPH) were determined. The formulation containing the coconut oil demonstrated antibacterial activity against both E. coli and S. aureus with the minimal inhibitory concentration (MIC) of 8.75% V/V as same as MOPH. However, the WHO-modified formulation has the highest antimicrobial activity with the MIC value of 2.19% V/V. The stability result of 3 ABHSs showed that the preserved had the same efficacy compared to that of the fresh formulations. Hand washing with coconut formulation produced an average score of 7.19+or-1.71 on color, 7.06+or-1.56 on appearance, 5.82+or-2.10 on odor, 6.77+or-1.68 on moisture, 6.88+or-1.42 on overall acceptance out of 9. However, the sensory analysis of these three formulations results showed no significant difference in all parameters. The data suggest that moisturizing agents tested in our study do not affect the efficacy of ethanol. The coconut oil formulation is another good option for people searching for an effective hand sanitizer for germs protection and moisturizing.

15.
Revista Cubana de Plantas Medicinales ; 27(1), 2022.
Article in Spanish | CAB Abstracts | ID: covidwho-1929327

ABSTRACT

Introduction: The world has been suffering from the SARS-CoV-2 (COVID-19) pandemic since December 2019. To date there is no specific treatment for such a deadly disease, but there are some plants with different phytochemical components that help the body to combat and reduce the sequelae along with the other treatments.

16.
Northwest Pharmaceutical Journal ; 37(1):168-171, 2022.
Article in Chinese | CAB Abstracts | ID: covidwho-1918649

ABSTRACT

Objective To summarize and analyze the susceptible constitution of coronavirus disease 19(COVID-19), put forward the diet prescription of traditional Chinese medicine for prevention based on the thought of treating non-disease and the theory of constitution, and to provide reference for COVID-19's prevention. Methods The relevant literatures in the past 5 years were reviewed, and the current situation of COVID-19's clinical manifestations, etiology, pathogenesis, disease location, disease transmission, susceptible physique, physique differentiation and prevention were summarized. Results The symptoms of COVID-19 were similar in the initial stage of infection, which was caused by damp pathogen. People with different physique were different in susceptibility to COVID-19 and the development and outcome of syndrome type after infection. The susceptible constitution was phlegm-dampness, dampness-heat, Qi deficiency and yang deficiency, blood stasis and Qi depression. Invigorating vital Qi, dispelling dampness, and nourishing lung are the basic treatment principles. Combined with physical differences and dialectical prevention, tonifying, invigorating spleen and stomach, and aromatic dampness-transforming drugs are major drugs, which are supplemented by drugs for promoting lung-Qi. Conclusion The formulation of preventive prescriptions of traditional Chinese medicine according to different physique can provide some guidance for the clinical prevention of COVID-19.

17.
Louisiana Agriculture ; 64:3, 2021.
Article in English | CAB Abstracts | ID: covidwho-1918553

ABSTRACT

The COVID-19 pandemic presented many challenges for the LSU AgCenter 4-H program. To meet social distancing guidelines and ensure the safety of youth and agents, many of programming efforts transitioned to a virtual format. However, the need remained for hands-on learning opportunities. 4-H programming is driven by the motto "learn by doing", and it was paramount that agents provide purposeful and engaging activities. The 4-H Seed-of-the-Month Club is a project club that emerged to meet that need. Agents created a nine-month seed subscription made available to youth across the region beginning in August 2020. With this project, participating youth were provided seeds of various plants, including pine seedlings, rainbow carrots, easter egg radishes, lettuce, green beans, okra, squash and coneflowers. Agents used the LSU AgCenter Louisiana planting guide to select the seeds to offer each month. In the future, agents and youth alike have expressed an interest in continuing to provide horticulture opportunities through the delivery mode of the Seed-of-the-Month Club. Participants were asked to provide top choices for their gardens by receiving carrots, lettuce and green bean seeds for the future.

18.
International Journal of Life Sciences ; 9(Special Issue):3-46, 2021.
Article in English | CAB Abstracts | ID: covidwho-1918440

ABSTRACT

This special issue consists of 4 research articles and 2 review articles on the spread and transmission of COVID-19 in India as well as the available treatment options for this disease.

19.
Journal of Agricultural Extension ; 26(1 (Annual Conference):31-40, 2022.
Article in English | CAB Abstracts | ID: covidwho-1911912

ABSTRACT

This study investigated the impact of the COVID-19 pandemic on agro-inputs distribution and sales along the agricultural supply chain (ASC) in gun State, Nigeria. A simple random sampling technique was used to select 96 agro-dealers from the Abeokuta and Ilaro ADP zones of Ogun State. Data were collected and analysed using a computer assisted personalized interviewing (CAPI) system. Findings showed that 89% of the respondents sold agro-inputs in the shops, 26% in the rural villages, and 19.8% at market stands. Due to the lockdown, 68.8% closed down shops for 35-39 days, 92.7% found it difficult to move agroinputs from the stores to the villages, and 85.4% incurred high costs in transporting agroinputs from urban to the rural areas. Likewise, 61.5% reported low patronage of fewer than 10 customers per week while the average weekly sales dropped from 60,000 to 15,600 for maize seeds, 78,000 to 27,000 for herbicides, and 336,000 to 120,000 for fertilizers. The lockdown was significantly affected patronage (beta = 0.64) and sales (beta = 0.72). The COVID19 pandemic affected patronage and sales of agro-inputs in Ogun State.

20.
Natural Product Communications ; 17(6), 2022.
Article in English | CAB Abstracts | ID: covidwho-1909973

ABSTRACT

The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is causing coronavirus disease 2019 (COVID-19) pandemic. Ancient Chinese herbal formulas are effective for diseases caused by viral infection, and their effects on COVID-19 are currently being examined. To directly evaluate the role of Chinese herbs in inhibiting replication of SARS-CoV-2, we investigated how the phytochemicals from Chinese herbs interact with the viral RNA-dependent RNA polymerase (RdRP). Total 1025 compounds were screened, and then 181compounds were selected for molecular docking analysis. Four phytochemicals licorice glycoside E, diisooctyl phthalate, (-)-medicocarpin, and glycyroside showed good binding affinity with RdRp. The best complex licorice glycoside E/RdRp forms 3 hydrogen bonds, 4 hydrophobic interactions, 1 pair of Pi-cation/stacking, and 4 salt bridges. Furthermore, docking complexes licorice glycoside E/RdRp and diisooctyl phthalate/RdRp were optimized by molecular dynamics simulation to obtain the stable conformation. These studies indicate that they are promising as antivirals against SARS-CoV-2.

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