Overcoming Engineering Challenges to Enable Commercial-Scale mRNA Vaccine Manufacturing

Increasing production capacity may necessitate the facility to cater for higher hazardous area category (e.g., H-Occupancy) design features, such as specialized building construction and potential blast zones. [...]an assessment should cover: * Quantification of flammable material use for production steps, including buffer preparation and LNP storage * Equipment and facility cleaning strategies that contribute to the facility flammable materials inventory * Impact of HVAC design to avoid hazardous atmospheres (e.g., full fresh air), use of local exhaust ventilation (LEV) or fume hoods * Solvent distribution methods (e.g., closed solvent delivery and waste removal systems) * Location of solvent bulk storage outside of the processing area/ facility, and piping in what is necessary plus removing spent solvent in a timely manner (e.g., piped transfer to a waste tank for removal by a specialist contractor). At present, the process cannot be fully single-use, so thought needs to be put into the cleaning and sterilization processes, plus the analytical support infrastructure needed for reusable product-contact surfaces. [...]it is recommended that for each mRNA project, consideration is given to the following aspects to determine the link between the equipment available and the facility design: * Need for custom/proprietary equipment * Independent production rooms with "through-wall" buffer transfer through iris ports in from logistics corridor (Buffer Prep/Hold) * Room electrical classification needs versus process step. * Equipment selection versus electrical and fire code requirements * Benefits and limitations of implementing single-use technologies, given that the process will be hybrid (with stainless steel). [...]the limited capacity for outsourcing of supporting functions, such as facility environmental monitoring or product sterility testing, should be considered during concept design.

It's been a good pandemic for me': Working with coaching and psychotherapy clients, with a focus on clients with a diagnosis of pure obsessive compulsive disorder

Many of the coaching clients are high achievers and in most of the prepandemic sessions presented as confident, in control and professional. Their reasons for coaching were often focused on their desire to move to the next level, which called for them to identify their strengths and perceived weaknesses and take action to address the identified gaps in their skills and knowledge through the coaching or through further training. This chapter offers a 'good enough' experience for clients and so, during the pandemic, moved reluctantly to working via online platforms or telephone sessions, depending on the client's preference. During the pandemic it is encouraged to build in the time to take walks before and after online sessions and, when it became possible to do so, to start taking that coffee time again rather than going straight from an online psychotherapy session to online business. The client with a pure obsessive compulsive disorder (POCD) diagnosis also saw benefits to their being-in-the-world from the pandemic. POCD often manifests as intrusive, inappropriate and shameful thoughts on which the person will ruminate. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

Information technology & media sociology in a (still) pandemic world

The current period of disruptive social change is inextricably bound up with new means and modes of communication, information, and media streams. The Communication, Information Technologies & Media Sociology section of the American Sociological Association (CITAMS) locates these factors at the center of our collective interests, investigating them through a plethora of methods, theories, and empirical cases. Each year, CITAMS runs a special issue in ICS showcasing select works presented at the previous year's American Sociological Association conference and the affiliated Media Sociology preconference. Papers in the 2022 CITAMS Special Issue reflect a social context defined by a prolonged global pandemic and wrought by democratic uncertainty. Across these social circumstances, technology and media loom large. Simultaneously, everyday life continues and classic CITAMS scholarship sustains relevance for the ways people interact, construct identity, consume, and mobilize. All of this and more are contained in the pages of this year's Special Issue, from which readers can get a sense of what CITAMS has to offer and consider how their own work may fit within the broad CITAMS umbrella. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

Impact of Pandemic on Permanent Procedures

Conducting virtual audits, conducting effective virtual training, and enhancing communications with suppliers to ensure an uninterrupted supply chain are among the changes implemented to maintain operations, stay compliant, and continue manufacturing medically necessary products. The necessity for virtual audits was to allow companies and regulators to continue to evaluate the compliance stature of manufacturers while respecting stay-at-home and social distancing requirements that prevented in-person site audits. Some of these venues are free, and some require a registration fee. supply chain quality Enhanced communication with suppliers to ensure an uninterrupted supply chain has also become a priority during the pandemic.

Following Guidelines During a Crisis

The guidance states, "These preventative measures can include steps to prepare personnel such as: * "Educating employees on topics such as, in the case of a pandemic, personal hygiene (hand washing and coughing and sneezing etiquette), social distancing, and appropriate use of sick leave * "Encouraging employees to get immunized as appropriate by providing information on local vaccination services or by offering on-site vaccination services, if reasonable * "Providing information for and encouraging employees to develop family emergency preparedness plans * "Reviewing CGMP [current good manufacturing practice] regulations regarding appropriate sanitation practices and restriction of ill or sick employees from production areas (see 21 CFR [Code of Federal Regulations] 211.28)" (2). Examples include: * "Production equipment routine maintenance * "Utility system performance checks and maintenance (e.g., air temperature, lighting, compressed air) * "Environmental monitoring of facilities such as cell culture, harvesting, and purification rooms during production * "Stability testing for certain drug products and components * "Periodic examinations of data and of reserve samples" (2). EMA, Guidance on the Format of the Risk Management Plan (RMP) in the EU-in Integrated Format, EMA/164014/2018 Rev.2.0.1 accompanying GVP Module V Rev.2 Human Medicines Evaluation (EMA, 31 October 2018).

The Experiences of COVID-19 Patients in Intensive Care Units: A Qualitative Study.

This exploratory qualitative study explores the experiences of COVID-19 patients in intensive care units and after discharge. Semi- structured telephone interviews were conducted with 18 COVID-19 patients admitted to and discharged from intensive care units between March and September in 2020. The themes of this study were determined as "feelings about the illness and intensive care," "psychological and physical damages," "nurses' efforts and the importance of care.", and "protecting health and life". COVID-19 patients in intensive care units may experience permanent physical and psychological damages. The findings suggest that the first step in carrying out interventions in the intensive care units is to ensure that continuous communication with patients is maintained so that their orientation to the new circumstances can be achieved. Nursing interventions to patients missing their families can have compensated for the loss of family support and care during their critical illness.

Minor psychiatric disorders among nursing workers during the pandemic: a multicenter study / Distúrbios psíquicos menores entre trabalhadores de enfermagem durante a pandemia: estudo multicêntrico / Disturbios psíquicos menores en trabajadores de enfermería durante la pandemia: estudio multicéntrico

Resumo Objetivo Analisar os fatores associados à presença de Distúrbios Psíquicos Menores entre trabalhadores de enfermagem que atuam na pandemia da COVID-19. Métodos Estudo transversal multicêntrico, realizado em quatro instituições hospitalares, no Estado do Rio Grande do Sul, com 845 trabalhadores de enfermagem. Utilizou-se um formulário eletrônico composto por questões sociodemográficas, laborais, de condições de saúde e pelo Self-Reporting Questionnaire-20. Aplicaram-se testes de Mann-Whitney, Qui-Quadrado e Regressão de Poisson expressa na Razão de Prevalência (IC 95%). Resultados A prevalência de Distúrbios Psíquicos Menores (49,3%) foi associada ao aumento do consumo de álcool (RP = 1,2; IC95% = 1,1-1,4), não praticar atividade física (RP = 1,5; IC95% = 1,3-1,8), iniciar o uso de medicação na pandemia (RP = 1,5; IC95% = 1,3-1,7), não possuir um turno de trabalho fixo (RP = 1,4; IC95% = 1,1-1,9) e sentir medo frente à exposição ao risco de contaminação (RP = 1,2; IC95% = 1,1-1,3) Conclusão Na atual pandemia, os Distúrbios Psíquicos Menores mostram-se associados ao consumo de bebida alcoólica, falta de atividade física, uso de medicamento, turno de trabalho e medo de contaminar-se.

Resumen Objetivo Analizar los factores asociados con la presencia de disturbios psíquicos menores en trabajadores de enfermería que trabajan en la pandemia de COVID-19. Métodos Estudio transversal multicéntrico, realizado en cuatro instituciones hospitalarias, en el estado de Rio Grande do Sul, con 845 trabajadores del área de enfermería. Se utilizó un formulario electrónico compuesto por cuestiones sociodemográficas, laborales, de condiciones de salud y por el Self-Reporting Questionnaire-20. Se aplicaron las pruebas de Mann-Whitney, Ji Cuadrado y de Regresión de Poisson expresada en la Razón de Prevalencia (IC 95 %). Resultados La prevalencia de disturbios psíquicos menores (49,3 %) estuvo asociada al aumento del consumo de alcohol (RP = 1,2; IC95 % = 1,1-1,4), a no practicar actividades físicas (RP = 1,5; IC95 % = 1,3-1,8), al comiendo del uso de medicación durante la pandemia (RP = 1,5; IC95 % = 1,3-1,7), a no tener un turno de trabajo fijo (RP = 1,4; IC95 % = 1,1-1,9) y a sentir miedo frente a la exposición al riesgo de contaminación (RP = 1,2; IC95 % = 1,1-1,3) Conclusión En la actual pandemia, los disturbios psíquicos menores demostraron estar asociados al consumo de bebida alcohólica, falta de actividad física, uso de medicamentos, turnos de trabajo y miedo a contaminarse.

Abstract Objective To analyze the factors associated with the presence of minor psychiatric disorders among nursing workers working in the COVID-19 pandemic. Methods A multicenter cross-sectional study was conducted in four hospitals in the state of Rio Grande do Sul, Brazil, with 845 nursing workers. An electronic form composed of sociodemographic, labor, health conditions and Self-Reporting Questionnaire-20 was used. Mann-Whitney, chi-square and Poisson Regression tests, expressed in Prevalence Ratio (95% CI), were applied. Results The prevalence of minor psychiatric disorders (49.3%) was associated with increased alcohol consumption (PR = 1.2; 95% CI = 1.1-1.4), not practicing physical activity (PR = 1.5; 95% CI = 1.3-1.8), starting the use of medication in the pandemic (PR = 1.5; 95% CI = 1.3-1.7), not having a fixed work shift (PR = 1.4; 95% CI = 1.1-1.9) and feeling afraid of exposure to the risk of contamination (PR = 1.2; 95% CI = 1.1-1.3) Conclusion In the current pandemic, minor psychiatric disorders are associated with alcohol consumption, lack of physical activity, use of medication, work shift and fear of contamination.

Impact of COVID-19 on nursing work in emergency units / Impacto da COVID-19 no trabalho de enfermagem em unidades de urgência/emergência / Impacto del COVID-19 en el trabajo de enfermería en unidades de urgencia/emergencia

Resumo Objetivo Analisar o impacto da pandemia da Coronavirus Disease 2019 (COVID-19) no trabalho de enfermagem em unidades de urgência e emergência. Métodos Pesquisa de abordagem qualitativa realizada entre profissionais de enfermagem atuantes em unidades de urgência e emergência no estado do Rio de Janeiro, Brasil. Dados coletados via online por meio de formulário semiestruturado e submetidos à análise lexicográfica no software Interface de R pour Analyses Multidimensionnelles de Textes Et de Questionnaires (IRAMUTEQ). Resultados Participaram 31 profissionais de enfermagem. O aproveitamento do corpus textual foi de 94,9% mediante a geração de seis classes de segmentos de textos, que possibilitou identificar que os profissionais que atuam nessas unidades têm vivenciado sobrecarga no desenvolver laboral, dada a carga horária de trabalho exaustiva, bem como a falta de infraestrutura, de equipamentos de proteção e de recursos humanos. Ainda, evidenciaram-se desgastes físicos e mentais, com ênfase para o estresse e a exaustão, além do sentimento de medo pelo receio de contaminação. Conclusão A pandemia da COVID-19 promoveu impactos diretos no trabalho de enfermagem em unidades de urgência e emergência no que tange a aspectos relacionados a recursos humanos e materiais e infraestrutura, além da assistência prestada aos pacientes em condições graves.

Resumen Objetivo Analizar el impacto de la pandemia de Coronavirus Disease 2019 (COVID-19) en el trabajo de enfermería en unidades de urgencia y emergencia. Métodos Investigación de enfoque cualitativo realizada entre profesionales de enfermería que actúan en unidades de urgencia y emergencia en el estado de Rio de Janeiro, Brasil. Datos recopilados en línea a través de formulario semiestructurado y presentados para análisis lexicográfico en el software Interface de R pour Analyses Multidimensionnelles de Textes Et de Questionnaires (IRAMUTEQ). Resultados Participaron 31 profesionales de enfermería. El aprovechamiento del corpus textual fue del 94,9 % mediante la producción de seis clases de segmentos de textos, lo que posibilitó identificar que los profesionales que actúan en esas unidades han vivido una sobrecarga en el quehacer laboral, considerando la duración de la jornada de trabajo agotadora, como también la ausencia de infraestructura, de equipos de protección y de recursos humanos. Además, se evidenciaron desgastes físicos y mentales, con énfasis en el estrés y el agotamiento, además del sentimiento de miedo por el temor a la contaminación. Conclusión La pandemia de COVID-19 ocasionó impactos directos en el trabajo de enfermería en unidades de urgencia y emergencia en lo que se refiere a aspectos relacionados con recursos humanos y materiales y con la infraestructura, además de la atención brindada a los pacientes en condiciones graves.

Abstract Objective To analyze the impact of the Coronavirus Disease 2019 pandemic (COVID-19) on nursing work in emergency units. Methods A qualitative research conducted among nursing professionals operating in emergency units in the state of Rio de Janeiro, Brazil. Data collected online through a semi-structured form and submitted to lexicographic analysis in the software Interface de R pour Analyses Multidimensionnelles de Textes Et de Questionnaires (IRAMUTEQ). Results Thirty-one nursing professionals participated. The use of the text corpus accounted for 94.9%, through the generation of six classes of text segments, which made it possible to identify that professionals working in these units have experienced overload in developing work, given the exhausting workload, as well as the lack of infrastructure, protective equipment and human resources. Also, physical and mental exhaustion was evidenced, with emphasis on stress and exhaustion, in addition to the feeling of fear for fear of contamination. Conclusion The COVID-19 pandemic promoted direct impacts on nursing work in emergency units regarding aspects related to human and material resources and infrastructure, in addition to the care provided to patients in severe conditions.

Challenges for exercising health advocacy to hospitalized children during the COVID-19 pandemic / Challenges for exercising health advocacy to hospitalized children during the COVID-19 pandemic / Desafios para o exercício da advocacia em saúde à criança hospitalizada durante a pandemia COVID-19 / Desafíos para el ejercicio de la defensa en salud de niños hospitalizados durante la pandemia de COVID-19

Resumo Objetivo Analisar os desafios para o exercício da advocacia em saúde à criança hospitalizada durante a pandemia COVID-19. Métodos Estudo qualitativo descritivo-exploratório on-line. Participaram 28 profissionais de enfermagem matriculados na disciplina Enfermagem na Atenção à Saúde da Criança e do Adolescente em um Programa de pós-graduação de uma universidade federal do nordeste brasileiro. A coleta de dados ocorreu em junho de 2021 através de roda de conversa e entrevista coletiva. Como instrumentos utilizou-se: o formulário do google forms e roteiro semiestruturado. O estudo foi aprovado pelo Comitê de Ética em Pesquisa. Como método de análise, foi empregada a Análise Textual Discursiva (ATD). Para a organização dos dados, utilizou-se o software Atlas.ti 8.4.15 (Qualitative Research and Solutions). Resultados Emergiram duas categorias: 1) Impactos da pandemia para assistência e advocacia pediátrica, constatou-se o isolamento infantil e um cenário de atenção à saúde onde a criança foi colocada em segundo plano. 2) Barreiras existentes que se agravaram com a crise sanitária, identificou-se: sobrecarga de trabalho, precarização da estrutura e dificuldade nas condições de trabalho, que gerou violações nos direitos infantis e agravou o panorama de dificuldades na oferta de serviços pediátricos. Conclusão Os desafios para o exercício da advocacia em saúde à criança hospitalizada durante a pandemia, evidenciados pelos impactos e barreiras para a assistência, ampliaram o trabalho das equipes de saúde tornando o exercício da advocacia no cuidado pediátrico ainda mais dificultoso. Cabe repensar e ajustar políticas de acesso e atendimento após a pandemia para assegurar que o cuidado infantil não seja restringido.

Resumen Objetivo Analizar los desafíos para el ejercicio de la defensa en salud de niños hospitalizados durante la pandemia de COVID-19. Métodos Estudio cualitativo descriptivo exploratorio en línea. Participaron 28 profesionales de enfermería inscriptos en la asignatura Enfermería en Atención a la Salud del Niño y del Adolescente en un programa de posgrado de una universidad nacional del nordeste brasileño. La recopilación de datos ocurrió en junio de 2021 a través de rondas de conversación y entrevista colectiva. Como instrumentos se utilizaron: un formulario de google forms y un guion semiestructurado. El estudio fue aprobado por el Comité de Ética en Investigación. Como método de análisis, se utilizó el Análisis Textual Discursivo (ATD). Para la organización de los datos, se utilizó el software Atlas.ti 8.4.15 (Qualitative Research and Solutions). Resultados Surgieron dos categorías: 1) Impactos de la pandemia en la atención y en la defensa pediátrica, se verificó el aislamiento infantil y un escenario de atención en salud en la que el niño fue colocado en segundo plano. 2) Barreras existentes que se agravaron con la crisis sanitaria, se identificó: sobrecarga de trabajo, precarización de la estructura y dificultad en las condiciones de trabajo, lo que generó violaciones de los derechos infantiles y agravó el panorama de dificultades en la oferta de servicios pediátricos. Conclusión Los desafíos para el ejercicio de la defensa en salud de niños hospitalizados durante la pandemia, evidenciados por los impactos y barreras para la atención, ampliaron el trabajo de los equipos de salud, lo que dificultó aún más el ejercicio de la defensa del cuidado pediátrico. Cabe reflexionar y ajustar políticas de acceso y atención después de la pandemia para asegurar que no se restrinja el cuidado infantil.

Abstract Objective To analyze the challenges for exercising health advocacy to hospitalized children during the COVID-19 pandemic. Methods This is an online descriptive-exploratory qualitative study. Participants were 28 nursing professionals enrolled in the subject Nursing in Health Care for Children and Adolescents in a graduate program at a federal university in northeastern Brazil. Data collection took place in June 2021 through a conversation wheel and press conference. As instruments, we used Google forms and a semi-structured script. The study was approved by the Research Ethics Committee. As an analysis method, Discursive Textual Analysis (DTA) was used. For data organization, Atlas.ti 8.4.15 software (Qualitative Research and Solutions) was used. Results Two categories emerged: 1) Impacts of the pandemic on pediatric care and advocacy: child isolation and a health care scenario where children were placed in the background were observed. 2) Existing barriers that worsened with the health crisis: work overload, precarious structure and difficulty in working conditions were identified, which led to violations of children's rights and aggravated the overview of difficulties in the provision of pediatric services. Conclusion The challenges for exercising health advocacy for hospitalized children during the pandemic, evidenced by the impacts and barriers to care, have expanded health teams' work, making the exercise of advocacy in pediatric care even more difficult. It is necessary to rethink and adjust access and care policies after the pandemic to ensure that child care is not restricted.

Coping with the COVID-19 pandemic addressed in Brazilian federal public universities / Enfrentamento da pandemia de COVID-19 retratado nas Universidades Públicas Federais do Brasil / Enfrentamiento de la pandemia de COVID-19 reflejado en las universidades públicas nacionales de Brasil

Resumo Objetivo O presente estudo teve como objetivo identificar as medidas sanitárias adotadas pelas universidades públicas federais no contexto da pandemia da COVID-19. Métodos Trata-se de uma pesquisa quali-quantitativa, exploratória e descritiva feita por meio da análise documental dos protocolos, diretrizes, portarias e cartilhas confeccionadas no âmbito universitário federal do Brasil. Quanto aos critérios de inclusão foram o documento estar disponível no site de cada universidade federal no período da coleta e a livre consulta do acervo pela internet. O período de coleta foi de março de 2020 a novembro de 2021. Resultados Foram encontrados 51 documentos. As universidades do Nordeste e Sudeste foram responsáveis por 46,4% das publicações totais das universidades federais do Brasil. Conclusão Diante das medidas adotadas pelas Instituições Federais de Ensino Superior, foi perceptível a congruência em tentar estabelecer rotinas e procedimentos padronizados que fossem capazes de controlar e minimizar a disseminação da COVID-19 dentro da universidade.

Resumen Objetivo El presente estudio tuvo como objetivo identificar las medidas sanitarias adoptadas por las universidades públicas nacionales en el contexto de la pandemia de COVID-19. Métodos Se trata de un estudio cuali-cuantitativo, exploratorio y descriptivo, realizado mediante el análisis documental de los protocolos, directrices, resoluciones y cartillas confeccionadas en el contexto universitario nacional de Brasil. Los criterios de inclusión fueron la disponibilidad del documento en el sitio web de cada universidad nacional en el período de la recopilación y la libre consulta del acervo por internet. El período de recopilación fue de marzo de 2020 a noviembre de 2021. Resultados Se encontraron 51 documentos. Las universidades del nordeste y del sudeste fueron responsables por el 46,4 % de las publicaciones totales de las universidades nacionales de Brasil. Conclusión Ante las medidas adoptadas por las instituciones nacionales de educación superior, se percibió congruencia para intentar establecer rutinas y procedimientos estandarizados que fueran capaces de controlar y minimizar la diseminación de COVID-19 dentro de la universidad.

Abstract Objective The present study aimed to identify the health measures adopted by federal public universities in the context of the COVID-19 pandemic. Methods This is a qualitative-quantitative, exploratory and descriptive research carried out through documental analysis of protocols, guidelines, ordinances and booklets made in the federal university scope of Brazil. As for the inclusion criteria, documents must be available on the website of each federal university during the collection period and free consultation of the collection on the internet. The collection period was from March 2020 to November 2021. Results We found 51 documents. Northeastern and southeastern universities were responsible for 46.4% of the total publications of federal universities in Brazil. Conclusion Considering the measures adopted by Higher Education Federal Institutions, the congruence in trying to establish standardized routines and procedures that were able to manage and minimize the spread of COVID-19 within the university was noticeable.

COVID-19 pandemic and impact on dental education: perception of Brazilian dental students

Aim: The aim of the present study is to assess the perception of undergraduate students on the impact of the COVID-19 pandemic on Brazilian dental education. Methods: This crosssectional study was conducted using an online questionnaire hosted in Google Forms platform and publicized on Instagram® and Facebook®. The questionnaire was available between July 8-27, 2020. Absolute and relative frequencies were obtained for variables of interest using Pearson's chi-squared and considering 95% confidence intervals. Prevalence of learning resource variables according to self-reported skin color, educational institution, and Brazilian region were presented using equiplots. Results: A total of 1,050 undergraduate dental students answered the questionnaire. Most students reported being in full-distance learning mode. Among the undergraduate students, 65.4% reported perceiving a very high impact in dental education, and 16.6% of students reported not being able to follow distance learning. In addition, 14% reported not having a personal laptop or desktop to study with, with this condition being more prevalent among non-white than white individuals. Conclusion: We conclude that Brazilian dental students perceived a high impact of COVID-19 on dental education, as well as one-sixth of the students reported not having adequate resources to continue with distance learning. It is important that different policies are developed at the institutional and governmental levels to reduce the impact of the pandemic on dental education

Nurses' practice environment before and during the COVID-19 pandemic / Ambiente de prática dos enfermeiros antes e durante a pandemia de COVID-19 / Ambiente de práctica de enfermeros antes y durante la pandemia de COVID-19

Resumo Objetivo Comparar a percepção do ambiente de prática profissional dos enfermeiros antes e durante a pandemia da COVID-19. Métodos Estudo descritivo, tipo survey realizado em um hospital acreditado, situado no município de São Paulo - SP. Os enfermeiros foram convidados a responderem o instrumento Practice Environment Scale versão brasileira, em dois momentos: 10 meses antes da pandemia (Grupo 1) e seis meses após o início do atendimento de pacientes com a COVID-19 (Grupo 2). Foi adotado o nível de significância de p≤0,05 e empregado o teste de hipótese não-paramétrico Mann-Whitney para comparação entre dois grupos não pareados. Resultados O Grupo 1 foi composto por 55 enfermeiros e o Grupo 2 por 53. Todas as subescalas apresentaram médias superiores a 2,5, variando entre 2,8 a 3,3 no Grupo I e 3,0 a 3,4 no Grupo 2. As subescalas Habilidade, liderança e suporte dos coordenadores/ supervisores de enfermagem aos enfermeiros/ equipe de enfermagem; Adequação da equipe e de recursos e Relações de trabalho positivas entre médicos e enfermeiros foram melhor avaliadas no período pandêmico, com diferenças estatisticamente significantes (p = 0,05; 0,04 e 0,04, respectivamente). Conclusão O ambiente de prática profissional do enfermeiro foi classificado como favorável nos dois momentos, mas apresentou melhores resultados durante a pandemia.

Resumen Objetivo Comparar la percepción del ambiente de práctica profesional de los enfermeros antes y durante la pandemia de COVID-19. Métodos Estudio descriptivo, tipo survey realizado en un hospital acreditado, ubicado en el municipio de São Paulo, estado de São Paulo. Los enfermeros fueron invitados a responder el instrumento Practice Environment Scale versión brasileña, en dos momentos: 10 meses antes de la pandemia (Grupo 1) y seis meses después del inicio de la atención de pacientes con COVID-19 (Grupo 2). Se adoptó el nivel de significancia de p≤0,05 y se utilizó la prueba de hipótesis no paramétrica Mann-Whitney para comparación entre dos grupos no pareados. Resultados El Grupo 1 estuvo compuesto por 55 enfermeros y el Grupo 2 por 53. Todas las subescalas presentaron promedios superiores a 2,5, que variaron entre 2,8 y 3,3 en el Grupo 1, y entre 3,0 y 3,4 en el Grupo 2. Las subescalas Habilidad, liderazgo y apoyo de los coordinadores/supervisores de enfermería a los enfermeros/equipo de enfermería; Adaptación del equipo y de los recursos, y Relaciones laborales positivas entre médicos y enfermeros fueron mejor evaluadas en el período pandémico, con diferencias estadísticamente significantes (p = 0,05; 0,04 y 0,04, respectivamente). Conclusión El ambiente de práctica profesional de enfermeros fue clasificado como favorable en los dos momentos, pero presentó mejores resultados durante la pandemia.

Abstract Objective To compare nurses' perception of the professional practice environment before and during the COVID-19 pandemic. Methods Descriptive, survey-type study conducted in an accredited hospital located in the city of São Paulo - SP. Nurses were invited to answer the Brazilian version of the Practice Environment Scale instrument in two moments: ten months before the pandemic (Group 1) and six months after the start of care for patients with COVID-19 (Group 2). A significance level of p≤0.05 was adopted and the Mann-Whitney non-parametric hypothesis test was used to compare two unpaired groups. Results Group 1 consisted of 55 nurses and Group 2 of 53. All subscales had means above 2.5, ranging from 2.8 to 3.3 in Group 1 and 3.0 to 3.4 in Group 2. The subscales Nurse manager ability, leadership and support to nurses; Staffing and resource adequacy; and Collegial nurse-physician relations were better evaluated in the pandemic period, with statistically significant differences (p = 0.05; 0.04 and 0.04, respectively). Conclusion Although nurse's professional practice environment was classified as favorable at both times, results were better during the pandemic.

Work in health during the pandemic: Experiences of linking with the community related to the social production of care in Mar del Plata, Argentina / Trabajar en salud durante la pandemia: Experiencias de vinculación con la comunidad relativas a la producción social del cuidado en Mar del Plata, Argentina

Resumen En este artículo proponemos visibilizar las estrategias de vinculación comunitaria de trabajadores/as de salud pública relativas a la producción del cuidado en el contexto crítico de la pandemia de la covid-19, signado por la profundización de la pobreza, la restricción de los servicios de salud y las tensiones del sistema sanitario en Argentina. Con un diseño metodológico cualitativo y enfoque etnográfico, entrevistamos a trabajadoras/es de distintas disciplinas, ocupaciones y géneros que se desempeñan en centros de salud y hospitales públicos en Mar del Plata y zonas rurales circundantes, entre los meses de marzo y diciembre de 2021. A partir de sus narrativas, analizamos las dimensiones de acceso a la alimentación, medicación y terapias holísticas, las dificultades encontradas y su contribución a la producción social del cuidado en salud. Concluimos que las estrategias generadas conllevan el potencial instituyente para la reorientación de los servicios públicos de salud de acuerdo con los desafíos del derecho a la salud desde la perspectiva de género y derechos en el tránsito a la postpandemia.

Abstract In this article we propose to make visible the strategies of community engagement of public health workers related to the production of care in the critical context of the covid-19 pandemic, marked by the deepening of poverty, the restriction of health services and the tensions of the health system in Argentina. With a qualitative methodological design and ethnographic approach, we interviewed workers from different disciplines, occupations and genders, who work in health centers and public hospitals in Mar del Plata and surrounding rural areas, between the months of March and December 2021. Based on their narratives, we analyze the dimensions of access to food, medication and holistic therapies, the difficulties encountered and their contribution to the social production of health care. We conclude that the strategies generated carry the instituting potential for the reorientation of public health services in accordance with the challenges of the right to health from the perspective of gender and rights in the transition to the post-pandemic.

Spatial Interactions and the Spread of COVID-19: A Network Perspective

We use unique data on the travel history of confirmed patients at a daily frequency across 31 provinces in China to study how spatial interactions influence the geographic spread of pandemic COVID-19. We develop and simultaneously estimate a structural model of dynamic disease transmission network formation and spatial interaction. This allows us to understand what externalities the disease risk associated with a single place may create for the entire country. We find a positive and significant spatial interaction effect that strongly influences the duration and severity of pandemic COVID-19. And there exists heterogeneity in this interaction effect: the spatial spillover effect from the source province is significantly higher than from other provinces. Further counterfactual policy analysis shows that targeting the key province can improve the effectiveness of policy interventions for containing the geographic spread of pandemic COVID-19, and the effect of such targeted policy decreases with an increase in the time of delay.

The Syncretic Effect of Dual-Source Data on Affective Computing in Online Learning Contexts: A Perspective from Convolutional Neural Network with Attention Mechanism

Affective computing (AC) has been regarded as a relevant approach to identifying online learners' mental states and predicting their learning performance. Previous research mainly used one single-source data set, typically learners' facial expression, to compute learners' affection. However, a single facial expression may represent different affections in various head poses. This study proposed a dual-source data approach to solve the problem. Facial expression and head pose are two typical data sources that can be captured from online learning videos. The current study collected a dual-source data set of facial expressions and head poses from an online learning class in a middle school. A deep learning neural network using AlexNet with an attention mechanism was developed to verify the syncretic effect on affective computing of the proposed dual-source fusion strategy. The results show that the dual-source fusion approach significantly outperforms the single-source approach based on the AC recognition accuracy between the two approaches (dual-source approach using Attention-AlexNet model 80.96%;single-source approach, facial expression 76.65% and head pose 64.34%). This study contributes to the theoretical construction of the dual-source data fusion approach, and the empirical validation of the effect of the Attention-AlexNet neural network approach on affective computing in online learning contexts.

IMPACT OF THE COVID-19 PANDEMIC ON SEPTIC ARTHRITIS MANAGEMENT

BackgroundSince 2020, the SARS-Cov-2 pandemic has disrupted the organization of healthcare systems worldwide.ObjectivesThis study aimed to assess the impact of this pandemic on septic arthritis management in a tertiary rheumatology department.MethodsIt was a single-center descriptive case-control study, which included patients hospitalized for septic arthritis between January 2018 and December 2021, whose diagnosis was retained after positive bacterial growthor on culture on according to presumptive criteria. Our patients were divided into two groups: G1: patients hospitalized during the COVID-19 pandemic (2020-2021), and G2: patients hospitalized during a similar period before the COVID-19 pandemic (2018-2019). In both groups, septic arthritis prevalence was calculated, socio-demographic characteristics, risk factors, clinical, paraclinical, and therapeutic data were collected. COVID-19 status was reported in the G1.ResultsTwenty-two patients were enrolled: G1 (n = 15), G2 (n = 7). The prevalence of septic arthritis was 0.77% and 0.36% respectively. The median age was 54.6±12.25 and 54.29±21.81 years old respectively. Diabetes was found in 26, 7% in G1 and 28.6% in G2. During the pandemic, arthropathy and oral corticosteroids use were noted in 53.3% and 28.6% of patients versus 26.7% and 14.3% in G2. The diagnosis delay and the prior use of antibiotic therapy were more significant in G1: 14.08[7-30] d versus 6.5[3.25-19.25] d, and 46.7% versus 14.3%. The knee was the most common localization in both groups. Other joints were affected in G1: shoulder (n = 2), hip (n = 1), and sacroiliac (n = 1). The most common germ was staphylococcus aureus. The duration of hospitalization and duration of antibiotic therapy in G1 and G2 were 26.07±9.12d versus 27.43±10.87d and 50±10d versus 48±25.79d, respectively. Concerning COVID-19 status, 33.3% of patients in G1 have received their vaccination and no recent SARS-Cov2 infection was noted before hospitalization. During the pandemic, synovectomy was required in three patients, one of whom was also transferred to intensive care for septic shock (two of these three patients are being followed for rheumatoid arthritis, and only one has never been vaccinated against COVID-19).ConclusionDuring the COVID-19 pandemic, the prevalence of septic arthritis in our department was higher and the diagnosis was delayed. Duration of hospitalization was not impacted, however, atypical localisations, prior use of antibiotics, recourse to synovectomy, and transfer to intensive care were reported. These results suggest an inadequate and difficult access to healthcare services during the lockdown, as well as an impact of social distancing on the immune system [1, 2]. More studies are needed to confirm these findings.References[1]Robinson E. Pires et al, What Do We Need to Know about Musculoskeletal Manifestations of COVID-19? A Systematic Review, JBJS Rev. 2022 Jun 3;10(6)[2]Pantea Kiani et al, Immune Fitness and the Psychosocial and Health Consequences of the COVID-19 Pandemic Lockdown in The Netherlands: Methodology and Design of the CLOFIT Study, Eur J Investig Health Psychol Educ. 2021 Feb 20;11(1):199-218Acknowledgements:NIL.Disclosure of InterestsNone Declared.

Coping Orientation of Academic Community in the Time of COVID-19 Pandemic: A Pilot Multi-Country Survey Study

In this paper, we have mapped the coping methods used to address the coronavirus pandemic by members of the academic community. We conducted an anonymous survey of a convenient sample of 674 faculty/staff members and students from September to December 2020. A modified version of the RCOPE scale was used for data collection. The results indicate that both religious and existential coping methods were used by respondents. The study also indicates that even though 71% of informants believed in God or another religious figure, 61% reported that they had tried to gain control of the situation directly without the help of God or another religious figure. The ranking of the coping strategies used indicates that the first five methods used by informants were all non-religious coping methods (i.e., secular existential coping methods): regarding life as a part of a greater whole, regarding nature as an important resource, listening to the sound of surrounding nature, being alone and contemplating, and walking/engaging in any activities outdoors giving a spiritual feeling. Our results contribute to the new area of research on academic community's coping with pandemic-related stress and challenges.

Interrogating Chilean community psychology in times of crisis

The social outbreak that occurred in Chile in October 2019, added to the COVID-19 pandemic, has made visible and exacerbated inequities of all kinds in the country (health, work, housing, education etc). This has resulted in the activation of various social and community processes that try to reverse situations of injustice and also to subvert the economic and social logic that has led us to this situation. In this scenario, the question arises, what can Chilean Community Psychology contribute to this crisis? An attempt is made to answer this question in this chapter, which addresses, from an integrated perspective, the various alternatives that our discipline has to contribute to this process of social transformation. (PsycInfo Database Record (c) 2023 APA, all rights reserved) (Spanish) El estallido social que se produjo en Chile en octubre de 2019, sumado a la pandemia por COVID-19, ha hecho visibles y ha agudizado las inequidades de todo tipo en el pais (salud, trabajo, vivienda, educacion, etc.). Lo anterior ha tenido como consecuencia la activacion de diversos procesos sociales y comunitarios que intentan, por un lado, revertir las situaciones de injusticia y, por otro, subvertir la logica economica y social que nos ha llevado a esta situacion. En este escenario surge la pregunta: ?que puede aportar la psicologia comunitaria chilena en esta crisis? A esta interrogante se intenta dar respuesta en este capitulo que aborda desde una mirada integrada las diversas alternativas que tiene nuestra disciplina para aportar a este proceso de transformacion social. (PsycInfo Database Record (c) 2023 APA, all rights reserved)