Impedimetric Sensing: An Emerging Tool for Combating the COVID-19 Pandemic.

The COVID-19 pandemic revealed a pressing need for the development of sensitive and low-cost point-of-care sensors for disease diagnosis. The current standard of care for COVID-19 is quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). This method is sensitive, but takes time, effort, and requires specialized equipment and reagents to be performed correctly. This make it unsuitable for widespread, rapid testing and causes poor individual and policy decision-making. Rapid antigen tests (RATs) are a widely used alternative that provide results quickly but have low sensitivity and are prone to false negatives, particularly in cases with lower viral burden. Electrochemical sensors have shown much promise in filling this technology gap, and impedance spectroscopy specifically has exciting potential in rapid screening of COVID-19. Due to the data-rich nature of impedance measurements performed at different frequencies, this method lends itself to machine-leaning (ML) algorithms for further data processing. This review summarizes the current state of impedance spectroscopy-based point-of-care sensors for the detection of the SARS-CoV-2 virus. This article also suggests future directions to address the technology's current limitations to move forward in this current pandemic and prepare for future outbreaks.

The 17th National Annual Conference on Neurological Infectious Diseases and Cerebrospinal Fluid Cytology of the Chinese Medical Association Neurology Branch was successfully held

The 17th National Annual Conference on Neurological Infectious Diseases and Cerebrospinal Fluid Cytology of the Chinese Medical Association Neurology Branch was successfully held in Wuhan, Hubei, China. During the conference, many well-known neurology experts in China conducted in-depth and detailed discussions on the research progress of infectious diseases of the nervous system and cerebrospinal fluid cytology, which benefited the participants a lot.Copyright © 2021

Effect of Process Variables on Pulp Yield of Indigenous Raw Materials

The biggest issue before pulp and paper producers is availability of quality raw material. India is fiber deficit country, this message has become more intense after covid when price of different raw materials are increased by 20-25%, . Chemical pulp is produced by chemical delignification of wood and non-wood plants. After kraft pulping the remaining lignin is removed by oxygen delignification and bleaching to produce higher purity cellulosic pulp. The goal of delignification processes is to remove lignin from the raw material without a negative effect on the cellulose and strength of pulp. The economics of pulp and paper production is more related to the yield of unbleached and bleached pulp production. Marginal increment in pulp yield reflects into savings of crore of rupees on yearly basis. An overall vigilant concern on process conditions and variables is required during production of pulp. BAT technology for pulping along with utilization of various additives and pretreatment methods allow to fine tune these process to obtain pulp with desired yield and quality. The primary aim of this paper is to review different process variables in respect to the yield of the pulp. © 2022 Indian Pulp and Paper Technical Association. All rights reserved.

Stacking Classifier-based Automated Insurance Fraud Detection System

During the Covid-19 pandemic, the insurance industry's digital shift quickened, resulting in a surge in insurance fraud. To combat insurance fraud, a system that securely manages and monitors insurance processes must be built by combining a machine learning classification framework with a web application. Examining and identifying fraudulent features is a frequent method of detecting fraud, but it takes a long time and can result in false results. One of these issues is addressed by the proposed solution. By digitalizing the paper-based workflow in insurance firms, this paper intends to improve the efficiency of the existing approach. This method also aimed to improve the present approach's data management by integrating a web application with a machine learning stacking classifier framework experimented on a linear regression-based iterative imputed data for detecting fraud claims and making the entire claim processing and documentation process more robust and agile. © 2022 IEEE.

Paper-Based Devices for Virus Detection in Water

Viral infections are global health concerns that can cause high infection and mortality rates, as of the example from SARS-CoV-2 pandemic. Although conventional methods, e.g., polymerize chain reaction (PCR), can provide reliable and robust detection results, they are often time- and cost-consuming, limiting their application in resource-poor settings. Recently, paper-based devices, as a new biosensing technique, have emerged as a promising tool to conventional methods for pathogen detection including bacteria and virus. In this chapter, we provide a comprehensive introduction and insights on the development of paper-based devices for the pathogen detection in water. Firstly, the substrate materials and fabrication methods for paper-based devices are introduced. Engineering assay onto paper-based devices for virus detection is subsequently discussed for the rapid and on-site monitoring. We also compare the strengths and drawbacks between paper-based devices and the conventional analytical methods for virus detection, including culture method, biochemical test, immune assay, and molecular method. This chapter also discusses the feasibility of paper-based devices for point-of-use detection in water matrix, and the challenges and prospects of paper-based devices in water and environmental monitoring. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

FINANCIAL SECURITIES FOR TOUR OPERATORS IN CASE OF INSOLVENCY RESULTING FROM THE DIRECTIVE 2015/2302 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL WHICH ARE IN FORCE IN POLAND

The insolvency of travel agencies is dealt with in a special way by the EU legislator. European Union law introduces legal solutions for the benefit of consumers insofar as the relevant services are not performed by organizers as a consequence of its insolvency. The current 2015/2302 Directive provides much more comprehensive protection than 90/314/EWG Directive for travelers in the event of insolvency of a tour operator. However, in the past, in the practical functioning of travel agencies, it has repeatedly turned out that the Polish legislation has not been able to guarantee full protection provided for in EU law. This situation has changed. In Poland, since August 1, 2018 the system of security and financial guarantees in the event of insolvency of organizers and traders facilitating linked travel arrangements consists of two pillars. If Pillar I funds are exhausted, the costs of actions taken by the Marshal of the Province related to the repatriation of the customers of an insolvent tour operator will be covered from Pillar II, which is created from contributions to the Tourist Guarantee Fund. Due to the COVID pandemic, another form of security was introduced in Poland from January 1,2021 - Tourist Assistance Fund. The fund is designed to support tourism entrepreneurs in the event of extraordinary circumstances. The aim of the paper is to present the legal regulations in force in Poland in the field of financial security of tour operators in the event of their insolvency and to analyze whether these solutions sufficiently protect the interests of travelers. Conclusions included in the paper justify the statement that the extension of the security system by Pillar II make the full protection possible. The two-pillar solution should be sufficient in case of insolvency of a travel agency and that it fully implements the EU recommendations.

Dangerous liaisons? Applying the social harm perspective to the social inequality, housing and health trifecta during the Covid-19 pandemic

Global rates of excess mortality attributable to the Covid-19 pandemic provide a fresh impetus to make sense of the associations between income inequality, housing inequality and the social gradient in health, suggesting new questions about the ways in which housing and health are treated in the framing and development of public policy. The first half of the paper uses a social harm lens to examine the threefold associations of the social inequality, housing and health trifecta and offers new insights for policy analysis which foregrounds the production, transmission, and experience of various types of harm which occur within the home. The main body of the paper then draws upon the outcomes of an international systematic literature mapping review of 213 Covid-19 research papers to demonstrate three specific harms associated with stay-at-home lockdowns: (i) intimate partner and domestic violence, (ii) poor mental health and (iii) health harming behaviours. The reported findings are interpreted using a social harm perspective and some implications for policy analysis are illustrated. The paper concludes with a reflection on the efficacy of social harm as a lens for policy analysis and suggests directions for further research in housing studies and zemiology.

Disintegration of toilet papers used in shopping malls

Paper has been used in the field of hygiene for centuries. Tissue papers have low grammage, creped or non-creped surface, and consisting of one or more layers from virgin papers. Toilet paper, which has an important area of use, comes at the beginning of the tissue papers divided into various product groups. Its use has increased even more with the effect of the coronavirus pandemic. Increasing use of toilet paper causes clogging in sewers as solid waste. Because an important and large part of the sewage is composed of cellulosic structures. Therefore, the disintegration of toilet paper is an important issue. The main properties of toilet paper are characterized by grammage, thickness, polymerization degree, softness and wet tensile strength. This study, it was aimed to determine the relationship between the degree of polymerization, thickness, grammage, softness and wet tension strength of toilet papers, which accumulate in the sewer pipes and cause clogging, and their disintegration in tap water and pure water at environment of different pH levels. A great level and positive linear relationship was found between grammage and in disintegration pH9. It was determined a low level and positive relationship with wet tensile strength in disintegration tap water.

Improvement of the Quality of Question Papers for Online Examinations Toward Simultaneous Enhancement of Students', Learning

The present study is related to the problem associated with student assessment with online examinations at higher educational institutes (HEIs). With the current COVID-19 outbreak, the majority of educational institutes are conducting online examinations to assess their students, where there would always be a chance that the students go for malpractice. It is difficult to set a question paper for any technical course with great novelty. Under these circumstances, safeguarding academic integrity has become a challenge for HEIs. This study is aimed at improving the quality of questions for online exams to increase the accountability of HEIs by proper evaluation of their students. A detailed procedure with suggestions for setting the questions for technical courses, in the format of assertion and reason, matching, multiple select types, etc., has been discussed with adequate examples. It deals with a strategy for ensuring that all the students are held to the standards that are reflected in their grades. The proposed evaluation method has been implemented on a test batch and presented the results along with a comparison with that of traditional question papers. It is witnessed that there is a simultaneous enhancement of students'learning as an additional benefit of implementing the proposed learning-oriented assessment method. IEEE

Paper-based colorimetric detection of COVID-19 using aptasenor based on biomimetic peroxidase like activity of ChF/ZnO/CNT nano-hybrid.

Corona Virus Disease 2019 (COVID-19) as the infectious disease caused the pandemic disease around the world through infection by SARS-CoV-2 virus. The common diagnosis approach is Quantitative RT-PCR (qRT-PCR) which is time consuming and labor intensive. In the present study a novel colorimetric aptasensor was developed based on intrinsic catalytic activity of chitosan film embedded with ZnO/CNT (ChF/ZnO/CNT) on 3,3',5,5'-tetramethylbenzidine (TMB) substrate. The main nanocomposite platform was constructed and functionalized with specific COVID-19 aptamer. The construction subjected with TMB substrate and H2O2 in the presence of different concentration of COVID-19 virus. Separation of aptamer after binding with virus particles declined the nanozyme activity. Upon addition of virus concentration, the peroxidase like activity of developed platform and colorimetric signals of oxidized TMB decreased gradually. Under optimal conditions the nanozyme could detect the virus in the linear range of 1-500 pg mL and LOD of 0.05 pg mL. Also, a paper-based platform was used for set up the strategy on applicable device. The paper-based strategy showed a linear range between 50 and 500 pg mL with LOD of 8 pg mL. The applied paper based colorimetric strategy showed reliable results for sensitive and selective detection of COVID-19 virus with the cost-effective approach.

Citation advantage of COVID-19-related publications

With the global spread of the COVID-19 pandemic, scientists from various disciplines responded quickly to this historical public health emergency. The sudden boom of COVID-19-related papers in a short period of time may bring unexpected influence to some commonly used bibliometric indicators. By a large-scale investigation using Science Citation Index Expanded and Social Sciences Citation Index, this brief communication confirms the citation advantage of COVID-19-related papers empirically through the lens of Essential Science Indicators' highly cited paper. More than 8% of COVID-19-related papers published during 2020 and 2021 were selected as Essential Science Indicators highly cited papers, which was much higher than the set global benchmark value of 1%. The citation advantage of COVID-19-related papers for different Web of Science categories/countries/journal impact factor quartiles was also demonstrated. The distortions of COVID-19-related papers' citation advantage to some bibliometric indicators such as journal impact factor were discussed at the end of this brief communication.

Scientific sinkhole: estimating the cost of peer review based on survey data with snowball sampling.

BACKGROUND: There are a variety of costs associated with publication of scientific findings. The purpose of this work was to estimate the cost of peer review in scientific publishing per reviewer, per year and for the entire scientific community. METHODS: Internet-based self-report, cross-sectional survey, live between June 28, 2021 and August 2, 2021 was used. Participants were recruited via snowball sampling. No restrictions were placed on geographic location or field of study. Respondents who were asked to act as a peer-reviewer for at least one manuscript submitted to a scientific journal in 2020 were eligible. The primary outcome measure was the cost of peer review per person, per year (calculated as wage-cost x number of initial reviews and number of re-reviews per year). The secondary outcome was the cost of peer review globally (calculated as the number of peer-reviewed papers in Scopus x median wage-cost of initial review and re-review). RESULTS: A total of 354 participants completed at least one question of the survey, and information necessary to calculate the cost of peer-review was available for 308 participants from 33 countries (44% from Canada). The cost of peer review was estimated at $US1,272 per person, per year ($US1,015 for initial review and $US256 for re-review), or US$1.1-1.7 billion for the scientific community per year. The global cost of peer-review was estimated at US$6 billion in 2020 when relying on the Dimensions database and taking into account reviewed-but-rejected manuscripts. CONCLUSIONS: Peer review represents an important financial piece of scientific publishing. Our results may not represent all countries or fields of study, but are consistent with previous estimates and provide additional context from peer reviewers themselves. Researchers and scientists have long provided peer review as a contribution to the scientific community. Recognizing the importance of peer-review, institutions should acknowledge these costs in job descriptions, performance measurement, promotion packages, and funding applications. Journals should develop methods to compensate reviewers for their time and improve transparency while maintaining the integrity of the peer-review process.

Novel polymer composite coated with ethylcellulose nanoparticle from waste paper as an alternative material to extracorporeal oxygenation membrane

Extracorporeal membrane oxygenator (ECMO) is a valuable technology to support people with acute respiratory distress syndrome (ARDS) and is recommended for COVID-19 patients. This study aims to fabricate polymer-based composite membranes coated with ethylcellulose nanoparticles from waste paper and identify the performance of the composite as ECMO candidates. Composite membranes were made from four types of polymers, namely, nylon, PTFE (polytetrafluoroethylene), Pebax® MH-1657, and SBS (poly-(styrene-b-butadiene-b-styrene)). PDMS (polydimethylsiloxane) 1 wt.% and ethylcellulose nanoparticles (3% and 10 wt.%) were used as membrane coatings to increase their hydrophobic properties. The success of cellulose isolation and ethylcellulose synthesis from waste paper was confirmed by the FTIR and XRD analysis. The size of the synthesized ethylcellulose nanoparticles was 32.68 nm. The coating effect on composite membranes was studied by measuring the contact angle, membrane porosity, protein quantification tests, and single gas permeation of O2 and CO2. Based on the protein quantification test, the protein could not pass through the Pebax/PDMS and SBS/PDMS composites coated with 10 wt.% ethylcellulose;this indicated less risk of plasma leakage. The gas permeation test on nylon/PDMS, PTFE/PDMS, and SBS/PDMS composites coated with 10% ethylcellulose resulted high CO2/O2 selectivity, respectively, 2.17, 3.48, and 3.22 as good indication for extracorporeal oxygenation membrane.

Labour market dualization and social policy in pandemic times: an in-depth analysis of private consumption services in Europe

PurposeThis article contributes to the debate on how social policies and labour market regulation have been used to limit the socio-economic consequences of the pandemic by focusing on one specific economic segment of European labour markets: private consumption services, such as trade, tourism, catering and other support services.Design/methodology/approachThe analysis combines mixed methods and a variety of sources. First, we built a set of indicators from the EU-LFS microdata for 2019 and the 2018 Eurostat "Structure of earnings survey” and performed a cluster analysis (k-means) on the dimensions and indicators considered. Second, we elaborated EU-LFS data covering 2019 and 2020 (by quarter) and OECD 2020 data, and finally we traced Covid-related policy reforms for the period March 2020–December 2021 and analysed documents and information collected in different policy repositories.FindingsThe paper shows the relevance and characteristics of private consumption services in different countries, demonstrating that so-called labour market "outsiders” are highly represented in this sector and illustrates the policies adopted to respond to the pandemic in different European countries. The paper asks whether this emergency has been a window of opportunity to redefine regulation in this sector, making it more inclusive. It demonstrates, however, that the common approach in Europe has been dominated by temporary, short-term and one-off measures, which do not represent major changes to the social security schemes that were in place before the pandemic.Originality/valueThis article builds on the literature on labour market dualization, but approaches the concept from a different perspective – one not centred on the nature of employment relations (stable/unstable) but on economic sectors/branches. This article does not, therefore, discuss in general terms what happened to labour market outsiders during the pandemic, but rather focus attention on a specific group of workers who are highly exposed to risks stemming from dualization: those employed in the private consumption services. The economic sector perspective is an integrative way of framing dualization which is still under-researched.

WeChat as a platform for blending problem/case-based learning and paper review methods in undergraduate paediatric orthopaedics internships: a feasibility and effectiveness study.

BACKGROUND: Paediatric orthopaedics is a significant and difficult for undergraduate students to master. During the COVID-19 pandemic, we used the WeChat platform to combine the advantages offered by problem-based learning (PBL), case-based learning (CBL) and paper review teaching methods to establish a new blended online teaching model and demonstrated its feasibility and effectiveness. OBJECTIVE: This study aims to demonstrate the feasibility and effectiveness of a new blended pedagogical method that uses the WeChat platform and combines PBL, CBL and paper review. METHODS: We enrolled 22 students participating in the Department of Paediatric Orthopaedics. They participated in the WeChat blended pedagogy mode. Their departmental rotation examination scores were compared with those of 23 students who participated in the traditional teaching method. Moreover, an anonymous questionnaire was used to evaluate students' perceptions and experiences. RESULTS: The total average scores of students who participated in the WeChat blended pedagogy mode and the traditional teaching method were 47.27 and 44.52, respectively. There were no statistically significant differences between the online teaching mode and the traditional teaching method in terms of possessing professional accomplishment, gaining knowledge and promoting interpersonal skills (P = 0.07, P = 0.12 and P = 0.65, respectively). In terms of independent clinical thinking, self-improving capability and improving clinical skills, the scores associated with the WeChat blended pedagogy mode were 8.00, 8.00 and 6.00, whereas those associated with the traditional teaching method were 6.70, 6.87 and 7.48. The overall satisfaction with the WeChat blended pedagogy mode reached 100%. A total of 64%, 86%, 68%, 64% and 59% of students chose very large or large in response to the items concerning professional accomplishment, knowledge absorption, independent clinical thinking skills, English reading and literature exploring capacity, as well as interpersonal skills, respectively. Fifteen participants claimed that the WeChat blended pedagogy mode was less helpful to them with regard to promoting the improvement of their clinical skills. Nine students claimed that the WeChat blended pedagogy mode was time-consuming. CONCLUSIONS: Our study verified the feasibility and effectiveness of the WeChat blended pedagogy mode for undergraduate paediatric orthopaedics internships. TRIAL REGISTRATION: Retrospectively registered.

The necessary, albeit belated, transition to computerized cognitive assessment.

Cognitive assessment is a common and daily process in educational, clinical, or research settings, among others. Currently, most professionals use classic pencil-and-paper screenings, tests, and assessment batteries. However, as the SARS-CoV-2 health crisis has shown, the pencil-and-paper format is becoming increasingly outdated and it is necessary to transition to new technologies, using computerized cognitive assessments (CCA). This article discusses the advantages, disadvantages, and implications of this necessary transition that professionals should face in the immediate future, and encourages careful adoption of this change to ensure a smooth transition.

Effectiveness of Computerized Cognitive Training by VIRTRAEL on Memory and Executive Function in Older People: A Pilot Study.

The prevalence of people over 60 years of age with cognitive impairment has increased in recent decades. As a consequence, numerous computerized cognitive trainings (CCT) have been developed. This pilot study aimed to determine the effectiveness of the CCT with VIRTRAEL in improving older adults' cognition. Fifty-five participants (x¯ = 72.7 years; SD = 6.5) underwent CCT, and twenty participants (x¯ = 76.1 years; SD = 7.6) received face-to-face cognitive stimulation with a paper-and-pencil methodology. Both trainings were conducted in nine sessions (45-60 min each). Participants completed a pre-post training neuropsychological assessment. ANCOVAs and the standardized clinical change were performed. VIRTRAEL's group showed a significant and greater improvement in verbal learning (p < 0.006) and delayed recall (p ≤ 0.001), working memory (p < 0.005), abstract (p < 0.002) and semantic reasoning (p < 0.015), and planning (p < 0.021). Additionally, more large clinical changes (d > 0.8) were found in the VIRTRAEL condition (in verbal learning and delayed free and cued recall) than in the standard group. Here we show that the CCT with VIRTRAEL is effective in improving cognitive function in older adults and is superior to the standard format. These preliminary findings indicate that CCT is a useful tool potentially applicable in the fight against cognitive symptomatology associated with aging and neurodegenerative diseases. VIRTRAEL represents a breakthrough in this field as it is inexpensive and easily accessible to any older person, regardless of whether they live far from health care resources.

The 25th Bangkok International Symposium on HIV Medicine

Proceedings of: 25th Bangkok International Symposium on HIV Medicine, 18-20 January 2023, held virtually and on site at Samyan Mitrtown Hall, Bangkok, Thailand. The Bangkok International Symposium on HIV Medicine has commenced on the third Wednesday of January since 1998. The Symposium aims to provide professional healthcare workers in Thailand and the region an opportunity to receive the most up-to-date information on HIV and its related conditions if they are unable to attend other HIV conferences abroad. This year's hybrid symposium was held from 18 January to 20 January 2023. A total of six plenary sessions were held in the mornings, and four afternoon workshops held on Wednesday and Thursday. Expert speakers from Thailand, China, Malaysia, Singapore, India, Hong Kong, the Philippines, Australia, the UK, The Netherlands and the USA participated in the symposium.Copyright © 2023 Future Medicine Ltd.