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Science Advances ; 9(2):1-13, 2023.
Article in English | Academic Search Complete | ID: covidwho-2193381
Frontiers in Microbiology ; 13, 2022.
Article in English | Web of Science | ID: covidwho-2163053
Case Rep Ophthalmol ; 13(3): 988-992, 2022.
Article in English | MEDLINE | ID: covidwho-2138294


Parvovirus B-19 (B19V) is a common infection in children, occasionally complicated by ocular manifestations. In patients infected with severe acute respiratory syndrome virus (SARS-CoV-2), many cases of bacterial, fungal, and viral co-infections have been described. We report on a case of bilateral conjunctivitis, keratitis, and anterior uveitis that occurred in a patient co-infected by B19V and SARS-CoV-2. A young nurse developed, 20 days after the onset of asthenia and fever, a maculopapular rash and, in the following month, B19V-related arthritis. Shortly after a course of antibiotics and corticosteroids and the resolution of the arthritis, she began to complain of hearing loss and tinnitus. A polymerase chain reaction for SARS-CoV-2, previously negative, turned out positive; IgM for B19V decreased while IgG increased and antinuclear autoantibody and rheumatoid factor test results were positive. Ear symptoms disappeared after a course of prednisone, but eye burning and itching appeared 2 weeks after the coronavirus disease 2019 (COVID-19) positive swab. Bilateral conjunctivitis, keratitis, and anterior uveitis were diagnosed, which responded completely to a topical corticosteroid and mydriatic therapy. No relapses were observed in the following 12 months. The onset and progression of the symptoms, along with the laboratory findings, suggest a double pathogenesis of the ocular manifestations: keratitis and uveitis, along with the ear symptoms, seem to be the expression of an autoimmune reaction to B19V infection, while the conjunctivitis was likely related to direct infection of the conjunctiva by SARS-CoV-2.

Berliner und Munchener Tierarztliche Wochenschrift ; 135(no pagination), 2022.
Article in English | EMBASE | ID: covidwho-2141502
Journal of Fish Diseases ; 45(12):1893-1898, 2022.
Article in English | Academic Search Complete | ID: covidwho-2113142
Ital J Pediatr ; 48(1): 183, 2022 Oct 28.
Article in English | MEDLINE | ID: covidwho-2098410


BACKGROUND: Lymphomatoid papulosis (LyP) is a rare condition in pediatrics; LyP histological type D has been reported in only 7 children. The differential diagnosis of LyP in the spectrum of lymphoid proliferation remains controversial. CASE PRESENTATION: A 6-year-old boy presented to Emergency Department with a 3-week history of an erythematous papulo-vesicular itchy eruption over the submandibular regions, trunk and extremities. History, symptoms and laboratory tests were unremarkable. SARS-CoV-2 antigen was negative. The clinical suspicion of pityriasis lichenoides et varioliformis acuta (PLEVA) was posed, and topical steroids were introduced. One week after, he returned with an extensive painful scaly papulo-erythematous rash, with some ulcerated and necrotic lesions, and fever; therefore the child was hospitalized. Biochemical results were within reference limits, except for high level of C-reactive protein, aspartate aminotransferase, alanine transaminase and bilirubin. Due to a persistently high fever, systemic corticosteroid treatment was administered, with a good clinical response and an improvement of the skin lesions. Anti-PVB-19 Immunoglobulin M was detected. Elevated levels of IL-6, IL-10 and IFN-γ were also recorded. Five days post-admission, most of the lesions had cleared, and the child was discharged. Methotrexate was started, with a positive response. At skin biopsy a "PLEVA-like" pattern was apparent, with a dense, wedge shaped lymphoid infiltrate featuring epidermotropism and morphologically comprising pleomorphic and blastic cells. The pattern of infiltration was highlighted by immunohistochemical stains, which prove the process to feature a CD8+/CD30 + phenotype, the latter being intense on larger cells, with antigenic loss. Polymerase chain reaction for T-cell receptor gamma (TCRG) chain clonality assessment documented a monoclonal peak. A diagnosis of LyP type D was favored. CONCLUSION: The reported case encompasses most of the critical features of two separated entities-PLEVA and LyP-thus providing further support to the concept of them representing declinations within a sole spectrum of disease. Studying the role of infectious agents as trigger potential in lymphoproliferative cutaneous disorders and detecting novel markers of disease, such as cytokines, could have a crucial impact on pathogenic disease mechanisms and perspective therapies.

COVID-19 , Lymphomatoid Papulosis , Parvoviridae Infections , Pityriasis Lichenoides , Child , Humans , Male , Lymphomatoid Papulosis/diagnosis , Lymphomatoid Papulosis/pathology , Pityriasis Lichenoides/diagnosis , Pityriasis Lichenoides/drug therapy , SARS-CoV-2 , Cell Proliferation
Chest ; 162(4):A281-A282, 2022.
Article in English | EMBASE | ID: covidwho-2060548
International Journal of Veterinary Science and Medicine ; 10(1):64-71, 2022.
Article in English | Scopus | ID: covidwho-2017530
The Lancet Child and Adolescent Health ; 6(9):593, 2022.
Article in English | Scopus | ID: covidwho-2016304
Applied Microbiology and Biotechnology ; 106(17):5757-5769, 2022.
Article in English | CAB Abstracts | ID: covidwho-2014103
Frontiers in Pharmacology ; 13, 2022.
Article in English | EMBASE | ID: covidwho-2009895
Annals of Intensive Care ; 12(1), 2022.
Article in English | EMBASE | ID: covidwho-2009461
IOP Conference Series : Earth and Environmental Science ; 976(34), 2022.
Article in English | CAB Abstracts | ID: covidwho-2001167
Revista Alergia Mexico ; 69(1):14-20, 2022.
Article in Spanish | EMBASE | ID: covidwho-1969988
Journal of Southwest Minzu University Natural Science Edition ; 48(2):135-141, 2022.
Article in Chinese | CAB Abstracts | ID: covidwho-1958497
ILAR Journal ; 62(1-2):133-168, 2021.
Article in English | EMBASE | ID: covidwho-1937673
Infectious disease management in animal shelters ; 2(656), 2021.
Article in English | CAB Abstracts | ID: covidwho-1918436
Cureus ; 14(5): e24952, 2022 May.
Article in English | MEDLINE | ID: covidwho-1903870


Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare clinical entity characterized by "remitting," "seronegative," and "symmetrical" synovitis with pitting edema on the dorsum of the hands and feet. Although rheumatic or malignant diseases are diseases that are known to coexist with RS3PE, other factors such as medication, infection, and vaccination have been reported to be associated with RS3PE. Here, we present a case of RS3PE syndrome that satisfied all four diagnostic criteria of RS3PE (pitting edema in the limbs, acute onset, age ≥ 50 years, and/or rheumatoid factor negativity) after mRNA-1273 SARS-CoV-2 vaccination.

Letters in Applied Microbiology ; 74(6):1001-1007, 2022.
Article in English | CAB Abstracts | ID: covidwho-1891648