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1.
British Food Journal ; 2022.
Article in English | Web of Science | ID: covidwho-2107727

ABSTRACT

Purpose To study the consumption pattern, attitude and knowledge of the general population about dietary supplements (DS) in the United Arab Emirates (UAE). Design/methodology/approach A community-based cross-sectional study was conducted to collect data on knowledge, attitude and consumption pattern related to the use of DS. Participants aged = 18 years were asked to complete a self-administered online questionnaire that included demographic characteristics, health and lifestyle information, consumption patterns, attitudes and knowledge levels regarding the use of DS. Findings A total of 207 individuals participated in the study, and 117 (56.5%) participants reported using DS products as influenced by the pandemic of coronavirus disease 2019 (COVID-19), of which 63 (53.8%) participants had been using DS for more than one month but less than one year. The majority of the participants was females (64.7%), non-UAE nationals (60.9%) and employed (51.7%). Multivitamins (77.8%) were the most commonly used DS. Use of DS was more prevalent among older participants (n = 78 (61.9%), p = 0.006), non-UAE nationals (n = 79 (62.7%), p = 0.025) and employed (n = 69 (64.5%), p = 0.023). Improving general health (76.1%) and immune booster (47%) were the most frequently identified reasons for using DS, which is relatable to the COVID-19 pandemic. The majority of study participants (72.12%) reported knowing relatively little about the use of DS. About 154 participants (74.4%) did not know that DS products do not treat diseases. Research limitations/implications Further studies with a larger sample size need to be conducted to examine the association between gender or chronic disease and the consumption and type of DS products used to fill the gap in the literature and overcome the limitations identified in this study. Originality/value This study highlights the need for community education programs and strategies that can raise awareness of the health benefits and risks of using DS. Further studies with a larger sample size need to be conducted to examine the association between gender or chronic disease and the consumption and type of DS products used to fill the gap in the literature and overcome the limitations identified in this study.

2.
BMC Oral Health ; 22(1): 475, 2022 11 08.
Article in English | MEDLINE | ID: covidwho-2108765

ABSTRACT

BACKGROUND: To evaluate the relationship between pandemic events and dental emergency service frequentation. Utilization patterns in the scope of the COVID-19 pandemic were analyzed and considered in regard of seasonal parameters. METHODS: All outpatients seeking treatment in a university hospital's dental emergency service were analyzed in the years 2019, 2019 and 2020 according to demographic data and emergencies were subdivided into "absolute" and "relative". The years 2018 and 2019 were used to compare COVID-19 and non-COVID-19 phases. Defined waves of the pandemic were compared with equivalent prior-year periods. RESULTS: Our study includes 11,219 dental emergency patients over a period of three years with a slight surplus of male patients. Comparing the pre-COVID-19 years and 2020 as a year of pandemic, the total count of cases decreased by more than 25%. The share of absolute emergencies in 2020 was higher than in the years before (p < 0.0001). The under-utilization during the waves was more pronounced during the first wave compared to the second waves. CONCLUSIONS: Additionally to the clear decrease by more than 25% in 2020, we found an inverse dependency of 7-day-incidence of COVID-19 and number of visits. This effect was more distinct for relative emergencies, while the number of patients with absolute emergencies remains rather constant. Probably, there is an acclimatization effect regarding the waves. Patients older than 60 years who suffered from relative emergencies showed an under-utilzation during 2020. During a pandemic such as COVID-19, the effect of under-utilization is more pronounced among elderly patients. However, a pandemic acclimatization effect seems to occur. This can be taken into account in the administration of this kind of circumstances in the future.


Subject(s)
COVID-19 , Pandemics , Humans , Male , Aged , COVID-19/epidemiology , Emergencies , SARS-CoV-2 , Seasons , Emergency Service, Hospital , Retrospective Studies
3.
J Res Nurs ; 27(6): 532-542, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2108651

ABSTRACT

Background: Neurological patients often suffer physical, cognitive, communicative, behavioural or psychosocial limitations. This may weaken the preconditions for participating in decisions about their treatment, rehabilitation and future. These impairments often cause relatives to care and advocate for the patient. This practice was gravely interrupted by the COVID-19 visitor ban. Aims: This study aims to investigate how relatives of neurological patients experienced the visitor ban and to identify potential areas for improvement. Methods: Twelve semi-structured interviews with relatives of neurological patients were conducted. Data were analysed by performing a thematic analysis inspired by Braun and Clark. Results: The following six themes emerged: Visitor ban as a necessary evil, Losing control and feeling checkmate, Mending the information gap, Waiting by the phone, Empathy and compassion as the core of a good relationship and Caring for a loved one from a distance. Conclusions: Having a loved one admitted to a neurological ward during the COVID-19 visitor ban greatly restrains relatives and affects the relationship with their loved one and the hospital healthcare staff. Healthcare staff need to take responsibility and reach out, while simultaneously exploring new ways of communicating.

4.
Cancers (Basel) ; 14(22)2022 Nov 11.
Article in English | MEDLINE | ID: covidwho-2109951

ABSTRACT

In this prospective, real-life cohort study, we followed 523 cancer patients (CP) and 579 healthcare workers (HCW) from two cancer centers to evaluate the biological and clinical results of the COVID-19 vaccination campaign. Seventy percent of the CP and 90% of the HCW received an mRNA vaccine or the AZD1222 vaccine. Seropositivity was high after the first vaccine among HCW and poor among CP. The second dose resulted in almost 100% seropositivity in both cohorts. Antibody response was higher after the second injection than the first in both populations. Despite at least two doses, 8 CP (1.5%) and 14 HCW (2.4%) were infected, corresponding either to a weak level of antibody or a new strain of virus (particularly the Omicron variant of concern). Sixteen CP and three HCW were hospitalized but none of them died from COVID-19. To conclude, this study showed that two doses of COVID-19 vaccines were crucially necessary to attain sufficient seropositivity. However, the post-vaccination antibody level declines in individuals from the two cohorts and could not totally prevent new SARS-CoV-2 infections.

5.
Front Public Health ; 10: 981780, 2022.
Article in English | MEDLINE | ID: covidwho-2109879

ABSTRACT

Background: In Greece, there is still limited research on death in isolation due to COVID-19. This deserves attention because of the recent financial crisis, which profoundly impacted public health, and the high relevance of the Hippocratic tradition to the moral values of clinical practice. Methods: A prospective qualitative study using in-depth interviews with 15 frontline nursing practitioners working in a COVID-19 ward or intensive care unit (ICU) was conducted from July 2021 to December 2021. Results: The inability of family members to say a final goodbye before, during, or after death by performing proper mourning rituals is extremely inhuman and profoundly impacts the mental health status of patients, family members, and nursing practitioners. Patients and their family members strongly desire to see each other. Epidemiology, liability, and proper nursing performance emerged as reasons for the enforced strict visitation restrictions. Participants emphasized that visitations should be allowed on an individual basis and highlighted the need for the effective use of remote communication technology, which, however, does not substitute for in-person contact. Importantly, physicians allowed "clandestine" visits on an individual basis. Nursing practitioners had a strong empathic attitude toward both patients and their families, and a strong willingness to provide holistic care and pay respect to dead bodies. However, they also experienced moral distress. Witnessing heartbreaking scenes with patients and/or their families causes nursing practitioners to experience intense psychological distress, which affects their family life rather than nursing performance. Ultimately, there was a shift from a patient-centered care model to a population-centered care model. Furthermore, we identified a range of policy- and culture-related factors that exaggerate the negative consequences of dying alone of COVID-19. Conclusion: These results reinforce the existing literature on several fronts. However, we identified some nuances related to political decisions and, most importantly, convictions that are deeply rooted in Greek culture. These findings are of great importance in planning tailored interventions to mitigate the problem of interest and have implications for other similar national contexts.


Subject(s)
COVID-19 , Humans , COVID-19/epidemiology , Greece/epidemiology , Prospective Studies , Qualitative Research , Family/psychology
6.
J Integr Complement Med ; 28(11): 887-894, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2107304

ABSTRACT

Background: Asymptomatic patients are unneglected sources in propagating transmission chain due to their high viral loads. However, treatments available based on symptoms seem not applicable to asymptomatic patients. In this study, the authors want to estimate the effectiveness of Lianhua Qingwen (LH) capsule on asymptomatic coronavirus disease 2019 (COVID-19) patients. Methods: A randomized controlled trial (RCT) was performed to explore the effectiveness and safety of LH capsule in treating asymptomatic COVID-19 patients. Patients were randomized to control group (isolated observation) and treatment group (LH, 4 capsules, thrice daily) for 14 days. The primary endpoints were the rate and time of nucleic acid turning negative during the isolation observation. Results: A total of 120 participants were included in the full analysis set (60 each in the control and treatment groups). Data showed that the rate of nucleic acid turning negative during the isolation observation in the treatment group was higher than that in the control group (rate difference: 21.66%, 95% confidence interval [CI]: 4.34 to 37.27, p = 0.0142). Patients in the treatment group have a shorter time of nucleic acid turning negative (7.5 vs. 14.5 days, p = 0.018). Moreover, the rate of clinical symptoms appearance in the treatment group was lower compared with that in the control group (rate difference: -31.67, 95% CI: -46.83 to -13.82, p = 0.0005). The proportion of confirmed mild and common cases in the treatment group was also lower (35.00% vs. 66.67%, p = 0.0005). No serious adverse events were documented. Conclusions: In this study, the authors illustrated that LH capsule is beneficial to asymptomatic COVID-19 patients. Considering the lack of interventions for treating asymptomatic COVID-19 patients at this stage, LH capsule could be considered as a choice. Chinese Clinical Trial Registry: ChiCTR2100042066.


Subject(s)
COVID-19 , Drugs, Chinese Herbal , Nucleic Acids , Humans , COVID-19/drug therapy , Drugs, Chinese Herbal/adverse effects
7.
Value Health Reg Issues ; 33: 76-82, 2022 Oct 18.
Article in English | MEDLINE | ID: covidwho-2106134

ABSTRACT

OBJECTIVES: This study aimed to describe clinical outcomes and medical expenditures associated with COVID-19 admissions. In addition, this study aimed to investigate the impact of patients' characteristics and baseline comorbidities on intensive care unit (ICU) admission, mortality, and medical expenditures for hospitalized patients with COVID-19. METHODS: This retrospective cohort study included all hospitalized patients with confirmed COVID-19 in Prince Hamza Hospital and King Abdullah University Hospital, during the period from March 2020 to June 2021. Medical records and pharmacy data were followed and reviewed throughout their admissions. The ICU admission, inpatient mortality, hospital length of stay, and inpatient charges were described. Predictors of ICU admission and inpatient charges were evaluated. RESULTS: A total of 7694 COVID-19 hospital admissions were included. Approximately 1189 patients (15.5%) were admitted to ICU and 21.4% died in the hospital. The fatality rate among those admitted to ICU was 82.6% compared with 10.2% for non-ICU admitted patients. The average admission charge and charge per admission day were 1598.2 and 200.2 Jordanian dinar, respectively, and both charges were higher in ICU admitted patients than non-ICU admitted patients. Being older in age, smoker or ex-smoker, and having chronic diseases were all significantly associated with a higher likelihood of ICU admission and mortality among admitted patients. CONCLUSIONS: ICU admission in patients with COVID-19 is associated with poor clinical outcomes and substantial medical expenditures and is more likely among older adults, smokers, and those with chronic diseases.

8.
J Infect Public Health ; 15(12): 1472-1476, 2022 Nov 11.
Article in English | MEDLINE | ID: covidwho-2105414

ABSTRACT

BACKGROUND: Coronavirus disease 2019 (COVID-19) causes malnutrition in infected patients. This study aimed to investigate the use of systemic immune-inflammatory index (SII), platelet-to-lymphocyte ratio (PLR), the Glasgow Prognostic Score (GPS), and neutrophil-to-lymphocyte ratio (NLR) for malnutrition assessment among COVID-19 inpatients. METHODS: This is a single-center retrospective study on 108 hospitalized COVID-19 patients; 14 were admitted to the intensive care unit (ICU). Data were collected from patients' profiles while NLR, PLR, GPS, and SII were calculated. Inflammatory indices' predictive power was analyzed using the receiver operating characteristic curve (ROC). A P-value of < 0.05 was considered statistically significant. RESULTS: Hospitalization days, neutrophils count, C-reactive protein (CRP), and serum urea levels were significantly higher in ICU patients. None of SII, PLR, and NLR were significantly different between ICU and non-ICU groups. Also, albumin and GPS showed a higher sensitivity level (100.0), followed by PLR and SII (78.57 and 71.34, respectively). Regarding ROC curves, even though NLR, PLR, and SII provided the largest area under the curve (AUC) (0.687, 0.682, 0.645; respectively), they have shown a poor discrimination ability, while GPS and albumin were ineffective in predicting malnutrition in COVID-19 patients. CONCLUSION: NLR, SII, and PLR showed poor predicting ability for malnutrition among COVID-19 inpatients. Additional consideration should be taken for using inflammatory parameters (SII, PLR, GPS, and NLR) to predict malnutrition in COVID-19 inpatients.

9.
Int J Infect Dis ; 2022 Nov 09.
Article in English | MEDLINE | ID: covidwho-2105085

ABSTRACT

PURPOSE: This study aimed to investigate the differences between elderly patients hospitalized with coronavirus disease 2019 (COVID-19) or influenza A H1N1 virus infections. METHODS: We contrasted two absolute groups of patients (age ≥ 60) infected with either COVID-19 (n = 222) or influenza A H1N1 virus infections (n = 96). Propensity score matching was used to reduce the imbalance between the two matched groups. The clinical features, imaging presentations, therapies, and prognosis data were compared between the two groups. RESULTS: The influenza patients showed higher proportions of cough, expectoration, fatigue and shortness of breath. Higher counts of lymphocytes, hemoglobin and creatine kinase and lower counts of WBCs, neutrophils, blood urea nitrogen and C-reactive protein were found in the COVID-19 patients. Regarding the imaging characteristics, bilateral pneumonia was the most abnormal pattern in the two groups of patients. The incidence of ARDS or death was lower among the COVID-19 patients. CONCLUSIONS: The clinical manifestations of COVID-19 patients are more concealed than those of influenza patients. Fewer symptoms of sputum production, fatigue, and shortness of breath combined with lower counts of WBCs, neutrophils and CRP are possible predictive factors of COVID-19 among elderly patients.

10.
Adv Med Sci ; 68(1): 31-37, 2022 Nov 08.
Article in English | MEDLINE | ID: covidwho-2104238

ABSTRACT

PURPOSE: The aim of this study is to investigate insulin-like growth factor binding protein 5 (IGFBP5) expression in coronavirus disease 2019 (COVID-19) patients and its relationships with COVID-19 laboratory findings and plasma osteopontin (OPN) levels. MATERIALS AND METHODS: We enrolled 60 patients with COVID-19 and 30 healthy individuals in this study. mRNA expression of IGFBP5 was measured by RT-PCR. Plasma OPN levels were measured via the ELISA method. RESULTS: Plasma OPN levels were higher and IGFBP5 expression levels were lower in COVID-19 patients than in the healthy individuals (p â€‹= â€‹0.0057 and p â€‹= â€‹0.0142, respectively). Critically ill patients had higher OPN and lower IGFBP5 than non-critically ill patients. Patients with affected lungs demonstrated increased OPN and decreased IGFBP5 (p â€‹= â€‹0.00032 and p â€‹= â€‹0.044, respectively). Receiver operating characteristic (ROC) analysis indicated that IGFBP5 expression and OPN levels can be used discriminate non-critically from critically ill patients (p â€‹= â€‹0.049; p â€‹= â€‹0.0016, respectively). CONCLUSION: This study demonstrated that patients with a poor prognosis had increased OPN and decreased IGFBP5. High values of OPN and low values of IGFBP5 may be considered as signs of disease severity. Tissue-specific IGFBP5 expression may contribute to understanding the role of IGFBP5 in the lungs in COVID-19 cases.

11.
Curr Psychiatry Rep ; 24(11): 635-643, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2104097

ABSTRACT

PURPOSE OF REVIEW: We reviewed current evidence on the impact of coronavirus disease 2019 (COVID-19) pandemic on sleep of different populations. RECENT FINDINGS: Several studies demonstrated that sleep deprivation may cause immune system dysregulation, which deteriorates the course of COVID-19. The increased prevalence of sleep disorders among COVID-19 patients has been associated with more severe disease and worse clinical outcomes. Healthcare workers who were subjected to atypical workload and more nightshifts developed sleep disorders which associated with work-related errors and COVID-19 infection susceptibility. In general population, circadian misalignment and excessive stressors impaired sleep quality. Sleep dysfunction has been recorded due to the pandemic. It is essential to implement interventions in order to alleviate pandemic-related sleep disorders. Telemedicine, cognitive behavioral therapy, and sleep hygiene practices appear to be helpful. Psychotropic medication should be cautiously administered, while other pharmacological agents, such as melatonin, have shown promising results.


Subject(s)
COVID-19 , Sleep Wake Disorders , Humans , Pandemics , SARS-CoV-2 , Sleep/physiology , Sleep Wake Disorders/therapy , Sleep Wake Disorders/epidemiology
12.
Lett Appl Microbiol ; 75(5): 1225-1231, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2103163

ABSTRACT

Human adenoviruses (HAdVs) are prevalent worldwide and are a common cause of respiratory tract infection in people of all ages. However, little is known about HAdV infection among children with severe acute respiratory infection (SARI). The present study retrospectively analysed the molecular typing and epidemiological characteristics of HAdV-positive samples from children with SARI from January 2017 to December 2021 in Huzhou. The results showed that 89 (8·27%) of 1078 SARI paediatric patients were positive for HAdVs. Children <5 years of age accounted for 87·64% of the positive cases. The peak seasons for HAdV infection were the first quarter and the fourth quarter. In addition, HAdV-B and HAdV-C were circulating among paediatric patients with SARI, of which the B3 genotype (n = 30, 51·72%) was the most prevalent and was detected every year, indicating that B3 is the main epidemic strain in the Huzhou area, followed by C1 (n = 9, 15·52%), C2 (n = 7, 12·07%) and B7 (n = 5, 8·62%). These findings provide a benchmark for future epidemiology and prevention strategies for HAdVs.


Subject(s)
Adenovirus Infections, Human , Adenoviruses, Human , Pneumonia , Respiratory Tract Infections , Humans , Child , Infant , Adenovirus Infections, Human/epidemiology , Retrospective Studies , Phylogeny , Adenoviruses, Human/genetics , Molecular Typing , Respiratory Tract Infections/epidemiology , Genotype , China/epidemiology , Molecular Epidemiology
13.
HIV Nursing ; 22(2):1159-1162, 2022.
Article in English | Scopus | ID: covidwho-2100949

ABSTRACT

Background: Because of the rapid spread of the covid 19 as a pandemic, unexpected measures had been done to control this pandemic all over the world. the knowledge, attitudes, and practices (KAP) toward the disease are important to implement these measures [1]. Material and methods: A cross-sectional study of convenience nonprobability sampling was done that which 400 previous covid 19 detected patients were interviewed in Al-Andalus health center of Ramadi city during the period from September- to December 2021. Results: The study revealed that the average mean age was 40±14 years that 60% of the patients were over 40 years in which more than half of them had cardiovascular diseases, hypertension, and diabetes mellitus. 55% (220) of the patients were females that most of them were housewives and had not graduated while 45% (180) of them were males, smokers, working, and graduated. 50% (200) were obese and 25% (100) were overweight with BMI was 35, 38 for males and females respectively concerning 34% were gaining weight. Only 35% of patients had changed toward a healthier lifestyle by changing their diet habits, and physical activity, because of worry from complications. There was a positive correlation between sex, knowledge, and education, P value<0.001. Regarding practice toward corona preventive measures, 50% of the patients had hygiene measures at home and preventive measures with people. 20% (50) of them had taken garlic, vegetables, and fruit frequently, had donned physical activity with sunlight exposure, and had an agreement for vaccination. Most of the patients were anxious. For dietary patterns, more than half of the patients had fatty-junky food, a lot of carbohydrates, home sweets frequently, with la ack of intake of garlic, fish, vegetables, orange juices, fruits, and doing exercise. © 2022, ResearchTrentz Academy Publishing Education Services. All rights reserved.

14.
HIV Nursing ; 22(2):981-985, 2022.
Article in English | Scopus | ID: covidwho-2100946

ABSTRACT

Background: Coronavirus disease 2019 (COVID-19) has rapidly become a global health issue. The current coronavirus disease (COVID-19) epidemic necessitates the rapid development of therapies that enhance the outcomes of persons suffering from severe illness. To enhance the treatment of COVID-19 patients, early and effective indicators of disease severity are required. Gelsolin (GSN) is a circulating protein that is promptly consumed by extreme tissue injury and causes actin filament depolymerization, blocking downstream inflammatory processes. Objective: The aim of the presented work is to study if serum gelsolin levels had any relationship with Covid-19 infection and severity indicator in order to revealed if serum gelsolin could be utilized as a disease predictor marker severity. Materials and Methods: A case-control study was conducted with 90 Covid-19 patients and 90 healthy volunteers as the control group (with age ranged between 45-60 years) The patients were obtained from Al-Amal hospitals in Najaf city, Iraq, between Nov., 2020 and June, 2021. COVID-19 patients were separated into two groups based on the degree of their condition, which are mild/moderate disease and severe disease. Blood samples were taken and all demographic and clinical data of the sick and healthy groups were recorded. GSN levels in the blood were determined using enzyme-linked immunosorbent assays (ELISA). Colorimetric techniques were used to determine the activity of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin levels. ichroma assessed serum ferritin and D-dimer, and CBC by spincell3. Ran a statistical analysis to noticed if they were linked to illness severity. Results: GSN levels were considerably lower in some patient groups. However, as compared to the mild/moderate instance of patients, the level of GSN was considerably lower in the mild and severe COVID-19 groups. Patients (95.45 ± 35.36) had considerably lower serum (GSN) levels than mild/moderate patients (172.32 ± 44.76) while. Healthy group (289.52 ± 71.33) (P 0.001). suggesting that it is an independent predictor of coronavirus infection Serum (GSN) levels were significantly and adversely connected with Age (year), SBP mmHg ferritin, (AST, ALT, ALP activity levels), and D-dimer levels, whereas GSN levels were significantly and positively correlated with Lymph percent levels. Conclusion: In conclusion, serum GSN concentration was lower in COVID-19 patients compared to the mild/moderate case group and healthy controls. Extensive tissue injury depletes and quickly consumes serum gelsolin (GSN), a naturally occurring, abundant circulating protein. The finding that considerable depletion is linked to eventual bad outcomes in a variety of clinical situations in severe inflammatory diseases holds hope for preventing lung harm and other injury organs. © 2022, ResearchTrentz Academy Publishing Education Services. All rights reserved.

15.
Bali Medical Journal ; 11(3):1074-1079, 2022.
Article in English | Web of Science | ID: covidwho-2100512

ABSTRACT

Background: The initial presentation of hospitalized End-Stage Kidney Disease (ESKD) patients with and without coronavirus disease 2019 (COVID-19) is similar and can overlap. We aimed to compare clinical dan laboratory characteristics of the COVID-19 positive and negative patients to help clinicians screen and differentiate hospitalized ESKD patients. Methods: We reviewed data from the medical record of ESKD patients hospitalized between May 1, 2020, and April 30, 2021. The study comprised all suspected COVID-19 patients. The COVID-19 positive was based on results from RT-PCR for SARS-CoV-2. The bivariate analysis was used to compare the positive and negative groups. The association of all characteristics and diagnosis of COVID-19 were then evaluated by multivariable analysis. Results: There was twenty-nine percent of confirmed COVID-19 in 176 ESKD patients. The proportion of dyspnea, pulmonary edema, pleural effusion, and cardiomegaly were lower in the COVID-19 positive group. Diastolic blood pressure, pulse rate, white blood cell differential counts, and potassium were lower in the COVID-19 positive group. Using a multivariate analysis, eosinophil count <0.04 x103 mu l (P<0.001, OR 3.50, 9596CI:0.123-0.665), monocyte count <0.69 x103 mu l (P=0.004, OR 2.54, 9596CI:0.166-0.931), and neutrophil-to-lymphocyte ratio (NLR) <3.13 (P=0.044, OR 3.18, 9596CI:0.102-0.968) were associated with the presence of COVID-19. Conclusions: Leukocyte differential count and chest x-ray should be evaluated as an initial screening of COVID-19 in hospitalized ESKD. Low levels of monocyte and eosinophil count and mild elevation of NLR were associated with COVID-19 in ESKD patients.

16.
Chirurgia (Bucur) ; 117(5): 526-534, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2100672

ABSTRACT

Background: Spontaneous retroperitoneal hematoma is a severe and potentially fatal complication that appears in the course of anticoagulation therapy. Therapeutic doses of low molecular weight heparin (LMWH) are used for the prevention of thrombosis in patients seriously ill with Covid-19. Methods: We describe 27 (0.14%) patients with retroperitoneal hematomas who required emergency surgery out of 19108 patients with Covid-19 who were hospitalized in Batajnica COVID Hospital between March 2021 and March 2022. All the patients were on therapeutic doses of LMWH. The existence of retroperitoneal hematoma was confirmed by abdominal ultrasound and computed tomography scans. Results: Open surgery was performed on 27 patients with spontaneous retroperitoneal hematomas (12 female and 15 male). The mean age of the study population was 71.6+-11.9 years. D-dimer was significantly elevated two days before the surgery in comparison with the values on the day of surgery (p=0.011). Six patients (22.23%) survived, while 21 (77.77%) patients died. Conclusion: Bleeding in Covid-19 patients treated by LMWH is associated with an increased risk of developing retroperitoneal hematoma. Open surgery for retroperitoneal hematoma in Covid-19 patients on anticoagulation therapy is a procedure associated with a high rate of mortality.


Subject(s)
COVID-19 , Peritoneal Diseases , Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Heparin, Low-Molecular-Weight , Anticoagulants , Treatment Outcome , Hematoma , Gastrointestinal Hemorrhage
17.
Microorganisms ; 10(11)2022 Nov 04.
Article in English | MEDLINE | ID: covidwho-2099664

ABSTRACT

We sought to investigate the influence of SARS-CoV-2 infection on the cytokine profiles of peripheral blood mononuclear cells (PBMCs) and neutrophils from coronavirus disease 2019 (COVID-19) intensive care unit (ICU) patients. Neutrophils and PBMCs were separated and stimulated with the mitogen phytohemagglutinin. Culture supernatants of mitogen-stimulated PBMCs and neutrophils from 88 COVID-19 ICU patients and 88 healthy controls were evaluated for levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-α, IFN-γ, interleukin (IL)-2, -4, -5, -6, -9, -10, -12, -17A, and tumor necrosis factor (TNF)-α using anti-cytokine antibody MACSPlex capture beads. Cytokine profiles of PBMCs showed significantly lower levels of GM-CSF, IFN-γ, IL-6, IL-9, IL-10, IL-17A, and TNF-α (p < 0.0001) in COVID-19 ICU patients. In contrast, COVID-19 ICU patients showed higher median levels of IL-2 (p < 0.001) and IL-5 (p < 0.01) by PBMCs. As for neutrophils, COVID-19 ICU patients showed significantly lower levels of GM-CSF, IFN-γ, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-17A, IL-12, TNF-α (p < 0.0001), and IFN-α (p < 0.01). T-helper (Th)1:Th2 cytokine ratios revealed lower inflammatory cytokine for PBMCs and neutrophils in COVID-19 ICU patients. Cytokine production profiles and Th1:Th2 cytokine ratios suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has an immunomodulatory effect on PBMCs and neutrophils. This study also suggests that the increased levels of several cytokines in the serum are not sourced from PBMCs and neutrophils.

18.
Int J Mol Sci ; 23(21)2022 Nov 05.
Article in English | MEDLINE | ID: covidwho-2099580

ABSTRACT

Transcriptome studies have reported the dysregulation of cell cycle-related genes and the global inhibition of host mRNA translation in COVID-19 cases. However, the key genes and cellular mechanisms that are most affected by the severe outcome of this disease remain unclear. For this work, the RNA-seq approach was used to study the differential expression in buffy coat cells of two groups of people infected with SARS-CoV-2: (a) Mild, with mild symptoms; and (b) SARS (Severe Acute Respiratory Syndrome), who were admitted to the intensive care unit with the severe COVID-19 outcome. Transcriptomic analysis revealed 1009 up-regulated and 501 down-regulated genes in the SARS group, with 10% of both being composed of long non-coding RNA. Ribosome and cell cycle pathways were enriched among down-regulated genes. The most connected proteins among the differentially expressed genes involved transport dysregulation, proteasome degradation, interferon response, cytokinesis failure, and host translation inhibition. Furthermore, interactome analysis showed Fibrillarin to be one of the key genes affected by SARS-CoV-2. This protein interacts directly with the N protein and long non-coding RNAs affecting transcription, translation, and ribosomal processes. This work reveals a group of dysregulated processes, including translation and cell cycle, as key pathways altered in severe COVID-19 outcomes.


Subject(s)
COVID-19 , RNA, Long Noncoding , Humans , COVID-19/genetics , SARS-CoV-2 , Transcriptome , Gene Expression Profiling , RNA, Long Noncoding/genetics , Cell Cycle/genetics
19.
Ricerche Di Psicologia ; 45(2), 2022.
Article in Italian | Web of Science | ID: covidwho-2099084

ABSTRACT

The Coronavirus-19 (COVID-19) disease pandemic has a huge impact on global health and hospitals, which have had to reorganize their services to deal with an unprecedented health emergency. This paper describes the experience of the Clinical Psychology Unit of a large healthcare organization in Milan (Italy), focusing on the interventions delivered for hospitalized COVID-19 patients with the aim of highlighting their experiences and related psychological needs, and propose reflections on the functions that the psychologist can have with respect to these needs. The reflections are based on an extensive clinical experience conducted in presence for over a year with those patients hospitalized for COVID-19 who have received treatment with C-PAP, helmet, or low-flow oxygen. This led to the bottom-up identification of three macro-areas of issues that these patients face: isolation, fear of death, grief. In addition, two further transversal themes have been identified - guilt and the perception of time - which seem to modulate the articulation of the three macro-areas. Starting from these experiences and needs, two lines of actions of the psychologist with the hospitalized COVID- 19 patient are identified that correspond to the two phases of hospitalization: 1) an action in the `here and now' when the patient is still in a critical phase;2) an action of narrative recovery of the lived experience when the patient is recovering. The importance for hospitalized COVID-19 patients of delivering psychological consultations in presence is supported by clinical experience;however, its effectiveness in preventing subsequent maladjustments should be evaluated in further studies.

20.
Front Psychiatry ; 13: 1010004, 2022.
Article in English | MEDLINE | ID: covidwho-2099251

ABSTRACT

Background: Previous studies have showed that individuals infected with COVID-19 were more likely to report psychological symptoms. However, little is known about the changes from testing positive to negative to positive again. Methods: This survey was conducted through the questionnaires including the 7-item Generalized Anxiety Disorder (GAD-7), the 9-item Patient Health Questionnaire (PHQ-9), as well as the Self-Rating Scale of Sleep (SRSS) to explore the psychological status of COVID-19 and re-positive cases.″re-positive″ is defined as a positive RT-PCR test at any time during the recovery period after testing negative. Results: A total of 94 COVID-19 patients presented the prevalence rates of anxiety, depression, insomnia, and any of the three psychological symptoms being 26.6, 8.6, 12.8, and 31.9%, respectively. Among these, 32 cases were re-tested positive during the recovery period, with the prevalence rates of anxiety, depression, insomnia, and any of the three psychological symptoms being 21.9, 18.7, 31.2, and 37.5%, respectively. The psychological status after re-positive showed a significant decrease in anxiety (P = 0.023), an increase in depression, and a significant rise in insomnia (P = 0.035). For those with no psychological symptoms during initial-positive, after re-positive, 5.88% reported anxiety, 5.88% reported depression, and 11.76% reported insomnia. For those who experienced only anxiety symptoms during initial-positive, after re-positive, 33.3% reported depression, and 33.3% reported insomnia. Conclusions: Our findings encompassed the urgent concern for anxiety in initial-positive COVID-19 patients, depression in re-positive COVID-19 patients, and insomnia in both initial and re-positive patients, hence enabling targeted interventions for appeasing the psychological burden of COVID-19 patients.

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