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1.
CEN Case Reports ; 2023.
Article in English | EMBASE | ID: covidwho-2175247

ABSTRACT

A 77-year-old male patient on maintenance hemodialysis therapy who underwent unilateral adrenonephrectomy 9 years ago was transferred to our hospital after 4 months of acute treatment for skull base osteomyelitis. He presented with unexplained hypotension during dialysis sessions. Further evaluation led to a diagnosis of primary adrenal insufficiency, followed by the start of oral hydrocortisone. Six months after admission, the patient was found to have a positive COVID-19 result on a rapid antigen test and mild symptoms. The patient complained of fatigue after the disappearance of the symptoms. Subsequently, the systolic blood pressure gradually declined despite the additional administration of fludrocortisone and caused difficulties in undergoing hemodialysis. The patient's lasting fatigue raised a suspicion of post-COVID-19 syndrome, requiring larger dosages of corticosteroids by stress dosing. Hypotension was interpreted as a symptom associated with adrenal insufficiency. The dosages of corticosteroids were increased beyond the upper recommended limits. The effect eventually stabilized the patient's hemodynamics. Hydrocortisone was increased as follows: 35 mg/day for nondialysis days and 55 mg/day for dialysis days, divided into three or four doses per day (20 mg in the morning, 20 mg before dialysis, 10 mg in the afternoon, and 5 mg in the evening). The dosage of fludrocortisone was increased up to 0.5 mg/day. In conclusion, the requirement for corticosteroids significantly increased in association with post-COVID-19 syndrome. The management of patients with adrenal insufficiency in the context of concomitant post-COVID-19 syndrome needs further investigation. Copyright © 2023, The Author(s) under exclusive licence to The Japan Society of Nephrology.

2.
Biological Psychiatry & Psychopharmacology ; 24(1/2):3-9, 2022.
Article in Lithuanian | Academic Search Complete | ID: covidwho-2169613

ABSTRACT

Introduction. With the increasing number of COVID-19 cases, there is a growing need for tools that can assess not only the recovery process but also the impact of the disease on a person's functioning abilities. Therefore, the aim of this study was to evaluate construct validity of Lithuanian version of Post-COVID-19 Functional Status (PCFS) Scale. Methods. The study was performed in two retrospective samples: hospitalized patients (n=133, 51.9% female, mean age 56.0 years old, date of assessment: 7.9±2.6 months after infection) and milder COVID-19 home-treated patients (n=230, 80,4% female, mean age 35.6 years old, date of assessment: 7.4±3.5 months after infection). A set of self-report questionnaires was used, which consisted of the PCFS Scale, the assessment of subjective symptoms of COVID-19 (acute symptoms, prolonged symptoms and cognitive complaints), PHQ-9 and GAD-7 scales. Results. 25.6% of hospitalized and 40.4% of home-treated COVID-19 patients reported functional limitations at various levels. In both samples, PCFS Scale scores were significantly correlated with the sum of acute COVID-19 symptoms (r=0.382 and r=0.259, respectively), the sum of prolonged COVID-19 symptoms (r=0.399 and r=0.346, respectively), and prolonged cognitive complains scales (r=0.346 and r=0.301, respectively). Subjects who had functional limitations were also found to have significantly higher rates of clinically significant depression and anxiety, compared to subjects with no limitations (p<0.001). Conclusions. Lithuanian version of the Post-COVID-19 Functional Status Scale can be considered as a valid instrument that can assess the functional status of adults with different severity of COVID-19 after 7 months after infection. (English) [ FROM AUTHOR]

3.
Adv Gerontol ; 35(5):726-736, 2022.
Article in Russian | PubMed | ID: covidwho-2168826

ABSTRACT

The global aging of the population in the modern world leads to an increase in the number of people of older age groups. Polymorbid pathology and geriatric syndromes, which include frailty and sarcopenia, can cause organism instability to various factors of the external and internal environment. The current COVID-19 pandemic, accompanied by a significant increase in mortality among the elderly and senile, makes it necessary to investigate the reasons underlying the increased vulnerability of geriatric patients to this disease. This review of the literature is devoted to this problem.

4.
Neurology Asia ; 27(4):899-908, 2022.
Article in English | EMBASE | ID: covidwho-2207121

ABSTRACT

Background: COVID-19 was declared as a pandemic by World Health Organization on March 11, 2020, and still constitutes a serious health problem affecting millions of people across the world. The evaluation and follow-up of ongoing and/or newly developing neurological involvement after recovery from COVID-19 are important. This study aims to reveal post-COVID-19 neurological symptoms and risk factors for their development. Method(s): Patients over the age of 18 years who applied to centers, at least 4 weeks after COVID-19 infection and agreed to participate in the study were included in this cross-sectional study between January 20 and March 15, 2021. The patients were evaluated face to face, and their sociodemographic data, medical history, post-COVID-19 neurological symptoms, treatments, and Beck Depression Inventory scores were recorded. All statistical analyses were performed using SPSS 23 for Windows software package (SPSS Inc., Chicago, IL). Result(s): Four hundred patients were included in this study, an average of 108+5.12 days had passed after the onset of COVID-19. The rate of post-COVID-19 neurological involvement was 73.3%, and the top 3 most common symptoms were headache (47%), myalgia (43%), and sleep disturbance (39%). Having depression (OR: 4.54, 95% Cl:1.88-10.96), female gender (OR:2.18, 95% Cl:1.36-3.49), hospitalization (OR: 2.01, 95% Cl:103-3.64), and usage of favipiravir (OR:2.07 95 Cl:1.15-3.72) were determined as independent predictors of developing prolonged neurological symptoms. Conclusion(s): The long-term consequences of COVID-19 remain uncertain. It should be remembered that neurological symptoms are very common in post-infectious patients and long-term follow-up may be required in the management of this condition. Copyright © 2022, ASEAN Neurological Association. All rights reserved.

5.
Revista de Investigacion e Innovacion en Ciencias de la Salud ; 4(2):160-169, 2022.
Article in Spanish | Scopus | ID: covidwho-2206526

ABSTRACT

Introduction. Not all people exposed to COVID-19 develop a severe respiratory disease and the number of young adults without previous pathologies, seriously affected by the virus, is increasing. Many of non-specific symptoms and complications have been evidenced after the recovery. Objective. To evaluate the repercussions in a healthy and physically active subject who presented serious medical complications and post-COVID-19 complications. Case report. A 41-year-old man, physically active and without known diseases, in whom SARS-CoV2 infection with a positive PCR test is documented. He required 22 days in the ICU, 17 days in general hospitalization, 57 days of disability and after twelve months there is evident weight and memory loss, difficulty thinking and concentrating, loss of muscle mass, compromised liver function, tiredness and fatigue, muscle pain, sleep problems, changes in mood, and alterations in the taste. According to the current findings, the production of a type of antibody prevents the immune system from having an adequate response against the disease. In addition to this, a new gateway for the virus into the body has been described: the protein neuropilin-1 (NRP1), as well as the possible decrease in surfactant that allows the flexibility of the lungs. This could provide answers to complications in healthy and physically active people after COVID-19 infection. Conclusions. Understanding that COVID-19 is a recent disease, there is still a lot of information to collect to understand its behavior in the human body. However, research is providing evidence on why COVID-19 can cause serious medical complications in healthy and physically active people. Understanding that it is a multifactorial situation, more research is necessary with this population in order to carry out clinical management approaches according to the disease and avoid fatal outcomes. © 2022. Fundación Universitaria María Cano.

6.
Med Pr ; 73(6):449-456, 2022.
Article in English | Web of Science | ID: covidwho-2203824

ABSTRACT

BACKGROUND: The SARS-CoV-2 virus, causing acute respiratory disease, is responsible for the COVID-19 pandemic, which began in early 2020. In addition to symptoms typical of respiratory tract infections, the virus causes a number of non-specific, often long-lasting effects that hinder the daily functioning of individuals. The aim of the study was a subjective assessment of life quality and health perception among recovered COVID-19 patients. MATERIAL AND METHODS: The study included 337 subjects who had been infected with SARS-CoV-2 confirmed by a positive RT-PCR test. The study participants were of legal age. The convalescents completed a questionnaire that contained 26 questions about gender, height, body weight, blood type, general and specific symptoms, comorbidities, hospital stay and duration of specific symptoms, the severity of which was assessed on the Visual Analogue Scale (VAS). The subjects determined whether the COVID-19 infection influenced their health perception and life quality. RESULTS: According to 46% of the respondents, COVID-19 had an impact on their quality of life and health. The chance for patients to notice the negative effects of COVID-19 on their current health status and life quality increased with each subsequent symptom of the disease by 49%, with each day of its occurrence by 3%, and with each VAS point of the severity of all infection symptoms by 30%. CONCLUSIONS: The study shows that COVID-19 disease affects life quality and overall health perception after recovery. Significant impact of COVID-19 on the quality of life should be a signal to create mental support and rehabilitation programs for convalescents to minimize discomfort and shorten the duration of absenteeism from work. Med Pr. 2022;73(6):449-56.

7.
Immunobiology ; 228(1):152316, 2023.
Article in English | ScienceDirect | ID: covidwho-2165411

ABSTRACT

We studied the role of cytotoxic components (DAMPs) formed in the body of patients with COVID-19 in ensuring the long-term preservation of post-COVID-19 manifestations and the possibility of creating an experimental model by transferring DAMPs to rats. In patients with post-COVID-19 syndrome (PCS) 2 months after SARS-CoV-2 infection we determined the presence of cytotoxic components in the blood serum (Terasaki test, Dunaliella viridis test and content of DAMPs). In post-COVID-19 syndrome patients with a high content of serum cytotoxic oligopeptide fraction (selective group, n = 16) we determined the number of leukocytes, lymphocytes, neutrophil granulocytes and monocytes in the blood, the content of C-reactive protein (CRP), the concentration of C3 and C4 complement components and circulating immune complexes, the serum content of IL-6, IL −10, IL-18, TNF-α, phagocytic activity of neutrophils, presence of neutrophil traps and autoantibodies ANA. It has been shown that in patients with PCS, there are components with cytotoxicity in the blood serum, form specific immunopathological patterns, which are characterized by: an increased content of CRP, complement system components C3 and C4 and cytokines (TNF-α, IL-6, IL-10, IL-18) activation, the formation of a wide range of autoantibodies ANA, the low efficiency of endocytosis in oxygen-independent phagocytosis;their phagocytic activity reaches its functional limit, and against this background, activation of neutrophil traps occurs, which can contribute to further induction of DAMPs. This self-sustaining cell-killing activation provided long-term preservation of PCS symptoms. The transfer of blood serum components from selective group patients with PCS to rats was accompanied by the appearance of cytotoxic components in them which induced sensitization and immunopathological reactions. Preventive administration of a biologically active substance with polyfunctional properties MF to experimental animals "corrected” the initial functional state of the body's immune-metabolic system and eliminated or facilitated immuno-inflammatory reactions.

8.
Vestnik Vosstanovitel'noj Mediciny ; 21(4):41-50, 2022.
Article in Russian | Scopus | ID: covidwho-2164739

ABSTRACT

INTRODUCTION. To expand the range of the pantohematogen based drugs usage, to develop indications for their use in various forms and methods, scientific research is necessary and appropriate on evaluation of the effectiveness of the antler drugs use for the rehabilitation of patients with post-coronavirus syndrome, which is detected in most patients after the coronavirus infection COVID-19 and is characterized by various changes in metabolism and hemostasis, autonomic nervous system, external respiration, indicators of central and peripheral hemodynamics, reduced exercise tolerance, quality of life and working capacity of patients. AIM. To scientifically establish and develop of a comprehensive program of COVID-rehabilitation of patients with the use of pantohematogen at the sanatorium-resort stage. MATERIAL AND METHODS. We conducted randomized study in parallel groups. The study included women aged 39 to 65 years (mean age 53.9±1.18 years) - 30 patients. The rehabilitation program of the patients who had pneumonia associated with COVID-19 novel coronary virus infection was evaluated 3-4 months after the disease. The study group was additionally prescribed 1 capsule of pantohematogen, three times a day with meals, for 10-12 days (dietary supplements with increased iron content). The comparison group received the same rehabilitation program, but without the use of pantohematogen. RESULTS AND DISCUSSION. According to the severity of post-COVID pneumonia, 66.6% were diagnosed with pneumonia of moderate severity and 33.4% with mild severity. Mild degree of dyspnea was revealed in 63.3% of patients, physical asthenia was diagnosed in 70% of patients. The use of pantohematogen showed an advantage in terms of a more significant decrease in the level of physical asthenia, a decrease in dyspnea during physical exertion, a decrease in the frequency of autonomic disorders, an improvement in the psycho-emotional status, and a more significant decrease in reactive anxiety in these patients. In order to prolong the effectiveness of the post-COVID rehabilitation program for patients, it is advisable to continue taking pantohematogen in outpatient or home conditions for 2 weeks, 1 capsule three times a day. CONCLUSION. For the first time the possibility and expediency of using pantogematogen with additional iron content to increase the efficiency of the health center rehabilitation program has been studied and proved;it can be used in patients with post-COVID conditions for normalization of functional disorders, vegetative-status and normalization of psycho-emotional status in all organizational forms of sanatorium-resort organizations, as well as at home. © 2022, Alexander V. Shakula, Irina A Nesina, Alexander I. Pavlov, Elena A. Kurniavkina, Vareria S. Chursina, Irina V. Telepanova This is an open article under the CC BY license.

9.
Electronic Journal of General Medicine ; 20(1), 2023.
Article in English | Web of Science | ID: covidwho-2164613

ABSTRACT

Background: At present, during the coronavirus disease (COVID-19) pandemic, chronic pain is becoming more prominent, and it is also associated with the post-COVID-19 syndrome. Thanks to quick decisions on the therapy and as part of COVID-19 prevention, we have succeeded in stabilising the situation all over the world. On the other hand, 'quick decisions' have contributed to other significant issues which we are beginning to deal with now: in the effort to defeat the virus, many experts regarded the adverse effects of the medications used to be of secondary importance. Purpose: The article aims to demonstrate the side effects of treatment with various drugs (and their combinations) that are used to treat COVID-19 disease. Method: From the beginning of January until mid-May, the COVID-19 department of the 2nd Surgical Clinic of the Faculty of Medicine of the Comenius University in Bratislava (University Hospital Bratislava, Hospital of Saints Cyril and Methodius) treated 221 patients with moderate and severe course of COVID-19 (2nd wave of the pandemic). We saw some adverse effects and lack of effect of certain drugs for COVID-19. Results: The benefits of preventive measures compared to treatment are enormous. For example, corticoids can impair metabolism, cause diabetes, or suppress immunity. Antibiotics may cause colitis and blood pressure medications may negatively impact blood circulation. Conclusion: Preventive measures such as vaccination and activation of intrinsic antiviral immune systems are based on an incomparable benefit. Important in the process of the activation of antiviral immunity (linked to interferon synthesis) in the prevention of COVID-19 is the improvement of vitamin D deficit and the use of other micronutrients. Practical value: The results of the study will be valuable in the field of medicine, for virologists, pharmacologists, pharmacists, and medical professionals.

10.
J Appl Physiol (1985) ; 2022.
Article in English | PubMed | ID: covidwho-2153163

ABSTRACT

The aim of this study was to determine the effectiveness of physical exercise, respiratory muscle training and the self-management WHO recommendations leaflet on the recovery of physical fitness, quality of life and symptom status in people with post COVID-19 conditions. Eighty non-hospitalized adults with a post-COVID-19 condition were randomly assigned to one of four 8-week parallel intervention groups: multicomponent exercise program based on concurrent training- CT (n= 20;3 resistance and endurance supervised sessions per week at low-moderate intensity);b) inspiratory muscle training- RM (n= 17;2 standardized daily sessions);c) a combination of both of the above- CTRM (n= 23);d) control group- CON (n= 20;following the WHO guidelines for post-COVID-19 related illness rehabilitation). No significant differences between groups were detected at baseline. While no significant differences between interventions were detected in the VO(2max), significant individual improvements were identified in the CT (7.5%;ES=0.38) and CTRM (7.8%;ES=0.28) groups. Lower body muscle strength significantly improved in the CT and CTRM (14.5-32.6%;ES=0.27-1.13) groups compared to RM and CON (-0.3-11.3%;ES=0.19-0.00). The CT and CTRM groups improved significantly for dyspnea and fatigue, as did the health status. In addition, significant differences between interventions were described in fatigue and depression scales favouring CT and CTRM interventions. An individualized and supervised concurrent training with or without respiratory muscle training was safer and more effective than self-care recommendations and inspiratory muscle training alone, to regain cardiovascular and muscular fitness, improve symptom severity and health status in outpatients with post-COVID-19 conditions.

11.
J Neurol ; 2022 Nov 23.
Article in English | MEDLINE | ID: covidwho-2128630

ABSTRACT

BACKGROUND: A fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part of the post-COVID-19 syndrome. This study aimed to assess the neuropsychological profile of these patients. METHODS: Assessment at baseline (three months or more following acute COVID-19) of a monocentric prospective cohort of patients with post-COVID-19 syndrome. Multidomain neuropsychological tests were performed, and questionnaires on depression, anxiety, fatigue, sleep, and general health status were administered. RESULTS: Of the 58 patients screened, six were excluded due to possible alternative causes of cognitive impairment (major depression, neurodegenerative disease). Of the remaining 52 individuals, only one had a below-threshold screening result on Mini-Mental State Examination, and 13 scored below the cut-off on Montreal Cognitive Assessment. Extended neuropsychological testing revealed a neurocognitive disorder (NCD) in 31 (59.6%) participants with minor NCD in the majority of cases (n = 26). In patients with NCD, the cognitive domains learning/memory and executive functions were impaired in 60.7%, complex attention in 51.6%, language in 35.5%, and perceptual-motor function in 29.0%. Cognitive profiles were associated with daytime sleepiness but not with depression, anxiety, sleep quality, total general health status, or fatigue. CONCLUSION: Neurocognitive impairment can be confirmed in around 60% of individuals with self-reported deficits as part of post-COVID-19 syndrome following a mild acute COVID-19 disease course. Notably, screening tests cannot reliably detect this dysfunction. Standard psychiatric assessments showed no association with cognitive profiles. Longitudinal studies are needed to further evaluate the course of neurocognitive deficits and clarify pathophysiology.

12.
National Science Review ; 9(11), 2022.
Article in English | Web of Science | ID: covidwho-2123132

ABSTRACT

This is the first study to characterize post-COVID-19 syndrome and identify risk factors for clinical and psychological sequelae of COVID-19 in two distinct cohorts of patients in China. This cross-sectional study evaluated the long-term health effects of coronavirus disease 2019 (COVID-19) in Jianghan District (Wuhan, China). The results showed that 61.4% of COVID-19 patients reported at least one symptom and 8.8% had depressive symptoms at the 17-month follow-up. The proportion of patients with chest radiographic abnormalities in Fangcang shelter hospitals and designated COVID-19 hospitals was 31.6% and 41.1%, respectively, and the proportion of patients with impaired pulmonary diffusion capacity in these hospitals was 52.8% and 60.9%, respectively. Female sex (odds ratio [OR] = 1.48, 95% confidence interval [CI]: 1.16-1.88), severe disease (OR = 1.46, 95% CI: 1.01-2.10) and a higher number of initial symptoms (OR = 1.31, 95% CI: 1.23-1.40) were associated with the development of sequelae symptoms at 17 months. This study involving community-dwelling COVID-19 adults may help determine the long-term effects of COVID-19 during the first pandemic wave. Nonetheless, larger follow-up studies are needed to characterize the post-COVID-19 condition.

13.
Bali Medical Journal ; 11(3):1527-1532, 2022.
Article in English | Web of Science | ID: covidwho-2124128

ABSTRACT

Introduction: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARSCoV-2) infection, may result in musculoskeletal tissue injury and is assumingly regulated through central and peripheral pathways. Muscle-specific creatinine kinase (CK-MM) is a specific biomarker used to indicate the presence of musculoskeletal tissue damage. This study aimed to investigate the correlation between the levels of CK-MM and the incidence of persistent myalgia in patients with post-COVID-19 syndromes.Methods: A cross-sectional study was conducted among COVID-19 survivors at the Faculty of Medicine and Clinical Pathology Laboratory, Universitas Airlangga, Surabaya from June - August 2022. The degree of pain of the myalgia was assessed using a visual analog scale (VAS), while CK-MM level was measured using a sandwich enzyme-linked immunosorbent assay (ELISA). Pearson correlation test at alpha=0.05 was used to identify the correlation between the levels of CK-MM and the incidence of persistent myalgia in patients with post-COVID-19 syndromes.Results: A total of 84 participants were enrolled in the study and half (50%) of them reported persistent myalgia postCOVID-19 recovery. Fatigue was the patients' most common persistent symptom (63%). Of the total 42 patients with persistent myalgia, more than half (56%) had mild pain intensity (VAS score: 1-3), and almost all of them (41 patients) experienced myalgia during the COVID-19 diagnosis. All the patients with post-COVID-19 myalgia had normal levels of CK-MM (mean: 32.7 ng/mL;range: 12-93 ng/mL), suggesting no musculoskeletal tissue damage. Anova test suggested no significant different of CK-MM levels between those with and without myalgia in patients with post-COVID-19 syndromes p=0.054).Conclusion: There was no significant association between CK-MM levels and the incidence of persistent myalgia in patients with post-COVID-19 syndromes.

14.
Russian Journal of Cardiology ; 26(9):135-151, 2021.
Article in Russian | EMBASE | ID: covidwho-2113942

ABSTRACT

By the middle of 2021, the official global number of coronavirus disease 2019 (COVID-19) patients was close to 230 million, but the number accounting for asymptomatic patients was much higher. Consequences and rehabilitation after COVID-19 are of particular interest and raise many controversial and unresolved issues. On May 18, 2021, the Eurasian Association of Therapists organized an international panel of experts to analyze challenges associated with the post-COVID-19 period. This panel aimed to develop approaches to identify gaps in the discussed issues. This interdisciplinary team of leading experts reviewed the current literature and presented their data to formulate practical guidance on management of patients after COVID-19. The panel of experts also presented recommendations on how to implement the gained knowledge into health care practices. Copyright © 2021, Silicea-Poligraf. All rights reserved.

15.
Int J Mol Sci ; 23(22)2022 Nov 08.
Article in English | MEDLINE | ID: covidwho-2110126

ABSTRACT

Post-COVID-19 syndrome (PCS) is characterized by persisting sequelae after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). PCS can affect patients with all COVID-19 disease severities. As previous studies have revealed impaired blood flow as a provoking factor triggering PCS, it was the aim of the present study to investigate the potential association between self-reported chronic fatigue and retinal microcirculation in patients with PCS, potentially indicating an objective biomarker. A prospective study was performed, including 201 subjects: 173 patients with PCS and 28 controls. Retinal microcirculation was visualized by OCT angiography (OCT-A) and quantified using the Erlangen-Angio-Tool as macula and peripapillary vessel density (VD). Chronic fatigue (CF) was assessed according to the variables of Bell's score, age and gender. VDs in the superficial vascular plexus (SVP), intermediate capillary plexus (ICP) and deep capillary plexus (DCP) were analyzed, considering the repetitions (12 times). Seropositivity for autoantibodies targeting G protein-coupled receptors (GPCR-AAbs) was determined by an established cardiomyocyte bioassay. Taking account of the repetitions, a mixed model was performed to detect possible differences in the least square means between the different groups included in the analysis. An age effect in relation to VD was observed between patients and controls (p < 0.0001). Gender analysis showed that women with PCS showed lower VD levels in the SVP compared to male patients (p = 0.0015). The PCS patients showed significantly lower VDs in the ICP as compared to the controls (p = 0.0001 (CI: 0.32; 1)). Moreover, considering PCS patients, the mixed model revealed a significant difference between those with chronic fatigue (CF) and those without CF with respect to VDs in the SVP (p = 0.0033 (CI: -4.5; -0.92)). The model included variables of age, gender and Bell's score, representing a subjective marker for CF. Consequently, retinal microcirculation might serve as an objective biomarker in subjectively reported chronic fatigue in patients with PCS.


Subject(s)
COVID-19 , Fatigue Syndrome, Chronic , Humans , Male , Female , Fluorescein Angiography/methods , COVID-19/complications , Retinal Vessels , Microcirculation , Tomography, Optical Coherence/methods , Prospective Studies , SARS-CoV-2 , Fatigue , Biomarkers
16.
Int J Environ Res Public Health ; 19(22)2022 Nov 17.
Article in English | MEDLINE | ID: covidwho-2116052

ABSTRACT

INTRODUCTION: The COVID-19 pandemic is the result of the SARS-CoV-2 virus, which has caused more than 100 million infections and more than 2.5 million deaths worldwide, representing a serious public health problem. The gold method for detecting this virus is qRT-PCR, which is a semiquantitative technique where the viral load can be established through its cycle threshold (Ct). It has also been reported that COVID-19 generates long-term symptoms (post-COVID-19). METHODS: After three months, a survey was performed on 70 COVID-19 confirmed patients; subsequently, we divided them into four groups (persistent symptoms, chemo-sensitive, cognitive issues, and changes in habit) in order to determine the correlation between viral load and post-COVID-19 symptoms. RESULTS: Data show that fatigue, nervousness, anosmia, and diet changes are common long-term symptoms; in addition, a negative correlation was found between viral load and the number of post-COVID-19 symptoms. CONCLUSION: COVID-19 generates long-term symptoms which can cause problems with psychological and social repercussions.


Subject(s)
COVID-19 , Humans , Viral Load , Outpatients , Pandemics , SARS-CoV-2 , Syndrome
17.
Front Mol Biosci ; 9: 1016352, 2022.
Article in English | MEDLINE | ID: covidwho-2109801

ABSTRACT

European Association of Spa Rehabilitation recommend spa rehabilitation for patients with post COVID-19 syndrome (post C-19). We studied effects of special mountain spa rehabilitation program and its combination with ubiquinol (reduced form of coenzyme Q10-CoQ10) supplementation on pulmonary function, clinical symptoms, endogenous CoQ10 levels, and platelet mitochondrial bioenergetics of patients with post C-19. 36 patients with post C-19 enrolled for rehabilitation in mountain spa resort and 15 healthy volunteers representing the control group were included in this study. 14 patients with post C-19 (MR group) were on mountain spa rehabilitation lasting 16-18 days, 22 patients (MRQ group) were supplemented with ubiquinol (2 × 100 mg/day) during the rehabilitation and additional 12-14 days at home. Clinical symptoms and functional capacity of the lungs were determined in the patients before and after the spa rehabilitation program. Platelet bioenergetics by high-resolution respirometry, plasma TBARS concentration, and CoQ10 concentration in blood, plasma and platelets were evaluated before and after the spa rehabilitation program, and in 8 patients of MRQ group also after additional 12-14 days of CoQ10 supplementation. Pulmonary function and clinical symptoms improved after the rehabilitation program in both groups, 51.8% of symptoms disappeared in the MR group and 62.8% in the MRQ group. Platelet mitochondrial Complex I (CI)-linked oxidative phosphorylation (OXPHOS) and electron transfer (ET) capacity were markedly reduced in both groups of patients. After the rehabilitation program the improvement of these parameters was significant in the MRQ group and moderate in the MR group. CI-linked OXPHOS and ET capacity increased further after additional 12-14 days of CoQ10 supplementation. CoQ10 concentration in platelets, blood and plasma markedly raised after the spa rehabilitation with ubiquinol supplementation, not in non-supplemented group. In the MRQ group all parameters of platelet mitochondrial respiration correlated with CoQ10 concentration in platelets, and the increase in CI-linked OXPHOS and ET capacity correlated with the increase of CoQ10 concentration in platelets. Our data show a significant role of supplemented ubiquinol in accelerating the recovery of mitochondrial health in patients with post C-19. Mountain spa rehabilitation with coenzyme Q10 supplementation could be recommended to patients with post C-19. This study was registered as a clinical trial: ClinicalTrials.gov ID: NCT05178225.

18.
J Prim Care Community Health ; 13: 21501319221134560, 2022.
Article in English | MEDLINE | ID: covidwho-2098281

ABSTRACT

BACKGROUND: As of July 2022, there have been more than 91.3 million cases of COVID-19 and nearly 1.03 million deaths in the United States alone. In addition, many people who survived COVID-19 had long-term symptoms, such as fatigue, dyspnea, loss of smell and taste, depression, and anxiety. OBJECTIVES: The purpose of our study is to evaluate the status of COVID-19 patients who were previously hospitalized. METHODS: We conducted a single-center retrospective cohort study at Texas Tech University Health Sciences Center and its affiliated University Medical Center under IRB of L21-144. We included all patients hospitalized for COVID-19 and followed up in our Internal Medicine Clinic at any time between April 1, 2020, and April 1, 2021, and reviewed follow-up data for these patients after discharge. RESULTS: A total of 128 patients were included; 59 (46%) were men, and 69 (54%) were women with an average age of 59.7 ± 14.8 years. Most of the patients (n = 78, 60.9%) identified their race as Hispanic or Latino origin; the next largest group was Caucasian (n = 29, 22.65%). The average number of days until post-hospitalization follow-up was 36 ± 38 days. The 50% of the patients (n = 64) used telemedicine for follow-up visits. Important comorbidities in these patients included diabetes (n = 84, 65.6%) and hypertension (n = 94, 73.4%). Thirty-four patients (26.6%) reported respiratory symptoms at their follow-up appointments, 24 patients (18.8%) reported constitutional symptoms, 12 patients (9.4%) reported GI symptoms, and 25 patients (19.5%) reported other symptoms, such as paresthesia, lower extremity edema, or psychological symptoms. After hospital discharge, 54 patients had follow-up chest x-rays, and 41 (75.9%) still had abnormal findings consistent with COVID-19 imaging characteristics. Follow-up laboratory tests identified 44 patients (77.2%, 57 tested) with elevated D-dimer levels, 44 patients (78.6%, 56 tested) with high ferritin levels, and 21patients (35.6%, 59 tested) with elevated troponin T HS levels. CONCLUSION: Long-lasting COVID-19 symptoms in these patients included respiratory symptoms (26.6%), constitutional symptoms (18.8%), GI symptoms (9.4%), and other symptoms, such as paresthesia, lower extremity edema, or psychological symptoms (19.5%). The rate of telehealth follow-up was 50%. Many patients had elevated inflammatory markers that will need follow up to determine the clinical implications.


Subject(s)
COVID-19 , SARS-CoV-2 , Male , Humans , Female , Adult , Middle Aged , Aged , Outpatients , Retrospective Studies , Paresthesia , Follow-Up Studies , Hospitalization , Hospitals
19.
Int Immunopharmacol ; 113(Pt B): 109428, 2022 Nov 07.
Article in English | MEDLINE | ID: covidwho-2095518

ABSTRACT

Coronavirus disease 2019 (COVID-19) outbreak has become a global public health emergency and has led to devastating results. Mounting evidence proposes that the disease causes severe pulmonary involvement and influences different organs, leading to a critical situation named multi-organ failure. It is yet to be fully clarified how the disease becomes so deadly in some patients. However, it is proven that a condition called "cytokine storm" is involved in the deterioration of COVID-19. Although beneficial, sustained production of cytokines and overabundance of inflammatory mediators causing cytokine storm can lead to collateral vital organ damages. Furthermore, cytokine storm can cause post-COVID-19 syndrome (PCS), an important cause of morbidity after the acute phase of COVID-19. Herein, we aim to explain the possible pathophysiology mechanisms involved in COVID-19-related cytokine storm and its association with multi-organ failure and PCS. We also discuss the latest advances in finding the potential therapeutic targets to control cytokine storm wishing to answer unmet clinical demands for treatment of COVID-19.

20.
Infection ; 2022 Oct 29.
Article in English | MEDLINE | ID: covidwho-2094831

ABSTRACT

PURPOSE: Health care workers (HCWs) are frontliners in facing Cornoravirus disease (COVID-19) and hence are amongst the high risk groups of acquiring COVID-19 infection. The impact of COVID-19 infection and post-infection sequelae on work performance has deleterious effects on HCWs and the whole community. The aim of the current study is to assess the impact of COVID-19 infection particularly those with post-COVID-19 syndrome on work performance among HCWs and to determine if a possible relationship with antibody response exists. METHODS: A sample of 69 previously PCR-positive health care workers matched to another group of 69 control PCR-negative health care workers from the same clinical departments were subjected to full medical history, clinical examination, measuring serum specific immunoglobulins against severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), Health work performance questionnaire short form of absenteeism and presenteeism and Functional dysfunction grading questionnaire. RESULTS: The most frequently encountered symptom by patients with post-acute COVID-19 was fatigue while it was dyspnea for those who were chronic COVID patients. Patients with post-acute COVID-19 had a significantly longer time for PCR negative conversion and had a more severe disease. There was no association between post-acute COVID-19 and immunoglobulin positivity. COVID-19 syndrome had a negative impact on work performance manifested by lower relative presenteeism and lower month/year performance ratio (p < 0.001, p < 0.001). However comparing patients with post-COVID-19 syndrome to patients without the syndrome revealed no significant work performance difference between both groups. CONCLUSION: COVID-19 syndrome negatively impacts work performance in HCWs manifested by lower relative presenteeism and lower month/year performance ratio. Although post-COVID-19 results resulted in higher levels of fatigue and functional limitation, it did not have a significant negative impact on work performance. Specific immunoglobulins against SARS CoV-2 were not associated with the post-COVID-19 syndrome.

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