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1.
Zhongguo Yufang Shouyi Xuebao / Chinese Journal of Preventive Veterinary Medicine ; 44(3):345-345, 2022.
Article in English, Chinese | CAB Abstracts | ID: covidwho-2034497

ABSTRACT

Since the outbreak of the new crown pneumonia, the new coronavirus (SARSCoV-2) has been mutating continuously, and it has now become prevalent in more than 200 countries. The cumulative number of confirmed cases in the world has exceeded 460 million, and the number of deaths has exceeded 6 million. The rapid mutation of SARS-CoV-2 highlights the importance of preventive and therapeutic drugs, however, effective therapeutic drugs for new coronary pneumonia are still very scarce. It is still the common goal of scientists from all over the world to develop a safe and effective drug for the treatment of new coronary pneumonia that can inhibit the infection of multiple SARS-CoV-2 mutant strains.

2.
Zhongguo Yufang Shouyi Xuebao / Chinese Journal of Preventive Veterinary Medicine ; 44(3):346-346, 2022.
Article in English, Chinese | CAB Abstracts | ID: covidwho-2034493

ABSTRACT

The new coronavirus (SARS-CoV-2) is raging around the world, infecting more than 460 million people and killing more than 6 million people, posing a serious threat to human health. Analyzing the pathogenic mechanism of the virus and discovering new drug targets are the keys to the development of antiviral drugs. Similar to the envelope proteins of many important viruses such as Ebola virus and Marburg virus, the spike (S) protein of SARS-CoV-2 relies on the cleavage and processing of cellular furin to mature during infection, and then make the virus infective, so furin is an important potential target for antiviral therapy. However, the regulation mechanism of furin enzyme activity in cells under physiological and infection conditions is not yet very clear.

3.
Hygiene & Medizin ; 46(1/2):D23-D27, 2021.
Article in German | GIM | ID: covidwho-2034492

ABSTRACT

This article discusses efforts and challenges concerning the prevention of SARS-CoV-2 transmission in specialized schools or daycare facilities for handicapped children and adolescents. In this heterogeneous group, a relevant proportion may face an increased risk of a complicated infection due to underlying chronic conditions. Their capability to adhere to the rules of physical distance, hand hygiene, face masks plus aeration may be limited. In addition, wearing a mask and keeping distance impaires necessary contacts concerning nursing care and nonverbal/visual communication between children and their caregivers.

4.
Boletin de Malariologia y Salud Ambiental ; 62(2):129-133, 2022.
Article in Spanish | CAB Abstracts | ID: covidwho-2034484

ABSTRACT

Individual responsibility implies horizontality of participation in the formulation of small models of self-care and local decision-making of what and how to do for prevention, however, in addition to the deployment of education and social communication formulas that provide important tools so that each citizen knows what humanity is facing and to generate shared responsibilities (Rios, 2020), in a practical sense, in a certain percentage of citizens, it has been possible to observe the abandonment of elementary aspects of social coexistence in times of pandemic. This topic has raised interesting controversies that take up a set of valid questions. The present work takes as its starting point two questions to which it does not attempt to answer, but rather fulfill a guiding function for the arguments presented here: Why are there human groups that do not consciously act on the global call for vaccination? Why do human groups persist in dispensing with biosafety measures, not abiding by health guidelines? Our concern when carrying out this analysis arose from understanding that, as is the case in various parts of the world, the Ecuadorian provinces with similar community mitigation measures presented very different trends in infection rates. As far as we know, there is no epidemiological model that can help us understand this phenomenon.

5.
Boletin de Malariologia y Salud Ambiental ; 62(2):251-259, 2022.
Article in Spanish | CAB Abstracts | ID: covidwho-2034476

ABSTRACT

Background: Invasive mechanical ventilation as a therapeutic strategy is not without complications. It is imperative to have protective ventilation parameters in those patients who are subjected to it. We aim to demonstrate whether mechanical power as a ventilatory parameter has prognostic validity for mortality in critically ill patients with prolonged invasive mechanical ventilation. Material and Methods: An analytical cross-sectional study was carried out of critically ill patients on prolonged invasive mechanical ventilation due to Acute Respiratory Distress Syndrome due to COVID-19 who were admitted to the Intensive Care Unit of the Hospital Regional de Trujillo during the March 2020 to March 2021 period.

6.
Boletin de Malariologia y Salud Ambiental ; 62(2):227-232, 2022.
Article in Spanish | CAB Abstracts | ID: covidwho-2034474

ABSTRACT

Introduction: The COVID-19 disease is complicated by severe acute respiratory syndrome (ARDS), which is considered the main cause of mortality within intensive care units, despite providing early and optimal ventilatory support. However, it is necessary to identify the factors associated with mortality in these patients.

7.
Boletin de Malariologia y Salud Ambiental ; 61(Edicion Especial II 2021):26-34, 2021.
Article in Spanish | GIM | ID: covidwho-2034459

ABSTRACT

Introduction: SARS-CoV2 infection with severe clinical manifestations has been associated with a decrease in plasma hemoglobin levels. This suggests the need to understand the impact that anemia has in the clinical outcomes of patients with COVID-19.

8.
Veterinary Ireland Journal ; 10(11):614-615, 2020.
Article in English | CAB Abstracts | ID: covidwho-2034344
9.
Journal of Krishna Institute of Medical Sciences University ; 11(1):1-13, 2022.
Article in English | GIM | ID: covidwho-2034336

ABSTRACT

Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) infection has created global devastation in the past three years. The Corona Virus Disease-19 (COVID-19) vaccine is the only available resource to fight SARSCoV- 2 infection and its associated complications. As world is trying to recover with the help of vaccines, the change in vaccine development strategy and allowing the usage of vaccines at an emergency level with small size clinical data has created a storm of confusion among many individuals concerning efficiency and efficacy of the vaccine. Though multiple pieces of literature are available regarding the different types and strategies of vaccine development, no paper gives an idea about which vaccine should be used in this emergency. More than 90 vaccine candidates are in the race showing 70-95% efficiency at clinical trials, and still, people are afraid to take vaccines due to lack of awareness. This review compares the available vaccines and evaluates their efficiency based on the available clinical trial results to answer the most frequently asked question of which vaccine is best to be taken at this time?

10.
Boletin de Malariologia y Salud Ambiental ; 61(Edicion Especial II 2021):123-131, 2021.
Article in Spanish | CAB Abstracts | ID: covidwho-2034323

ABSTRACT

It has been observed that some groups of patients had the perception that if they fell ill from COVID-19 they could have greater complications. The aim of this study was to determine the association between fatalistic thinking about the possible infection of coronavirus according to the type of disease suffered by Peruvian patients. An analytical study of secondary data was carried out, which used a previous data to obtain respondents who had a disease (according to 9 groups/medical specialties), and cross-checked this according to fatalistic thinking (from a validated test). Of the 4483 respondents, 15% had a disease. Those with a respiratory disease perceived that they would be complicated post infection (p<0.001), also those with a cancer or tumor (p<0.001) or those with an endocrinological disease (p=0.002). Those who thought they would become depressed if they became ill were those with a respiratory (p=0.013) or gastroenterological disease (p=0.001). Those who perceived that they might die were those with a respiratory disease (p<0.001), those with any cancer or tumor (p=0.007), endocrinological (p<0.001) and neurological or psychiatric diseases (p<0.001). They could make a fatal decision upon learning of the infection are those who had an endocrinological disease (p=0.039). In conclusion, some groups of patients have a higher perception of getting sick, getting complicated, dying or even taking other fatal actions after learning that they have coronavirus infection;therefore, they should be given psychological support.

11.
Journal of Bhutan Studies ; 42:1-43, 2020.
Article in English | GIM | ID: covidwho-2034320

ABSTRACT

When COVID-19 first emerged in late-2019 in Wuhan, China, without adequate containment, the virus and the economic shock waves that followed quickly spread across the world, leaving few countries unaffected by the contagion. COVID-19 quickly escalated into an ongoing and widespread global crisis, placing acute pressure on prevailing economic systems, governance structures, development institutions and health systems not experienced since the Spanish flu of 1918. In doing so, it crippled economies and ruptured trajectories of globalization and development, with a myriad of negative impacts as well as unintended positive effects such as reduced carbon emissions. As the pandemic continues to unfold, the responses of individual nation-states and sub-national regions have been both varied and divergent.

12.
Hygiene & Medizin ; 46(1/2):D28-D33, 2021.
Article in German | GIM | ID: covidwho-2034319

ABSTRACT

The sensitive and specific detection of an infection with SARS-CoV-2 is the basis of all infection control management. Since the beginning of the pandemic, the discussion has primarily focused on the availability of diagnostic options, then on correct material collection and effective handling of the scarce test resource, and finally on the value of individual procedures and the use of rapid test methods. The following overview attempts to summarize in a compact form the current state of knowledge on the rational and effective working with laboratory diagnostics of SARS-CoV-2 infections using predominantly scientific review articles.

13.
Zycie Weterynaryjne ; 96(1):15-23, 2021.
Article in Polish | CAB Abstracts | ID: covidwho-2034286

ABSTRACT

SARS-CoV-2, the betacoronavirus that causes COVID-19, has spread rapidly around the world since December 2019. It was suspected from the beginning that the primary outbreak in China, was of a zoonotic origin, but the SARS- CoV-2 animal reservoir(s) has not been definitively identified yet. So far, it has been confirmed that numerous animal species are susceptible to infection and that experimentally infected cats, shrews, hamsters and ferrets can also shed the virus. The SARS-CoV-2 was also detected in farmed mink (Neovison vison), in which it caused both, the clinical and subclinical disease, with respiratory symptoms and increased mortality. In April 2020, the first SARS-CoV-2 cases were detected in minks in the Netherlands, and to date (November 2020), further outbreaks have been confirmed in Denmark, Italy, Spain, Sweden, the United States, Greece, France and Poland. It has also been shown that the transmission of infection from humans to minks and from minks to humans may occur. The OIE is working on the inclusion of mink in the WAHIS database and encouraging the Members to provide appropriate data for this species to improve the monitoring of the epidemiological situation worldwide and prevent the establishment of a possible new reservoir for SARS-CoV-2.

14.
Boletin de Malariologia y Salud Ambiental ; 62(2):241-250, 2022.
Article in Spanish | CAB Abstracts | ID: covidwho-2034274

ABSTRACT

Objective: To establish the diagnostic validity of the CALL score as a predictor of mortality in patients with severe COVID-19 in the Intensive Care Unit of the Trujillo Regional Teaching Hospital from April 2020 to July 2021. Material and methods: An analytical, retrospective study was carried out, in which 177 patients with severe COVID-19 admitted to the Intensive Care Unit of the Regional Teaching Hospital of Trujillo were included, according to selection criteria, the CALL score was calculated for each one and was associated with the mortality found;applying the statistical chi 2 test;Subsequently, a multivariate regression analysis was performed to identify risk factors associated with mortality. In turn, the AUROC (area under the ROC curve) was used to establish the predictive performance of the CALL score.

15.
Boletin de Malariologia y Salud Ambiental ; 61(2):299-306, 2021.
Article in Spanish | GIM | ID: covidwho-2034265

ABSTRACT

Environmental Health takes on a relevant role in the framework of the COVID-19 pandemic due to the different activities that must be developed from its approach to the prevention and control of the virus transmission, being useful for its containment and the progressive population deconfinement. In this sense, educational training in the area is necessary, and considering the restrictions and limitations to access, it was established the creation of a basic virtual course on the actions of the different protocols issued in Ecuador from Universidad Laica Eloy Alfaro de Manabi, The proposal is made up of six (6) completely remote modules: Relevant definitions, Basic lines of action, Personal actions, Cleaning and disinfection of spaces, Drinking water and comprehensive sanitation system, and Environmental surveillance of recreational spaces. The contents will be taught completely remotely, set on the Moodle digital platform, with didactic resources and different evaluation strategies in order to build knowledge.

16.
Boletin de Malariologia y Salud Ambiental ; 61(Edicion Especial II 2021):188-194, 2021.
Article in Spanish | GIM | ID: covidwho-2034255

ABSTRACT

EHealth is defined as the use of information and communication technologies (ICT) for health, a concept that has evolved in the last two decades, along with advances in this field. Given the arrival of the COVID-19 pandemic, ICTs have played an important role in society, informing the scope, risks and care of this disease, facilitating the care and monitoring of patients and allowing the logistics of Nations and organizations, among many other aspects. Additionally, technology has been a protagonist in the medical and scientific community, in the search for knowledge and understanding about the new coronavirus Sars-Cov-2, from its appearance in a Chinese town to the worrying impact by the new circulating variants, derived from the genetic mutation of the pathogen. This research study by Alphafold, GISAID and MasterOfPores, innovative technologies of public access, free and of high scientific reliability, which make up a new methodology in mutagenic detection, structural modeling and antigen research, in the fight against COVID-19 and its new variants. Finally, ICTs have been and will continue to be vital in the fight against COVID-19, in the research and development of antigens that make it possible to immunize a large part of the world's population.

17.
Field Exchange Emergency Nutrition Network ENN ; 67:40-42, 2022.
Article in English | CAB Abstracts | ID: covidwho-2034248

ABSTRACT

The objectives of this study were to (1) describe the family-centred MUAC pilot programme, and (2) describe the accuracy of MUAC measurements by caregivers and CHVs during the ongoing COVID-19 pandemic. The programme employed a train-thetrainer model. First, the CHVs received orientation from the PHC health workers on how to train caregivers;CHVs were provided with MUAC tapes and information, education and communication materials for distribution to caregivers. Then, CHVs were responsible for training and mentoring five to12 nearby caregivers either online or in-person based on an existing list of children under the age of five years who lived within their area of operation. Screening resulted in 2,249 children being referred to PHCs, including 1,684 children screened by CHVs and 565 by caregivers, for confirmation of their wasting diagnosis. Of these, less than half (42%) of children visited a PHC as instructed with a higher proportion of children screened by caregivers (86%) visiting the PHC compared to those referred by CHVs (27%). This trend was largely driven by differences in attendance among children in Kupang District;in this peri-urban setting, only 26% of children referred by CHVs attended the health centres compared to 87% of children referred by caregivers. Attendance was more comparable among CHVs (100%) and caregivers (86%) in Kupang Municipality. Therefore, given the accuracy of caregiver screening, continuing the family-centred MUAC screening programme beyond the COVID-19 pandemic warrants consideration. Future work should aim to better understand the differences in attendance between caregivers and CHV referrals in order to address any barriers to case confirmation.

18.
Chinese Journal of Nosocomiology ; 32(12):1900-1905, 2022.
Article in English, Chinese | GIM | ID: covidwho-2034232

ABSTRACT

The transmission routes of SARS-CoV-2 include droplet, air and contact transmission, but regardless of the transmission route, the virus must eventually be exposed through the oral, nasal and ocular mucous membranes to invade the human body. Guaranteeing the respiratory protection of front-line medical staff in the prevention and control of COVID-19 is one of the primary tasks of nosocomial infection management. According to "Technical Guidelines for Prevention and Control of COVID-19 in Healthcare Settings (3rd Edition)", oral/nasal cavity can be disinfected with hydrogen peroxide, iodophor, in the event of occupational respiratory exposure. But, at the moment, In the field of nosocomial management, compared with hand hygiene, "mucosal hygiene" is rarely mentioned, especially the treatment of respiratory mucosa after exposure to acute infectious respiratory pathogens, which is still blank in the domestic research. After a rapid literature review, it is found that some antiseptics have been widely used in clinical practices, such as gargling with bactericidal solution before the diagnosis and treatment procedure for dental patients under COVID-19 epidemic, nasal decolonization for patients undergoing elective surgery to prevent surgical site infection, and use of eye drops of antiseptics to prevent neonatal conjunctivitis. In view of the current lack of effective antiviral drugs for treatment of SARS-CoV-2, and the constantly emerging mutant strains can break through the immune barrier of human body, this paper recommends that medical personnel use antiseptics for emergency mucosal disinfection as an supporting measure for respiratory tract protection after accidental exposure to SARS-CoV-2 of oral, nasal and ocular mucosa.

19.
International Journal of Public Health Research ; 11(1):1326-1328, 2021.
Article in English | CAB Abstracts | ID: covidwho-2034206

ABSTRACT

The first coronavirus disease 2019(Covid-19) in Malaysia was first detected on the 25th of January 2020. Numbers remained low until March where local clusters began to sprout. This rapid rise was alarming to the Ministry of Health Malaysia (MOH) and Movement Control Order (MCO) was declared on the 18th of March 2020 to flatten the curve. As Malaysia enters the fourth phase of MCO, the country has over six thousand cases of COVID-19 with over a hundred fatalities. Efforts within the MCO entails social distancing, increasing testing capacity and isolation. This combination of measures led to Malaysia being recognised to have one of the lowest death rate and highest recovery rate exceeding 50% of total cases.

20.
Boletin de Malariologia y Salud Ambiental ; 61(2):352-359, 2021.
Article in Spanish | GIM | ID: covidwho-2034187

ABSTRACT

The pandemic caused many changes due to social distancing, one of them is in terms of virtual university classes. Therefore, the objective was to validate an instrument that measures the perception of the effects of COVID-19 on distance education in university students of health sciences and other careers in Peru. An instrumental and cross-sectional study was carried out. Thousands of distance learning students from health sciences and other careers participated during the first wave of the Coronavirus. The survey on the perception that it has of the repercussions caused by the health emergency on face-to-face and distance education was designed and validated;in addition, another scale was exploratory to measure the perception of the spread of the coronavirus. The analysis showed high reliability and good internal consistency, with adequate Cronbach's alpha values. For the Exploratory Factor Analysis (EFA), the Bartlett test and the Kaiser-Meyer-Olkin coefficient were used. All the items received a favorable evaluation by the experts (Aiken's V> 0.70);this with respect to relevance, representativeness and clarity. Three virtual average factors were identified, their use and presence, all saturation indices were greater than 0.50. The survey proved to be reliable and representative, this above all because it was evaluated in students from the different Peruvian departments;which can be used to evaluate this in diverse similar populations.

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