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1.
Medecine d'Afrique Noire ; 69(3):141-146, 2022.
Article | GIM | ID: covidwho-1824452

ABSTRACT

Introduction: The cardiovascular impact of SARS CoV-2 infection in black subjects is poorly described in the literature. This article reports a case of myocardial injury during this viral infection. Case report: A 63-year-old, hypertensive and diabetic woman whose symptomatology started with chest pain, was admitted in cardiogenic shock associated with severe bradycardia at 25 bpm due to complete atrioventricular block. Troponinemia was elevated at 33769.8 ng/mL and NT-proBNP greater than 25,000 pg/mL. Transthoracic echocardiography had shown abnormalities of left ventricular segmental kinetics with preserved ejection fraction and right ventricular dysfunction. The chest Computed Tomography (CT) scan diagnosed SARS CoV-2 infection by showing central and peripheral ground-glass opacity of the lungs. The SARS CoV-2 PCR test was negative twice. After a temporary transvenous cardiac pacing, heparin therapy, a combination of Ceftriaxone and antivirals, the evolution was marked by an initial clinical improvement followed by a secondary deterioration with aggravation of the biological inflammatory syndrome contrasting with the regression of atrioventricular block and myocardial injury. Death occurred on the 12th day of hospitalization.

2.
Journal of the Association of Physicians of India ; 70(January):28-32, 2022.
Article in English | GIM | ID: covidwho-1824435

ABSTRACT

Background: Although hydroxychloroquine (HCQ) lacks benefit in patients with moderate-to-severe COVID-19, its role in asymptomatic and mildly symptomatic disease needs better elucidation.

3.
Journal of the Dow University of Health Sciences ; 16(1):41-45, 2022.
Article in English | CAB Abstracts | ID: covidwho-1824381

ABSTRACT

The pandemic of CoronaVirus-19 (COVID-19) is an alarming situation worldwide as it poses a considerable threat to the healthcare system. Various study results suggested the effect of COVID-19 on non-communicable diseases (NCDs) including asthma. The present study aims to review, describe and assess the impact of COVID-19 on asthma patients. The results of the current review suggest a non-significant impact of asthma on COVID-19 outcomes. However, the impact of COVID-19 on asthmatics is complex that may vary according to the clinical severity, patient age, or genetics in different populations. Hence it is needed to conduct studies with a large number of cohorts in different populations that may provide us with conclusive results. The use of corticosteroids is not recommended, but some studies suggested that by monitoring certain factors corticosteroids can be used for COVID-19 patients suffering from asthma. The future care of asthmatic patients in COVID-19 should include self-management, remote interventions, and social distancing.

4.
Acta Medica Iranica ; 60(4):202-209, 2022.
Article in English | Academic Search Complete | ID: covidwho-1824333

ABSTRACT

The coronavirus disease 2019 (COVID-19) is a single-stranded RNA (+) virus and causes infectious disease by the viral strain "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2). Now, COVID-19 has become pandemic, and there are neither potential vaccines nor drugs discovered. Its RNA contains genes for structural (S, E, M, N) and non-structural proteins (PLpro, 3CLpro, RdRp, Hel). Interaction between the S protein of SARS-CoV-2 and the ACE 2 receptor of the host cell plays a vital role in the entry of the virus into the cell. Favipiravir, ribavirin, remdesivir, galidesivir, lopinavir, ritonavir, chloroquine, and hydroxychloroquine are the few effective drugs against SARS-CoV-2. Live attenuated virus (mutant MERS-CoV and SARS-CoV or recombination with another live attenuated virus) can act as vaccine platforms against SARS CoV-2 along with DNA vaccine and subunit vaccine. [ FROM AUTHOR] Copyright of Acta Medica Iranica is the property of Tehran University of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

5.
Obshta Meditsina / General Medicine ; 24(2):29-42, 2022.
Article in Bulgarian | GIM | ID: covidwho-1824315

ABSTRACT

During the COVID-19 pandemic, pharmacists have proved their role as the most accessible medical professionals who have the potential and knowledge to participate in vaccination campaigns. The aim is to conduct a systematic review of the published articles that analyze the available evidence for the benefits of pharmacists' participation in vaccination. A systematic review was conducted in the scientific database PubMed. A total of 39 studies were included in the qualitative synthesis based on a screening of the identified 980 studies in the databases. The benefits are related to increasing the percentage of immunized people and preventing the spread of vaccine-preventable diseases, better informing and motivating patients, positive impact on the level of immunization, helping to achieve the goals of immunization, improving population access to vaccines. The systematic review shows the essential role of the pharmacist in vaccination campaigns, as well as the benefits for the individual and for society as a whole.

6.
Revista Medica del Instituto Mexicano del Seguro Social ; 59(5):377-386, 2021.
Article in Spanish | MEDLINE | ID: covidwho-1824313

ABSTRACT

BACKGROUND: The characteristics of the transmission of SARS-CoV-2 virus increased the need to implement prevention measures, in order to avoid its spread;therefore, there is an interest in the risk perception and an intention in people to adopt protective measures against COVID-19. OBJECTIVE: To show the causal factors that contribute to a high/low perception of risk during the COVID-19 pandemic. MATERIAL AND METHODS: A quantitative, analytical and explanatory exploratory study was carried out with a crosssectional design. To collect data, a self-access survey was designed, using the Dimensional Assessment of Perceived Risk procedure, based on the psychometric paradigm. For data analysis, the classification tree method was utilized. RESULTS: The descriptive analysis indicated that the surveyed population had a concern about the pandemic of 3.8 on a scale ranging from 1 to 5, which shows a medium-high perception of COVID-19 risk;however, respondents underestimated their personal risk (vulnerability) in relation to that of others. The classification tree analysis showed that the independent variables that contribute directly to the global perception of risk are the severity of the pandemic, vulnerability and catastrophic power. CONCLUSIONS: It was found a positive effect: The greater perception of severity, and susceptibility to acquiring the virus, the more taking of preventive measures.

7.
Annali Italiani di Chirurgia ; 93:147-151, 2022.
Article in English | MEDLINE | ID: covidwho-1824293

ABSTRACT

AIM: We analysed our one-year surgical activity in a spoke 'COVID-19 free' centre during the pandemic in South Italy. MATERIAL OF STUDY: From Feb 2020 to Feb 2021 we performed 800 operations (40% in emergency and 60% of major surgery). We applied restrictive measures for the access of patients in our department from 15/2/2020 after several cases of unclear fever. Visitors were not allowed to stay in the ward. RESULTS: In the first period of lockdown, from March to June 2020, in our Region, biomolecular test was indicated only for symptomatic people. We organized the hospitalization with a sealed compartment system (that we defined "boing system") in which the patient stationed in an 'isolation room' for at least 48 hours upon the entry. From July 2020 molecular test were made to all patients before hospitalization. The boing system remains for emergency recovery. DISCUSSION: In the first phase of pandemia we chose to subject patients to serological examination based on the IgM assay to consider them negative. We organized the hospitalization with a sealed compartment system (that we defined "boing system") CONCLUSION: In the first phase of the pandemic the serological examination has shown high specificity in identifying positive patients for COVID 19. In that period we supposed that patients with negative serology could be considered non-contagious Neither patients or staff has been resulted positive to SarS CoV2 test. KEY WORDS: Covid 19, Emercency Surgery, Spoke Center, Pandemia, Serological Tests.

8.
Journal of Ayub Medical College, Abbottabad: JAMC ; 33(Suppl 1)(4):S778-S787, 2021.
Article in English | MEDLINE | ID: covidwho-1824266

ABSTRACT

BACKGROUND: Health care workers (HCWs) working on frontlines in COVID-19 pandemic are highly vulnerable to deteriorating physical and mental health. The quality of life of health care workers plays an important role in their skilful delivery of work. Our study assesses their quality of life (QOL) during COVID-19 pandemic so that appropriate measures can be taken to improve their well-being. METHODS: This was an online crosssectional survey among healthcare workers of COVID-19 designated government hospitals in districts Abbottabad, Manshera and Haripur, Khyber Pakhtunkhwa, Pakistan from 23rdJune till 25thJuly, 2020. QOL was assessed using validated WHO QOL BREF. Univariate and multivariate linear regression were used to assess the factors associated with QOL among HCWs. RESULTS: A total of 362 HCWs participated in the study. The mean scores of physical, psychological, social relationships, environmental domains were 60.7 (+/-17.40), 59.70 (+/-17.30), 67.90 (+/-17.90), and 58.20 (+/-18.40) respectively. Hospital where the respondents were working was the consistent predictor of QOL scores in all four domains with generally lower scores associated with other hospitals compared to Ayub Medical Hospital. Years of experience were positively associated with psychological, social relationship and environmental domains. Designation was associated with social relationship domain only. The scores were lower for trainee medical officers (adjusted beta - 11.5) and higher for house officer (adjusted beta 10.0) and nurses and technicians (adjusted beta 7.0) compared to heads of departments and specialists. CONCLUSION: Quality of life of health care workers has been affected negatively in hospitals of Abbottabad, Pakistan during COVID-19. This calls for hospital administrations, policymakers and the government to take necessary actions to protect the wellbeing of the backbone of the healthcare system.

9.
Journal of the Association of Physicians of India ; 70(January):44-49, 2022.
Article in English | GIM | ID: covidwho-1824227

ABSTRACT

Objective: Though systemic corticosteroid is used for treatment of COVID 19, questions regarding the appropriate dose, duration and type of corticosteroid use still remain unanswered. This study aimed to address, whether choice of systemic corticosteroid significantly influences the clinical outcome of COVID 19 patients. Materials and Methods: Studies reporting the comparison between clinical outcome of dexamethasone and methylprednisolone in treatment of COVID 19 were searched from inception till April, 2021. Random-effect model was used. Odd's ratio (OR) and 95% confidence interval was expressed. I2 statistics used for test of heterogeneity. Result: Three studies with 373 patients (160 in dexamethasone group and 213 in methyl prednisolone group) were included. Though, statistically significant reduction in all-cause mortality with methyl prednisolone group in comparison to dexamethasone group (OR=1.80, 95%CI: 1.08 to 3.01, P=0.02) estimated, sub group analysis of observational studies did not support the finding (OR=1.60, 95% CI: 0.88 to 2.92, P=0.12). No significant difference in terms of need for invasive ventilator or intensive care unit (ICU) between the 2 groups. The grade of evidence was very low for both the outcomes. Conclusion and Relevance: In the present context, both dexamethasone and methyl prednisolone are equally effective in the management of COVID 19.

10.
Economic and Political Weekly ; 56(44), 2021.
Article in English | CAB Abstracts | ID: covidwho-1824226

ABSTRACT

Through a series of data visualisations, the article attempts to illustrate the economic repercussions of the COVID-19-induced lockdown of 2020 on rural households. It focuses on how consumption, labour and income, healthcare, access to relief programmes and migration were effected by the lockdown in six major states.

11.
Tehran University Medical Journal ; 79(9), 2021.
Article in Persian | CAB Abstracts | ID: covidwho-1824225

ABSTRACT

Background: Age is a strong risk factor for increasing the risk of severity and death from Covid-19. The risk of hospitalization for Covid-19 disease increases with age. Since the elderly constitute a large proportion of Covid-19 patients, the present study was performed to evaluate the severity of the disease in the hospitalized elderly due to Covid-19 and the delay in hospitalization and death resulting from it, for better disease management .

12.
Journal of the Association of Physicians of India ; 70(January):14-17, 2022.
Article in English | GIM | ID: covidwho-1824219

ABSTRACT

Importance: As there is no definitive treatment available for covid-19 pneumonia, with timed administration of tocilizumab as an adjuvant therapy in moderate to severe covid-19 pneumonia, we can reduce mortality due to cytokine storm.

13.
Revista Espanola de Salud Publica ; 96:14, 2022.
Article in Spanish | MEDLINE | ID: covidwho-1824209

ABSTRACT

OBJECTIVE: Primary Care (PC) must attend and follow COVID-19 patients with mild and moderate symptoms, and identify severe cases. The aim of this study was to describe the characteristics of patients attended in PC with suspicious COVID-19 and health care provision by PC. METHODS: Retrospective longitudinal observational study of electronic health records (EHR) and agendas. Probabilistic sampling of suspicious COVID-19 patients' pathway in 5 health centers in Madrid between March 16 and 20, 2020. The variables used were sociodemographic, symptoms, examination, radiography, characteristics of schedules and professional sick leaves. Descriptive analysis and time to event (pneumonia). RESULTS: 240 EHR were reviewed. Average age 48 years, 60% women. Most frequent symptoms: cough (80%) and elevation of temperature (63%). Pneumonia appeared in 23%. 73% were bilateral. Age and male gender were related to pneumonia. 20% required admission. 7 patients died (2.9%). 19,027 COVID-19 appointments were scheduled in PC. 60% of patients were attended in PC without performing chest X-ray or assistance by other care level. 22.4% of GPs working days were absent because of sick leaves. Differences were found amongst facilities in chest X-ray requesting (max. 62%, min. 2%). The PC center with the fewest X-rays requested was the one with the major number of sick leaves. CONCLUSIONS: Age and male gender were related to pneumonia onset in PC. Health care activity was intense, and variability was found amongst facilities. Professional sick leaves could affect the quality of care.

14.
Revista Espanola de Salud Publica ; 96:31, 2022.
Article in Spanish | MEDLINE | ID: covidwho-1824200

ABSTRACT

OBJECTIVE: One of the steps adopted to mitigate the pandemic due to SARS-CoV-2 is the use of face masks by the general population. For a face mask to be effective it should cover the nose and the mouth. We wanted to measure the correct use of the face mask by the general population in open public spaces through direct observation. METHODS: We conducted an observational study of the proper use of face masks among the general population in open public places in Bilbao, Santander, Oviedo and Zaragoza from 16th to 26th July, 2020 and from 23rd January to 2nd March, 2021. Sampling for convenience;compliance of the proper use of a mask was evaluated when adults completely covered their mouth and nose. The type of mask and its improper use was registered using a standardized form. The results were obtained using frequency distribution, Pearson's chi-squared test and multivariate logistic regression analysis. RESULTS: A total of 5,464 observations were documented. The overall compliance was 89.5%. We observed that the compliance in 2021 (94.7%) was 10.9 percentage points higher than in 2020 (83.8%) (p<0.001). The main cause of non-compliance was the incorrect placement of face masks (64%);36% were without masks. The non-reusable face masks were most commonly worn (54.1%). We observed a significant increase in use of high-efficiency face masks in 2021 (27.1%) versus 2020 (13.7%). CONCLUSIONS: In all the cities where the study was conducted we observed an increase in compliance of the proper use of face masks as well as an increased usage of high-efficiency masks. The main cause of non-compliance was incorrect placement.

15.
Revista Medica del Instituto Mexicano del Seguro Social ; 59(5):395-403, 2021.
Article in Spanish | MEDLINE | ID: covidwho-1824166

ABSTRACT

BACKGROUND: The possibility that the blood group (BG) predisposes to SARS-CoV-2 infection is controversial. OBJECTIVE: To compare the prevalence of BG, anti-IgG SARS-CoV-2, and more frequent symptoms in convalescent health personnel vs controls prior to vaccination. MATERIAL AND METHODS: Analytical cross-sectional design of cases and controls, which included health personnel, from March to June 2020, confirmed with (polymerase chain reaction) PCR-SARS-CoV-2 and negative controls with PCR and anti-IgG-SARS-CoV-2. Participants were questioned concerning symptoms and BG was determined. It was used descriptive statistics and comparative analysis with chi squared, Fisher's exact test, Student's t, and Mann Whitney's U tests. RESULTS: Of 218 workers, 102 (46.8%) were confirmed cases for SARS-CoV-2 (convalescent) and 116 controls. The distribution of BG was similar between cases and controls, being BG-O + the most frequent (52.9%). The risk of becoming infected by SARS-CoV-2 for BG-O compared to BGNo-O showed a lower trend (odds ratio [OR] 0.725, 95% confidence interval [95% CI] 0.416-1.261, p = ns). The BG-A (28.4%) compared with BG-No-A (71.6%) showed a trend of increased risk in BG-A (OR 1.523, 95% CI 0.818-2.837, p = ns). The presence of SARS-CoV-2 IgG antibodies was 85% in the convalescent group. CONCLUSIONS: The prevalence of infected was proportionally higher for BG-A and lower for BG-O. About 15% did not develop SARS-CoV-2 antibodies after overcoming COVID-19 disease.

16.
Urologiia (Moscow, Russia) ; - (2):122-125, 2022.
Article in Russian | MEDLINE | ID: covidwho-1824112

ABSTRACT

The SARS-CoV-2 pandemic has brought serious economic and social problems worldwide'. Due to its medical consequences, it is of importance to study the mechanisms of the disease and new therapeutic interventions, as well as rehabilitation processes. Despite the fact that the genome of the new coronavirus has been sequenced and studied, clinical and epidemiological data are constantly updated and analyzed, and exact pathogenesis has not yet been understood. At the same time, domestic and foreign studies suggest that the virus is an agent that affects not only the lungs, vascular wall, hemostasis, but also the reproductive system. The aim of the review is to summarize the current knowledge about novel SARS-CoV-2, including its pathophysiology and potential impact on male reproductive function.

17.
International Journal of Aquatic Science ; 12(3):202-214, 2021.
Article in English | GIM | ID: covidwho-1824102

ABSTRACT

The covid-19 pandemic has caused a great health crisis, and which is the main challenge of human beings. The whole world is been fighting this pandemic. The rise of the coronavirus is being from Wuhan where we found the greatest number of patients. This epidemic disease of covid-19 has killed big number of groups around the globe. In this article, we've taken statistics from countries around the world and exposed the number of recovered, treated, and death cases. The fundamental goal of this article is to forecast the healthier, cured, and death cases with the assist of the prophet base model. The information has been gathered from 28 states of India and afterward compare the information with Wuhan and south Korea using machine learning and predicted the number of cases will come for coronavirus using the prophet basemodel.

18.
Nederlands Tijdschrift voor Geneeskunde ; 166(02):16, 2022.
Article in Dutch | MEDLINE | ID: covidwho-1823989

ABSTRACT

With air travel continuing after the SARS-CoV-2 pandemic as before, is there a risk of in-flight-transmission? We found 18 papers describing a total number of 306 index patients on 150 flights, 79 infected passengers and four infected cabin crew. Infection transmission within the aircraft cabin depends on flight occupancy, proximity to the index patient, duration of flight and the prevailing virus variant. A negative PCR-test has a sensitivity of 95 %, around 5 % of travelers will get a false negative result. Airborne transmission of virus-containing saliva droplets (aerosols) is considered the most important infection mechanism;infection via contaminated surfaces is less common. Strict distancing, with an empty middle seat, is essential. The risk of in-flight transmission can be further minimized by mandatory masking, restricting passenger movements, restricting meals and beverages, frequent hand sanitizing and complying to rules while boarding or at disembarkation.

19.
Al Ameen Journal of Medical Sciences ; 15(1):32-37, 2022.
Article in English | CAB Abstracts | ID: covidwho-1823916

ABSTRACT

Introduction: COVID 19 disease has wrecked a havoc as pandemic in the entire world. It causes cardiac manifestations, digestive system disturbances, and adversely affecting other organs. As a result, ardent efforts are underway to find effective antiviral treatments targeting possible mechanisms to identify a specific medication for the disease to curb its progression and to prevent patients sufferings, one such therapy being injectable antiviral treatment namely, Remdesivir. Objectives: To evaluate the clinical outcomes and safety profile of Remdesivir in COVID-19 patients in a tertiary care center. Methods: An observational retrospective cohort study was planned with sample size of 210 patients suffering from active moderate to severe COVID 19 disease admitted in a single center tertiary care hospital requiring injectable anti-viral therapy that is Remdesivir. Patient data was collected from the case record forms. Primary outcomes in terms of length of hospital stay, duration of treatment with Remdesivir, survival rate in patients on Remdesivir and assessment of the days for the COVID 19 positive test to eventually become negative in patients and secondary outcome in terms of safety were evaluated. Results: There was a clinically significant improvement in the SPO2 levels from the time of admission till discharge. The appearance of adverse effects was taken as the secondary outcome. Hepatic and renal toxicity was observed after completion of treatment whereas no immunological abnormalities were observed. Conclusion: Until stronger evidences come to the fore, we cannot derive substantial inference that our injectable antiviral therapy drug namely, Remdesivir is efficacious for treating COVID-19.

20.
Obshta Meditsina / General Medicine ; 24(2):9-12, 2022.
Article in Bulgarian | GIM | ID: covidwho-1823891

ABSTRACT

Introduction. Based on the WHO statistical overview of the past year the overall mortality rate across the EU showed a significant upward trend compared to the preceding three-year period, i.e. excessive mortality rates. In Bulgaria, during the COVID-19 pandemic, over the last year mortality rates peaked by 61.4% compared to the average rates observed in the period from 2017 to 2019. Data from official sources show that in the region of Plovdiv the number of confirmed COVID-19 cases is 36,484, of them - 1579 fatalities. Aim. An attempt to investigate and analyze the mortality rates due to COVID-19 and the most common related underlying medical conditions over a year period at St. George Hospital in Plovdiv was made. Materials and methods. The study is a retrospective analysis of descriptive design;a review of patient's medical records was applied for the last year. Results. In the study period registered deaths due to COVID-19 in the hospital were 492. The mortality rate in males was approximately twice, exceeding that of females - 316 (64.2%). The average age of diseased patients was 70.40 (SD +or-11.93), the youngest and oldest were 31 and 97 years of age, respectively. Deaths are more frequent in the age group over 65 (70.1%), compared to the 18 to 64.99 age group (29.9%). Conclusions. Hospital mortality rate due to COVID-19 is higher in men. The most frequent underlying medical conditions in deceased patients with COVID-19 are cardiovascular disorders, followed by endocrine diseases.

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