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1.
Medecine d'Afrique Noire ; 69(3):141-146, 2022.
Article | GIM | ID: covidwho-1824452

ABSTRACT

Introduction: The cardiovascular impact of SARS CoV-2 infection in black subjects is poorly described in the literature. This article reports a case of myocardial injury during this viral infection. Case report: A 63-year-old, hypertensive and diabetic woman whose symptomatology started with chest pain, was admitted in cardiogenic shock associated with severe bradycardia at 25 bpm due to complete atrioventricular block. Troponinemia was elevated at 33769.8 ng/mL and NT-proBNP greater than 25,000 pg/mL. Transthoracic echocardiography had shown abnormalities of left ventricular segmental kinetics with preserved ejection fraction and right ventricular dysfunction. The chest Computed Tomography (CT) scan diagnosed SARS CoV-2 infection by showing central and peripheral ground-glass opacity of the lungs. The SARS CoV-2 PCR test was negative twice. After a temporary transvenous cardiac pacing, heparin therapy, a combination of Ceftriaxone and antivirals, the evolution was marked by an initial clinical improvement followed by a secondary deterioration with aggravation of the biological inflammatory syndrome contrasting with the regression of atrioventricular block and myocardial injury. Death occurred on the 12th day of hospitalization.

2.
Journal of the Association of Physicians of India ; 70(January):28-32, 2022.
Article in English | GIM | ID: covidwho-1824435

ABSTRACT

Background: Although hydroxychloroquine (HCQ) lacks benefit in patients with moderate-to-severe COVID-19, its role in asymptomatic and mildly symptomatic disease needs better elucidation.

3.
Journal of the Dow University of Health Sciences ; 16(1):41-45, 2022.
Article in English | CAB Abstracts | ID: covidwho-1824381

ABSTRACT

The pandemic of CoronaVirus-19 (COVID-19) is an alarming situation worldwide as it poses a considerable threat to the healthcare system. Various study results suggested the effect of COVID-19 on non-communicable diseases (NCDs) including asthma. The present study aims to review, describe and assess the impact of COVID-19 on asthma patients. The results of the current review suggest a non-significant impact of asthma on COVID-19 outcomes. However, the impact of COVID-19 on asthmatics is complex that may vary according to the clinical severity, patient age, or genetics in different populations. Hence it is needed to conduct studies with a large number of cohorts in different populations that may provide us with conclusive results. The use of corticosteroids is not recommended, but some studies suggested that by monitoring certain factors corticosteroids can be used for COVID-19 patients suffering from asthma. The future care of asthmatic patients in COVID-19 should include self-management, remote interventions, and social distancing.

4.
Internal Medicine Alert ; 44(9), 2022.
Article in English | ProQuest Central | ID: covidwho-1824365

ABSTRACT

Post-COVID-19 vaccination changes to the menstrual cycle have been reported, particularly through social media, but little evidence exists.1,2 Fewer than 200 individuals have self-reported menstrual disturbances through the Vaccine Adverse Event Reporting System. The authors of this retrospective analysis used prospectively collected menstrual cycle data from the FDA-cleared digital fertility awareness application “Natural Cycles” to assess associations between changes in the menstrual cycle or menses length and the COVID-19 vaccine. When stressors occur during the first half of the menstrual cycle (the follicular phase, when a dominant follicle is recruited and matures), cycle length can change.3 The immune response generated by mRNA vaccines could function as a stressor and temporarily affect the H-P-O axis, depending on the timing of vaccination. Because of the 21-day dosing schedule for the Pfizer mRNA vaccine and 28-day dosing schedule for the Moderna mRNA vaccine, receiving two doses in a single cycle necessitates that the first dose occurs during the early follicular phase for a normal cycling individual.

5.
Case Reports in Ophthalmology ; 13(1):297-304, 2022.
Article in English | ProQuest Central | ID: covidwho-1824363

ABSTRACT

The recent outbreak of the severe acute respiratory syndrome coronavirus-2 has been declared a worldwide pandemic by the WHO. Within various multi-organ involvements, several ocular manifestations have been described. We report the case of a patient diagnosed with COVID-19 who presented with a progressive increase of bilateral cotton wool spots over a 1-week period, despite quick and complete recovery of systemic signs of the disease and no ocular symptoms. We followed the evolution of such lesions over a 3-month period. Here, we underline the importance of retinal screening even if no ocular symptom is reported. Furthermore, we demonstrate the essential role of fundus examination as a reflection of systemic vascular changes.

6.
Acta Medica Iranica ; 60(4):202-209, 2022.
Article in English | Academic Search Complete | ID: covidwho-1824333

ABSTRACT

The coronavirus disease 2019 (COVID-19) is a single-stranded RNA (+) virus and causes infectious disease by the viral strain "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2). Now, COVID-19 has become pandemic, and there are neither potential vaccines nor drugs discovered. Its RNA contains genes for structural (S, E, M, N) and non-structural proteins (PLpro, 3CLpro, RdRp, Hel). Interaction between the S protein of SARS-CoV-2 and the ACE 2 receptor of the host cell plays a vital role in the entry of the virus into the cell. Favipiravir, ribavirin, remdesivir, galidesivir, lopinavir, ritonavir, chloroquine, and hydroxychloroquine are the few effective drugs against SARS-CoV-2. Live attenuated virus (mutant MERS-CoV and SARS-CoV or recombination with another live attenuated virus) can act as vaccine platforms against SARS CoV-2 along with DNA vaccine and subunit vaccine. [ FROM AUTHOR] Copyright of Acta Medica Iranica is the property of Tehran University of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

7.
Obshta Meditsina / General Medicine ; 24(2):29-42, 2022.
Article in Bulgarian | GIM | ID: covidwho-1824315

ABSTRACT

During the COVID-19 pandemic, pharmacists have proved their role as the most accessible medical professionals who have the potential and knowledge to participate in vaccination campaigns. The aim is to conduct a systematic review of the published articles that analyze the available evidence for the benefits of pharmacists' participation in vaccination. A systematic review was conducted in the scientific database PubMed. A total of 39 studies were included in the qualitative synthesis based on a screening of the identified 980 studies in the databases. The benefits are related to increasing the percentage of immunized people and preventing the spread of vaccine-preventable diseases, better informing and motivating patients, positive impact on the level of immunization, helping to achieve the goals of immunization, improving population access to vaccines. The systematic review shows the essential role of the pharmacist in vaccination campaigns, as well as the benefits for the individual and for society as a whole.

8.
Case Reports in Dermatology ; 14(1):1-5, 2022.
Article in English | ProQuest Central | ID: covidwho-1824228

ABSTRACT

The clinical presentation of dermatomyositis (DM) is diverse, with varied phenotypes that may be correlated with specific autoantibodies. The anti-melanoma differentiation-associated gene 5 (MDA5) antibody in DM is associated with an amyopathic phenotype of DM, with several unusual cutaneous manifestation and increased risk for rapidly progressive interstitial lung disease. Initial presentation may be subtle, but early diagnosis is key to initiation of proper immunosuppressive therapy. In this report, we describe perinasal edema and erythema as a presenting complaint of anti-MDA5 DM in an otherwise healthy 40-year-old woman. The edema began shortly after heavy sun exposure and was followed by painful papules in her hands and arthritis within a few weeks. She was found to have high titer of anti-CCP and anti-MDA5, and thus was diagnosed with DM and rheumatoid arthritis overlap. A CT chest, abdomen, and pelvis showed patchy ground-glass and interstitial opacities in bilateral lower lobes consistent with mild interstitial lung disease without evidence of malignancy. Perinasal cutaneous findings and arthralgias improved with initiation of prednisone. To our knowledge, this is the first report of perinasal edema as a presenting symptom for DM and should raise suspicion for MDA-5 disease.

9.
Journal of the Association of Physicians of India ; 70(January):44-49, 2022.
Article in English | GIM | ID: covidwho-1824227

ABSTRACT

Objective: Though systemic corticosteroid is used for treatment of COVID 19, questions regarding the appropriate dose, duration and type of corticosteroid use still remain unanswered. This study aimed to address, whether choice of systemic corticosteroid significantly influences the clinical outcome of COVID 19 patients. Materials and Methods: Studies reporting the comparison between clinical outcome of dexamethasone and methylprednisolone in treatment of COVID 19 were searched from inception till April, 2021. Random-effect model was used. Odd's ratio (OR) and 95% confidence interval was expressed. I2 statistics used for test of heterogeneity. Result: Three studies with 373 patients (160 in dexamethasone group and 213 in methyl prednisolone group) were included. Though, statistically significant reduction in all-cause mortality with methyl prednisolone group in comparison to dexamethasone group (OR=1.80, 95%CI: 1.08 to 3.01, P=0.02) estimated, sub group analysis of observational studies did not support the finding (OR=1.60, 95% CI: 0.88 to 2.92, P=0.12). No significant difference in terms of need for invasive ventilator or intensive care unit (ICU) between the 2 groups. The grade of evidence was very low for both the outcomes. Conclusion and Relevance: In the present context, both dexamethasone and methyl prednisolone are equally effective in the management of COVID 19.

10.
Economic and Political Weekly ; 56(44), 2021.
Article in English | CAB Abstracts | ID: covidwho-1824226

ABSTRACT

Through a series of data visualisations, the article attempts to illustrate the economic repercussions of the COVID-19-induced lockdown of 2020 on rural households. It focuses on how consumption, labour and income, healthcare, access to relief programmes and migration were effected by the lockdown in six major states.

11.
Tehran University Medical Journal ; 79(9), 2021.
Article in Persian | CAB Abstracts | ID: covidwho-1824225

ABSTRACT

Background: Age is a strong risk factor for increasing the risk of severity and death from Covid-19. The risk of hospitalization for Covid-19 disease increases with age. Since the elderly constitute a large proportion of Covid-19 patients, the present study was performed to evaluate the severity of the disease in the hospitalized elderly due to Covid-19 and the delay in hospitalization and death resulting from it, for better disease management .

12.
Journal of the Association of Physicians of India ; 70(January):14-17, 2022.
Article in English | GIM | ID: covidwho-1824219

ABSTRACT

Importance: As there is no definitive treatment available for covid-19 pneumonia, with timed administration of tocilizumab as an adjuvant therapy in moderate to severe covid-19 pneumonia, we can reduce mortality due to cytokine storm.

13.
Case Reports in Neurology ; 14(1):58-67, 2022.
Article in English | ProQuest Central | ID: covidwho-1824156

ABSTRACT

Parsonage-Turner syndrome (PTS) following COVID-19 infection or vaccination is rare. The pathophysiology may involve an immune-mediated inflammatory reaction against brachial plexus nerve fibers in a genetically predisposed individual. We describe the clinical and electromyographic features of 6 patients presenting with the clinical picture of PTS following COVID-19 vaccination. All patients were referred for electromyographic studies to evaluate the acute onset of pain in the shoulder girdle/upper limb accompanied by muscle weakness in the distribution of one or more branches of the brachial plexus. Each patient had received the COVID-19 vaccine within a few weeks prior to the onset of symptoms. Patients underwent detailed neurological examinations followed by nerve conduction and EMG studies. The patients developed symptoms after a mean duration of 17 days (5 days–8 weeks) after receiving the COVID-19 vaccine. The initial symptom was pain in the shoulder girdle/upper limb, followed within days by muscle weakness. Physical examinations and EMG studies showed upper trunk brachial plexopathy in 2 patients, lower trunk plexopathy in 1 patient, posterior cord brachial plexopathy in 1 patient, and anterior/posterior interosseous nerve involvement in 2 patients. All patients either improved or attained complete resolution of the arm pain at follow-up. Three (50%) patients did not have any improvement in the arm/hand weakness, while 3 (50%) patients had some recovery in strength. PTS may occur after the COVID-19 vaccine and should be suspected in patients with symptoms and signs suggestive of acute brachial plexopathy. Studies of a larger series may provide insight into predisposing factors.

14.
International Journal of Aquatic Science ; 12(3):202-214, 2021.
Article in English | GIM | ID: covidwho-1824102

ABSTRACT

The covid-19 pandemic has caused a great health crisis, and which is the main challenge of human beings. The whole world is been fighting this pandemic. The rise of the coronavirus is being from Wuhan where we found the greatest number of patients. This epidemic disease of covid-19 has killed big number of groups around the globe. In this article, we've taken statistics from countries around the world and exposed the number of recovered, treated, and death cases. The fundamental goal of this article is to forecast the healthier, cured, and death cases with the assist of the prophet base model. The information has been gathered from 28 states of India and afterward compare the information with Wuhan and south Korea using machine learning and predicted the number of cases will come for coronavirus using the prophet basemodel.

15.
Case Reports in Ophthalmology ; 13(1):124-127, 2022.
Article in English | ProQuest Central | ID: covidwho-1824043

ABSTRACT

This report describes a case of acute uveitis following COVID-19 vaccination. A 21-year-old patient was referred to our department for decreased visual acuity and injection of the left eye. Two days prior, the patient received her second dose of the severe acute respiratory syndrome coronavirus 2 vaccine (BNT162b2, Pfizer-BioNTech). On ocular examination, her left eye’s best-corrected visual acuity was 20/250, and its intraocular pressure was 16 mm Hg on a noncontact tonometer. Hypopyon, 4+ cells, and flares were observed in the anterior chamber. The patient was diagnosed with acute uveitis. She received topical dexamethasone (0.1%) hourly and systemic prednisone (50 mg/day). After 7 days, her inflammatory symptoms were mostly resolved. COVID-19 vaccination can cause acute anterior uveitis, which is responsive to steroids.

16.
Working Paper - Department of Economics, Appalachian State University|2021. (21-05):32 pp. 19 ref. ; 2021.
Article in English | CAB Abstracts | ID: covidwho-1824028

ABSTRACT

The COVID-19 pandemic caused substantial economic changes. The airborne transmission of the coronavirus increased the environmental health risks associated with many activities that entailed little risk in the pre-pandemic period, including workplace risks and risks faced by consumers. While a large literature estimates local tradeoffs between money and reduced risk of negative health outcomes in many settings, little empirical evidence addresses consumer willingness to pay for reduction in environmental health risks associated with coronavirus transmission. We estimate professional sports fans' willingness to pay (WTP) for reduced likelihood of coronavirus infection through mask and social distancing policies at games using a stated preference approach. Regression results based on a latent class logit model using survey data collected from 1,391 fans of professional sports teams in five large U.S. metropolitan areas indicate increased attendance likelihood if the venue requires masks and limits attendance to below capacity. Latent class logit models indicate significant heterogeneity in WTP across risk scenarios and sports. We characterize the types of professional sports fan as casual fans who prefer a mask requirement but are indifferent to stadium and arena capacity, rabid fans who are anti-maskers and indifferent to capacity and fans who only have a positive WTP when there is a mask requirement and low stadium/arena capacity (i.e., opportunities for the greatest amount of social distancing).

17.
Case Reports in Ophthalmology ; 13(1):210-214, 2022.
Article in English | ProQuest Central | ID: covidwho-1823996

ABSTRACT

A 72-year-old male patient was referred to our outpatient clinic with a painful left eye protrusion accompanied by marked conjunctival chemosis and external ophthalmoplegia being progressed despite topical and oral antibiotic therapy. He developed ocular symptoms 9 days after receiving his second SARS-CoV-2 vaccine (VeroCell). Of note, in previous history, 2 weeks after the first dose of the COVID-19 vaccine, he also developed a life-threatening laryngeal oedema treated at an emergency care unit. MRI of the orbit excluded pansinusitis as possible origin of the orbital cellulitis, and repeated COVID-19 antigen and antibody PCR tests were negative during his hospitalization. On the next day after his admittance, parenteral dexamethasone 250 mg/die treatment was commenced resulting in a quick and complete resolution of the symptoms. Due to the facts regarding this case, such as the temporal coincidence and the lack of respective comorbidity, there might be a causative relationship between the vaccination and the presented orbital cellulitis. To the best of our knowledge, this is the first report on orbital cellulitis as a possible ocular adverse event following COVID-19 vaccination.

18.
Al Ameen Journal of Medical Sciences ; 15(1):32-37, 2022.
Article in English | CAB Abstracts | ID: covidwho-1823916

ABSTRACT

Introduction: COVID 19 disease has wrecked a havoc as pandemic in the entire world. It causes cardiac manifestations, digestive system disturbances, and adversely affecting other organs. As a result, ardent efforts are underway to find effective antiviral treatments targeting possible mechanisms to identify a specific medication for the disease to curb its progression and to prevent patients sufferings, one such therapy being injectable antiviral treatment namely, Remdesivir. Objectives: To evaluate the clinical outcomes and safety profile of Remdesivir in COVID-19 patients in a tertiary care center. Methods: An observational retrospective cohort study was planned with sample size of 210 patients suffering from active moderate to severe COVID 19 disease admitted in a single center tertiary care hospital requiring injectable anti-viral therapy that is Remdesivir. Patient data was collected from the case record forms. Primary outcomes in terms of length of hospital stay, duration of treatment with Remdesivir, survival rate in patients on Remdesivir and assessment of the days for the COVID 19 positive test to eventually become negative in patients and secondary outcome in terms of safety were evaluated. Results: There was a clinically significant improvement in the SPO2 levels from the time of admission till discharge. The appearance of adverse effects was taken as the secondary outcome. Hepatic and renal toxicity was observed after completion of treatment whereas no immunological abnormalities were observed. Conclusion: Until stronger evidences come to the fore, we cannot derive substantial inference that our injectable antiviral therapy drug namely, Remdesivir is efficacious for treating COVID-19.

19.
Obshta Meditsina / General Medicine ; 24(2):9-12, 2022.
Article in Bulgarian | GIM | ID: covidwho-1823891

ABSTRACT

Introduction. Based on the WHO statistical overview of the past year the overall mortality rate across the EU showed a significant upward trend compared to the preceding three-year period, i.e. excessive mortality rates. In Bulgaria, during the COVID-19 pandemic, over the last year mortality rates peaked by 61.4% compared to the average rates observed in the period from 2017 to 2019. Data from official sources show that in the region of Plovdiv the number of confirmed COVID-19 cases is 36,484, of them - 1579 fatalities. Aim. An attempt to investigate and analyze the mortality rates due to COVID-19 and the most common related underlying medical conditions over a year period at St. George Hospital in Plovdiv was made. Materials and methods. The study is a retrospective analysis of descriptive design;a review of patient's medical records was applied for the last year. Results. In the study period registered deaths due to COVID-19 in the hospital were 492. The mortality rate in males was approximately twice, exceeding that of females - 316 (64.2%). The average age of diseased patients was 70.40 (SD +or-11.93), the youngest and oldest were 31 and 97 years of age, respectively. Deaths are more frequent in the age group over 65 (70.1%), compared to the 18 to 64.99 age group (29.9%). Conclusions. Hospital mortality rate due to COVID-19 is higher in men. The most frequent underlying medical conditions in deceased patients with COVID-19 are cardiovascular disorders, followed by endocrine diseases.

20.
Case Reports in Ophthalmology ; 13(1):185-190, 2022.
Article in English | ProQuest Central | ID: covidwho-1823840

ABSTRACT

Coronavirus disease-19 (COVID-19) patients are at an increased risk of cerebral venous sinus thrombosis (CVST). Rapid diagnosis and treatment are vital to ensure a favorable outcome for CVST, so clinicians need to be aware of all its potential presentations. We describe a unique case where transient visual obscurations (TVOs) from papilledema were the presenting symptoms of COVID-19-related CVST. A 43-year-old woman, who had tested positive for severe acute respiratory syndrome coronavirus-2 1 month earlier, developed holocephalic headache, TVOs, and bilateral disc edema. She did not seek medical attention until she developed TVOs. Visual acuity was 20/20 and Humphrey visual field testing showed enlarged blind spots in both eyes. She was diagnosed with papilledema and underwent magnetic resonance imaging and magnetic resonance venography of the brain, which revealed right transverse sinus thrombosis. Lumbar puncture was performed, showing elevated opening pressure and normal cerebrospinal fluid contents. Her optic disc edema resolved and visual function remained normal 6 weeks following warfarin and topiramate therapy. Recanalization of the right transverse sinus occurred after 3 months. Although rare, TVOs are important presenting symptoms of COVID-19-related CVST. Ophthalmologists, who may be the first physicians to assess patients with this presentation, should be aware of TVOs as potential presenting symptoms of CVST, so diagnoses can be made in a timely manner.

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