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Journal of Pharmacology and Pharmacotherapeutics ; 13(1):95-96, 2022.
Article in English | EMBASE | ID: covidwho-1916510
Journal of Food Processing and Preservation ; : 12, 2021.
Article in English | Web of Science | ID: covidwho-1559472


An attempt was made to develop chicken protein-based shelf-stable snacks and to improve their lipid-oxidative and microbial-stability using Solanum nigrum extract. The snacks were developed using different levels of chicken protein-powder viz. 20% (T-1), 30% (T-2), 40% (T-3), and 0.0% (control). Products containing optimum level of protein-powder (40%) and S. nigrum extract (1.0%) were stored for 75 days (25 +/- 1 degrees C). The addition of protein-powder significantly decreased the carbohydrate whereas increased protein and fat contents. Products containing 40% protein-powder showed the highest scores for all sensory attributes. The 1,1 diphenyl-2picrylhydrazyl-radical scavenging and total-phenolic content of S. nigrum extract was 79.0% and 80 mg GAE/g, respectively. The extract significantly reduced the free-fatty acids, thiobarbituric acid reacting substances, and microbial counts while improving the sensory quality of the products during storage. S. nigrum and protein-powder improved the nutritive value and storage stability of the shelf-stable snacks. S. nigrum-based snacks can have health importance during the pandemic of SARS-CoV-2 due to their strong immune-boosting properties. Novelty impact statement Chicken protein-based shelf-stable snacks were developed and Solanum nigrum extract was used to improve their storage quality and functional value. The extract improved the lipid oxidative and microbial stability of the developed products.

J Biomol Struct Dyn ; : 1-22, 2021 Sep 17.
Article in English | MEDLINE | ID: covidwho-1416028


Stem and bark of the tree Terminalia arjuna Wight & Arn. (Combretaceae) has been documented to exhibit therapeutic properties like cardiotonic, anticancer, antiviral, antibacterial, antifungal, hypercholesterolemia, hypolipidemic, and anti-coagulant. Our previous studies have shown that, ethanolic extract of T. arjuna bark exhibits radical scavenging anti-oxidant activity and also effectively inhibited catalase activity. In this study, oleanane triterpenoids type compounds viz., oleanolic acid, arjunolic acid, arjunolitin, arjunetin were isolated from ethanolic bark extract as bio-active compound and their structures were elucidated using 1H, 13C NMR, HR-ESIMS, IR. Of the various compounds, Arjunetin showed significant inhibition of catalase activity as compared to the other compounds. Based on the structural similarity between arjunetin and current antiviral drugs, we propose that arjunetin might exhibit antiviral activity. Molecular docking and molecular dynamics studies showed that arjunetin binds to the binds to key targets of SARS-CoV-2 namely, 3CLpro, PLpro, and RdRp) with a higher binding energy values (3CLpro, -8.4 kcal/mol; PLpro, -7.6 kcal/mol and RdRp, -8.1 kcal/mol) as compared with FDA approved protease inhibitor drugs to Lopinavir (3CLpro, -7.2 kcal/mole and PLpro -7.7 kcal/mole) and Remdesivir (RdRp -7.6 kcal/mole). To further investigate this, we performed 200-500 ns molecular dynamics simulation studies. The results transpired that the binding affinity of Arjunetin is higher than Remdesivir in the RNA binding cavity of RdRp. Based on structural similarity between arjunetin and Saikosaponin (a known antiviral agents) and based on our molecular docking and molecular dynamic simulation studies, we propose that arjunetin can be a promising drug candidate against Covid-19.Communicated by Ramaswamy H. Sarma.