Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 3.146
Filter
Add filters

Year range
1.
Eur J Pediatr ; 2022 Nov 04.
Article in English | MEDLINE | ID: covidwho-2103890

ABSTRACT

There is a considerable burden of children being hospitalized due to infectious diseases worldwide. The COVID-19 pandemic provided a unique opportunity to examine effects of worldwide efforts to control spread of infection. We aimed to investigate overall age-specific hospitalizations due to viral and bacterial infections and diseases triggered by respiratory tract infections during and after lockdown. This nationwide register-based observational study included children from 29 days to 17 years old hospitalized in all Danish pediatric emergency departments during the years 2015-2021. Main outcomes were ICD-10 diagnoses for infectious diseases and infection triggered illnesses. Fluctuations in hospitalization events were explored using figures with weekly events per 100,000. Total events followed a predictable pattern during 2015-2019. In 2020-2021, there was a drop in hospital encounters after lockdowns and surge after reopenings. In 2021, there was a surge of hospital encounters in the late summer due to respiratory syncytial virus infections and asthmatic bronchitis mostly in infants from 29 days to 2 years. For the infectious diseases, there was a dramatic decrease in events after lockdowns and immediate increase in cases that followed the same pattern of previous years after reopenings. Bacterial infections, like urinary tract infections, sepsis, and meningitis followed a steady pattern throughout all calendar-years. CONCLUSIONS: Nationwide efforts to minimize infectious disease spread like lockdowns have a preventative and period lasting effect but reopenings/reunions result in surges of infectious diseases. This might be due to children not getting immunized steadily thereby increasing the pool of possible hosts for potential viral infections. WHAT IS KNOWN: • There is a seasonal fluctuation in viral/respiratory infections in children with higher infection rates in the winter and lower rates in the summer. • RSV infection is a major source of concern. WHAT IS NEW: • Major lockdowns and reopenings disrupt the seasonal fluctuations which can result in high surges in infections that increases the burden of children emergency departments and the risk of serious complications.

2.
Meditsinskiy Sovet ; 2022(18):95-99, 2022.
Article in Russian | Scopus | ID: covidwho-2100669

ABSTRACT

Introduction. At the present time, the incidence of acute respiratory viral infections (ARVI) remains at a high level. Some patients who have undergone ARVI and COVID-19 have been disturbed by astheno-neurotic syndrome and chronic fatigue syndrome for quite a long time. Aim. To study the efficacy and safety dietary supplement treatment in the rehabilitation of patients recovered after acute respiratory viral infections. Materials and methods. We have examined 50 patients diagnosed with acute respiratory viral infections (38 people) and COVID-19 (12 people). Age of patients: from 25 years to 60 years old, average age 35 ± 11.84 years old. All patients were randomized into two study groups: the first group (25 people) received a biologically active food supplement and the second group (25 people) did not receive such complex. Сomplex was prescribed to the participants of the first group in amount of two capsules once a day. The course of therapy was 14 days. Before and after taking, all patients were assessed for shortness of breath on the MRC scale, depression on the Beck scale, chronic fatigue syndrome on the FAS scale, and the level of C-reactive protein (CRP) was assessed as well. Results. In the course of the observation, no significant difference between the groups was recorded in the dynamics of the state of assessment for dyspnea, depression and hemoglobin level. The average level of CRP before taking in the first group was 4.4 mg/l (from 0 to 22 mg/l), in the second – 3.8 mg/l (from 0 to 14 mg/l). When comparing the dynamics in the first group, there was more pronounced decrease in the level of CRP. In the first group, decrease in manifestations of pathological fatigue was revealed, characterized by decrease in FAS scores compared to the control group, where the number of scores, on the contrary, increased. Conclusions. Сomplex has a corrective effect on astheno-neurotic symptoms after suffering from acute respiratory viral infections or post-COVID syndrome. © 2022, Remedium Group Ltd. All rights reserved.

3.
Ann Glob Health ; 88(1): 94, 2022.
Article in English | MEDLINE | ID: covidwho-2100231

ABSTRACT

Background: Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in >554M cases and >6.3M deaths worldwide. The disease caused by SARS-CoV-2, COVID-19, has resulted in a broad range of clinical symptoms differing in severity. Initially, the elderly were identified as particularly susceptible to severe COVID-19, with children experiencing less severe disease. However, as new variants arise, the epidemiology of SARS-CoV-2 infection is changing, and the disease severity in children is increasing. While environmental impacts on COVID-19 have been described, the underlying mechanisms are poorly described. Objective: The Pacific Basin Consortium for Environment and Health (PBC) held meeting on September 16, 2021, to explore environmental impacts on infectious diseases, including COVID-19. Methods: The PBC is an international group of environmental scientists and those interested in health outcomes. The PBC met to present preliminary data and discuss the role of exposures to airborne pollutants in enhancing susceptibility to and severity of respiratory tract viral infections, including COVID-19. Findings: Analysis of the literature and data presented identified age as an important factor in vulnerability to air pollution and enhanced COVID-19 susceptibility and severity. Mechanisms involved in increasing severity of COVID-19 were discussed, and gaps in knowledge were identified. Conclusions: Exposure to particulate matter (PM) pollution enhanced morbidity and mortality to COVID-19 in a pediatric population associated with induction of oxidative stress. In addition, free radicals present on PM can induce rapid changes in the viral genome that can lead to vaccine escape, altered host susceptibility, and viral pathogenicity. Nutritional antioxidant supplements have been shown to reduce the severity of viral infections, inhibit the inflammatory cytokine storm, and boost host immunity and may be of benefit in combating COVID-19.


Subject(s)
Air Pollution , COVID-19 , Virus Diseases , Child , Humans , Aged , COVID-19/epidemiology , SARS-CoV-2 , Air Pollution/adverse effects , Particulate Matter/adverse effects , Particulate Matter/analysis , Environment
4.
Micromachines (Basel) ; 13(11)2022 Nov 03.
Article in English | MEDLINE | ID: covidwho-2099662

ABSTRACT

Abundant immunological assays currently exist for detecting pathogens and identifying infected individuals, making detection of diseases at early stages integral to preventing their spread, together with the consequent emergence of global health crises. Lateral flow immunoassay (LFIA) is a test characterized by simplicity, low cost, and quick results. Furthermore, LFIA testing does not need well-trained individuals or laboratory settings. Therefore, it has been serving as an attractive tool that has been extensively used during the ongoing COVID-19 pandemic. Here, the LFIA strip's available formats, reporter systems, components, and preparation are discussed. Moreover, this review provides an overview of the current LFIAs in detecting infectious viral antigens and humoral responses to viral infections.

5.
Front Microbiol ; 13: 1035267, 2022.
Article in English | MEDLINE | ID: covidwho-2099189
6.
Commun Dis Intell (2018) ; 462022 Oct 20.
Article in English | MEDLINE | ID: covidwho-2091647

ABSTRACT

Abstract: Imported, minimally processed food products have been historically associated with several hepatitis A outbreaks in Australia. Here, we report the first known hepatitis A outbreak in Australia linked to consumption of imported fresh Medjool dates. Between June and September 2021, six genetically identical hepatitis A cases were notified in New South Wales and the Australian Capital Territory. All cases reported date consumption during their exposure period. The implicated dates were positive for hepatitis A virus (HAV) by reverse transcription polymerase chain reaction. Rapid detection of this outbreak and the swift implementation of control measures was facilitated by two key factors. Firstly, Australian international border closures implemented in response to the COVID-19 pandemic meant that a common locally-acquired, as opposed to travel-acquired, source for cases was strongly suspected. Secondly, prompt awareness of a hepatitis A outbreak in the United Kingdom (which was found to be associated with date consumption) allowed for early hypothesis generation and investigation. This paper details the epidemiological and microbiological factors involved in this outbreak investigation and the actions taken to mitigate public health risk.


Subject(s)
COVID-19 , Hepatitis A , Humans , Australia/epidemiology , Hepatitis A/epidemiology , Pandemics , COVID-19/epidemiology , Disease Outbreaks
7.
Annals of Phytomedicine-an International Journal ; 10:12-28, 2021.
Article in English | Web of Science | ID: covidwho-2072557

ABSTRACT

Viral infections are contagious and deadly. Many viral attacks in the past decades including COVID-19 have turned into pandemics and cost millions of lives. Treatment to virus is difficult as they transform themselves into many variants. Thus, an intelligent way of keeping oneself out of the trouble is through better nutrition that enhance immune responses. Foods that provide high quantities of nutrients are vegetables, fruits and nuts. They are rich in fibres, fats, protein, vitamins, minerals and plant bioactive compounds like phytosterols, polyphenolics, flavonoids, etc. Many studies and randomised control trials have proven their therapeutic effects and health promoting capacities. These compounds interfere with the pathways of metabolic mechanisms in the human body and work by either providing a protective scope or by destroying any harmful incomings into the body;that would disrupt the homeostasis. In this article, nuts and their nutritive components that administer healthy benefits are discussed. Almonds, cashew nuts, pistachios, peanuts, chestnuts and Brazil nuts are examined and reviewed here. The nutritional composition of these nuts and their mechanism to offer medicinal properties are explained in detail. Apart from nutritional values, these nuts are rich source of antioxidants that confer anti-inflammatory and immunomodulatory features. These activities enhance the immune responses by activating the defense mechanisms. Apart from the intake of highly nutritious diet, practising social distancing, isolation and better sanitation procedures are highly beneficial to avoid the severity of the viral attacks.

8.
3rd IEEE Bombay Section Signature Conference, IBSSC 2021 ; 2021.
Article in English | Scopus | ID: covidwho-1711317

ABSTRACT

Chest Radiography proves to be a faster, cheaper, and less invasive diagnosis mode for respiratory diseases like pneumonia and viral infections like the coronavirus. The utilization of AI based strategies for programmed finding or imaging are pretty prevalent. In this work, a deep learning model is proposed for automatically segmenting chest X-ray images. The model comprises 20 fully convolutional layers that simplify images to precisely section the lung lobes from the X-ray images. The utilization of transposed convolution offers a lesser computational overhead than traditional methods. The proposed model achieves an accuracy of 97%, with an average Dice coefficient of 0.95 and an average Jaccard (IoU) score of 0.90. The proposed model is trained and tested on publicly available Montgomery County (MC) and Shenzen Hospital (SH) datasets. The segmentation ability of the proposed model can be used as input for predictive models, achieving better accuracy and faster convergence. © 2021 IEEE.

9.
Przegl Epidemiol ; 76(2): 147-149, 2022.
Article in English | MEDLINE | ID: covidwho-2067617

ABSTRACT

People living with HIV (PLWH) are a heterogeneous group of immunocompromised persons. Detectable HIV viral load and chronic comorbidities are independently increasing the risk of severe outcomes from COVID-19 among PLWH. We aimed to assess the efficacy and safety of the COVID-19 vaccines in PLWH. A significant increase in S-RBD antibody titers >100 AU/mL was observed when compared the titers measured one week after the 1st dose to titers performed after the 2nd vaccine dose.


Subject(s)
COVID-19 , HIV Infections , Viral Vaccines , Antibodies, Viral , COVID-19/prevention & control , COVID-19 Vaccines , HIV Infections/prevention & control , Humans , Poland , SARS-CoV-2 , Vaccination
10.
Pakistan Journal of Psychological Research ; 37(3):381-397, 2022.
Article in English | ProQuest Central | ID: covidwho-2067643

ABSTRACT

The outbreak of the contagion corona virus disease has engrossed worldwide attention. The nature of the disease and its spread has put excessive burden on service providers leading to burn out. In the face of health threats and work pressure during pandemic, the current study aimed to investigate the impact of COVID-19 stress on Burnout among health care providers. Following a convenient sampling technique, a sample of 153 healthcare providers with an age ranged from 24 to 60 years were assessed with COVID Stress Scale (Taylor, et al., 2020) and Maslach Burnout Inventory (MBI;Maslach et al., 1997). SPSS 21 was used for statistical analysis of data. Findings revealed that Sub-Scales of COVID stress collectively explained 48% of variance in predicting emotional exhaustion and 39% variance in producing depersonalization among healthcare providers. However, COVID stress negatively predicted personal accomplishment among healthcare providers. Moreover, t-test revealed that female healthcare providers showed higher level of COVID stress i.e. danger, socio-economic consequence, xenophobia and compulsive checking as compared to males while non-significant gender differences were observed for contamination and traumatic stress. The study also found a higher level of personal accomplishment among male healthcare providers whereas female healthcare providers demonstrated higher level of emotional exhaustion and depersonalization in comparison to male health care providers.

11.
African Journal of Reproductive Health ; 26(8):9-12, 2022.
Article in English | ProQuest Central | ID: covidwho-2067583

ABSTRACT

In sum, the totality of the available evidence suggests that there is currently limited research data relating to the pathogenesis, consequences, and outcomes of pregnancy in African women infected with new viral illnesses such as COVID-19, Lassa fever, and Ebola virus disease. World Health Organization (2020) Ebola virus disease. https://www.who.int/news-room/fact-sheets/detail/ebolavirus-disease 7. In Guidelines for screening and caring for pregnant women with Ebola virus disease for health care providers in US hospitals. Jamieson DJ, Uyeki TM, Callaghan WM, Meaney-Delman D, Rasmussen SA. What obstetrician-gynecologist should know about Ebola: a perspective from the Centers for Disease Control and Prevention.

12.
J Xenobiot ; 12(4): 289-306, 2022 Oct 08.
Article in English | MEDLINE | ID: covidwho-2066215

ABSTRACT

The highly contagious coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a global pandemic and public health emergency as it has taken the lives of over 5.7 million in more than 180 different countries. This disease is characterized by respiratory tract symptoms, such as dry cough and shortness of breath, as well as other symptoms, including fever, chills, and fatigue. COVID-19 is also characterized by the excessive release of cytokines causing inflammatory injury to the lungs and other organs. It is advised to undergo precautionary measures, such as vaccination, social distancing, use of masks, hygiene, and a healthy diet. This review is aimed at summarizing the pathophysiology of COVID-19 and potential biologically active compounds (bioactive) found in plants and plant food. We conclude that many plant food bioactive compounds exhibit antiviral and anti-inflammatory properties and support in attenuating organ damage due to reduced cytokine release and improving the recovery process from COVID-19 infection.

13.
CAB Abstracts; 2022.
Preprint in English | CAB Abstracts | ID: ppcovidwho-345451

ABSTRACT

Background: Over 50 million cases of COVID-19 have been confirmed globally as of November 2020. Evidence is rapidly emerging on the epidemiology of COVID-19, and its impact on individuals and potential burden on health services and society. Between 10-35% of people with COVID-19 may experience post-acute long Covid. This currently equates to between 8,129 and 28,453 people in Scotland. Some of these people will require rehabilitation to support their recovery. Currently, we do not know how to optimally configure community rehabilitation services for people with long Covid.

14.
Encyclopedia of Sensors and Biosensors (First Edition) ; : 158-173, 2023.
Article in English | ScienceDirect | ID: covidwho-2060202

ABSTRACT

This article focuses upon new challenges faced by today’s society which electrochemical sensors maybe able to address. Focusing primarily upon two of the major challenges faced at the time of writing;the opioid crisis caused by fentanyl and the deadly Covid-19 pandemic, the employment of electrochemical sensors is assessed to determine the contribution they could make toward tackling these problems. Although only a small scope of the electrochemical research present is covered within this article the principles discussed are directly translated to other fields where electrochemical sensors could be applied. This article to aims to highlight the uses of electrochemical sensors and discusses in detail both their advantages but also where further improvements are required to improve their applications across a range of fields.

15.
Antimicrobial Activity of Nanoparticles ; : 1-18, 2023.
Article in English | ScienceDirect | ID: covidwho-2060199

ABSTRACT

Infectious diseases cause around 20% of global mortality. Bacterial and viral infections stand among the top 10 global causes of death, including respiratory infections, tuberculosis, HIV/AIDS, dengue, and most recently severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical approach to treat bacterial infections has been the use of antibiotics, whereas for viral infections the use of vaccines and specific drugs that reduce viral replication have been the most effective approaches, respectively. The overuse of antibiotics and antifungal compounds added to the natural evolution of microorganisms has opened a new era of multidrug-resistant bacteria and fungi. The development and clinical trial of novel antimicrobial agents require many years and millions of dollars in research. During the last decade, the area of nanotechnology has evolved to produce innovative solutions for human problems. Here, we present an overview of the uses and applications of nanoparticles targeting the main responsible of human infections, particularly bacterial, fungal, and viral infections. The use of nanoparticles is considered as an alternative or complementary strategy to the clinical treatment of infections. The versatility and multifunctionality of nanoparticles make them ideal to treat, inhibit, and diagnose infections, especially emerging infectious agents that do not have a specific treatment or vaccine available.

16.
Pakistan Journal of Medical Sciences Quarterly ; 38(7):1808, 2022.
Article in English | ProQuest Central | ID: covidwho-2058002

ABSTRACT

Objectives: To investigate the role of asymmetric dimethylarginine (ADMA) level in predicting intensive care and mortality in patients affected with coronavirus disease 2019 (COVID-19). Methods: This retrospective, cross-sectional study was conducted at Sakarya University Training and Research Hospital (Sakarya, Turkey) between April and August of 2020. We enrolled patients who were diagnosed with COVID-19 via real-time reverse-transcription polymerase chain reaction and admitted to the intensive care (Severe COVID-19;S-COVID) or non intensive care (Moderate COVID-19;M-COVID). We then analyzed the relationship of the ADMA level with various parameters between S-COVID and M-COVID groups. Results: This study included 87 patients, comprising 43 females and 44 males, with a mean age of 61 and 71.50 years, respectively. The male/female distribution was 22/25 (46.8%/53.2%) in the M-COVID group and 22/18 (55%/45%) in the S-COVID group. The hospitalization time, white blood cell count, neutrophil count, lymphocyte-to-albumin ratio, international normalization ratio, D-dimer, troponin, ferritin, lactate dehydrogenase, C-reactive protein, procalcitonin, erythrocyte sedimentation rate, fibrinogen, lactate, ADMA, and mortality rate were significantly higher (p < 0.05). In contrast, lymphocyte, total cholesterol, high-density lipoprotein, calcium, and albumin values were lower (p < 0.05) in the S-COVID group than in the M-COVID group. While the mortality rate was 55% in S-COVID patients, no mortality was detected in M-COVID patients (p < 0.05). Moreover, ADMA level was 6618 ± 3000 (6400) in S-COVID patients and 5365 ± 3571 (3130) in M-COVID patients, indicating a statistically significant difference (p = 0.012). Conclusion: The asymmetric dimethylarginine level increases in severe outcomes;hence, it can potentially predict severity in patients with COVID-19.

17.
Pakistan Journal of Medical Sciences Quarterly ; 38(7):1870, 2022.
Article in English | ProQuest Central | ID: covidwho-2057467

ABSTRACT

Background and Objective: Biological markers for the prediction of acquiring Covid-19 risk are deficient and there is a dire need of immediate research data. The objective of the study was to predict the link of ABO blood group types along with Rh factor distribution with the severity of Covid-19. Methods: This was an observational cross-sectional survey conducted in medicine department of Pakistan Ordnance Factory Hospital, Wah Cantt Pakistan, from August 2020 to December 2020 after approval of IRB. Participants tested positive for presence of Covid-19 infection by polymerase chain reaction (PCR) were included in the study. Covid-19 infection severity was measured through mild, moderate and severe disease categories and analyzed. ABO blood group and Rh subgroups data for all the Covid-19 infected patients were obtained from the laboratory section of the hospital and analyzed. Data was entered in SPSS v 26 and analyzed. Cox regression model was used to find out the severity of Covid-19. Results: Total 248 patients were included;75% patients were male and 25% were females. The mean age of the patients was 52.77±15.58 years. A very significant association was found between ABO blood group types, Rh factor antigen and severity of Covid-19 (p=0.001). When stratified ABO, Rh antigen blood group with health status of all patients there was a very significant association between them (p=0.013). An insignificant association between male and female odds ratio of ABO blood group types but blood group B, Rh positive antigen was more susceptible in Covid-19 positive patients. Conclusion: There is a link between ABO blood group types along with Rh factor antigen (B+ and O+) with the severity of Covid-19 positive patients. ABO blood group types and Rh factor can be used as a potential marker/tool to predict the susceptibility of acquiring Covid-19 infection as well as for severity of the infection.

18.
Journal of Clinical and Basic Research ; 6(1):37-45, 2022.
Article in English | GIM | ID: covidwho-2057220

ABSTRACT

Background and objectives: The coronavirus disease 2019 (COVID-19) pandemic is one of the most important healthcare and social challenges. The aim of this study was to evaluate the effect of acceptance and commitment therapy (ACT) on depression and quality of life among women with chronic pain during the COVID-19 pandemic lockdown.

19.
Journal of Clinical and Basic Research ; 6(1):11-27, 2022.
Article in English | CAB Abstracts | ID: covidwho-2057219

ABSTRACT

Coronavirus disease 2019 (COVID-19) is a severe acute respiratory disease with a high prevalence. According to the research and statistical data, in January 2021, there have been 92,262,621 confirmed cases of COVID-19 and more than two million deaths. Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the main cause of this disease. In addition to the respiratory system, the disease affects the gastrointestinal tract, central-peripheral nervous system, circulatory system, and kidneys. Therefore, any therapeutic action to reduce COVID-19-related symptoms and complications is essential. In this study, we conducted a systematic review of the published literature and preprints on the efficacy of erythropoietin (EPO) and recombinant human EPO as a safe stimulant and tissue protector in the treatment of COVID-19. We also briefly described the structure of coronavirus, its pathogenesis, and the structure of EPO and recombinant human EPO. All relevant articles published in the Science Direct, PubMed, and Google Scholar databases were searched. According to the results, EPO is a cytoprotective cytokine induced by hypoxia. The pleiotropic effects of EPO are associated with its erythrocyte-forming, anti-apoptotic, anti-inflammatory activities. It also exerts protective effects on the heart, lungs, kidneys, arteries, and central and peripheral nervous systems. It has been demonstrated that EPO can increase hemoglobin levels, thereby increasing oxygen delivery to the tissues. Therefore, recombinant human EPO therapy can be used for counteracting the adverse effects of COVID-19 including hypoxic myocarditis, acute renal failure, pulmonary edema, and brain-spinal cord ischemic injury. Overall, the use of EPO and recombinant human EPO therapy increases blood coagulation, tumor growth, thromboembolism, and purification of red blood cells, which must be accompanied by anticoagulants such as heparin.

20.
Journal of Guilan University of Medical Sciences ; 30(2), 2021.
Article in Persian | CAB Abstracts | ID: covidwho-2057029

ABSTRACT

The current study sought to examine the clinical, laboratory, and imaging aspects of COVID-19-positive critically sick patients who were admitted to the intensive care units (ICUs) at three hospitals in Rash City, Iran. The goal of this retrospective study was to examine 138 COVID-19 patients who had been hospitalized to the intensive care unit. Data on the study participants' demographics, underlying diseases, laboratory and imaging results, and prognosis of the diseases were taken from their medical records. 138 COVID-19 patients who were hospitalised to the intensive care unit were the subject of this retrospective analysis. Patient records were used to extract information about the patient, including demographic details, underlying diseases, laboratory and imaging results, and disease outcomes. The majority of the patients in this study were male and between the ages of 55 and 69. The most prevalent underlying conditions were diabetes mellitus, hypertension, and chronic heart disease;the most prevalent symptoms were shortness of breath, fever, and cough. The most prevalent lung Computer Tomography (CT) scan finding was ground glass opacities, and the most frequent laboratory findings in the study participants were an increase in LDH, ESR, CRP, neutrophil percentage, and lymphopenia. A 90.58% fatality rate was recorded. This study showed that the majority of patients with severe disease presentations were older, had a history of underlying disease, symptoms of shortness of breath, cough, and fever, substantial lung involvement in imaging, and altered laboratory findings. Despite medical treatment and mechanical ventilation, mortality remained high.

SELECTION OF CITATIONS
SEARCH DETAIL